pcDNA4 myc PGC-1 alpha Citations (28)

Originally described in: Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).
Ichida M, Nemoto S, Finkel T J Biol Chem. 2002 Dec 27. 277(52):50991-5. PubMed Journal

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Articles Citing pcDNA4 myc PGC-1 alpha

Articles
TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model. Palomer X, Alvarez-Guardia D, Rodríguez-Calvo R, Coll T, Laguna JC, Davidson MM, Chan TO, Feldman AM, Vázquez-Carrera M. Cardiovasc Res. 2009 Mar 1. 81(4):703-12. PubMed
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A. J Biol Chem. 2009 Aug 7. 284(32):21379-85. PubMed
The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells. Alvarez-Guardia D, Palomer X, Coll T, Davidson MM, Chan TO, Feldman AM, Laguna JC, Vázquez-Carrera M. Cardiovasc Res. 2010 Aug 1. 87(3):449-58. PubMed
Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor alpha (ERRalpha) cellular localization and inhibits its transcriptional activity. Rossi M, Colecchia D, Iavarone C, Strambi A, Piccioni F, Verrotti di Pianella A, Chiariello M. J Biol Chem. 2011 Mar 11;286(10):8507-22. doi: 10.1074/jbc.M110.179523. Epub 2010 Dec 28. PubMed
Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1alpha. Song W, Song Y, Kincaid B, Bossy B, Bossy-Wetzel E. Neurobiol Dis. 2013 Mar;51:72-81. doi: 10.1016/j.nbd.2012.07.004. Epub 2012 Jul 20. PubMed
The metabolic sensors FXRalpha, PGC-1alpha, and SIRT1 cooperatively regulate hepatitis B virus transcription. Curtil C, Enache LS, Radreau P, Dron AG, Scholtes C, Deloire A, Roche D, Lotteau V, Andre P, Ramiere C. FASEB J. 2014 Mar;28(3):1454-63. doi: 10.1096/fj.13-236372. Epub 2013 Dec 2. PubMed
Ethanol suppresses PGC-1alpha expression by interfering with the cAMP-CREB pathway in neuronal cells. Liu Z, Liu Y, Gao R, Li H, Dunn T, Wu P, Smith RG, Sarkar PS, Fang X. PLoS One. 2014 Aug 6;9(8):e104247. doi: 10.1371/journal.pone.0104247. eCollection 2014. PubMed
Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor gamma Coactivator 1alpha. Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R. Arthritis Rheumatol. 2015 May;67(8):2141-2153. doi: 10.1002/art.39182. PubMed
Down-regulation of peroxisome proliferator activated receptor gamma coactivator 1alpha induces oxidative stress and toxicity of 1-(4-Chlorophenyl)-benzo-2,5-quinone in HaCaT human keratinocytes. Xiao W, Goswami PC. Toxicol In Vitro. 2015 May 22;29(7):1332-1338. doi: 10.1016/j.tiv.2015.05.009. PubMed
G Protein-Coupled Receptor 40 (GPR40) and Peroxisome Proliferator-Activated Receptor gamma (PPARgamma): An Integrated Two-Receptor Signaling Pathway. Wang S, Awad KS, Elinoff JM, Dougherty EJ, Ferreyra GA, Wang JY, Cai R, Sun J, Ptasinska A, Danner RL. J Biol Chem. 2015 Jun 23. pii: jbc.M115.638924. PubMed
Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. Aging Cell. 2015 Dec 14. doi: 10.1111/acel.12434. PubMed
Mitochondrial biogenesis is required for axonal growth. Vaarmann A, Mandel M, Zeb A, Wareski P, Liiv J, Kuum M, Antsov E, Liiv M, Cagalinec M, Choubey V, Kaasik A. Development. 2016 Jun 1;143(11):1981-92. doi: 10.1242/dev.128926. Epub 2016 Apr 27. PubMed
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N. Nat Commun. 2016 Aug 31;7:12639. doi: 10.1038/ncomms12639. PubMed
Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-gamma Coactivator 1alpha to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease. Besse-Patin A, Leveille M, Oropeza D, Nguyen BN, Prat A, Estall JL. Gastroenterology. 2017 Jan;152(1):243-256. doi: 10.1053/j.gastro.2016.09.017. Epub 2016 Sep 20. PubMed
Co-activator candidate interactions for orphan nuclear receptor NR2E1. Corso-Diaz X, de Leeuw CN, Alonso V, Melchers D, Wong BK, Houtman R, Simpson EM. BMC Genomics. 2016 Oct 26;17(1):832. PubMed
PGC-1alpha attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3beta inactivation mediated by activated p38 in HK-2 Cells. Choi HI, Kim HJ, Park JS, Kim IJ, Bae EH, Ma SK, Kim SW. Sci Rep. 2017 Jun 28;7(1):4319. doi: 10.1038/s41598-017-04593-w. PubMed
Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design. Bastarrachea RA, Chen J, Kent JW Jr, Nava-Gonzalez EJ, Rodriguez-Ayala E, Daadi MM, Jorge B, Laviada-Molina H, Comuzzie AG, Chen S, Grayburn PA. IUBMB Life. 2017 Sep;69(9):745-755. doi: 10.1002/iub.1658. Epub 2017 Jul 31. PubMed
Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar PB, Kumar A, Joshi SD, Sarkar C, Sen E. J Neurochem. 2017 Dec;143(6):671-683. doi: 10.1111/jnc.14152. Epub 2017 Sep 22. PubMed
PGC1alpha induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Kim B, Jung JW, Jung J, Han Y, Suh DH, Kim HS, Dhanasekaran DN, Song YS. Oncotarget. 2017 Jul 10;8(36):60299-60311. doi: 10.18632/oncotarget.19140. eCollection 2017 Sep 1. PubMed
Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation. Huang CL, Wang KC, Yang YC, Chiou CT, Tan CH, Lin YL, Huang NK. Phytomedicine. 2018 Jan 15;39:75-84. doi: 10.1016/j.phymed.2017.12.017. Epub 2017 Dec 18. PubMed
AMP kinase promotes glioblastoma bioenergetics and tumour growth. Chhipa RR, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, Chen X, Waclaw R, Chow LM, Khuchua Z, Kofron M, Weirauch MT, Kendler A, McPherson C, Ratner N, Nakano I, Dasgupta N, Komurov K, Dasgupta B. Nat Cell Biol. 2018 Jul;20(7):823-835. doi: 10.1038/s41556-018-0126-z. Epub 2018 Jun 18. PubMed
Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy. Chen S, Bastarrachea RA, Shen JS, Laviada-Nagel A, Rodriguez-Ayala E, Nava-Gonzalez EJ, Huang P, DeFronzo RA, Kent JW Jr, Grayburn PA. Gene Ther. 2018 Oct;25(7):497-509. doi: 10.1038/s41434-018-0036-5. Epub 2018 Aug 2. PubMed
Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Wu MJ, Chen YS, Kim MR, Chang CC, Gampala S, Zhang Y, Wang Y, Chang CY, Yang JY, Chang CJ. Cell Metab. 2019 Apr 2;29(4):993-1002.e6. doi: 10.1016/j.cmet.2018.11.004. Epub 2018 Dec 6. PubMed
CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad. Liu L, He Z, Xu L, Lu L, Feng H, Leong DJ, Kim SJ, Hirsh DM, Majeska RJ, Goldring MB, Cobelli NJ, Sun HB. Ann N Y Acad Sci. 2019 Apr;1442(1):153-164. doi: 10.1111/nyas.14025. Epub 2019 Mar 19. PubMed
Mitochondrial calcium uniporter regulates PGC-1alpha expression to mediate metabolic reprogramming in pulmonary fibrosis. Gu L, Larson Casey JL, Andrabi SA, Lee JH, Meza-Perez S, Randall TD, Carter AB. Redox Biol. 2019 Sep;26:101307. doi: 10.1016/j.redox.2019.101307. Epub 2019 Aug 25. PubMed
CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells. Kim S, Piao S, Lee I, Nagar H, Choi SJ, Shin N, Kim DW, Shong M, Jeon BH, Kim CS. Free Radic Biol Med. 2020 Apr;150:161-171. doi: 10.1016/j.freeradbiomed.2020.02.017. Epub 2020 Feb 25. PubMed
Post-translational regulation of PGC-1alpha modulates fibrotic repair. Larson-Casey JL, Gu L, Davis D, Cai GQ, Ding Q, He C, Carter AB. FASEB J. 2021 Jun;35(6):e21675. doi: 10.1096/fj.202100339R. PubMed
Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks AD. Oncogene. 2022 Oct;41(43):4808-4822. doi: 10.1038/s41388-022-02465-w. Epub 2022 Sep 24. PubMed

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