dCas9-KRAB-MeCP2 Citations (23)
Originally described in: An enhanced CRISPR repressor for targeted mammalian gene regulation.Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM Nat Methods. 2018 Jul 16. pii: 10.1038/s41592-018-0048-5. doi: 10.1038/s41592-018-0048-5. PubMed Journal
Articles Citing dCas9-KRAB-MeCP2
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Multi-input chemical control of protein dimerization for programming graded cellular responses.
Foight GW, Wang Z, Wei CT, Jr Greisen P, Warner KM, Cunningham-Bryant D, Park K, Brunette TJ, Sheffler W, Baker D, Maly DJ.
Nat Biotechnol. 2019 Sep 9. pii: 10.1038/s41587-019-0242-8. doi: 10.1038/s41587-019-0242-8.
PubMed
Associated Plasmids |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.
Choi J, Zhang T, Vu A, Ablain J, Makowski MM, Colli LM, Xu M, Hennessey RC, Yin J, Rothschild H, Grawe C, Kovacs MA, Funderburk KM, Brossard M, Taylor J, Pasaniuc B, Chari R, Chanock SJ, Hoggart CJ, Demenais F, Barrett JH, Law MH, Iles MM, Yu K, Vermeulen M, Zon LI, Brown KM.
Nat Commun. 2020 Jun 1;11(1):2718. doi: 10.1038/s41467-020-16590-1.
PubMed
Associated Plasmids |
| A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors. Mattar P, Jolicoeur C, Dang T, Shah S, Clark BS, Cayouette M. Sci Rep. 2021 Feb 16;11(1):3858. doi: 10.1038/s41598-021-83395-7. PubMed |
| Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation. Devulapalli R, Jones N, Farrell K, Musaus M, Kugler H, McFadden T, Orsi SA, Martin K, Nelsen J, Navabpour S, O'Donnell M, McCoig E, Jarome TJ. Neurobiol Learn Mem. 2021 Apr;180:107404. doi: 10.1016/j.nlm.2021.107404. Epub 2021 Feb 18. PubMed |
| Lupus susceptibility region containing CDKN1B rs34330 mechanistically influences expression and function of multiple target genes, also linked to proliferation and apoptosis. Singh B, Maiti GP, Zhou X, Fazel-Najafabadi M, Bae SC, Sun C, Terao C, Okada Y, Chua KH, Kochi Y, Guthridge JM, Zhang H, Weirauch M, James JA, Harley JB, Varshney GK, Looger LL, Nath SK. Arthritis Rheumatol. 2021 May 13. doi: 10.1002/art.41799. PubMed |
| Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations. Zhao Q, Kong Y, Kittredge A, Li Y, Shen Y, Zhang Y, Tsang SH, Yang T. Elife. 2021 Jun 1;10. pii: 67622. doi: 10.7554/eLife.67622. PubMed |
| An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation? Brandt M, Kim-Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, Recinos Y, Daniloski Z, Morris JA, Hornung V, Schumacher J, Lappalainen T. PLoS Genet. 2021 Jul 27;17(7):e1009684. doi: 10.1371/journal.pgen.1009684. eCollection 2021 Jul. PubMed |
| A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer. Liu Y, Wu Z, Zhou J, Ramadurai DKA, Mortenson KL, Aguilera-Jimenez E, Yan Y, Yang X, Taylor AM, Varley KE, Gertz J, Choi PS, Cherniack AD, Chen X, Bass AJ, Bailey SD, Zhang X. Nat Commun. 2021 Dec 8;12(1):7139. doi: 10.1038/s41467-021-27055-4. PubMed |
| A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological CaV3.2 Channelopathies by Promoter-Mediated Transcription Control. Tsortouktzidis D, Troscher AR, Schulz H, Opitz T, Schoch S, Becker AJ, van Loo KMJ. Front Mol Neurosci. 2022 Jan 6;14:667143. doi: 10.3389/fnmol.2021.667143. eCollection 2021. PubMed |
| DNA methylation-independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins. Ding L, Schmitt LT, Brux M, Surun D, Augsburg M, Lansing F, Mircetic J, Theis M, Buchholz F. Life Sci Alliance. 2022 Mar 14;5(6). pii: 5/6/e202101321. doi: 10.26508/lsa.202101321. Print 2022 Jun. PubMed |
An integrated pipeline for mammalian genetic screening.
Kramme C, Plesa AM, Wang HH, Wolf B, Smela MP, Guo X, Kohman RE, Chatterjee P, Church GM.
Cell Rep Methods. 2021 Sep 27;1(6):100082. doi: 10.1016/j.crmeth.2021.100082. eCollection 2021 Oct 25.
PubMed
Associated Plasmids |
| A 3'-end capture sequencing method for high-throughput targeted gene expression profiling. de Bony E, Gysens F, Yigit N, Anckaert J, Everaert C, Vanden Eynde E, Verniers K, van Snippenberg W, Trypsteen W, Mestdagh P. Biotechnol J. 2022 Sep;17(9):e2100660. doi: 10.1002/biot.202100660. Epub 2022 May 24. PubMed |
| Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells. Wei W, Li Y, Wang C, Gao S, Zhao Y, Yang Z, Wang H, Gao Z, Jiang Y, He Y, Zhao L, Gao H, Yao X, Hu Y. Pharmacol Res. 2022 Aug;182:106285. doi: 10.1016/j.phrs.2022.106285. Epub 2022 Jun 1. PubMed |
| YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer. Shen J, Huang Q, Jia W, Feng S, Liu L, Li X, Tao D, Xie D. Oncogene. 2022 Jul;41(31):3830-3845. doi: 10.1038/s41388-022-02344-4. Epub 2022 Jun 30. PubMed |
| The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes. Pizzolato G, Moparthi L, Soderholm S, Cantu C, Koch S. J Cell Sci. 2022 Oct 1;135(19):jcs260082. doi: 10.1242/jcs.260082. Epub 2022 Oct 10. PubMed |
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.
Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M.
Elife. 2022 Dec 28;11:e81856. doi: 10.7554/eLife.81856.
PubMed
Associated Plasmids |
| A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons. Brookes E, Martinez De La Cruz B, Boulasiki P, Au HYA, Varsally W, Barrington C, Hadjur S, Riccio A. iScience. 2022 Dec 1;26(1):105695. doi: 10.1016/j.isci.2022.105695. eCollection 2023 Jan 20. PubMed |
Construction of a Set of Novel Transposon Vectors for Efficient Silencing of Protein and lncRNA Genes via CRISPR Interference.
Czarnek M, Kochan J, Wawro M, Myrczek R, Bereta J.
Mol Biotechnol. 2023 Jan 28. doi: 10.1007/s12033-023-00675-5.
PubMed
Associated Plasmids |
| CTCF mediates CD8+ effector differentiation through dynamic redistribution and genomic reorganization. Liu J, Zhu S, Hu W, Zhao X, Shan Q, Peng W, Xue HH. J Exp Med. 2023 Apr 3;220(4):e20221288. doi: 10.1084/jem.20221288. Epub 2023 Feb 8. PubMed |
| Distinct tumor architectures for metastatic colonization of the brain. Gan S, Macalinao DG, Shahoei SH, Tian L, Jin X, Basnet H, Muller JT, Atri P, Seffar E, Chatila W, Hadjantonakis AK, Schultz N, Brogi E, Bale TA, Pe'er D, Massague J. bioRxiv. 2023 Jan 28:2023.01.27.525190. doi: 10.1101/2023.01.27.525190. Preprint. PubMed |
| Identification of the primary ciliary proteins IFT38 and IFT144 to enhance serum-mediated YAP activation and cell proliferation. Yu JH, Kim JH, Soung NK, Moon EY, Koo JH. Biochem Biophys Res Commun. 2023 Nov 12;681:186-193. doi: 10.1016/j.bbrc.2023.09.082. Epub 2023 Sep 27. PubMed |
| beta1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4. Sun Z, Cernilogar FM, Horvatic H, Yeroslaviz A, Abdullah Z, Schotta G, Hornung V. Cell Rep. 2023 Nov 28;42(11):113322. doi: 10.1016/j.celrep.2023.113322. Epub 2023 Oct 25. PubMed |
| Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinoma. Liu SX, Wang C, Lin RB, Ding WY, Roy G, Wang HB, Yang T, Liu Q, Luo YL, Jin SL, Zeng MS, Zhao B, Zhong Q. EBioMedicine. 2023 Dec;98:104870. doi: 10.1016/j.ebiom.2023.104870. Epub 2023 Nov 14. PubMed |
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