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pFLAG/HA-DGCR8 Citations (10)

Originally described in: The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.
Landthaler M, Yalcin A, Tuschl T Curr Biol. 2004 Dec 14. 14(23):2162-7. PubMed Journal

Articles Citing pFLAG/HA-DGCR8

Articles
A primate herpesvirus uses the integrator complex to generate viral microRNAs. Cazalla D, Xie M, Steitz JA. Mol Cell. 2011 Sep 16;43(6):982-92. doi: 10.1016/j.molcel.2011.07.025. PubMed
Nucleolin protein interacts with microprocessor complex to affect biogenesis of microRNAs 15a and 16. Pickering BF, Yu D, Van Dyke MW. J Biol Chem. 2011 Dec 23;286(51):44095-103. doi: 10.1074/jbc.M111.265439. Epub 2011 Nov 2. PubMed
Backbone (1)HN, (1)(3)C, and (1)(5)N resonance assignments of the tandem RNA-binding domains of human DGCR8. Roth BM, Hennig M. Biomol NMR Assign. 2013 Oct;7(2):183-6. doi: 10.1007/s12104-012-9406-x. Epub 2012 Jul 3. PubMed
Drosha mediates destabilization of Lin28 mRNA targets. Qiao C, Ma J, Xu J, Xie M, Ma W, Huang Y. Cell Cycle. 2012 Oct 1;11(19):3590-8. doi: 10.4161/cc.21871. Epub 2012 Aug 30. PubMed
Canonical MicroRNA Activity Facilitates but May Be Dispensable for Transcription Factor-Mediated Reprogramming. Liu Z, Skamagki M, Kim K, Zhao R. Stem Cell Reports. 2015 Dec 8;5(6):1119-27. doi: 10.1016/j.stemcr.2015.11.002. PubMed
Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex. Girvan HM, Bradley JM, Cheesman MR, Kincaid JR, Liu Y, Czarnecki K, Fisher K, Leys D, Rigby SE, Munro AW. Biochemistry. 2016 Sep 13;55(36):5073-83. doi: 10.1021/acs.biochem.6b00204. Epub 2016 Sep 1. PubMed
The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity. Loo TH, Ye X, Chai RJ, Ito M, Bonne G, Ferguson-Smith AC, Stewart CL. Elife. 2019 Nov 5;8. pii: 49485. doi: 10.7554/eLife.49485. PubMed
MicroRNA Clustering Assists Processing of Suboptimal MicroRNA Hairpins through the Action of the ERH Protein. Fang W, Bartel DP. Mol Cell. 2020 Apr 16;78(2):289-302.e6. doi: 10.1016/j.molcel.2020.01.026. PubMed

Associated Plasmids
The orf virus (ORFV) protein OV20.0 interacts with the microprocessor complex subunit DGCR8 to regulate miRNA biogenesis and ORFV infection. Liao GR, Tseng YY, Tseng CY, Lo CY, Hsu WL. FEBS Lett. 2021 Dec;595(23):2897-2908. doi: 10.1002/1873-3468.14231. Epub 2021 Nov 22. PubMed
Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, Lim J, Linsalata A, Kang Y, Malik I, Allen EG, Cao Y, Shubeck L, Johnston R, Huang Y, Gu Y, Guo X, Zwick ME, Qin Z, Wingo TS, Juncos J, Nelson DL, Epstein MP, Cutler DJ, Todd PK, Sherman SL, Warren ST, Jin P. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2118124119. doi: 10.1073/pnas.2118124119. Epub 2022 May 26. PubMed

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