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pMDLg/pRRE Citations (321)

Plasmid Article: A third-generation lentivirus vector with a conditional packaging system.
Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L J Virol. 1998 Nov . 72(11):8463-71.
PubMed

Articles Citing pMDLg/pRRE

Articles
Determination of the transforming activities of adenovirus oncogenes. Nevels M, Dobner T. Methods Mol Med. 2007;131:187-95. PubMed
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation. Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES. J Virol. 2009 Jul;83(14):7129-41. doi: 10.1128/JVI.00397-09. Epub 2009 May 13. PubMed
In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Krupka N, Strappe P, Götz J, Ittner LM. Plasmid. 2010 Feb 2. ():. PubMed

Associated Plasmids

The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1. Ellis SL, Gysbers V, Manders PM, Li W, Hofer MJ, Muller M, Campbell IL. J Immunol. 2010 Aug 1;185(3):1864-77. doi: 10.4049/jimmunol.1000900. Epub 2010 Jun 28. PubMed
EGFR/Met association regulates EGFR TKI resistance in breast cancer. Mueller KL, Yang ZQ, Haddad R, Ethier SP, Boerner JL. J Mol Signal. 2010 Jul 12;5:8. doi: 10.1186/1750-2187-5-8. PubMed
Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon alpha-induced early antiviral signalling. Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, Kummer U, Klingmuller U. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x. Epub 2010 Oct 21. PubMed
Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. J Virol. 2011 Jan;85(1):146-55. doi: 10.1128/JVI.01265-10. Epub 2010 Oct 27. PubMed
Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. Harris SJ, Parry RV, Foster JG, Blunt MD, Wang A, Marelli-Berg F, Westwick J, Ward SG. J Immunol. 2011 Apr 15;186(8):4936-45. doi: 10.4049/jimmunol.1002350. Epub 2011 Mar 14. PubMed
Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. Irwin ME, Mueller KL, Bohin N, Ge Y, Boerner JL. J Cell Physiol. 2011 Sep;226(9):2316-28. doi: 10.1002/jcp.22570. PubMed
Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. McGuire KA, Barlan AU, Griffin TM, Wiethoff CM. J Virol. 2011 Oct;85(20):10806-13. doi: 10.1128/JVI.00675-11. Epub 2011 Aug 10. PubMed
FOSL1 is integral to establishing the maternal-fetal interface. Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. Mol Cell Biol. 2011 Dec;31(23):4801-13. doi: 10.1128/MCB.05780-11. Epub 2011 Sep 26. PubMed
Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES. PLoS Pathog. 2011 Dec;7(12):e1002418. doi: 10.1371/journal.ppat.1002418. Epub 2011 Dec 8. PubMed
The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. Al Sorkhy M, Ferraiuolo RM, Jalili E, Malysa A, Fratiloiu AR, Sloane BF, Porter LA. BMC Cancer. 2012 Jan 26;12:45. doi: 10.1186/1471-2407-12-45. PubMed
RGB marking with lentiviral vectors for multicolor clonal cell tracking. Weber K, Thomaschewski M, Benten D, Fehse B. Nat Protoc. 2012 Apr 5;7(5):839-49. doi: 10.1038/nprot.2012.026. PubMed
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR. RNA. 2012 Jun;18(6):1186-96. doi: 10.1261/rna.031369.111. Epub 2012 Apr 27. PubMed

Associated Plasmids

Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed
Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met. Mueller KL, Madden JM, Zoratti GL, Kuperwasser C, List K, Boerner JL. Breast Cancer Res. 2012 Jul 12;14(4):R104. doi: 10.1186/bcr3224. PubMed
Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ. Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11. PubMed
Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, Recchia A, Cathomen T, Goncalves MA. Nucleic Acids Res. 2013 Mar 1;41(5):e63. doi: 10.1093/nar/gks1446. Epub 2012 Dec 28. PubMed
Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine. DeRose YS, Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE. Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.23. doi: 10.1002/0471141755.ph1423s60. PubMed
Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. Friesland M, Mingorance L, Chung J, Chisari FV, Gastaminza P. J Virol. 2013 Jun;87(11):6377-90. doi: 10.1128/JVI.03557-12. Epub 2013 Mar 27. PubMed
A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy. Werling NJ, Thorpe R, Zhao Y. Hum Gene Ther Methods. 2013 Jun;24(3):171-84. doi: 10.1089/hgtb.2012.146. Epub 2013 Apr 30. PubMed
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11. PubMed
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23. PubMed
A robust method to derive functional neural crest cells from human pluripotent stem cells. Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR. Am J Stem Cells. 2013 Jun 30;2(2):119-31. Print 2013. PubMed
Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R. Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. PubMed
The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed
The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. Guo Y, Meng X, Wang Q, Wang Y, Shang H. PLoS One. 2013 Aug 13;8(8):e71453. doi: 10.1371/journal.pone.0071453. eCollection 2013. PubMed
Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging. Thalheimer A, Korb D, Bonicke L, Wiegering A, Muhling B, Schneider M, Koch S, Riedel SS, Germer CT, Beilhack A, Brandlein S, Otto C. J Surg Res. 2013 Nov;185(1):143-51. doi: 10.1016/j.jss.2013.03.024. Epub 2013 Mar 30. PubMed
Determination of the transforming activities of adenovirus oncogenes. Speiseder T, Nevels M, Dobner T. Methods Mol Biol. 2014;1089:105-15. doi: 10.1007/978-1-62703-679-5_8. PubMed
Parallel measurement of dynamic changes in translation rates in single cells. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10. PubMed

Associated Plasmids

A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. Perez-Lorenzo R, Gill KZ, Shen CH, Zhao FX, Zheng B, Schulze HJ, Silvers DN, Brunner G, Horst BA. J Invest Dermatol. 2014 May;134(5):1359-68. doi: 10.1038/jid.2013.511. Epub 2013 Nov 28. PubMed
Automated analysis of clonal cancer cells by intravital imaging. Coffey SE, Giedt RJ, Weissleder R. Intravital. 2013 Jul;2(3). doi: 10.4161/intv.26138. PubMed
A human torque teno virus encodes a microRNA that inhibits interferon signaling. Kincaid RP, Burke JM, Cox JC, de Villiers EM, Sullivan CS. PLoS Pathog. 2013;9(12):e1003818. doi: 10.1371/journal.ppat.1003818. Epub 2013 Dec 19. PubMed
The FOS transcription factor family differentially controls trophoblast migration and invasion. Renaud SJ, Kubota K, Rumi MA, Soares MJ. J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30. PubMed
Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A. Exp Cell Res. 2014 Apr 1;322(2):335-44. doi: 10.1016/j.yexcr.2014.02.006. Epub 2014 Feb 18. PubMed
Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M. PLoS One. 2014 Mar 6;9(6):e90736. doi: 10.1371/journal.pone.0090736. eCollection 2014. PubMed
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. Cell Rep. 2014 Mar 27;6(6):1059-72. doi: 10.1016/j.celrep.2014.02.038. Epub 2014 Mar 6. PubMed
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly. Joo EE, Yamada KM. Nat Commun. 2014 Mar 25;5:3510. doi: 10.1038/ncomms4510. PubMed

Associated Plasmids

Transdifferentiation of mouse fibroblasts and hepatocytes to functional neurons. Marro S, Yang N. Methods Mol Biol. 2014;1150:237-46. doi: 10.1007/978-1-4939-0512-6_16. PubMed
Human papillomavirus 16 E6 contributes HIF-1alpha induced Warburg effect by attenuating the VHL-HIF-1alpha interaction. Guo Y, Meng X, Ma J, Zheng Y, Wang Q, Wang Y, Shang H. Int J Mol Sci. 2014 May 7;15(5):7974-86. doi: 10.3390/ijms15057974. PubMed
FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed
Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. J Vis Exp. 2014 Jun 24;(88):e51666. doi: 10.3791/51666. PubMed
Lentiviral gene transduction of mouse and human hematopoietic stem cells. van Til NP, Wagemaker G. Methods Mol Biol. 2014;1185:311-9. doi: 10.1007/978-1-4939-1133-2_21. PubMed
StUbEx: Stable tagged ubiquitin exchange system for the global investigation of cellular ubiquitination. Akimov V, Henningsen J, Hallenborg P, Rigbolt KT, Jensen SS, Nielsen MM, Kratchmarova I, Blagoev B. J Proteome Res. 2014 Sep 5;13(9):4192-204. doi: 10.1021/pr500549h. Epub 2014 Aug 15. PubMed
Phosphorylation site dynamics of early T-cell receptor signaling. Chylek LA, Akimov V, Dengjel J, Rigbolt KT, Hu B, Hlavacek WS, Blagoev B. PLoS One. 2014 Aug 22;9(8):e104240. doi: 10.1371/journal.pone.0104240. eCollection 2014. PubMed
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Muller AM. Stem Cells. 2014 Dec;32(12):3112-25. doi: 10.1002/stem.1826. PubMed
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. Tang X, Benesch MG, Dewald J, Zhao YY, Patwardhan N, Santos WL, Curtis JM, McMullen TP, Brindley DN. J Lipid Res. 2014 Nov;55(11):2389-400. doi: 10.1194/jlr.M053462. Epub 2014 Sep 10. PubMed
HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells. Polakowski N, Terol M, Hoang K, Nash I, Laverdure S, Gazon H, Belrose G, Mesnard JM, Cesaire R, Peloponese JM, Lemasson I. J Virol. 2014 Nov;88(22):13482-94. doi: 10.1128/JVI.02285-14. Epub 2014 Sep 10. PubMed
Establishment of a cell line with stable expression of mCherry-EGFP tandem fluorescent-tagged LC3B for studying the impact of HIV-1 infection on autophagic flux. Liu B, Liu C, Zhao X, Shen W, Qian L, Wei Y, Kong X. J Virol Methods. 2014 Dec;209:95-102. doi: 10.1016/j.jviromet.2014.09.012. Epub 2014 Sep 18. PubMed
ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Plotnik JP, Budka JA, Ferris MW, Hollenhorst PC. Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. doi: 10.1093/nar/gku929. Epub 2014 Oct 7. PubMed
In vivo shRNA screens in solid tumors. Gargiulo G, Serresi M, Cesaroni M, Hulsman D, van Lohuizen M. Nat Protoc. 2014 Dec;9(12):2880-902. doi: 10.1038/nprot.2014.185. Epub 2014 Nov 20. PubMed
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J. Mol Cell. 2014 Nov 6;56(3):400-13. doi: 10.1016/j.molcel.2014.09.026. Epub 2014 Oct 21. PubMed
Fanconi anemia gene editing by the CRISPR/Cas9 system. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Hum Gene Ther. 2015 Feb;26(2):114-26. doi: 10.1089/hum.2014.111. PubMed
MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2. Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong le A, Zhu J, Ye S, Zhang L, Xiao Q. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):918-29. doi: 10.1161/ATVBAHA.114.305212. Epub 2015 Feb 26. PubMed
Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2. Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P. PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015. PubMed
Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW. Biomaterials. 2015 Jun;52:551-60. doi: 10.1016/j.biomaterials.2015.01.025. Epub 2015 Mar 18. PubMed
Ebola Virus Glycoprotein Promotes Enhanced Viral Egress by Preventing Ebola VP40 From Associating With the Host Restriction Factor BST2/Tetherin. Gustin JK, Bai Y, Moses AV, Douglas JL. J Infect Dis. 2015 Mar 27. pii: jiv125. PubMed
Lentiviral vectors for retrograde delivery of recombinases and transactivators. Wickersham IR, Sullivan HA, Pao GM, Hamanaka H, Goosens KA, Verma IM, Seung HS. Cold Spring Harb Protoc. 2015 Apr 1;2015(4):368-74. doi: 10.1101/pdb.prot075879. PubMed
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H. Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359. PubMed
alpha6beta1- and alphaV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF. Cattavarayane S, Palovuori R, Tanjore Ramanathan J, Manninen A. BMC Cell Biol. 2015 Feb 27;16:3. doi: 10.1186/s12860-015-0051-y. PubMed
Ex vivo aorta patch model for analysis of cellular adhesion. Lin YN, Thata RN, Failla AV, Geissen M, Daum G, Windhorst S. Tissue Cell. 2015 Jun;47(3):266-72. doi: 10.1016/j.tice.2015.03.004. Epub 2015 Mar 23. PubMed
Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells. Rodrigues AF, Formas-Oliveira AS, Guerreiro MR, Tomas HA, Alves PM, Coroadinha AS. Gene Ther. 2015 Sep;22(9):685-95. doi: 10.1038/gt.2015.44. Epub 2015 May 4. PubMed
Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. J Vis Exp. 2015 Apr 23;(98). doi: 10.3791/52740. PubMed
An alternative pluripotent state confers interspecies chimaeric competency. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6. PubMed
Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Negro-Demontel ML, Saccardo P, Giacomini C, Yanez-Munoz RJ, Ferrer-Miralles N, Vazquez E, Villaverde A, Peluffo H. Mol Ther Methods Clin Dev. 2014 Oct 15;1:14047. doi: 10.1038/mtm.2014.47. eCollection 2014. PubMed
Akt signaling dynamics in individual cells. Gross SM, Rotwein P. J Cell Sci. 2015 Jun 3. pii: jcs.168773. PubMed

Associated Plasmids

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed
More Tricks with Tetramers: A Practical Guide to Staining T cells with peptide-MHC Multimers. Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK. Immunology. 2015 Jun 16. doi: 10.1111/imm.12499. PubMed
Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK. Stem Cells Dev. 2015 Jun 25. PubMed
Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion. Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S. Oncotarget. 2015 Jul 30;6(21):18577-89. PubMed
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets. Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP. Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942. PubMed

Associated Plasmids

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed
RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Marlow LA, Bok I, Smallridge RC, Copland JA. Endocr Relat Cancer. 2015 Oct;22(5):777-92. doi: 10.1530/ERC-14-0302. Epub 2015 Jul 23. PubMed
Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. Friedrichs S, Malan D, Voss Y, Sasse P. J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102. PubMed
Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Gardner S, Gross SM, David LL, Klimek JE, Rotwein P. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C491-500. doi: 10.1152/ajpcell.00184.2015. Epub 2015 Aug 5. PubMed
CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed
Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. Stem Cell Res Ther. 2015 Sep 21;6:181. doi: 10.1186/s13287-015-0151-9. PubMed
The role of APC/C in replication stress and origin of genomic instability. Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, Wasch R. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.367. PubMed
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. Sci Rep. 2015 Nov 13;5:16595. doi: 10.1038/srep16595. PubMed
Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Oncotarget. 2016 Jan 12;7(2):1796-807. doi: 10.18632/oncotarget.6427. PubMed
C/EBPgamma is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. Mol Cell Biol. 2015 Dec 14. pii: MCB.00911-15. PubMed
Long-acting cocaine hydrolase for addiction therapy. Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan CG. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):422-7. doi: 10.1073/pnas.1517713113. Epub 2015 Dec 28. PubMed
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry S. PLoS Pathog. 2016 Jan 6;12(1):e1005379. doi: 10.1371/journal.ppat.1005379. eCollection 2016 Jan. PubMed
NBR1 enables autophagy-dependent focal adhesion turnover. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. J Cell Biol. 2016 Feb 29;212(5):577-590. Epub 2016 Feb 22. PubMed

Associated Plasmids

Integrin-linked kinase as a novel molecular switch of the IL-6-NF-kappaB signaling loop in breast cancer. Hsu EC, Kulp SK, Huang HL, Tu HJ, Chao MW, Tseng YC, Yang MC, Salunke SB, Sullivan NJ, Chen WC, Zhang J, Teng CM, Fu WM, Sun D, Wicha MS, Shapiro CL, Chen CS. Carcinogenesis. 2016 Apr;37(4):430-42. doi: 10.1093/carcin/bgw020. Epub 2016 Feb 19. PubMed
Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling. Hossain MS, Mineno K, Katafuchi T. PLoS One. 2016 Mar 2;11(3):e0150846. doi: 10.1371/journal.pone.0150846. eCollection 2016. PubMed
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed
Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects. Porlan E, Marti-Prado B, Consiglio A, Farinas I. J Vis Exp. 2016 Feb 17;(108). doi: 10.3791/53282. PubMed
Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells. Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP. Mol Ther. 2016 May 24. doi: 10.1038/mt.2016.70. PubMed
Development of Rabies Virus-Like Particles for Vaccine Applications: Production, Characterization, and Protection Studies. Fontana D, Etcheverrigaray M, Kratje R, Prieto C. Methods Mol Biol. 2016;1403:155-66. doi: 10.1007/978-1-4939-3387-7_7. PubMed
Analysis of Nuclear Lamina Proteins in Myoblast Differentiation by Functional Complementation. Tapia O, Gerace L. Methods Mol Biol. 2016;1411:177-94. doi: 10.1007/978-1-4939-3530-7_11. PubMed
MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed
Forced expression of Hnf4a induces hepatic gene activation through directed differentiation. Yahoo N, Pournasr B, Rostamzadeh J, Fathi F. Biochem Biophys Res Commun. 2016 Aug 5;476(4):313-8. doi: 10.1016/j.bbrc.2016.05.119. Epub 2016 May 24. PubMed
shRNA-Induced Gene Knockdown In Vivo to Investigate Neutrophil Function. Basit A, Tang W, Wu D. Methods Mol Biol. 2016;1407:169-77. doi: 10.1007/978-1-4939-3480-5_13. PubMed
Angiopoietin-2 promotes ER+ breast cancer cell survival in bone marrow niche. Han HH, Kim BG, Lee JH, Kang S, Kim JE, Cho NH. Endocr Relat Cancer. 2016 Aug;23(8):609-23. doi: 10.1530/ERC-16-0086. Epub 2016 Jun 27. PubMed
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lonnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E. EMBO J. 2016 Sep 15;35(18):1963-78. doi: 10.15252/embj.201593725. Epub 2016 Jun 28. PubMed
Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females. Jacobs DC, Veitch RE, Chappell PE. Endocrinology. 2016 Sep;157(9):3410-9. doi: 10.1210/en.2016-1294. Epub 2016 Jul 13. PubMed
Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection. Horne DJ, Graustein AD, Shah JA, Peterson G, Savlov M, Steele S, Narita M, Hawn TR. J Infect Dis. 2016 Oct 15;214(8):1260-7. doi: 10.1093/infdis/jiw347. Epub 2016 Aug 2. PubMed
Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells. Baumlin-Schmid N, Salathe M, Fregien NL. J Vis Exp. 2016 Jul 22;(113). doi: 10.3791/54176. PubMed
STAT3-induced WDR1 overexpression promotes breast cancer cell migration. Lee JH, Kim JE, Kim BG, Han HH, Kang S, Cho NH. Cell Signal. 2016 Nov;28(11):1753-60. doi: 10.1016/j.cellsig.2016.08.006. Epub 2016 Aug 10. PubMed
Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Kaminski R, Chen Y, Salkind J, Bella R, Young WB, Ferrante P, Karn J, Malcolm T, Hu W, Khalili K. Sci Rep. 2016 Aug 16;6:31527. doi: 10.1038/srep31527. PubMed
Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells. Haga K, Fujimoto A, Takai-Todaka R, Miki M, Doan YH, Murakami K, Yokoyama M, Murata K, Nakanishi A, Katayama K. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6248-E6255. Epub 2016 Sep 28. PubMed
The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism. Molck C, Ryall J, Failla LM, Coates JL, Pascussi JM, Heath JK, Stewart G, Hollande F. Cancer Lett. 2016 Dec 1;383(1):135-143. doi: 10.1016/j.canlet.2016.09.018. Epub 2016 Sep 28. PubMed
LDB1 overexpression is a negative prognostic factor in colorectal cancer. Garcia SA, Swiersy A, Radhakrishnan P, Branchi V, Kanth Nanduri L, Gyorffy B, Betzler AM, Bork U, Kahlert C, Reissfelder C, Rahbari NN, Weitz J, Scholch S. Oncotarget. 2016 Dec 20;7(51):84258-84270. doi: 10.18632/oncotarget.12481. PubMed
Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed
Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. Oncoimmunology. 2016 Aug 3;5(9):e1211221. eCollection 2016. PubMed
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed
The Hippo pathway regulates human megakaryocytic differentiation. Lorthongpanich C, Jiamvoraphong N, Supraditaporn K, Klaihmon P, U-Pratya Y, Issaragrisil S. Thromb Haemost. 2017 Jan 5;117(1):116-126. doi: 10.1160/TH16-07-0564. Epub 2016 Oct 27. PubMed
The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER. MBio. 2016 Oct 25;7(5). pii: e01747-16. doi: 10.1128/mBio.01747-16. PubMed
HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2. PubMed
Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport. Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K. Oncotarget. 2016 Nov 29;7(48):79885-79900. doi: 10.18632/oncotarget.13089. PubMed
Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. Nat Commun. 2016 Nov 11;7:13247. doi: 10.1038/ncomms13247. PubMed
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16. PubMed

Associated Plasmids

miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico. Barta T, Peskova L, Hampl A. Sci Rep. 2016 Nov 18;6:36625. doi: 10.1038/srep36625. PubMed
The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K. Oncotarget. 2016 Dec 27;7(52):86871-86888. doi: 10.18632/oncotarget.13508. PubMed
ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68. Wei W, Guo H, Chang J, Yu Y, Liu G, Zhang N, Willard SH, Zheng S, Yu XF. Cell Host Microbe. 2016 Nov 9;20(5):631-641. doi: 10.1016/j.chom.2016.09.013. Epub 2016 Oct 27. PubMed
Monitoring Synapses Via Trans-Synaptic GFP Complementation. Tsetsenis T. Methods Mol Biol. 2017;1538:45-52. PubMed
Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed
A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. Moser BA, Esser-Kahn AP. ACS Chem Biol. 2016 Dec 29. doi: 10.1021/acschembio.6b01012. PubMed
An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides. Peskova M, Heger Z, Janda P, Adam V, Pekarik V. Peptides. 2016 Dec 22;88:87-96. doi: 10.1016/j.peptides.2016.12.015. PubMed
De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy. Mufarrege EF, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot AS. Clin Immunol. 2017 Jan 10;176:31-41. doi: 10.1016/j.clim.2017.01.003. PubMed
Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed
Pooled CRISPR screening with single-cell transcriptome readout. Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C. Nat Methods. 2017 Jan 18. doi: 10.1038/nmeth.4177. PubMed

Associated Plasmids

Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2. Plotnik JP, Hollenhorst PC. Nucleic Acids Res. 2017 May 5;45(8):4452-4462. doi: 10.1093/nar/gkx039. PubMed
Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed
Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. PubMed
Enhancement of beta-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Phanthong P, Borwornpinyo S, Kitiyanant N, Jearawiriyapaisarn N, Nuntakarn L, Saetan J, Nualkaew T, Sa-Ngiamsuntorn K, Anurathapan U, Dinnyes A, Kitiyanant Y, Hongeng S. Stem Cells Transl Med. 2017 Apr;6(4):1059-1069. doi: 10.1002/sctm.16-0121. Epub 2017 Feb 18. PubMed
Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-kappaB Signal Leading to Microglial Activation. Hossain MS, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, Katafuchi T. J Neurosci. 2017 Apr 12;37(15):4074-4092. doi: 10.1523/JNEUROSCI.3941-15.2017. Epub 2017 Mar 14. PubMed
Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ. PLoS One. 2017 Apr 5;12(4):e0174863. doi: 10.1371/journal.pone.0174863. eCollection 2017. PubMed
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martin-Montanez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sanchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E. Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10. PubMed
Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, Grolla AA, Del Grosso E, Bellini R, Bianchi M, Travelli C, Garavaglia S, Sorci L, Raffaelli N, Ruggieri S, Genazzani AA, Orsomando G. Cell Chem Biol. 2017 May 18;24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. Epub 2017 Apr 13. PubMed
Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions. Pham ND, Pang PC, Krishnamurthy S, Wands AM, Grassi P, Dell A, Haslam SM, Kohler JJ. J Biol Chem. 2017 Jun 9;292(23):9637-9651. doi: 10.1074/jbc.M116.764597. Epub 2017 Apr 19. PubMed
Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Hossain MS, Oomura Y, Katafuchi T. Mol Neurobiol. 2017 May 13. doi: 10.1007/s12035-017-0578-3. PubMed
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x. PubMed
Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed
PI3K class II alpha regulates delta-opioid receptor export from the trans-Golgi network. Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA. Mol Biol Cell. 2017 Aug 1;28(16):2202-2219. doi: 10.1091/mbc.E17-01-0030. Epub 2017 May 31. PubMed
Generation of Induced Pluripotent Stem Cells in Defined Three-Dimensional Hydrogels. Caiazzo M, Tabata Y, Lutolf M. Methods Mol Biol. 2017;1612:65-78. doi: 10.1007/978-1-4939-7021-6_5. PubMed
Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Huang HL, Wu HY, Chu PC, Lai IL, Huang PH, Kulp SK, Pan SL, Teng CM, Chen CS. Oncogenesis. 2017 Jul 10;6(7):e359. doi: 10.1038/oncsis.2017.61. PubMed
Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Morgan SL, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Jia L, Chen H, Hu JF, Hoffman AR, Huang CC, Pitteri SJ, Wang KC. Nat Commun. 2017 Jul 13;8:15993. doi: 10.1038/ncomms15993. PubMed
CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions. Gasperini M, Findlay GM, McKenna A, Milbank JH, Lee C, Zhang MD, Cusanovich DA, Shendure J. Am J Hum Genet. 2017 Aug 3;101(2):192-205. doi: 10.1016/j.ajhg.2017.06.010. Epub 2017 Jul 14. PubMed
Intratumoral Lentivector-Mediated TGF-beta1 Gene Downregulation As a Potent Strategy for Enhancing the Antitumor Effect of Therapy Composed of Cyclophosphamide and Dendritic Cells. Rossowska J, Anger N, Szczygiel A, Mierzejewska J, Pajtasz-Piasecka E. Front Immunol. 2017 Jun 30;8:713. doi: 10.3389/fimmu.2017.00713. eCollection 2017. PubMed
Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus. Sa-Ngiamsuntorn K, Hongeng S, Wongkajornsilp A. Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.13.1-4A.13.34. doi: 10.1002/cpsc.35. PubMed
ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP. J Biol Chem. 2017 Oct 27;292(43):17703-17717. doi: 10.1074/jbc.M117.792937. Epub 2017 Aug 28. PubMed
Assessment of selected media supplements to improve F/HN lentiviral vector production yields. Gelinas JF, Davies LA, Gill DR, Hyde SC. Sci Rep. 2017 Aug 31;7(1):10198. doi: 10.1038/s41598-017-07893-3. PubMed
Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK. Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11. PubMed
Optimized PEI-based Transfection Method for Transient Transfection and Lentiviral Production. Yang S, Zhou X, Li R, Fu X, Sun P. Curr Protoc Chem Biol. 2017 Sep 14;9(3):147-157. doi: 10.1002/cpch.25. PubMed
Strategies to Develop Therapeutic N- and O-Hyperglycosylated Proteins. Gugliotta A, Ceaglio N, Etcheverrigaray M, Kratje R, Oggero M. Methods Mol Biol. 2018;1674:163-181. doi: 10.1007/978-1-4939-7312-5_13. PubMed
CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Wang Y, Chen L, Tian Z, Shen X, Wang X, Wu H, Wang Y, Zou J, Liang J. Cell Biol Int. 2018 Feb;42(2):187-193. doi: 10.1002/cbin.10885. Epub 2017 Nov 9. PubMed
MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. Sci Rep. 2017 Oct 12;7(1):13101. doi: 10.1038/s41598-017-13298-z. PubMed
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. Mol Metab. 2017 Oct;6(10):1137-1149. doi: 10.1016/j.molmet.2017.06.014. Epub 2017 Jun 29. PubMed

Associated Plasmids

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed
High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. Wang L, Leite de Oliveira R, Wang C, Fernandes Neto JM, Mainardi S, Evers B, Lieftink C, Morris B, Jochems F, Willemsen L, Beijersbergen RL, Bernards R. Cell Rep. 2017 Oct 17;21(3):773-783. doi: 10.1016/j.celrep.2017.09.085. PubMed
MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M. Mol Ther. 2018 Jan 3;26(1):238-255. doi: 10.1016/j.ymthe.2017.09.019. Epub 2017 Sep 21. PubMed
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9873-E9882. doi: 10.1073/pnas.1706365114. Epub 2017 Oct 24. PubMed
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed
StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites. Akimov V, Olsen LCB, Hansen SVF, Barrio-Hernandez I, Puglia M, Jensen SS, Solov'yov IA, Kratchmarova I, Blagoev B. J Proteome Res. 2018 Jan 5;17(1):296-304. doi: 10.1021/acs.jproteome.7b00566. Epub 2017 Nov 1. PubMed
Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed
C/EBPbeta mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XHD, Sundaram GM, Ramalingam R, Burke B, Sampath P. Nucleic Acids Res. 2018 Jan 9;46(1):336-349. doi: 10.1093/nar/gkx1105. PubMed
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. PubMed
Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy. Jin X, Jin X, Kim LJY, Dixit D, Jeon HY, Kim EJ, Kim JK, Lee SY, Yin J, Rich JN, Kim H. Clin Cancer Res. 2018 Jan 15;24(2):383-394. doi: 10.1158/1078-0432.CCR-17-1529. Epub 2017 Dec 5. PubMed
Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice. Gandara C, Affleck V, Stoll EA. Hum Gene Ther Methods. 2018 Feb;29(1):1-15. doi: 10.1089/hgtb.2017.098. Epub 2018 Jan 24. PubMed
Requirement of Treg-intrinsic CTLA4/PKCeta signaling pathway for suppressing tumor immunity. Pedros C, Canonigo-Balancio AJ, Kong KF, Altman A. JCI Insight. 2017 Dec 7;2(23). pii: 95692. doi: 10.1172/jci.insight.95692. PubMed
Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. Al-Agha AE, Ahmed IA, Nuebel E, Moriwaki M, Moore B, Peacock KA, Mosbruger T, Neklason DW, Jorde LB, Yandell M, Welt CK. J Clin Endocrinol Metab. 2018 Feb 1;103(2):555-563. doi: 10.1210/jc.2017-01966. PubMed
Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets. Basu SK, Lee S, Salotti J, Basu S, Sakchaisri K, Xiao Z, Walia V, Westlake CJ, Morrison DK, Johnson PF. Cancer Res. 2018 Feb 15;78(4):891-908. doi: 10.1158/0008-5472.CAN-17-2353. Epub 2017 Dec 19. PubMed
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. Vierbuchen T, Ling E, Cowley CJ, Couch CH, Wang X, Harmin DA, Roberts CWM, Greenberg ME. Mol Cell. 2017 Dec 21;68(6):1067-1082.e12. doi: 10.1016/j.molcel.2017.11.026. PubMed
Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway. Fink DM, Sun MR, Heyne GW, Everson JL, Chung HM, Park S, Sheets MD, Lipinski RJ. Cell Signal. 2018 Apr;44:1-9. doi: 10.1016/j.cellsig.2017.12.007. Epub 2017 Dec 26. PubMed
Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding. Nidetz NF, Gallagher TM, Wiethoff CM. Virology. 2018 Feb;515:150-157. doi: 10.1016/j.virol.2017.12.016. Epub 2017 Dec 27. PubMed
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An efficient method for the transduction of primary pediatric glioma neurospheres. Meel MH, Metselaar DS, Waranecki P, Kaspers GJL, Hulleman E. MethodsX. 2018 Feb 27;5:173-183. doi: 10.1016/j.mex.2018.02.006. eCollection 2018. PubMed
Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions. Castella M, Boronat A, Martin-Ibanez R, Rodriguez V, Sune G, Caballero M, Marzal B, Perez-Amill L, Martin-Antonio B, Castano J, Bueno C, Balague O, Gonzalez-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua A, Yague J, Perez-Galan P, Rives S, Delgado J, Juan M. Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15. PubMed
USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y. J Virol. 2019 Mar 5;93(6). pii: JVI.01708-18. doi: 10.1128/JVI.01708-18. Print 2019 Mar 15. PubMed
Non-Invasive Longitudinal Bioluminescence Imaging of Human Mesoangioblasts in Bioengineered Esophagi. Crowley C, Butler CR, Camilli C, Hynds RE, Kolluri KK, Janes SM, De Coppi P, Urbani L. Tissue Eng Part C Methods. 2019 Feb;25(2):103-113. doi: 10.1089/ten.TEC.2018.0351. PubMed
Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System. Moses C, Nugent F, Waryah CB, Garcia-Bloj B, Harvey AR, Blancafort P. Mol Ther Nucleic Acids. 2019 Mar 1;14:287-300. doi: 10.1016/j.omtn.2018.12.003. Epub 2018 Dec 14. PubMed
Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging. Nystrom NN, Hamilton AM, Xia W, Liu S, Scholl TJ, Ronald JA. Invest Radiol. 2019 May;54(5):302-311. doi: 10.1097/RLI.0000000000000542. PubMed
Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ. Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. Epub 2019 Jan 24. PubMed
Regenerative potential of mouse embryonic stem cell-derived PDGFRalpha(+) cardiac lineage committed cells in infarcted myocardium. Hong SP, Song S, Lee S, Jo H, Kim HK, Han J, Park JH, Cho SW. World J Stem Cells. 2019 Jan 26;11(1):44-54. doi: 10.4252/wjsc.v11.i1.44. PubMed
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed
Specific, sensitive and stable reporting of human mesenchymal stromal cell chondrogenesis. De La Vega RE, Scheu M, Brown LA, Evans C, Ferreira E, Porter RM. Tissue Eng Part C Methods. 2019 Feb 6. doi: 10.1089/ten.TEC.2018.0295. PubMed

Associated Plasmids

Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-small ka, CyrillicB Pathway in Bladder Cancer Cells. Deng Y, Bi R, Guo H, Yang J, Du Y, Wang C, Wei W. Int J Biol Sci. 2019 Jan 24;15(3):688-700. doi: 10.7150/ijbs.30847. eCollection 2019. PubMed
Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing. Lu B, Javidi-Parsijani P, Makani V, Mehraein-Ghomi F, Sarhan WM, Sun D, Yoo KW, Atala ZP, Lyu P, Atala A. Nucleic Acids Res. 2019 Feb 13. pii: 5316732. doi: 10.1093/nar/gkz093. PubMed

Associated Plasmids

A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-kappaB Activity. Li Y, Mooney EC, Holden SE, Xia XJ, Cohen DJ, Walsh SW, Ma A, Sahingur SE. J Immunol. 2019 Apr 1;202(7):2044-2056. doi: 10.4049/jimmunol.1801286. Epub 2019 Feb 13. PubMed
Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Hoke A, Mao HQ. Heliyon. 2018 Nov 29;4(11):e00982. doi: 10.1016/j.heliyon.2018.e00982. eCollection 2018 Nov. PubMed
Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Husic M, Barsyte-Lovejoy D, Lovejoy DA. Front Endocrinol (Lausanne). 2019 Feb 1;10:22. doi: 10.3389/fendo.2019.00022. eCollection 2019. PubMed
Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells. Hannafon BN, Gin AL, Xu YF, Bruns M, Calloway CL, Ding WQ. Cell Commun Signal. 2019 Feb 19;17(1):13. doi: 10.1186/s12964-019-0325-7. PubMed
PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T. Cell Rep. 2019 Feb 26;26(9):2316-2328.e6. doi: 10.1016/j.celrep.2019.02.001. PubMed
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. Angiolini F, Belloni E, Giordano M, Campioni M, Forneris F, Paronetto MP, Lupia M, Brandas C, Pradella D, Di Matteo A, Giampietro C, Jodice G, Luise C, Bertalot G, Freddi S, Malinverno M, Irimia M, Moulton JD, Summerton J, Chiapparino A, Ghilardi C, Giavazzi R, Nyqvist D, Gabellini D, Dejana E, Cavallaro U, Ghigna C. Elife. 2019 Mar 4;8. pii: 44305. doi: 10.7554/eLife.44305. PubMed
Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Yan X, Tang B, Chen B, Shan Y, Yang H, Iorns E, Tsui R, Denis A, Perfito N, Errington TM. Elife. 2019 Mar 12;8. pii: 43511. doi: 10.7554/eLife.43511. PubMed
Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Wang WY, Davidson CD, Lin D, Baker BM. Nat Commun. 2019 Mar 12;10(1):1186. doi: 10.1038/s41467-019-09121-0. PubMed
p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. Cell Rep. 2019 Mar 12;26(11):3051-3060.e4. doi: 10.1016/j.celrep.2019.02.037. PubMed
Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation. Lenz DR, Gunewardene N, Abdul-Aziz DE, Wang Q, Gibson TM, Edge ASB. Front Cell Dev Biol. 2019 Feb 19;7:14. doi: 10.3389/fcell.2019.00014. eCollection 2019. PubMed
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. Skjesol A, Yurchenko M, Bosl K, Gravastrand C, Nilsen KE, Grovdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H. PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar. PubMed
Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. Fenske P, Grauel MK, Brockmann MM, Dorrn AL, Trimbuch T, Rosenmund C. Sci Rep. 2019 Mar 20;9(1):4890. doi: 10.1038/s41598-019-41259-1. PubMed
Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. Ryo LB, Thomsen EA, Mikkelsen JG. Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7. PubMed
Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase. Milczarek M, Rossowska J, Klopotowska D, Stachowicz M, Kutner A, Wietrzyk J. J Steroid Biochem Mol Biol. 2019 Jun;190:139-151. doi: 10.1016/j.jsbmb.2019.03.017. Epub 2019 Mar 25. PubMed
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N. J Biol Chem. 2019 May 17;294(20):8197-8217. doi: 10.1074/jbc.RA118.002829. Epub 2019 Mar 29. PubMed
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schurch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galvan JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. Cell. 2019 Apr 18;177(3):572-586.e22. doi: 10.1016/j.cell.2019.03.010. Epub 2019 Apr 4. PubMed
Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity. Ho V, Yong HY, Chevrier M, Narang V, Lum J, Toh YX, Lee B, Chen J, Tan EY, Luo D, Fink K. J Virol. 2019 Jun 28;93(14). pii: JVI.00102-19. doi: 10.1128/JVI.00102-19. Print 2019 Jul 15. PubMed
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. J Clin Invest. 2019 May 6;130:2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6. PubMed
A standard procedure for lentiviral-mediated labeling of murine mesenchymal stromal cells in vitro. Lupan AM, Preda MB, Burlacu A. Biotechnol Appl Biochem. 2019 May 14. doi: 10.1002/bab.1765. PubMed
The Lentiviral Vector Pseudotyped by Modified Rabies Glycoprotein Does Not Cause Reactive Gliosis and Neurodegeneration in Rat Hippocampus Farzaneh M, Sayyah M, Eshraghi HR, Panahi N, Mirzapourdelavar H, Gholami Pourbadie H. Iran Biomed J. 2019 Sep;23(5):324-9. Epub 2019 May 19. PubMed
Detection and Quantification of Label-Free Infectious Adenovirus Using a Switch-On Cell-Based Fluorescent Biosensor. Guerreiro MR, Freitas DF, Alves PM, Coroadinha AS. ACS Sens. 2019 Jun 28;4(6):1654-1661. doi: 10.1021/acssensors.9b00489. Epub 2019 Jun 5. PubMed
Assessment of PARP4 as a candidate breast cancer susceptibility gene. Prawira A, Munusamy P, Yuan J, Chan CHT, Koh GL, Shuen TWH, Hu J, Yap YS, Tan MH, Ang P, Lee ASG. Breast Cancer Res Treat. 2019 Aug;177(1):145-153. doi: 10.1007/s10549-019-05286-w. Epub 2019 May 22. PubMed
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed
Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells. Cheng LC, Baboo S, Lindsay C, Brusman L, Martinez-Bartolome S, Tapia O, Zhang X, Yates JR 3rd, Gerace L. Nucleus. 2019 Dec;10(1):126-143. doi: 10.1080/19491034.2019.1618175. PubMed
Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy. Giorgio E, Lorenzati M, Rivetti di Val Cervo P, Brussino A, Cernigoj M, Della Sala E, Bartoletti Stella A, Ferrero M, Caiazzo M, Capellari S, Cortelli P, Conti L, Cattaneo E, Buffo A, Brusco A. Brain. 2019 May 29. pii: 5506062. doi: 10.1093/brain/awz139. PubMed
Embryonic Chimeras with Human Pluripotent Stem Cells. De Los Angeles A, Sakurai M, Wu J. Methods Mol Biol. 2019;2005:125-151. doi: 10.1007/978-1-4939-9524-0_9. PubMed
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO. Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w. PubMed

Associated Plasmids

Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation. Guo H, Shen S, Li Y, Bi R, Zhang N, Zheng W, Deng Y, Yang Y, Yu XF, Wang C, Wei W. Biochem Biophys Res Commun. 2019 Sep 3;516(4):1242-1247. doi: 10.1016/j.bbrc.2019.07.028. Epub 2019 Jul 10. PubMed
Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication. Avila-Perez G, Diaz-Beneitez E, Cubas-Gaona LL, Nieves-Molina G, Rodriguez JR, Rodriguez JF, Rodriguez D. PLoS One. 2019 Jul 15;14(7):e0219428. doi: 10.1371/journal.pone.0219428. eCollection 2019. PubMed
A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells. Olbrich T, Vega-Sendino M, Murga M, de Carcer G, Malumbres M, Ortega S, Ruiz S, Fernandez-Capetillo O. Cell Rep. 2019 Jul 16;28(3):597-604.e4. doi: 10.1016/j.celrep.2019.06.060. PubMed
Regulatory mechanisms for the axonal localization of tau protein in neurons. Iwata M, Watanabe S, Yamane A, Miyasaka T, Misonou H. Mol Biol Cell. 2019 Sep 1;30(19):2441-2457. doi: 10.1091/mbc.E19-03-0183. Epub 2019 Aug 7. PubMed
ESCRT-mediated phagophore sealing during mitophagy. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H. Autophagy. 2019 Aug 1:1-16. doi: 10.1080/15548627.2019.1639301. PubMed
A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S. J Biol Chem. 2019 Oct 4;294(40):14562-14573. doi: 10.1074/jbc.RA119.008544. Epub 2019 Aug 1. PubMed
Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1. Ramos I, Smith G, Ruf-Zamojski F, Martinez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, Garcia-Sastre A, Fernandez-Sesma A. J Virol. 2019 Sep 30;93(20). pii: JVI.00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15. PubMed
The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Gobbi G, Donati B, Do Valle IF, Reggiani F, Torricelli F, Remondini D, Castellani G, Ambrosetti DC, Ciarrocchi A, Sancisi V. Oncogene. 2019 Oct;38(42):6801-6817. doi: 10.1038/s41388-019-0924-1. Epub 2019 Aug 12. PubMed
Visualization of Single mRNAs in Live Neurons. Shim JY, Lee BH, Park HY. Methods Mol Biol. 2019;2038:47-61. doi: 10.1007/978-1-4939-9674-2_4. PubMed
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S. Cell Rep. 2019 Aug 13;28(7):1907-1922.e6. doi: 10.1016/j.celrep.2019.07.025. PubMed
Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed
A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes. Wu Z, Malty R, Moutaoufik MT, Zhang Q, Jessulat M, Babu M. Adv Exp Med Biol. 2019;1158:83-100. doi: 10.1007/978-981-13-8367-0_6. PubMed
Upregulated MiR-9-5p Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis via Inhibition of NF-kappaB p50. Ou M, Zhang Y, Cui S, Zhao S, Tu J. Inflammation. 2019 Dec;42(6):1925-1938. doi: 10.1007/s10753-019-01031-z. PubMed
MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression. Nama S, Muhuri M, Di Pascale F, Quah S, Aswad L, Fullwood M, Sampath P. Sci Rep. 2019 Sep 3;9(1):12718. doi: 10.1038/s41598-019-49155-4. PubMed
B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma. Tang X, Zhao S, Zhang Y, Wang Y, Zhang Z, Yang M, Zhu Y, Zhang G, Guo G, Tong A, Zhou L. Mol Ther Oncolytics. 2019 Jul 23;14:279-287. doi: 10.1016/j.omto.2019.07.002. eCollection 2019 Sep 27. PubMed
A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells. Guo H, Li Y, Liu G, Jiang Y, Shen S, Bi R, Huang H, Cheng T, Wang C, Wei W. Nat Commun. 2019 Sep 6;10(1):4066. doi: 10.1038/s41467-019-12040-9. PubMed
Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes. Tomas HA, Mestre DA, Rodrigues AF, Guerreiro MR, Carrondo MJT, Coroadinha AS. Mol Ther Methods Clin Dev. 2019 Aug 14;15:1-8. doi: 10.1016/j.omtm.2019.08.001. eCollection 2019 Dec 13. PubMed
Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing. Gorbea C, Mosbruger T, Nix DA, Cazalla D. Elife. 2019 Sep 20;8. pii: 50530. doi: 10.7554/eLife.50530. PubMed
CGGBP1 regulates CTCF occupancy at repeats. Patel D, Patel M, Datta S, Singh U. Epigenetics Chromatin. 2019 Sep 23;12(1):57. doi: 10.1186/s13072-019-0305-6. PubMed
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed
Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro. Arthur SE, Sorgeloos F, Hosmillo M, Goodfellow IG. mBio. 2019 Oct 1;10(5). pii: mBio.02155-19. doi: 10.1128/mBio.02155-19. PubMed
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP, Pan SL. Theranostics. 2019 Sep 18;9(22):6676-6689. doi: 10.7150/thno.34020. eCollection 2019. PubMed
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14. PubMed
Ectopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells. Abdi J, Rastgoo N, Chen Y, Chen GA, Chang H. BMC Cancer. 2019 Oct 21;19(1):975. doi: 10.1186/s12885-019-6151-x. PubMed
MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X, Wang X, Shen J, Zhang Y, Lang JY. EBioMedicine. 2019 Oct;48:289-300. doi: 10.1016/j.ebiom.2019.10.003. Epub 2019 Oct 21. PubMed
A centrosome-localized calcium signal is essential for mammalian cell mitosis. Helassa N, Nugues C, Rajamanoharan D, Burgoyne RD, Haynes LP. FASEB J. 2019 Dec;33(12):14602-14610. doi: 10.1096/fj.201901662R. Epub 2019 Nov 2. PubMed
LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brummendorf TH, Koschmieder S, Chatain N. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. PubMed
Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Saw G, Krishna K, Gupta N, Soong TW, Mallilankaraman K, Sajikumar S, Dheen ST. Glia. 2020 Mar;68(3):656-669. doi: 10.1002/glia.23748. Epub 2019 Nov 8. PubMed
Injectable, Hyaluronic Acid-Based Scaffolds with Macroporous Architecture for Gene Delivery. Ehsanipour A, Nguyen T, Aboufadel T, Sathialingam M, Cox P, Xiao W, Walthers CM, Seidlits SK. Cell Mol Bioeng. 2019 Sep 4;12(5):399-413. doi: 10.1007/s12195-019-00593-0. eCollection 2019 Oct. PubMed
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation. Li S, Hong X, Wei Z, Xie M, Li W, Liu G, Guo H, Yang J, Wei W, Zhang S. Front Microbiol. 2019 Oct 31;10:2483. doi: 10.3389/fmicb.2019.02483. eCollection 2019. PubMed
Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening. Doyle TB, Muntean BS, Ejendal KF, Hayes MP, Soto-Velasquez M, Martemyanov KA, Dessauer CW, Hu CD, Watts VJ. Cells. 2019 Nov 19;8(11). pii: cells8111468. doi: 10.3390/cells8111468. PubMed
A generic cell surface ligand system for studying cell-cell recognition. Denham EM, Barton MI, Black SM, Bridge MJ, de Wet B, Paterson RL, van der Merwe PA, Goyette J. PLoS Biol. 2019 Dec 9;17(12):e3000549. doi: 10.1371/journal.pbio.3000549. eCollection 2019 Dec. PubMed
TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets. Salas-Lloret D, Agabitini G, Gonzalez-Prieto R. Front Chem. 2019 Nov 26;7:802. doi: 10.3389/fchem.2019.00802. eCollection 2019. PubMed
Efficient Modulation of TP53 Expression in Human Induced Pluripotent Stem Cells. Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert UD. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e102. doi: 10.1002/cpsc.102. PubMed

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