pRK5-HA-Ubiquitin-K48R Citations (40)
Originally described in: Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM J Neurosci. 2005 Feb 23. 25(8):2002-9. PubMed Journal
Articles Citing pRK5-HA-Ubiquitin-K48R
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| Degradation of an intramitochondrial protein by the cytosolic proteasome. Azzu V, Brand MD. J Cell Sci. 2010 Feb 15;123(Pt 4):578-85. doi: 10.1242/jcs.060004. Epub 2010 Jan 26. PubMed |
| c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway. Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O. J Biol Chem. 2011 Sep 2;286(35):30263-73. doi: 10.1074/jbc.M111.232348. Epub 2011 Jul 18. PubMed |
| Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5. Taylor RT, Best SM. Methods. 2011 Oct;55(2):166-71. doi: 10.1016/j.ymeth.2011.08.003. Epub 2011 Aug 10. PubMed |
| Endoplasmic reticulum-associated degradation controls cell surface expression of gamma-aminobutyric acid, type B receptors. Zemoura K, Schenkel M, Acuna MA, Yevenes GE, Zeilhofer HU, Benke D. J Biol Chem. 2013 Nov 29;288(48):34897-905. doi: 10.1074/jbc.M113.514745. Epub 2013 Oct 10. PubMed |
| Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo. Tao RR, Wang H, Hong LJ, Huang JY, Lu YM, Liao MH, Ye WF, Lu NN, Zhu DY, Huang Q, Fukunaga K, Lou YJ, Shoji I, Wilcox CS, Lai EY, Han F. Antioxid Redox Signal. 2014 Jul 1;21(1):1-16. doi: 10.1089/ars.2013.5381. Epub 2014 Feb 4. PubMed |
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT.
J Biol Chem. 2014 May 23;289(21):14569-82. doi: 10.1074/jbc.M114.563031. Epub 2014 Mar 26.
PubMed
Associated Plasmids |
| AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. Ribeiro-Rodrigues TM, Catarino S, Marques C, Ferreira JV, Martins-Marques T, Pereira P, Girao H. FASEB J. 2014 Nov;28(11):4629-41. doi: 10.1096/fj.13-248963. Epub 2014 Jul 28. PubMed |
| SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN. De Melo J, Lin X, He L, Wei F, Major P, Tang D. Cell Signal. 2014 Dec;26(12):2749-56. doi: 10.1016/j.cellsig.2014.08.013. Epub 2014 Aug 22. PubMed |
| Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination. Xu C, Feng K, Zhao X, Huang S, Cheng Y, Qian L, Wang Y, Sun H, Jin M, Chuang TH, Zhang Y. Autophagy. 2014;10(12):2239-50. doi: 10.4161/15548627.2014.981792. PubMed |
| Enhanced ubiquitination and proteasomal degradation of catalytically deficient human choline acetyltransferase mutants. Morey TM, Albers S, Shilton BH, Rylett RJ. J Neurochem. 2016 May;137(4):630-46. doi: 10.1111/jnc.13574. Epub 2016 Mar 15. PubMed |
| Lys-63-linked Ubiquitination of gamma-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation. Zemoura K, Trumpler C, Benke D. J Biol Chem. 2016 Oct 7;291(41):21682-21693. Epub 2016 Aug 29. PubMed |
| Ubiquitin Ligase NEDD4 Regulates PPARgamma Stability and Adipocyte Differentiation in 3T3-L1 Cells. Li JJ, Wang R, Lama R, Wang X, Floyd ZE, Park EA, Liao FF. Sci Rep. 2016 Dec 5;6:38550. doi: 10.1038/srep38550. PubMed |
| Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Hasanov E, Chen G, Chowdhury P, Weldon J, Ding Z, Jonasch E, Sen S, Walker CL, Dere R. Oncogene. 2017 Jun 15;36(24):3450-3463. doi: 10.1038/onc.2016.495. Epub 2017 Jan 23. PubMed |
| Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity. Cetkovska K, Sustova H, Uldrijan S. Sci Rep. 2017 Feb 24;7:43180. doi: 10.1038/srep43180. PubMed |
| Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ, VanderVorst K, Rowson-Hodel A, Angelastro JM, Sweeney C, Carraway KL Rd. Oncogene. 2017 Sep 7;36(36):5158-5167. doi: 10.1038/onc.2017.126. Epub 2017 May 8. PubMed |
| The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Sabouny R, Fraunberger E, Geoffrion M, Ng AC, Baird SD, Screaton RA, Milne R, McBride HM, Shutt TE. Antioxid Redox Signal. 2017 Dec 20;27(18):1447-1459. doi: 10.1089/ars.2016.6855. Epub 2017 Jul 7. PubMed |
| A two-amino-acid substitution in the transcription factor RORgammat disrupts its function in TH17 differentiation but not in thymocyte development. He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, Sen S, Rothenberg EV, Sun Z. Nat Immunol. 2017 Oct;18(10):1128-1138. doi: 10.1038/ni.3832. Epub 2017 Aug 28. PubMed |
| Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates beta-Cell Mitophagy. Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA. Diabetes. 2018 Feb;67(2):265-277. doi: 10.2337/db17-0321. Epub 2017 Nov 27. PubMed |
| Inflachromene inhibits autophagy through modulation of Beclin 1 activity. Kim YH, Kwak MS, Shin JM, Hayuningtyas RA, Choi JE, Shin JS. J Cell Sci. 2018 Feb 20;131(4). pii: jcs.211201. doi: 10.1242/jcs.211201. PubMed |
| NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase alpha and its implication in breast cancer cell proliferation. Tran MH, Seo E, Min S, Nguyen QT, Choi J, Lee UJ, Hong SS, Kang H, Mansukhani A, Jou I, Lee SY. J Cell Mol Med. 2018 Sep;22(9):4117-4129. doi: 10.1111/jcmm.13689. Epub 2018 May 30. PubMed |
| Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) beta-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination. Zemoura K, Balakrishnan K, Grampp T, Benke D. Mol Neurobiol. 2019 Feb;56(2):1293-1309. doi: 10.1007/s12035-018-1142-5. Epub 2018 Jun 7. PubMed |
| SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. Nat Commun. 2018 Jun 11;9(1):2269. doi: 10.1038/s41467-018-04620-y. PubMed |
| Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed |
| Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia. Kanaujiya J, Bastow E, Luxmi R, Hao Z, Zattas D, Hochstrasser M, Reichenberger EJ, Chen IP. Sci Rep. 2018 Oct 24;8(1):15710. doi: 10.1038/s41598-018-34157-5. PubMed |
| Sumoylation of RORgammat regulates TH17 differentiation and thymocyte development. He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. Nat Commun. 2018 Nov 19;9(1):4870. doi: 10.1038/s41467-018-07203-z. PubMed |
| ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-kappaB via phosphoinosotide remodeling of endosomes. Fang C, Manes TD, Liu L, Liu K, Qin L, Li G, Tobiasova Z, Kirkiles-Smith NC, Patel M, Merola J, Fu W, Liu R, Xie C, Tietjen GT, Nigrovic PA, Tellides G, Pober JS, Jane-Wit D. Nat Commun. 2019 May 21;10(1):2247. doi: 10.1038/s41467-019-10041-2. PubMed |
| The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. Liu H, Ding J, Kohnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T. Autophagy. 2019 Dec 3:1-17. doi: 10.1080/15548627.2019.1695399. PubMed |
| Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Akiyama H, Umezawa Y, Watanabe D, Okada K, Ishida S, Nogami A, Miura O. Cancers (Basel). 2020 Feb 10;12(2). pii: cancers12020406. doi: 10.3390/cancers12020406. PubMed |
| RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S. Cancer Res. 2021 Jan 15;81(2):315-331. doi: 10.1158/0008-5472.CAN-20-1871. Epub 2020 Oct 16. PubMed |
| Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination. Langerova H, Lubyova B, Zabransky A, Hubalek M, Glendova K, Aillot L, Hodek J, Strunin D, Janovec V, Hirsch I, Weber J. Cells. 2020 Nov 26;9(12). pii: cells9122547. doi: 10.3390/cells9122547. PubMed |
| The ESCRT-III molecules regulate the apical targeting of bile salt export pump. Wu SH, Chang MH, Chen YH, Wu HL, Chua HH, Chien CS, Ni YH, Chen HL, Chen HL. J Biomed Sci. 2021 Mar 9;28(1):19. doi: 10.1186/s12929-020-00706-2. PubMed |
| mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma. Zhang S, Zhou YF, Cao J, Burley SK, Wang HY, Zheng XFS. Cancer Res. 2021 Nov 15;81(22):5652-5665. doi: 10.1158/0008-5472.CAN-21-0206. Epub 2021 Aug 24. PubMed |
| TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. Zhu G, Herlyn M, Yang X. Nat Cell Biol. 2021 Sep;23(9):978-991. doi: 10.1038/s41556-021-00732-8. Epub 2021 Sep 8. PubMed |
| PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, Han C, Liu H, Yin X, Du Q, Tong D, Huang Y. PLoS Pathog. 2021 Sep 20;17(9):e1009940. doi: 10.1371/journal.ppat.1009940. eCollection 2021 Sep. PubMed |
| A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout. Jang JH, Kim H, Jung IY, Cho JH. Int J Mol Sci. 2021 Sep 10;22(18). pii: ijms22189801. doi: 10.3390/ijms22189801. PubMed |
| Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy. Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J. Nat Commun. 2022 Sep 3;13(1):5204. doi: 10.1038/s41467-022-32957-y. PubMed |
| USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity. Shin J, Kim YH, Lee B, Chang JH, Choi HY, Lee H, Song KC, Kwak MS, Choi JE, Shin JS. Mol Med. 2022 Dec 30;28(1):164. doi: 10.1186/s10020-022-00596-0. PubMed |
| PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Zhang S, Guo M, Jiang X, Tang L, Wu T, Bi G, Yang X, Fan S, Bi H. Pharmacol Res. 2023 Feb;188:106666. doi: 10.1016/j.phrs.2023.106666. Epub 2023 Jan 16. PubMed |
| HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma. Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L. Cancer Lett. 2023 May 28;562:216158. doi: 10.1016/j.canlet.2023.216158. Epub 2023 Apr 5. PubMed |
| SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage. Wang F, Wang L, Gan S, Feng S, Ouyang S, Wang X, Yuan S. Research (Wash D C). 2023 Apr 12;6:0091. doi: 10.34133/research.0091. eCollection 2023. PubMed |
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