pHaMDRwt Citations (32)

Originally described in: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.
Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC Proc Natl Acad Sci U S A. 1988 Jun . 85(12):4486-90. PubMed Journal

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Articles Citing pHaMDRwt

Articles
The presence of P-glycoprotein in L1210 cells directly induces down-regulation of cell surface saccharide targets of concanavalin A. Sulova Z, Ditte P, Kurucova T, Polakova E, Rogozanova K, Gibalova L, Seres M, Skvarkova L, Sedlak J, Pastorek J, Breier A. Anticancer Res. 2010 Sep;30(9):3661-8. PubMed
Tunicamycin depresses P-glycoprotein glycosylation without an effect on its membrane localization and drug efflux activity in L1210 cells. Seres M, Cholujova D, Bubencikova T, Breier A, Sulova Z. Int J Mol Sci. 2011;12(11):7772-84. doi: 10.3390/ijms12117772. Epub 2011 Nov 10. PubMed
P-glycoprotein depresses cisplatin sensitivity in L1210 cells by inhibiting cisplatin-induced caspase-3 activation. Gibalova L, Seres M, Rusnak A, Ditte P, Labudova M, Uhrik B, Pastorek J, Sedlak J, Breier A, Sulova Z. Toxicol In Vitro. 2012 Apr;26(3):435-44. doi: 10.1016/j.tiv.2012.01.014. Epub 2012 Jan 17. PubMed
Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Malofeeva EV, Domanitskaya N, Gudima M, Hopper-Borge EA. Cancer Res. 2012 Dec 15;72(24):6457-67. doi: 10.1158/0008-5472.CAN-12-1340. Epub 2012 Oct 19. PubMed
Detection of glycomic alterations induced by overexpression of p-glycoprotein on the surfaces of L1210 cells using sialic acid binding lectins. Bubencikova T, Cholujova D, Messingerova L, Mislovicova D, Seres M, Breier A, Sulova Z. Int J Mol Sci. 2012 Nov 16;13(11):15177-92. doi: 10.3390/ijms131115177. PubMed
Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp. Li X, Hu J, Wang B, Sheng L, Liu Z, Yang S, Li Y. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):163-75. doi: 10.1016/j.taap.2013.12.015. Epub 2013 Dec 29. PubMed
Effect of 9-cis retinoic acid and all-trans retinoic acid in combination with verapamil on P-glycoprotein expression in L1210 cells. Breier A, Stetka J, Bohacova V, Macejova D, Brtko J, Sulova Z. Neoplasma. 2014;61(5):553-65. doi: 10.4149/neo_2014_068. PubMed
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Sci Transl Med. 2014 Nov 5;6(261):261ra152. doi: 10.1126/scitranslmed.3009318. PubMed
Reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity. Turakova K, Pavlikova L, Messingerova L, Lakatos B, Breier A, Sulova Z. Anticancer Res. 2015 May;35(5):2627-34. PubMed
Hesperetin Liposomes for Cancer Therapy. Wolfram J, Scott B, Boom K, Shen J, Borsoi C, Suri K, Grande R, Fresta M, Celia C, Zhao Y, Shen H, Ferrari M. Curr Drug Deliv. 2016;13(5):711-9. PubMed
HIF-1alpha/MDR1 pathway confers chemoresistance to cisplatin in bladder cancer. Sun Y, Guan Z, Liang L, Cheng Y, Zhou J, Li J, Xu Y. Oncol Rep. 2015 Dec 29. doi: 10.3892/or.2015.4536. PubMed
The expression of P-glycoprotein in leukemia cells is associated with the upregulated expression of nestin, a class 6 filament protein. Coculova M, Imrichova D, Seres M, Messingerova L, Bohacova V, Sulova Z, Breier A. Leuk Res. 2016 Sep;48:32-9. doi: 10.1016/j.leukres.2016.05.021. Epub 2016 Jul 21. PubMed
Rack1 Mediates the Interaction of P-Glycoprotein with Anxa2 and Regulates Migration and Invasion of Multidrug-Resistant Breast Cancer Cells. Yang Y, Wu N, Wang Z, Zhang F, Tian R, Ji W, Ren X, Niu R. Int J Mol Sci. 2016 Oct 13;17(10). pii: E1718. PubMed
The expression of P-gp in leukemia cells is associated with cross-resistance to protein N-glycosylation inhibitor tunicamycin. Pavlikova L, Seres M, Imrichova D, Hano M, Rusnak A, Zamorova M, Katrlik J, Breier A, Sulova Z. Gen Physiol Biophys. 2016 Oct;35(4):497-510. PubMed
Quantitating drug-target engagement in single cells in vitro and in vivo. Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG, Vinegoni C, Weissleder R. Nat Chem Biol. 2016 Dec 5. doi: 10.1038/nchembio.2248. PubMed
Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155. Nyquist MD, Corella A, Burns J, Coleman I, Gao S, Tharakan R, Riggan L, Cai C, Corey E, Nelson PS, Mostaghel EA. Mol Cancer Res. 2017 May;15(5):521-531. doi: 10.1158/1541-7786.MCR-16-0315-T. PubMed
L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins. Pavlikova L, Seres M, Hano M, Bohacova V, Sevcikova I, Kyca T, Breier A, Sulova Z. Molecules. 2017 Jul 3;22(7). pii: E1104. doi: 10.3390/molecules22071104. PubMed
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS. Immunity. 2017 Dec 19;47(6):1182-1196.e10. doi: 10.1016/j.immuni.2017.11.012. PubMed
SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression. Xia YQ, Hua RJ, Juan C, Zhong ZH, Tao CS, Fang R, Lin H, Rui G, Yong C. Front Pharmacol. 2018 Mar 6;9:194. doi: 10.3389/fphar.2018.00194. eCollection 2018. PubMed
Triorganotin Derivatives Induce Cell Death Effects on L1210 Leukemia Cells at Submicromolar Concentrations Independently of P-glycoprotein Expression. Bohacova V, Seres M, Pavlikova L, Kontar S, Cagala M, Bobal P, Otevrel J, Brtko J, Sulova Z, Breier A. Molecules. 2018 May 1;23(5). pii: molecules23051053. doi: 10.3390/molecules23051053. PubMed
Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter. Elefantova K, Lakatos B, Kubickova J, Sulova Z, Breier A. Int J Mol Sci. 2018 Jul 7;19(7). pii: ijms19071985. doi: 10.3390/ijms19071985. PubMed
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. Einarsdottir BO, Karlsson J, Soderberg EMV, Lindberg MF, Funck-Brentano E, Jespersen H, Brynjolfsson SF, Bagge RO, Carstam L, Scobie M, Koolmeister T, Wallner O, Stierner U, Berglund UW, Ny L, Nilsson LM, Larsson E, Helleday T, Nilsson JA. Cell Death Dis. 2018 Jul 24;9(8):810. doi: 10.1038/s41419-018-0865-6. PubMed
Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Hemming ML, Lawlor MA, Andersen JL, Hagan T, Chipashvili O, Scott TG, Raut CP, Sicinska E, Armstrong SA, Demetri GD, Bradner JE. Cancer Res. 2019 Mar 1;79(5):994-1009. doi: 10.1158/0008-5472.CAN-18-1888. Epub 2019 Jan 10. PubMed
Screening of Phenanthroquinolizidine Alkaloid Derivatives for Inducing Cell Death of L1210 Leukemia Cells with Negative and Positive P-glycoprotein Expression. Kubickova J, Elefantova K, Pavlikova L, Cagala M, Seres M, Safar P, Marchalin S, Durisova K, Bohacova V, Sulova Z, Lakatos B, Breier A, Olejnikova P. Molecules. 2019 Jun 5;24(11). pii: molecules24112127. doi: 10.3390/molecules24112127. PubMed
A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines. Durrant DE, Das A, Dyer S, Kukreja RC. Biochim Biophys Acta Gen Subj. 2020 Jun;1864(6):129556. doi: 10.1016/j.bbagen.2020.129556. Epub 2020 Feb 14. PubMed
Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum. Seres M, Pavlikova L, Bohacova V, Kyca T, Borovska I, Lakatos B, Breier A, Sulova Z. Cells. 2020 Apr 6;9(4). pii: cells9040890. doi: 10.3390/cells9040890. PubMed
Cell Death Effects Induced by Sulforaphane and Allyl Isothiocyanate on P-Glycoprotein Positive and Negative Variants in L1210 Cells. Kontar S, Imrichova D, Bertova A, Mackova K, Poturnayova A, Sulova Z, Breier A. Molecules. 2020 Apr 30;25(9). pii: molecules25092093. doi: 10.3390/molecules25092093. PubMed
Development of Resistance to Endoplasmic Reticulum Stress-Inducing Agents in Mouse Leukemic L1210 Cells. Cagala M, Pavlikova L, Seres M, Kadlecikova K, Breier A, Sulova Z. Molecules. 2020 May 28;25(11). pii: molecules25112517. doi: 10.3390/molecules25112517. PubMed
Upregulation of NOX-2 and Nrf-2 Promotes 5-Fluorouracil Resistance of Human Colon Carcinoma (HCT-116) Cells. Waghela BN, Vaidya FU, Pathak C. Biochemistry (Mosc). 2021 Mar;86(3):262-274. doi: 10.1134/S0006297921030044. PubMed
Insight into Bortezomib Focusing on Its Efficacy against P-gp-Positive MDR Leukemia Cells. Kyca T, Pavlikova L, Bohacova V, Misak A, Poturnayova A, Breier A, Sulova Z, Seres M. Int J Mol Sci. 2021 May 23;22(11). pii: ijms22115504. doi: 10.3390/ijms22115504. PubMed
Effects of Sulforaphane-Induced Cell Death upon Repeated Passage of Either P-Glycoprotein-Negative or P-Glycoprotein-Positive L1210 Cell Variants. Bertova A, Kontar S, Polozsanyi Z, Simkovic M, Rosenbergova Z, Rebros M, Sulova Z, Breier A, Imrichova D. Int J Mol Sci. 2022 Sep 16;23(18):10818. doi: 10.3390/ijms231810818. PubMed
USP7 Induces Chemoresistance in Triple-Negative Breast Cancer via Deubiquitination and Stabilization of ABCB1. Lin YT, Lin J, Liu YE, Chen YC, Liu ST, Hsu KW, Chen DR, Wu HT. Cells. 2022 Oct 19;11(20):3294. doi: 10.3390/cells11203294. PubMed

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