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800 pSG5L HA PTEN wt Citations (25)

Plasmid Article: Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR Proc Natl Acad Sci U S A. 1999 Mar 2. 96(5):2110-5.
PubMed Journal

Articles Citing 800 pSG5L HA PTEN wt

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA. EMBO J. 2009 May 20;28(10):1505-17. doi: 10.1038/emboj.2009.101. Epub 2009 Apr 16. PubMed
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. Neuropsychopharmacology. 2011 Jun;36(7):1397-411. doi: 10.1038/npp.2011.24. Epub 2011 Mar 9. PubMed
Adaptive basal phosphorylation of eIF2alpha is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles BL. Mol Cancer Res. 2011 Dec;9(12):1708-17. doi: 10.1158/1541-7786.MCR-11-0299. Epub 2011 Oct 18. PubMed
Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells. Jin W, Reddy MA, Chen Z, Putta S, Lanting L, Kato M, Park JT, Chandra M, Wang C, Tangirala RK, Natarajan R. J Biol Chem. 2012 May 4;287(19):15672-83. doi: 10.1074/jbc.M111.322669. Epub 2012 Mar 19. PubMed
A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin. Sonntag AG, Dalle Pezze P, Shanley DP, Thedieck K. FEBS J. 2012 Sep;279(18):3314-28. doi: 10.1111/j.1742-4658.2012.08582.x. Epub 2012 May 3. PubMed
SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT. Bhoopathi P, Gorantla B, Sailaja GS, Gondi CS, Gujrati M, Klopfenstein JD, Rao JS. PLoS One. 2012;7(5):e36093. doi: 10.1371/journal.pone.0036093. Epub 2012 May 2. PubMed
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. Beckham TH, Cheng JC, Lu P, Marrison ST, Norris JS, Liu X. PLoS One. 2013 Oct 1;8(10):e76593. doi: 10.1371/journal.pone.0076593. eCollection 2013. PubMed
Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells. Cordero-Espinoza L, Hagen T. J Biol Chem. 2013 Dec 13;288(50):36020-8. doi: 10.1074/jbc.M113.510289. Epub 2013 Oct 29. PubMed
The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury. Ohtake Y, Park D, Abdul-Muneer PM, Li H, Xu B, Sharma K, Smith GM, Selzer ME, Li S. Biomaterials. 2014 May;35(16):4610-26. doi: 10.1016/j.biomaterials.2014.02.037. Epub 2014 Mar 12. PubMed
FOXC2 promotes colorectal cancer metastasis by directly targeting MET. Cui YM, Jiao HL, Ye YP, Chen CM, Wang JX, Tang N, Li TT, Lin J, Qi L, Wu P, Wang SY, He MR, Liang L, Bian XW, Liao WT, Ding YQ. Oncogene. 2015 Aug 13;34(33):4379-90. doi: 10.1038/onc.2014.368. Epub 2014 Nov 10. PubMed
Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer. Dhar S, Kumar A, Li K, Tzivion G, Levenson AS. Biochim Biophys Acta. 2015 Feb;1853(2):265-75. doi: 10.1016/j.bbamcr.2014.11.004. Epub 2014 Nov 13. PubMed
Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1. Yang S, Zhang L, Chen X, Chen Y, Dong J. J Biol Chem. 2015 Mar 6;290(10):6191-202. doi: 10.1074/jbc.M114.624411. Epub 2015 Jan 20. PubMed
The mitochondrial permeability transition pore regulates endothelial bioenergetics and angiogenesis. Marcu R, Kotha S, Zhi Z, Qin W, Neeley CK, Wang RK, Zheng Y, Hawkins BJ. Circ Res. 2015 Apr 10;116(8):1336-45. doi: 10.1161/CIRCRESAHA.116.304881. Epub 2015 Feb 26. PubMed
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein. Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L. J Biol Chem. 2015 Oct 23;290(43):26270-81. doi: 10.1074/jbc.M115.684746. Epub 2015 Aug 31. PubMed
Discovery and functional characterization of a neomorphic PTEN mutation. Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13976-81. doi: 10.1073/pnas.1422504112. Epub 2015 Oct 26. PubMed
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nat Commun. 2016 Mar 4;7:10830. doi: 10.1038/ncomms10830. PubMed
CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity. Vallath S, Sage EK, Kolluri KK, Lourenco SN, Teixeira VS, Chimalapati S, George PJ, Janes SM, Giangreco A. Sci Rep. 2016 Apr 1;6:24006. doi: 10.1038/srep24006. PubMed
Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM. Nat Cell Biol. 2016 Jul;18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30. PubMed
Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids. Li YL, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI. Elife. 2016 Jun 2;5. pii: e16269. doi: 10.7554/eLife.16269. PubMed

Associated Plasmids

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness. Peng X, Gimenez-Cassina A, Petrus P, Conrad M, Ryden M, Arner ES. Sci Rep. 2016 Jun 27;6:28080. doi: 10.1038/srep28080. PubMed
Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes. Gonzalez-Sanchez A, Jaraiz-Rodriguez M, Dominguez-Prieto M, Herrero-Gonzalez S, Medina JM, Tabernero A. Oncotarget. 2016 Aug 2;7(31):49819-49833. doi: 10.18632/oncotarget.10454. PubMed
The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Ahmed SM, Macara IG. Nat Commun. 2017 Mar 30;8:14867. doi: 10.1038/ncomms14867. PubMed
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer. Malaney P, Palumbo E, Semidey-Hurtado J, Hardee J, Stanford K, Kathiriya JJ, Patel D, Tian Z, Allen-Gipson D, Dave V. Cell Cycle. 2017 Nov 6:0. doi: 10.1080/15384101.2017.1388970. PubMed
PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer. Wozniak DJ, Kajdacsy-Balla A, Macias V, Ball-Kell S, Zenner ML, Bie W, Tyner AL. Nat Commun. 2017 Nov 15;8(1):1508. doi: 10.1038/s41467-017-01574-5. PubMed
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Islam MA, Xu Y, Tao W, Ubellacker JM, Lim M, Aum D, Lee GY, Zhou K, Zope H, Yu M, Cao W, Oswald JT, Dinarvand M, Mahmoudi M, Langer R, Kantoff PW, Farokhzad OC, Zetter BR, Shi J. Nat Biomed Eng. 2018 Nov;2(11):850-864. doi: 10.1038/s41551-018-0284-0. Epub 2018 Sep 17. PubMed

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