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pAdDeltaF6 Citations (95)

Originally described in: AAV packaging plasmids
Unpublished

Articles Citing pAdDeltaF6

Articles
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts. Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC. Cell. 2019 Jun 27;178(1):122-134.e12. doi: 10.1016/j.cell.2019.05.049. Epub 2019 Jun 20. PubMed

Associated Plasmids

GPR108 Is a Highly Conserved AAV Entry Factor. Dudek AM, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, Franceschini JS, Estelien R, Carette JE, Zhou GL, Vandenberghe LH. Mol Ther. 2020 Feb 5;28(2):367-381. doi: 10.1016/j.ymthe.2019.11.005. Epub 2019 Nov 13. PubMed
Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Frazier HN, Anderson KL, Ghoweri AO, Lin RL, Hawkinson TR, Popa GJ, Sompol P, Mendenhall MD, Norris CM, Thibault O. Aging Cell. 2020 Oct;19(10):e13220. doi: 10.1111/acel.13220. Epub 2020 Aug 27. PubMed
CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain. Mathiesen SN, Lock JL, Schoderboeck L, Abraham WC, Hughes SM. Mol Ther Methods Clin Dev. 2020 Oct 20;19:447-458. doi: 10.1016/j.omtm.2020.10.011. eCollection 2020 Dec 11. PubMed
AAV-mediated in vivo genome editing in vascular endothelial cells. Wu W, Yang Y, Yao F, Dong L, Xia X, Zhang S, Lei H. Methods. 2020 Dec 9. pii: S1046-2023(20)30263-2. doi: 10.1016/j.ymeth.2020.12.001. PubMed
Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3(Mashl/+), Mouse Model of Alternating Hemiplegia of Childhood. Hunanyan AS, Kantor B, Puranam RS, Elliott C, McCall A, Dhindsa J, Pagadala P, Wallace K, Poe J, Gunduz T, Asokan A, Koeberl DD, ElMallah MK, Mikati MA. Hum Gene Ther. 2021 Apr;32(7-8):405-419. doi: 10.1089/hum.2020.191. Epub 2021 Feb 12. PubMed
Hunger enhances food-odour attraction through a neuropeptide Y spotlight. Horio N, Liberles SD. Nature. 2021 Apr;592(7853):262-266. doi: 10.1038/s41586-021-03299-4. Epub 2021 Mar 3. PubMed
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA. Acta Neuropathol Commun. 2021 Mar 12;9(1):41. doi: 10.1186/s40478-021-01141-6. PubMed
CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology. Xiao D, Zhang W, Wang Q, Li X, Zhang Y, Rasouli J, Casella G, Ciric B, Curtis M, Rostami A, Zhang GX. Mol Ther Methods Clin Dev. 2021 Feb 18;20:755-764. doi: 10.1016/j.omtm.2021.02.012. eCollection 2021 Mar 12. PubMed
CRISPR/Cas9 Mediated Deletion of the Angiotensinogen Gene Reduces Hypertension: A Potential for Cure? Sun H, Hodgkinson CP, Pratt RE, Dzau VJ. Hypertension. 2021 Jun;77(6):1990-2000. doi: 10.1161/HYPERTENSIONAHA.120.16870. Epub 2021 Apr 5. PubMed
Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models. Roy DS, Zhang Y, Aida T, Choi S, Chen Q, Hou Y, Lea NE, Skaggs KM, Quay JC, Liew M, Maisano H, Le V, Jones C, Xu J, Kong D, Sullivan HA, Saunders A, McCarroll SA, Wickersham IR, Feng G. Neuron. 2021 Aug 18;109(16):2590-2603.e13. doi: 10.1016/j.neuron.2021.06.005. Epub 2021 Jun 30. PubMed
Compact RNA editors with small Cas13 proteins. Kannan S, Altae-Tran H, Jin X, Madigan VJ, Oshiro R, Makarova KS, Koonin EV, Zhang F. Nat Biotechnol. 2021 Aug 30. pii: 10.1038/s41587-021-01030-2. doi: 10.1038/s41587-021-01030-2. PubMed

Associated Plasmids

Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL. Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27. PubMed

Associated Plasmids

NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis. Yu Y, Shen T, Zhong X, Wang LL, Tai W, Zou Y, Qin J, Zhang Z, Zhang CL. Glia. 2022 Feb;70(2):273-286. doi: 10.1002/glia.24104. Epub 2021 Oct 13. PubMed
Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells. Strasser L, Boi S, Guapo F, Donohue N, Barron N, Rainbow-Fletcher A, Bones J. Int J Mol Sci. 2021 Oct 25;22(21). pii: ijms222111499. doi: 10.3390/ijms222111499. PubMed
OGDHL ameliorates cognitive impairment and Alzheimer's disease-like pathology via activating Wnt/beta-catenin signaling in Alzheimer's disease mice. Yao L, Xu X, Xu Y, Li C, Xie F, Guo M, Liu Z, Liu X. Behav Brain Res. 2022 Feb 10;418:113673. doi: 10.1016/j.bbr.2021.113673. Epub 2021 Nov 16. PubMed
Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques. Arotcarena ML, Dovero S, Biendon N, Dutheil N, Planche V, Bezard E, Dehay B. Front Bioeng Biotechnol. 2021 Nov 15;9:762209. doi: 10.3389/fbioe.2021.762209. eCollection 2021. PubMed
Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. Hamann MV, Beschorner N, Vu XK, Hauber I, Lange UC, Traenkle B, Kaiser PD, Foth D, Schneider C, Buning H, Rothbauer U, Hauber J. PLoS One. 2021 Dec 20;16(12):e0261269. doi: 10.1371/journal.pone.0261269. eCollection 2021. PubMed
A fast, aqueous, reversible three-day tissue clearing method for adult and embryonic mouse brain and whole body. Kosmidis S, Negrean A, Dranovsky A, Losonczy A, Kandel ER. Cell Rep Methods. 2021 Nov 22;1(7):100090. doi: 10.1016/j.crmeth.2021.100090. Epub 2021 Oct 11. PubMed
Optimized protocols for efficient gene editing in mouse hepatocytes in vivo using CRISPR-Cas9 technology. Chen Y, Ding Q. STAR Protoc. 2021 Dec 23;3(1):101062. doi: 10.1016/j.xpro.2021.101062. eCollection 2022 Mar 18. PubMed
Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice. Yang MS, Park MJ, Lee J, Oh B, Kang KW, Kim Y, Lee SM, Lim JO, Jung TY, Park JH, Park SC, Lim YS, Hwang SB, Lyoo KS, Kim DI, Kim B. Mol Ther. 2022 May 4;30(5):1994-2004. doi: 10.1016/j.ymthe.2022.01.010. Epub 2022 Jan 7. PubMed
Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons. Han Z, Luo N, Kou J, Li L, Xu Z, Wei S, Wu Y, Wang J, Ye C, Lin K, Xu F. Mol Brain. 2022 Jan 29;15(1):13. doi: 10.1186/s13041-022-00898-8. PubMed
Only a small fraction of cells produce assembled capsids during transfection-based manufacturing of adeno-associated virus vectors. Dash S, Sharon DM, Mullick A, Kamen AA. Biotechnol Bioeng. 2022 Jun;119(6):1685-1690. doi: 10.1002/bit.28068. Epub 2022 Feb 28. PubMed
Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Abeta42-Mediated Neurotoxicity. Li X, Zhang Y, Ai HW. ACS Sens. 2022 Feb 28. doi: 10.1021/acssensors.1c01381. PubMed

Associated Plasmids

Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKbeta. Wu F, Hill K, Fang Q, He Z, Zheng H, Wang X, Xiong H, Sha SH. Cell Mol Life Sci. 2022 Apr 19;79(5):249. doi: 10.1007/s00018-022-04268-4. PubMed
m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Flamand MN, Meyer KD. Nucleic Acids Res. 2022 May 6;50(8):4464-4483. doi: 10.1093/nar/gkac251. PubMed
CMYA5 establishes cardiac dyad architecture and positioning. Lu F, Ma Q, Xie W, Liou CL, Zhang D, Sweat ME, Jardin BD, Naya FJ, Guo Y, Cheng H, Pu WT. Nat Commun. 2022 Apr 21;13(1):2185. doi: 10.1038/s41467-022-29902-4. PubMed
FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism. Zhao F, Zhang L, Zhang M, Huang J, Zhang J, Chang Y. Front Pharmacol. 2022 Apr 20;13:850128. doi: 10.3389/fphar.2022.850128. eCollection 2022. PubMed
Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice. Keasey MP, Lovins C, Jia C, Hagg T. Physiol Rep. 2022 May;10(9):e15301. doi: 10.14814/phy2.15301. PubMed
Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex. Kato K, Zhou W, Okazaki S, Isayama Y, Nishizawa T, Gootenberg JS, Abudayyeh OO, Nishimasu H. Cell. 2022 May 25. pii: S0092-8674(22)00581-5. doi: 10.1016/j.cell.2022.05.003. PubMed

Associated Plasmids

Dietary intervention preserves beta cell function in mice through CTCF-mediated transcriptional reprogramming. Wang RR, Qiu X, Pan R, Fu H, Zhang Z, Wang Q, Chen H, Wu QQ, Pan X, Zhou Y, Shan P, Wang S, Guo G, Zheng M, Zhu L, Meng ZX. J Exp Med. 2022 Jul 4;219(7). pii: 213256. doi: 10.1084/jem.20211779. Epub 2022 Jun 2. PubMed
Somatic genetics analysis of sleep in adult mice. Wang G, Li Q, Xu J, Zhao S, Zhou R, Chen Z, Jiang W, Gao X, Zhou S, Chen Z, Sun Q, Ma C, Chen L, Shi B, Guo Y, Wang H, Wang X, Li H, Cai T, Wang Y, Chen Z, Wang F, Liu Q. J Neurosci. 2022 Jun 3. pii: JNEUROSCI.0089-22.2022. doi: 10.1523/JNEUROSCI.0089-22.2022. PubMed
Neural circuit pathology driven by Shank3 mutation disrupts social behaviors. Kim S, Kim YE, Song I, Ujihara Y, Kim N, Jiang YH, Yin HH, Lee TH, Kim IH. Cell Rep. 2022 Jun 7;39(10):110906. doi: 10.1016/j.celrep.2022.110906. PubMed

Associated Plasmids

Formation of False Context Fear Memory Is Regulated by Hypothalamic Corticotropin-Releasing Factor in Mice. Kasama E, Moriya M, Kamimura R, Matsuki T, Seki K. Int J Mol Sci. 2022 Jun 3;23(11). pii: ijms23116286. doi: 10.3390/ijms23116286. PubMed
Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Ojima K, Kakegawa W, Yamasaki T, Miura Y, Itoh M, Michibata Y, Kubota R, Doura T, Miura E, Nonaka H, Mizuno S, Takahashi S, Yuzaki M, Hamachi I, Kiyonaka S. Nat Commun. 2022 Jun 16;13(1):3167. doi: 10.1038/s41467-022-30828-0. PubMed
Targeting miR-30d reverses pathological cardiac hypertrophy. Li J, Sha Z, Zhu X, Xu W, Yuan W, Yang T, Jin B, Yan Y, Chen R, Wang S, Yao J, Xu J, Wang Z, Li G, Das S, Yang L, Xiao J. EBioMedicine. 2022 Jul;81:104108. doi: 10.1016/j.ebiom.2022.104108. Epub 2022 Jun 22. PubMed
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y. EMBO J. 2022 Aug 16;41(16):e110439. doi: 10.15252/embj.2021110439. Epub 2022 Jul 4. PubMed
A luciferase prosubstrate and a red bioluminescent calcium indicator for imaging neuronal activity in mice. Tian X, Zhang Y, Li X, Xiong Y, Wu T, Ai HW. Nat Commun. 2022 Jul 8;13(1):3967. doi: 10.1038/s41467-022-31673-x. PubMed

Associated Plasmids

A truncated reverse transcriptase enhances prime editing by split AAV vectors. Gao Z, Ravendran S, Mikkelsen NS, Haldrup J, Cai H, Ding X, Paludan SR, Thomsen MK, Mikkelsen JG, Bak RO. Mol Ther. 2022 Jul 8. pii: S1525-0016(22)00422-1. doi: 10.1016/j.ymthe.2022.07.001. PubMed

Associated Plasmids

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity. Wu F, Luo S, Zhang Y, Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen, Guangsheng Du Xun Sun YO. Acta Pharm Sin B. 2022 Jul 12. doi: 10.1016/j.apsb.2022.07.004. PubMed
TOB is an effector of the hippocampus-mediated acute stress response. Youssef MMM, Hamada HT, Lai ESK, Kiyama Y, El-Tabbal M, Kiyonari H, Nakano K, Kuhn B, Yamamoto T. Transl Psychiatry. 2022 Jul 29;12(1):302. doi: 10.1038/s41398-022-02078-7. PubMed
The intrinsic and extrinsic effects of TET proteins during gastrulation. Cheng S, Mittnenzweig M, Mayshar Y, Lifshitz A, Dunjic M, Rais Y, Ben-Yair R, Gehrs S, Chomsky E, Mukamel Z, Rubinstein H, Schlereth K, Reines N, Orenbuch AH, Tanay A, Stelzer Y. Cell. 2022 Aug 18;185(17):3169-3185.e20. doi: 10.1016/j.cell.2022.06.049. Epub 2022 Jul 30. PubMed
Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. Guo T, Pan X, Jiang G, Zhang D, Qi J, Shao L, Wang Z, Xu H, Zhao Y. J Neurosci. 2022 Aug 9;42(38):7309-17. doi: 10.1523/JNEUROSCI.1060-22.2022. PubMed
LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway. Chen T, Shi Z, Zhao Y, Meng X, Zhao S, Zheng L, Han X, Hu Z, Yao Q, Lin H, Du X, Zhang K, Han T, Hong W. BMC Med. 2022 Sep 29;20(1):335. doi: 10.1186/s12916-022-02523-w. PubMed
Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits. Jiang Y, Han L, Meng J, Wang Z, Zhou Y, Yuan H, Xu H, Zhang X, Zhao Y, Lu J, Xu H, Zhang C, Zhang YW. Mol Ther Methods Clin Dev. 2022 Oct 7;27:246-258. doi: 10.1016/j.omtm.2022.10.002. eCollection 2022 Dec 8. PubMed
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. Nat Commun. 2022 Nov 2;13(1):6581. doi: 10.1038/s41467-022-34412-4. PubMed
Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4. D'Amato G, Phansalkar R, Naftaly JA, Fan X, Amir ZA, Rios Coronado PE, Cowley DO, Quinn KE, Sharma B, Caron KM, Vigilante A, Red-Horse K. Dev Cell. 2022 Nov 21;57(22):2517-2532.e6. doi: 10.1016/j.devcel.2022.10.007. Epub 2022 Nov 7. PubMed
Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins. Vos DY, Wijers M, Smit M, Huijkman N, Kloosterhuis NJ, Wolters JC, Tissink JJ, Pronk ACM, Kooijman S, Rensen PCN, Kuivenhoven JA, van de Sluis B. Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):e29-e45. doi: 10.1161/ATVBAHA.122.318169. Epub 2022 Nov 10. PubMed
Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y, Teng ZQ, Liu CM. EMBO Mol Med. 2022 Dec 7;14(12):e15795. doi: 10.15252/emmm.202215795. Epub 2022 Nov 17. PubMed
Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. Frohlich A, Olde Heuvel F, Rehman R, Krishnamurthy SS, Li S, Li Z, Bayer D, Conquest A, Hagenston AM, Ludolph A, Huber-Lang M, Boeckers T, Knoll B, Morganti-Kossmann MC, Bading H, Roselli F. J Neuroinflammation. 2022 Nov 19;19(1):279. doi: 10.1186/s12974-022-02634-4. PubMed
DOK7 Promotes NMJ Regeneration After Nerve Injury. Kosco ED, Jing H, Chen P, Xiong WC, Samuels IS, Mei L. Mol Neurobiol. 2023 Mar;60(3):1453-1464. doi: 10.1007/s12035-022-03143-4. Epub 2022 Dec 5. PubMed
Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants. Liebsch F, Eggersmann FR, Merkler Y, Kloppenburg P, Schwarz G. eNeuro. 2023 Jan 4;10(1):ENEURO.0102-22.2022. doi: 10.1523/ENEURO.0102-22.2022. Print 2023 Jan. PubMed

Associated Plasmids

Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors. Lim CKW, Miskalis AJ, Perez-Pinera P, Gaj T. Methods Mol Biol. 2023;2606:135-158. doi: 10.1007/978-1-0716-2879-9_11. PubMed
Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy. Xu J, Contractor A, Zhu Y. STAR Protoc. 2022 Dec 16;3(4):101907. doi: 10.1016/j.xpro.2022.101907. Epub 2022 Dec 6. PubMed
Lactate metabolism is essential in early-onset mitochondrial myopathy. Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P. Sci Adv. 2023 Jan 4;9(1):eadd3216. doi: 10.1126/sciadv.add3216. Epub 2023 Jan 4. PubMed
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy. Alves CRR, Ha LL, Yaworski R, Sutton ER, Lazzarotto CR, Christie KA, Reilly A, Beauvais A, Doll RM, de la Cruz D, Maguire CA, Swoboda KJ, Tsai SQ, Kothary R, Kleinstiver BP. Nat Biomed Eng. 2023 Dec 6. doi: 10.1038/s41551-023-01132-z. PubMed

Associated Plasmids

An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice. Grodem S, Nymoen I, Vatne GH, Rogge FS, Bjornsdottir V, Lensjo KK, Fyhn M. Nat Commun. 2023 Feb 4;14(1):608. doi: 10.1038/s41467-023-36324-3. PubMed

Associated Plasmids

A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing. Lin KZ, Li L, Ma WY, Yang X, Han ZP, Luo NS, Wang J, Xu FQ. Neural Regen Res. 2023 Aug;18(8):1827-1833. doi: 10.4103/1673-5374.358618. PubMed
Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice. Qiao S, Alasmi S, Wyatt A, Wartenberg P, Wang H, Candlish M, Das D, Aoki M, Grunewald R, Zhou Z, Tian Q, Yu Q, Gotz V, Belkacemi A, Raza A, Ectors F, Kattler K, Gasparoni G, Walter J, Lipp P, Mollard P, Bernard DJ, Karatayli E, Karatayli SC, Lammert F, Boehm U. Nat Commun. 2023 Feb 25;14(1):1098. doi: 10.1038/s41467-023-36681-z. PubMed
Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis. Yu Q, Gamayun I, Wartenberg P, Zhang Q, Qiao S, Kusumakshi S, Candlish S, Gotz V, Wen S, Das D, Wyatt A, Wahl V, Ectors F, Kattler K, Yildiz D, Prevot V, Schwaninger M, Ternier G, Giacobini P, Ciofi P, Muller TD, Boehm U. Nat Commun. 2023 Mar 22;14(1):1588. doi: 10.1038/s41467-023-37099-3. PubMed
A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo. Zoabi S, Andreyanov M, Heinrich R, Ron S, Carmi I, Gutfreund Y, Berlin S. Commun Biol. 2023 Mar 28;6(1):337. doi: 10.1038/s42003-023-04712-6. PubMed
Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin YH, Hsieh MH, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H. bioRxiv. 2023 Mar 21:2023.03.20.533505. doi: 10.1101/2023.03.20.533505. Preprint. PubMed
Genomic investigations of unexplained acute hepatitis in children. Morfopoulou S, Buddle S, Torres Montaguth OE, Atkinson L, Guerra-Assuncao JA, Moradi Marjaneh M, Zennezini Chiozzi R, Storey N, Campos L, Hutchinson JC, Counsell JR, Pollara G, Roy S, Venturini C, Antinao Diaz JF, Siam A, Tappouni LJ, Asgarian Z, Ng J, Hanlon KS, Lennon A, McArdle A, Czap A, Rosenheim J, Andrade C, Anderson G, Lee JCD, Williams R, Williams CA, Tutill H, Bayzid N, Martin Bernal LM, Macpherson H, Montgomery KA, Moore C, Templeton K, Neill C, Holden M, Gunson R, Shepherd SJ, Shah P, Cooray S, Voice M, Steele M, Fink C, Whittaker TE, Santilli G, Gissen P, Kaufer BB, Reich J, Andreani J, Simmonds P, Alrabiah DK, Castellano S, Chikowore P, Odam M, Rampling T, Houlihan C, Hoschler K, Talts T, Celma C, Gonzalez S, Gallagher E, Simmons R, Watson C, Mandal S, Zambon M, Chand M, Hatcher J, De S, Baillie K, Semple MG, Martin J, Ushiro-Lumb I, Noursadeghi M, Deheragoda M, Hadzic N, Grammatikopoulos T, Brown R, Kelgeri C, Thalassinos K, Waddington SN, Jacques TS, Thomson E, Levin M, Brown JR, Breuer J. Nature. 2023 May;617(7961):564-573. doi: 10.1038/s41586-023-06003-w. Epub 2023 Mar 30. PubMed
Role of TMEM100 in mechanically insensitive nociceptor un-silencing. Nees TA, Wang N, Adamek P, Zeitzschel N, Verkest C, La Porta C, Schaefer I, Virnich J, Balkaya S, Prato V, Morelli C, Begay V, Lee YJ, Tappe-Theodor A, Lewin GR, Heppenstall PA, Taberner FJ, Lechner SG. Nat Commun. 2023 Apr 5;14(1):1899. doi: 10.1038/s41467-023-37602-w. PubMed
In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration. Lin YH, Zeng Q, Jia Y, Wang Z, Li L, Hsieh MH, Cheng Q, Pagani CA, Livingston N, Lee J, Zhang Y, Sharma T, Siegwart DJ, Yimlamai D, Levi B, Zhu H. Hepatology. 2023 Oct 1;78(4):1133-1148. doi: 10.1097/HEP.0000000000000402. Epub 2023 Apr 12. PubMed
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. Wang Y, Hurley A, De Giorgi M, Tanner MR, Hu RC, Pennington MW, Lagor WR, Beeton C. PLoS One. 2023 Apr 11;18(4):e0283996. doi: 10.1371/journal.pone.0283996. eCollection 2023. PubMed
Computer-Aided Directed Evolution Generates Novel AAV Variants with High Transduction Efficiency. Han Z, Luo N, Wang F, Cai Y, Yang X, Feng W, Zhu Z, Wang J, Wu Y, Ye C, Lin K, Xu F. Viruses. 2023 Mar 26;15(4):848. doi: 10.3390/v15040848. PubMed
Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice. Bu W, Creighton CJ, Heavener KS, Gutierrez C, Dou Y, Ku AT, Zhang Y, Jiang W, Urrutia J, Jiang W, Yue F, Jia L, Ibrahim AA, Zhang B, Huang S, Li Y. Sci Adv. 2023 May 12;9(19):eade0059. doi: 10.1126/sciadv.ade0059. Epub 2023 May 12. PubMed
Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells. Jost P, Klein F, Brand B, Wahl V, Wyatt A, Yildiz D, Boehm U, Niemeyer BA, Vaeth M, Alansary D. Int J Mol Sci. 2023 Apr 24;24(9):7772. doi: 10.3390/ijms24097772. PubMed
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer. Maier CR, Hartmann O, Prieto-Garcia C, Al-Shami KM, Schlicker L, Vogel FCE, Haid S, Klann K, Buck V, Munch C, Schmitz W, Einig E, Krenz B, Calzado MA, Eilers M, Popov N, Rosenfeldt MT, Diefenbacher ME, Schulze A. Cell Death Differ. 2023 Jul;30(7):1710-1725. doi: 10.1038/s41418-023-01173-6. Epub 2023 May 18. PubMed
Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior. Al-Kachak A, Fulton SL, Di Salvo G, Chan JC, Farrelly LA, Lepack AE, Bastle RM, Kong L, Cathomas F, Newman EL, Menard C, Ramakrishnan A, Safovich P, Lyu Y, Covington HE 3rd, Shen L, Gleason K, Tamminga CA, Russo SJ, Maze I. bioRxiv [Preprint]. 2023 Sep 16:2023.05.04.539464. doi: 10.1101/2023.05.04.539464. PubMed
FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI. Cell Rep. 2023 May 30;42(5):112530. doi: 10.1016/j.celrep.2023.112530. Epub 2023 May 18. PubMed
Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state. Gotz V, Qiao S, Das D, Wartenberg P, Wyatt A, Wahl V, Gamayun I, Alasmi S, Fecher-Trost C, Meyer MR, Rad R, Kaltenbacher T, Kattler K, Lipp P, Becherer U, Mollard P, Candlish M, Boehm U. Cell Rep. 2023 May 23;42(6):112543. doi: 10.1016/j.celrep.2023.112543. PubMed
Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome. Tabata H, Mori D, Matsuki T, Yoshizaki K, Asai M, Nakayama A, Ozaki N, Nagata KI. Biomolecules. 2023 Apr 27;13(5):763. doi: 10.3390/biom13050763. PubMed
Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function. Renauer P, Park JJ, Bai M, Acosta A, Lee WH, Lin GH, Zhang Y, Dai X, Wang G, Errami Y, Wu T, Clark P, Ye L, Yang Q, Chen S. Cancer Immunol Res. 2023 Aug 3;11(8):1068-1084. doi: 10.1158/2326-6066.CIR-22-0565. PubMed
AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction. Han Z, Luo N, Ma W, Liu X, Cai Y, Kou J, Wang J, Li L, Peng S, Xu Z, Zhang W, Qiu Y, Wu Y, Ye C, Lin K, Xu F. Nat Commun. 2023 Jun 26;14(1):3792. doi: 10.1038/s41467-023-39554-7. PubMed
Scalable, cell type-selective, AAV-based in vivo CRISPR screening in the mouse brain. Ramani B, Rose IVL, Pan A, Tian R, Ma K, Palop JJ, Kampmann M. bioRxiv [Preprint]. 2023 Jun 27:2023.06.13.544831. doi: 10.1101/2023.06.13.544831. PubMed
Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing. Fu Q, Lee YS, Green EA, Wang Y, Park SY, Polanco A, Lee KH, Betenbaugh M, McNally D, Yoon S. Biotechnol Bioeng. 2023 Jul 21. doi: 10.1002/bit.28508. PubMed
KMT2C knockout generates ASD-like behaviors in mice. Brauer B, Merino-Veliz N, Ahumada-Marchant C, Arriagada G, Bustos FJ. Front Cell Dev Biol. 2023 Jul 19;11:1227723. doi: 10.3389/fcell.2023.1227723. eCollection 2023. PubMed
Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, Li X, Li M, Li J, Cheng S, Liu Y, Xu Y, Yan W. Nat Commun. 2023 Aug 24;14(1):5179. doi: 10.1038/s41467-023-40571-9. PubMed
A split and inducible adenine base editor for precise in vivo base editing. Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, Gilberd P, Osikpa EC, Sun Z, Gao X. Nat Commun. 2023 Sep 11;14(1):5573. doi: 10.1038/s41467-023-41331-5. PubMed

Associated Plasmids

Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia. Zhou DY, Su X, Wu Y, Yang Y, Zhang L, Cheng S, Shao M, Li W, Zhang Z, Wang L, Lv L, Li M, Song M. Neuropsychopharmacology. 2024 Jan;49(2):433-442. doi: 10.1038/s41386-023-01732-y. Epub 2023 Sep 15. PubMed
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography. Shastry S, Chu W, Barbieri E, Greback-Clarke P, Smith WK, Cummings C, Minzoni A, Pancorbo J, Gilleskie G, Ritola K, Daniele MA, Johnson TF, Menegatti S. Biotechnol J. 2024 Jan;19(1):e2300230. doi: 10.1002/biot.202300230. Epub 2023 Sep 28. PubMed
Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease. Sela M, Poley M, Mora-Raimundo P, Kagan S, Avital A, Kaduri M, Chen G, Adir O, Rozencweig A, Weiss Y, Sade O, Leichtmann-Bardoogo Y, Simchi L, Aga-Mizrachi S, Bell B, Yeretz-Peretz Y, Or AZ, Choudhary A, Rosh I, Cordeiro D, Cohen-Adiv S, Berdichevsky Y, Odeh A, Shklover J, Shainsky-Roitman J, Schroeder JE, Hershkovitz D, Hasson P, Ashkenazi A, Stern S, Laviv T, Ben-Zvi A, Avital A, Ashery U, Maoz BM, Schroeder A. Adv Mater. 2023 Dec;35(51):e2304654. doi: 10.1002/adma.202304654. Epub 2023 Oct 27. PubMed
Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Thurkauf M, Lin S, Oliveri F, Grimm D, Platt RJ, Ruegg MA. Nat Commun. 2023 Sep 30;14(1):6116. doi: 10.1038/s41467-023-41769-7. PubMed
Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors. Maurer AC, Benyamini B, Fan VB, Whitney ON, Dailey GM, Darzacq X, Weitzman MD, Tjian R. bioRxiv [Preprint]. 2023 Sep 19:2023.09.19.558438. doi: 10.1101/2023.09.19.558438. PubMed
Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis. Ma L, Chang Q, Pei F, Liu M, Zhang W, Hong YK, Chai Y, Chen JF. Cell Stem Cell. 2023 Nov 2;30(11):1472-1485.e7. doi: 10.1016/j.stem.2023.09.012. Epub 2023 Oct 19. PubMed
RNA-based translation activators for targeted gene upregulation. Cao Y, Liu H, Lu SS, Jones KA, Govind AP, Jeyifous O, Simmons CQ, Tabatabaei N, Green WN, Holder JL Jr, Tahmasebi S, George AL Jr, Dickinson BC. Nat Commun. 2023 Oct 26;14(1):6827. doi: 10.1038/s41467-023-42252-z. PubMed
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition. Verkade E, Shen W, Hovingh MV, Mulder NL, de Bruyn K, Koehorst M, de Vries HD, Bloks VW, Kuipers F, de Boer JF. Clin Sci (Lond). 2023 Nov 15;137(21):1637-1650. doi: 10.1042/CS20230812. PubMed
Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation. Tanwattana N, Wanasen N, Jantraphakorn Y, Srisutthisamphan K, Chailungkarn T, Boonrungsiman S, Lumlertdacha B, Lekchareonsuk P, Kaewborisuth C. PLoS One. 2023 Nov 3;18(11):e0292833. doi: 10.1371/journal.pone.0292833. eCollection 2023. PubMed
Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability. Pracucci E, Graham RT, Alberio L, Nardi G, Cozzolino O, Pillai V, Pasquini G, Saieva L, Walsh D, Landi S, Zhang J, Trevelyan AJ, Ratto GM. Nat Commun. 2023 Nov 4;14(1):7108. doi: 10.1038/s41467-023-42711-7. PubMed
Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors. Benyamini B, Esbin MN, Whitney O, Walther N, Maurer AC. J Vis Exp. 2023 Oct 20;(200). doi: 10.3791/65572. PubMed
Modular vector assembly enables rapid assessment of emerging CRISPR technologies. McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Velasco BE, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG. bioRxiv [Preprint]. 2023 Oct 27:2023.10.25.564061. doi: 10.1101/2023.10.25.564061. PubMed
Simple and Highly Specific Targeting of Resident Microglia with Adeno-Associated Virus. Serrano C, Cananzi S, Shen T, Wang LL, Zhang CL. bioRxiv [Preprint]. 2023 Dec 13:2023.12.12.571321. doi: 10.1101/2023.12.12.571321. PubMed
Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells. Shao J, Li S, Qiu X, Jiang J, Zhang L, Wang P, Si Y, Wu Y, He M, Xiong Q, Zhao L, Li Y, Fan Y, Viviani M, Fu Y, Wu C, Gao T, Zhu L, Fussenegger M, Wang H, Xie M. Cell Res. 2024 Jan;34(1):31-46. doi: 10.1038/s41422-023-00896-y. Epub 2024 Jan 4. PubMed

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