pBABE-puro Citations (218)
Originally described in: Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.Morgenstern JP, Land H Nucleic Acids Res. 1990 Jun 25;18(12):3587-96. PubMed
Articles Citing pBABE-puro
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| Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer. Kleeff J, Maruyama H, Friess H, Buchler MW, Falb D, Korc M. Biochem Biophys Res Commun. 1999 Feb 16;255(2):268-73. PubMed |
| Human pancreatic duct epithelial cell model for KRAS transformation. Radulovich N, Qian JY, Tsao MS. Methods Enzymol. 2008;439:1-13. doi: 10.1016/S0076-6879(07)00401-6. PubMed |
| Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures. Abu-Yousif AO, Smith KA, Getsios S, Green KJ, Van Dross RT, Pelling JC. Cancer Res. 2008 Apr 15;68(8):3057-65. doi: 10.1158/0008-5472.CAN-07-2763. PubMed |
| Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Chapman EJ, Kelly G, Knowles MA. Mol Cancer Res. 2008 Jul;6(7):1154-68. doi: 10.1158/1541-7786.MCR-07-2168. PubMed |
| Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. Han S, Ritzenthaler JD, Sun X, Zheng Y, Roman J. Am J Respir Cell Mol Biol. 2009 Mar;40(3):325-31. doi: 10.1165/rcmb.2008-0197OC. Epub 2008 Sep 5. PubMed |
| Systematic identification of cis-silenced genes by trans complementation. Lee JH, Bugarija B, Millan EJ, Walton NM, Gaetz J, Fernandes CJ, Yu WH, Mekel-Bobrov N, Vallender TW, Snyder GE, Xiang AP, Lahn BT. Hum Mol Genet. 2009 Mar 1;18(5):835-46. doi: 10.1093/hmg/ddn409. Epub 2008 Dec 2. PubMed |
| NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. Singh S, Zahid M, Saeed M, Gaikwad NW, Meza JL, Cavalieri EL, Rogan EG, Chakravarti D. J Steroid Biochem Mol Biol. 2009 Oct;117(1-3):56-66. doi: 10.1016/j.jsbmb.2009.07.003. Epub 2009 Jul 21. PubMed |
Ageing-related chromatin defects through loss of the NURD complex.
Pegoraro G, Kubben N, Wickert U, Göhler H, Hoffmann K, Misteli T.
Nat Cell Biol. 2009 Oct . 11(10):1261-7.
PubMed
Associated Plasmids |
| Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. PLoS One. 2009 . 4(11):e7982. PubMed |
| Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Ghosh S, Koblinski J, Johnson J, Liu Y, Ericsson A, Davis JW, Shi Z, Ravosa MJ, Crawford S, Frazier S, Stack MS. Mol Cancer Res. 2010 Feb;8(2):145-58. doi: 10.1158/1541-7786.MCR-09-0045. Epub 2010 Feb 9. PubMed |
| PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. Cancer Res. 2010 Sep 1;70(17):6804-14. doi: 10.1158/0008-5472.CAN-10-0409. Epub 2010 Aug 10. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M. Nat Med. 2010 Dec;16(12):1429-33. doi: 10.1038/nm.2251. Epub 2010 Nov 14. PubMed |
| Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. Tamama K, Kawasaki H, Kerpedjieva SS, Guan J, Ganju RK, Sen CK. J Cell Biochem. 2011 Mar;112(3):804-17. doi: 10.1002/jcb.22961. PubMed |
| Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase. Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R. J Biol Chem. 2011 Apr 29;286(17):14744-52. doi: 10.1074/jbc.M111.221259. Epub 2011 Mar 3. PubMed |
| Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. Wu N, Castel D, Debily MA, Vigano MA, Alibert O, Mantovani R, Iljin K, Romeo PH, Gidrol X. J Biol Chem. 2011 Jun 10;286(23):20870-9. doi: 10.1074/jbc.M110.169433. Epub 2011 Apr 10. PubMed |
| The role of Pea3 group transcription factors in esophageal squamous cell carcinoma. Yuen HF, McCrudden CM, Chan KK, Chan YP, Wong ML, Chan KY, Khoo US, Law S, Srivastava G, Lappin TR, Chan KW, El-Tanani M. Am J Pathol. 2011 Aug;179(2):992-1003. doi: 10.1016/j.ajpath.2011.04.004. Epub 2011 May 31. PubMed |
Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT).
Alvarez MB, Childress P, Philip BK, Gerard-O'Riley R, Hanlon M, Herbert BS, Robling AG, Pavalko FM, Bidwell JP.
J Cell Physiol. 2012 May;227(5):1873-82. doi: 10.1002/jcp.22915.
PubMed
Associated Plasmids |
| Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-beta in endothelial cells. Xie L, Vo-Ransdell C, Abel B, Willoughby C, Jang S, Sowa G. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1161-74. doi: 10.1152/ajpcell.00486.2010. Epub 2011 Aug 10. PubMed |
| The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement. Tai AW, Salloum S. PLoS One. 2011;6(10):e26300. doi: 10.1371/journal.pone.0026300. Epub 2011 Oct 12. PubMed |
| Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Wang C, Youle RJ. Oncogene. 2012 Jun 28;31(26):3177-89. doi: 10.1038/onc.2011.497. Epub 2011 Nov 7. PubMed |
| Calpain 2-dependent IkappaBalpha degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts. Fenouille N, Grosso S, Yunchao S, Mary D, Pontier-Bres R, Imbert V, Czerucka D, Caroli-Bosc FX, Peyron JF, Lagadec P. J Pathol. 2012 May;227(1):118-29. doi: 10.1002/path.3034. Epub 2012 Feb 9. PubMed |
| Identification of a link between Wnt/beta-catenin signalling and the cell fusion pathway. Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T. Nat Commun. 2011 Nov 22;2:548. doi: 10.1038/ncomms1551. PubMed |
| Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Campbell HG, Mehta R, Neumann AA, Rubio C, Baird M, Slatter TL, Braithwaite AW. Oncogene. 2013 Feb 14;32(7):827-36. doi: 10.1038/onc.2012.102. Epub 2012 Apr 9. PubMed |
| Genome-wide screen for miRNA targets using the MISSION target ID library. Coussens MJ, Forbes K, Kreader C, Sago J, Cupp C, Swarthout J. J Vis Exp. 2012 Apr 6;(62):e3303. doi: 10.3791/3303. PubMed |
| Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Law ME, Corsino PE, Jahn SC, Davis BJ, Chen S, Patel B, Pham K, Lu J, Sheppard B, Norgaard P, Hong J, Higgins P, Kim JS, Luesch H, Law BK. Oncogene. 2013 Mar 7;32(10):1316-29. doi: 10.1038/onc.2012.138. Epub 2012 Apr 30. PubMed |
| Role of the tripartite motif protein 27 in cancer development. Zoumpoulidou G, Broceno C, Li H, Bird D, Thomas G, Mittnacht S. J Natl Cancer Inst. 2012 Jun 20;104(12):941-52. doi: 10.1093/jnci/djs224. Epub 2012 May 3. PubMed |
| Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U. EMBO J. 2012 Jun 29;31(13):2839-51. doi: 10.1038/emboj.2012.132. Epub 2012 May 8. PubMed |
| Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Whitsett TG, Cheng E, Inge L, Asrani K, Jameson NM, Hostetter G, Weiss GJ, Kingsley CB, Loftus JC, Bremner R, Tran NL, Winkles JA. Am J Pathol. 2012 Jul;181(1):111-20. doi: 10.1016/j.ajpath.2012.03.026. Epub 2012 May 23. PubMed |
| Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, Vallentin A, Vial H, Vidal M, Szakacs G. PLoS One. 2012;7(5):e37378. doi: 10.1371/journal.pone.0037378. Epub 2012 May 24. PubMed |
| Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Cell. 2012 Jun 22;149(7):1565-77. doi: 10.1016/j.cell.2012.04.039. PubMed |
| The scaffold protein MEK Partner 1 is required for the survival of estrogen receptor positive breast cancer cells. Marina M, Wang L, Conrad SE. Cell Commun Signal. 2012 Jul 9;10(1):18. doi: 10.1186/1478-811X-10-18. PubMed |
| Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments. Boyd NL, Nunes SS, Krishnan L, Jokinen JD, Ramakrishnan VM, Bugg AR, Hoying JB. Tissue Eng Part A. 2013 Jan;19(1-2):211-23. doi: 10.1089/ten.tea.2011.0408. Epub 2012 Sep 12. PubMed |
| Role for telomerase in Listeria monocytogenes infection. Samba-Louaka A, Stavru F, Cossart P. Infect Immun. 2012 Dec;80(12):4257-63. doi: 10.1128/IAI.00614-12. Epub 2012 Sep 24. PubMed |
| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| Role of transcriptional corepressor ETO2 in erythroid cells. Fujiwara T, Alqadi YW, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. Exp Hematol. 2013 Mar;41(3):303-15.e1. doi: 10.1016/j.exphem.2012.10.015. Epub 2012 Nov 2. PubMed |
Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system.
Karimova M, Abi-Ghanem J, Berger N, Surendranath V, Pisabarro MT, Buchholz F.
Nucleic Acids Res. 2013 Jan;41(2):e37. doi: 10.1093/nar/gks1037. Epub 2012 Nov 9.
PubMed
Associated Plasmids |
| ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Thomas C, Rajapaksa G, Nikolos F, Hao R, Katchy A, McCollum CW, Bondesson M, Quinlan P, Thompson A, Krishnamurthy S, Esteva FJ, Gustafsson JA. Breast Cancer Res. 2012 Nov 16;14(6):R148. doi: 10.1186/bcr3358. PubMed |
| Monitoring nutrient signaling through the longevity protein p66(SHC(1)). Ranieri SC, Pani G. Methods Mol Biol. 2013;965:341-53. doi: 10.1007/978-1-62703-239-1_23. PubMed |
| LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. Cancer Cell. 2013 Feb 11;23(2):143-58. doi: 10.1016/j.ccr.2012.12.008. Epub 2013 Jan 24. PubMed |
| Constitutive CCND1/CDK2 activity substitutes for p53 loss, or MYC or oncogenic RAS expression in the transformation of human mammary epithelial cells. Junk DJ, Cipriano R, Stampfer M, Jackson MW. PLoS One. 2013;8(2):e53776. doi: 10.1371/journal.pone.0053776. Epub 2013 Feb 4. PubMed |
| Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function. Goutte-Gattat D, Shuaib M, Ouararhni K, Gautier T, Skoufias DA, Hamiche A, Dimitrov S. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8579-84. doi: 10.1073/pnas.1302955110. Epub 2013 May 8. PubMed |
| Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Chen QK, Lee K, Radisky DC, Nelson CM. Differentiation. 2013 Oct;86(3):126-32. doi: 10.1016/j.diff.2013.03.003. Epub 2013 May 6. PubMed |
| Transforming growth factor beta induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Ding ZY, Jin GN, Liang HF, Wang W, Chen WX, Datta PK, Zhang MZ, Zhang B, Chen XP. Cell Signal. 2013 Oct;25(10):1981-92. doi: 10.1016/j.cellsig.2013.05.027. Epub 2013 May 28. PubMed |
| Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing. O'Seaghdha M, Wessels MR. PLoS Pathog. 2013;9(6):e1003394. doi: 10.1371/journal.ppat.1003394. Epub 2013 Jun 6. PubMed |
| CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells. Lau WM, Doucet M, Huang D, Weber KL, Kominsky SL. Biochem Biophys Res Commun. 2013 Jul 26;437(2):261-6. doi: 10.1016/j.bbrc.2013.06.063. Epub 2013 Jun 27. PubMed |
| Enpp1: a potential facilitator of breast cancer bone metastasis. Lau WM, Doucet M, Stadel R, Huang D, Weber KL, Kominsky SL. PLoS One. 2013 Jul 5;8(7):e66752. doi: 10.1371/journal.pone.0066752. Print 2013. PubMed |
| Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Fogel AI, Dlouhy BJ, Wang C, Ryu SW, Neutzner A, Hasson SA, Sideris DP, Abeliovich H, Youle RJ. Mol Cell Biol. 2013 Sep;33(18):3675-88. doi: 10.1128/MCB.00079-13. Epub 2013 Jul 22. PubMed |
| A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth. Wang X, Li JP, Yang Y, Ding J, Meng LH. Acta Pharmacol Sin. 2013 Sep;34(9):1201-7. doi: 10.1038/aps.2013.81. Epub 2013 Jul 29. PubMed |
| Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Oncogene. 2014 Jun 26;33(26):3463-72. doi: 10.1038/onc.2013.301. Epub 2013 Aug 5. PubMed |
| Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Kitade M, Factor VM, Andersen JB, Tomokuni A, Kaji K, Akita H, Holczbauer A, Seo D, Marquardt JU, Conner EA, Lee SB, Lee YH, Thorgeirsson SS. Genes Dev. 2013 Aug 1;27(15):1706-17. doi: 10.1101/gad.214601.113. PubMed |
| AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation. Jackstadt R, Jung P, Hermeking H. Cell Death Dis. 2013 Aug 15;4:e775. doi: 10.1038/cddis.2013.282. PubMed |
| Elucidation of the role of LMO2 in human erythroid cells. Inoue A, Fujiwara T, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. Exp Hematol. 2013 Dec;41(12):1062-76.e1. doi: 10.1016/j.exphem.2013.09.003. Epub 2013 Sep 13. PubMed |
| A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. Fujiwara T, Ikeda T, Nagasaka Y, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Tomosugi N, Harigae H. PLoS One. 2013 Sep 27;8(9):e75568. doi: 10.1371/journal.pone.0075568. eCollection 2013. PubMed |
| DNMT1-interacting RNAs block gene-specific DNA methylation. Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alo F, Melnick A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG. Nature. 2013 Nov 21;503(7476):371-6. doi: 10.1038/nature12598. Epub 2013 Oct 9. PubMed |
| BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. Morotti A, Panuzzo C, Crivellaro S, Pergolizzi B, Familiari U, Berger AH, Saglio G, Pandolfi PP. Leukemia. 2014 Jun;28(6):1326-33. doi: 10.1038/leu.2013.370. Epub 2013 Dec 9. PubMed |
| Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed |
| Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors. Lezcano C, Lee CW, Larson AR, Menzies AM, Kefford RF, Thompson JF, Mihm MC Jr, Ogino S, Long GV, Scolyer RA, Murphy GF. Mod Pathol. 2014 Sep;27(9):1193-202. doi: 10.1038/modpathol.2013.226. Epub 2014 Jan 17. PubMed |
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.
Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ.
Elife (Cambridge). 2014 Feb 25;3:e01612. doi: 10.7554/eLife.01612.
PubMed
Associated Plasmids |
| A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Ablett MP, O'Brien CS, Sims AH, Farnie G, Clarke RB. Oncotarget. 2014 Feb 15;5(3):599-612. PubMed |
| ERbeta regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Nikolos F, Thomas C, Rajapaksa G, Bado I, Gustafsson JA. Mol Cancer Res. 2014 Jun;12(6):843-54. doi: 10.1158/1541-7786.MCR-13-0663. Epub 2014 Mar 11. PubMed |
| A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Serra RW, Fang M, Park SM, Hutchinson L, Green MR. Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313. PubMed |
| Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Gokturk C, Sanjiv K, Stromberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2. PubMed |
| Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia. Fujiwara T, Fukuhara N, Funayama R, Nariai N, Kamata M, Nagashima T, Kojima K, Onishi Y, Sasahara Y, Ishizawa K, Nagasaki M, Nakayama K, Harigae H. Ann Hematol. 2014 Sep;93(9):1515-22. doi: 10.1007/s00277-014-2090-4. Epub 2014 Apr 30. PubMed |
| A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, Lim D, Marchetti A, Viale A, Pirun M, Socci ND, Qin LX, Sciot R, Bridge J, Singer S, Meyers P, Wexler LH, Barr FG, Dogan S, Fletcher JA, Reis-Filho JS, Ladanyi M. Nat Genet. 2014 Jun;46(6):595-600. doi: 10.1038/ng.2969. Epub 2014 May 4. PubMed |
| Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. Gotz R, Sendtner M. PLoS One. 2014 Jun 24;9(6):e100944. doi: 10.1371/journal.pone.0100944. eCollection 2014. PubMed |
| Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition. Schaeffer D, Somarelli JA, Hanna G, Palmer GM, Garcia-Blanco MA. Mol Cell Biol. 2014 Sep 15;34(18):3486-99. doi: 10.1128/MCB.00694-14. Epub 2014 Jul 7. PubMed |
| The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response. Cao X, Kong CM, Mathi KM, Lim YP, Cacheux-Rataboul V, Wang X. BMC Biochem. 2014 Aug 7;15:17. doi: 10.1186/1471-2091-15-17. PubMed |
| The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Ravi D, Bhalla S, Gartenhaus RB, Crombie J, Kandela I, Sharma J, Mazar A, Evens AM. Clin Cancer Res. 2014 Dec 1;20(23):6023-33. doi: 10.1158/1078-0432.CCR-14-1532. Epub 2014 Oct 14. PubMed |
| Metformin and erlotinib synergize to inhibit basal breast cancer. Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA. Oncotarget. 2014 Nov 15;5(21):10503-17. PubMed |
| An increase in integrin-linked kinase non-canonically confers NF-kappaB-mediated growth advantages to gastric cancer cells by activating ERK1/2. Tseng PC, Chen CL, Shan YS, Chang WT, Liu HS, Hong TM, Hsieh CY, Lin SH, Lin CF. Cell Commun Signal. 2014 Nov 15;12:69. doi: 10.1186/s12964-014-0069-3. PubMed |
| Arhgef7 promotes activation of the Hippo pathway core kinase Lats. Heidary Arash E, Song KM, Song S, Shiban A, Attisano L. EMBO J. 2014 Dec 17;33(24):2997-3011. doi: 10.15252/embj.201490230. Epub 2014 Nov 25. PubMed |
| Focus formation: a cell-based assay to determine the oncogenic potential of a gene. Alvarez A, Barisone GA, Diaz E. J Vis Exp. 2014 Dec 31;(94). doi: 10.3791/51742. PubMed |
| hTERT-immortalized ovine microglia propagate natural scrapie isolates. Munoz-Gutierrez JF, Schneider DA, Baszler TV, Greenlee JJ, Nicholson EM, Stanton JB. Virus Res. 2015 Feb 16;198:35-43. doi: 10.1016/j.virusres.2014.10.028. Epub 2015 Jan 12. PubMed |
| Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein. Kiss K, Kucsma N, Brozik A, Tusnady GE, Bergam P, van Niel G, Szakacs G. Biochem J. 2015 Apr 1;467(1):127-39. doi: 10.1042/BJ20141085. PubMed |
Rapid, specific, no-wash, far-red fluorogen activation in subcellular compartments by targeted fluorogen activating proteins.
Telmer CA, Verma R, Teng H, Andreko S, Law L, Bruchez MP.
ACS Chem Biol. 2015 May 15;10(5):1239-46. doi: 10.1021/cb500957k. Epub 2015 Feb 16.
PubMed
Associated Plasmids |
| PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. Mol Cell Biol. 2015 May;35(10):1741-53. doi: 10.1128/MCB.01475-14. Epub 2015 Mar 9. PubMed |
| Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5alpha. Coren LV, Trivett MT, Jain S, Ayala VI, Del Prete GQ, Ohlen C, Ott DE. Retrovirology. 2015 Feb 7;12:11. doi: 10.1186/s12977-015-0137-9. PubMed |
| Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed |
| Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed |
| Simultaneous Inhibition of EGFR/VEGFR and Cyclooxygenase-2 Targets Stemness-Related Pathways in Colorectal Cancer Cells. Valverde A, Penarando J, Canas A, Lopez-Sanchez LM, Conde F, Hernandez V, Peralbo E, Lopez-Pedrera C, de la Haba-Rodriguez J, Aranda E, Rodriguez-Ariza A. PLoS One. 2015 Jun 24;10(6):e0131363. doi: 10.1371/journal.pone.0131363. eCollection 2015. PubMed |
| High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells. Saito Y, Fujiwara T, Ohashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. PLoS One. 2015 Sep 1;10(9):e0137079. doi: 10.1371/journal.pone.0137079. eCollection 2015. PubMed |
| Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Andersen RK, Zaher W, Larsen KH, Ditzel N, Drews K, Wruck W, Adjaye J, Abdallah BM, Kassem M. Stem Cell Res Ther. 2015 Oct 8;6:196. doi: 10.1186/s13287-015-0188-9. PubMed |
| The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-kappaB and RalB signaling pathways. Vasseur R, Skrypek N, Duchene B, Renaud F, Martinez-Maqueda D, Vincent A, Porchet N, Van Seuningen I, Jonckheere N. Biochim Biophys Acta. 2015 Dec;1849(12):1375-84. doi: 10.1016/j.bbagrm.2015.10.014. Epub 2015 Oct 22. PubMed |
| Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. Coffey RT, Shi Y, Long MJ, Marr MT 2nd, Hedstrom L. J Biol Chem. 2016 Jan 6. pii: jbc.M115.691584. PubMed |
| Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed |
| MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells. Lima CR, Geraldo MV, Fuziwara CS, Kimura ET, Santos MF. BMC Cancer. 2016 Feb 16;16:108. doi: 10.1186/s12885-016-2146-z. PubMed |
| Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z. Oncogene. 2016 Mar 14. doi: 10.1038/onc.2016.40. PubMed |
| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
| CLOCK promotes 3T3-L1 cell proliferation via Wnt signaling. Zhu Z, Hua B, Xu L, Yuan G, Li E, Li X, Sun N, Yan Z, Lu C, Qian R. IUBMB Life. 2016 Jul;68(7):557-68. doi: 10.1002/iub.1512. Epub 2016 May 18. PubMed |
| EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT. Choudhary KS, Rohatgi N, Halldorsson S, Briem E, Gudjonsson T, Gudmundsson S, Rolfsson O. PLoS Comput Biol. 2016 Jun 2;12(6):e1004924. doi: 10.1371/journal.pcbi.1004924. eCollection 2016 Jun. PubMed |
| Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Madureira PA, Bharadwaj AG, Bydoun M, Garant K, O'Connell P, Lee P, Waisman DM. Oncotarget. 2016 Jul 26;7(30):47720-47737. doi: 10.18632/oncotarget.10279. PubMed |
| Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22. PubMed |
| Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5024-33. doi: 10.1073/pnas.1602379113. Epub 2016 Aug 8. PubMed |
| BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM. Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620. PubMed |
| RNF168 and USP10 regulate topoisomerase IIalpha function via opposing effects on its ubiquitylation. Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638. PubMed |
| Familial Alzheimer's disease-associated presenilin 1 mutants promote gamma-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Tong BC, Lee CS, Cheng WH, Lai KO, Foskett JK, Cheung KH. Sci Signal. 2016 Sep 6;9(444):ra89. doi: 10.1126/scisignal.aaf1371. PubMed |
| LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A. Oncotarget. 2016 Dec 13;7(50):81981-81994. doi: 10.18632/oncotarget.11962. PubMed |
| Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT. Nature. 2016 Oct 6;538(7623):123-126. doi: 10.1038/nature19754. Epub 2016 Sep 14. PubMed |
| An alternative splicing program promotes adipose tissue thermogenesis. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. Elife. 2016 Sep 16;5. pii: e17672. doi: 10.7554/eLife.17672. PubMed |
| A novel isoform of the human mitochondrial complex I subunit NDUFV3. Dibley MG, Ryan MT, Stroud DA. FEBS Lett. 2017 Jan;591(1):109-117. doi: 10.1002/1873-3468.12527. Epub 2016 Dec 30. PubMed |
| LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. Nat Cell Biol. 2017 Jan;19(1):60-67. doi: 10.1038/ncb3453. Epub 2016 Dec 19. PubMed |
| Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production. Purwada A, Singh A. Nat Protoc. 2017 Jan;12(1):168-182. doi: 10.1038/nprot.2016.157. Epub 2016 Dec 22. PubMed |
| Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. Nakajima S, Aikawa C, Nozawa T, Minowa-Nozawa A, Toh H, Nakagawa I. PLoS One. 2017 Jan 13;12(1):e0170138. doi: 10.1371/journal.pone.0170138. eCollection 2017. PubMed |
| Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. Hsia HC, Hutti JE, Baldwin AS. J Biol Chem. 2017 Mar 31;292(13):5405-5417. doi: 10.1074/jbc.M116.771964. Epub 2017 Feb 10. PubMed |
| Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity. Chen NM, Neesse A, Dyck ML, Steuber B, Koenig AO, Lubeseder-Martellato C, Winter T, Forster T, Bohnenberger H, Kitz J, Reuter-Jessen K, Griesmann H, Gaedcke J, Grade M, Zhang JS, Tsai WC, Siveke J, Schildhaus HU, Strobel P, Johnsen SA, Ellenrieder V, Hessmann E. Gastroenterology. 2017 May;152(6):1507-1520.e15. doi: 10.1053/j.gastro.2017.01.043. Epub 2017 Feb 8. PubMed |
| Cancer cells exhibit clonal diversity in phenotypic plasticity. Mathis RA, Sokol ES, Gupta PB. Open Biol. 2017 Feb;7(2). pii: 160283. doi: 10.1098/rsob.160283. PubMed |
| Multivalent Small-Molecule Pan-RAS Inhibitors. Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR. Cell. 2017 Feb 23;168(5):878-889.e29. doi: 10.1016/j.cell.2017.02.006. PubMed |
| Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Jacquin E, Leclerc-Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Autophagy. 2017 May 4;13(5):854-867. doi: 10.1080/15548627.2017.1287653. Epub 2017 Feb 15. PubMed |
NRAS destines tumor cells to the lungs.
Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT.
EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978.
PubMed
Associated Plasmids |
| Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kalpha-selective Inhibitors in Breast Cancer. Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH. Theranostics. 2017 Feb 23;7(4):974-986. doi: 10.7150/thno.17830. eCollection 2017. PubMed |
| The addition of celecoxib improves the antitumor effect of cetuximab in colorectal cancer: role of EGFR-RAS-FOXM1-beta- catenin signaling axis. Valverde A, Penarando J, Canas A, Lopez-Sanchez LM, Conde F, Guil-Luna S, Hernandez V, Villar C, Morales-Estevez C, de la Haba-Rodriguez J, Aranda E, Rodriguez-Ariza A. Oncotarget. 2017 Mar 28;8(13):21754-21769. doi: 10.18632/oncotarget.15567. PubMed |
| TCF7L1 promotes skin tumorigenesis independently of beta-catenin through induction of LCN2. Ku AT, Shaver TM, Rao AS, Howard JM, Rodriguez CN, Miao Q, Garcia G, Le D, Yang D, Borowiak M, Cohen DN, Chitsazzadeh V, Diwan AH, Tsai KY, Nguyen H. Elife. 2017 May 3;6. pii: e23242. doi: 10.7554/eLife.23242. PubMed |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Dagg RA, Pickett HA, Neumann AA, Napier CE, Henson JD, Teber ET, Arthur JW, Reynolds CP, Murray J, Haber M, Sobinoff AP, Lau LMS, Reddel RR. Cell Rep. 2017 Jun 20;19(12):2544-2556. doi: 10.1016/j.celrep.2017.05.087. PubMed |
| m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vagbo CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB. Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117. PubMed |
| Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin E, Seifert EL, Metallo CM, Brody JR, Winter JM. Cancer Res. 2017 Jun 26. pii: canres.0015.2017. doi: 10.1158/0008-5472.CAN-17-0015. PubMed |
| Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. Yoo BH, Khan IA, Koomson A, Gowda P, Sasazuki T, Shirasawa S, Gujar S, Rosen KV. Autophagy. 2018;14(1):134-151. doi: 10.1080/15548627.2017.1370171. Epub 2017 Dec 21. PubMed |
| Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells. Ishihara S, Inman DR, Li WJ, Ponik SM, Keely PJ. Cancer Res. 2017 Nov 15;77(22):6179-6189. doi: 10.1158/0008-5472.CAN-17-0569. Epub 2017 Sep 28. PubMed |
| Survival of pancreatic cancer cells lacking KRAS function. Muzumdar MD, Chen PY, Dorans KJ, Chung KM, Bhutkar A, Hong E, Noll EM, Sprick MR, Trumpp A, Jacks T. Nat Commun. 2017 Oct 23;8(1):1090. doi: 10.1038/s41467-017-00942-5. PubMed |
| Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. Nat Genet. 2017 Dec;49(12):1693-1704. doi: 10.1038/ng.3990. Epub 2017 Nov 6. PubMed |
| Development of a genetic sensor that eliminates p53 deficient cells. Mircetic J, Dietrich A, Paszkowski-Rogacz M, Krause M, Buchholz F. Nat Commun. 2017 Nov 13;8(1):1463. doi: 10.1038/s41467-017-01688-w. PubMed |
| Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. PubMed |
| PPARdelta Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth. Martin-Martin N, Zabala-Letona A, Fernandez-Ruiz S, Arreal L, Camacho L, Castillo-Martin M, Cortazar AR, Torrano V, Astobiza I, Zuniga-Garcia P, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Valcarcel-Jimenez L, Arruabarrena-Aristorena A, Piva M, Sanchez-Mosquera P, Aransay AM, Gomez-Munoz A, Barrio R, Sutherland JD, Carracedo A. Cancer Res. 2018 Jan 15;78(2):399-409. doi: 10.1158/0008-5472.CAN-17-0908. Epub 2017 Nov 29. PubMed |
| The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh JM, Mayer U, Carding SR, Wileman T, Beale R, Florey O. EMBO J. 2018 Feb 15;37(4). pii: embj.201797840. doi: 10.15252/embj.201797840. Epub 2018 Jan 9. PubMed |
| Establishment of a Screening System to Identify Novel GATA-2 Transcriptional Regulators. Ohashi K, Fujiwara T, Onodera K, Saito Y, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Harigae H. Tohoku J Exp Med. 2018 Jan;244(1):41-52. doi: 10.1620/tjem.244.41. PubMed |
| Endosomal Rab cycles regulate Parkin-mediated mitophagy. Yamano K, Wang C, Sarraf SA, Munch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ. Elife. 2018 Jan 23;7. pii: 31326. doi: 10.7554/eLife.31326. PubMed |
| MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Giuliano CJ, Lin A, Smith JC, Palladino AC, Sheltzer JM. Elife. 2018 Feb 8;7. pii: 32838. doi: 10.7554/eLife.32838. PubMed |
| Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Rockfield S, Flores I, Nanjundan M. Oncotarget. 2017 Dec 28;9(4):5344-5367. doi: 10.18632/oncotarget.23747. eCollection 2018 Jan 12. PubMed |
Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators.
O'Geen H, Ren C, Coggins NB, Bates SL, Segal DJ.
PLoS One. 2018 Mar 27;13(3):e0193818. doi: 10.1371/journal.pone.0193818. eCollection 2018.
PubMed
Associated Plasmids |
| Real-time imaging of specific genomic loci in eukaryotic cells using the ANCHOR DNA labelling system. Germier T, Sylvain A, Silvia K, David L, Kerstin B. Methods. 2018 Jun 1;142:16-23. doi: 10.1016/j.ymeth.2018.04.008. Epub 2018 Apr 13. PubMed |
| Pituitary somatolactotropes evade an oncogenic response to Ras. Roof AK, Trudeau T, Gutierrez-Hartmann A. Mol Cell Endocrinol. 2018 Nov 15;476:165-172. doi: 10.1016/j.mce.2018.05.006. Epub 2018 May 9. PubMed |
| Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Karlin J, Allen J, Ahmad SF, Hughes G, Sheridan V, Odedra R, Farrington P, Cadogan EB, Riches LC, Garcia-Trinidad A, Thomason AG, Patel B, Vincent J, Lau A, Pike KG, Hunt TA, Sule A, Valerie NCK, Biddlestone-Thorpe L, Kahn J, Beckta JM, Mukhopadhyay N, Barlaam B, Degorce SL, Kettle J, Colclough N, Wilson J, Smith A, Barrett IP, Zheng L, Zhang T, Wang Y, Chen K, Pass M, Durant ST, Valerie K. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. doi: 10.1158/1535-7163.MCT-17-0975. Epub 2018 May 16. PubMed |
| Precision Tagging: A Novel Seamless Protein Tagging by Combinational Use of Type II and Type IIS Restriction Endonucleases. Xu Z, Rui YN, Hagan JP, Kim DH. Bio Protoc. 2018 Feb 5;8(3). doi: 10.21769/BioProtoc.2721. PubMed |
| In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Wei R, Wong JPC, Lyu P, Xi X, Tong O, Zhang SD, Yuen HF, Shirasawa S, Kwok HF. J Cell Mol Med. 2018 Sep;22(9):4097-4105. doi: 10.1111/jcmm.13686. Epub 2018 May 30. PubMed |
| Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth. Zulato E, Ciccarese F, Nardo G, Pinazza M, Agnusdei V, Silic-Benussi M, Ciminale V, Indraccolo S. Front Oncol. 2018 Jun 4;8:195. doi: 10.3389/fonc.2018.00195. eCollection 2018. PubMed |
| LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and gamma-irradiation. Zulato E, Ciccarese F, Agnusdei V, Pinazza M, Nardo G, Iorio E, Curtarello M, Silic-Benussi M, Rossi E, Venturoli C, Panieri E, Santoro MM, Di Paolo V, Quintieri L, Ciminale V, Indraccolo S. Biochem Pharmacol. 2018 Oct;156:479-490. doi: 10.1016/j.bcp.2018.09.019. Epub 2018 Sep 15. PubMed |
| Nuclear envelope assembly defects link mitotic errors to chromothripsis. Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D. Nature. 2018 Sep;561(7724):551-555. doi: 10.1038/s41586-018-0534-z. Epub 2018 Sep 19. PubMed |
| RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer. Zarei M, Lal S, Vaziri-Gohar A, O'Hayer K, Gunda V, Singh PK, Brody JR, Winter JM. Mol Cancer Res. 2019 Feb;17(2):508-520. doi: 10.1158/1541-7786.MCR-18-0557. Epub 2018 Sep 28. PubMed |
| Proteomic Profiling of Iron-Treated Ovarian Cells Identifies AKT Activation that Modulates the CLEAR Network. Rockfield S, Guergues J, Rehman N, Smith A, Bauckman KA, Stevens SM Jr, Nanjundan M. Proteomics. 2018 Dec;18(23):e1800244. doi: 10.1002/pmic.201800244. Epub 2018 Oct 30. PubMed |
| IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC. Wang J, Zhang ZG, Ding ZY, Dong W, Liang HF, Chu L, Zhang BX, Chen XP. J Surg Res. 2018 Nov;231:116-125. doi: 10.1016/j.jss.2018.04.056. Epub 2018 Jun 17. PubMed |
| MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZ. Mol Cell. 2018 Dec 6;72(5):836-848.e7. doi: 10.1016/j.molcel.2018.09.031. Epub 2018 Nov 8. PubMed |
| SOX2 as a novel contributor of oxidative metabolism in melanoma cells. Andreucci E, Pietrobono S, Peppicelli S, Ruzzolini J, Bianchini F, Biagioni A, Stecca B, Calorini L. Cell Commun Signal. 2018 Nov 22;16(1):87. doi: 10.1186/s12964-018-0297-z. PubMed |
Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission.
Kamerkar SC, Kraus F, Sharpe AJ, Pucadyil TJ, Ryan MT.
Nat Commun. 2018 Dec 7;9(1):5239. doi: 10.1038/s41467-018-07543-w.
PubMed
Associated Plasmids |
| FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Zhang ZQ, Chen J, Huang WQ, Ning D, Liu QM, Wang C, Zhang L, Ren L, Chu L, Liang HF, Fan HN, Zhang BX, Chen XP. Mol Oncol. 2019 Apr;13(4):792-810. doi: 10.1002/1878-0261.12429. Epub 2019 Jan 24. PubMed |
| Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. Murillo MM, Rana S, Spencer-Dene B, Nye E, Stamp G, Downward J. Cell Rep. 2018 Dec 26;25(13):3545-3553.e2. doi: 10.1016/j.celrep.2018.12.003. PubMed |
| KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs. Liu H, Sun M, Liu Z, Kong C, Kong W, Ye J, Gong J, Huang DCS, Qian F. J Control Release. 2019 Feb 28;296:40-53. doi: 10.1016/j.jconrel.2019.01.014. Epub 2019 Jan 15. PubMed |
| NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M. Cell Rep. 2019 Feb 19;26(8):2028-2036.e6. doi: 10.1016/j.celrep.2019.01.083. PubMed |
| FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, Chu L, Yu C, Liang HF, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Feb 26;38(1):101. doi: 10.1186/s13046-019-1058-6. PubMed |
| Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE. Yoshida Y, Saeki Y, Tsuchiya H, Tanaka K. Methods Enzymol. 2019;618:135-147. doi: 10.1016/bs.mie.2018.12.032. Epub 2019 Feb 1. PubMed |
| Annexin A2 Regulates AKT Upon H(2)O(2)-Dependent Signaling Activation in Cancer Cells. Castaldo SA, Ajime T, Serrao G, Anastacio F, Rosa JT, Giacomantonio CA, Howarth A, Hill R, Madureira PA. Cancers (Basel). 2019 Apr 7;11(4). pii: cancers11040492. doi: 10.3390/cancers11040492. PubMed |
| CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. Ito T, Nakamura A, Tanaka I, Tsuboi Y, Morikawa T, Nakajima J, Takai D, Fukayama M, Sekido Y, Niki T, Matsubara D, Murakami Y. Cancer Sci. 2019 Jul;110(7):2284-2295. doi: 10.1111/cas.14040. Epub 2019 May 29. PubMed |
| Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAF(V600E)-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. Robb R, Yang L, Shen C, Wolfe AR, Webb A, Zhang X, Vedaie M, Saji M, Jhiang S, Ringel MD, Williams TM. Clin Cancer Res. 2019 Aug 1;25(15):4749-4760. doi: 10.1158/1078-0432.CCR-18-3625. Epub 2019 May 16. PubMed |
| PI3Kalpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment. Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH. Cancer Lett. 2019 Sep 10;459:145-155. doi: 10.1016/j.canlet.2019.05.040. Epub 2019 Jun 4. PubMed |
| Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2. Sloat SR, Whitley BN, Engelhart EA, Hoppins S. Mol Biol Cell. 2019 Aug 1;30(17):2309-2319. doi: 10.1091/mbc.E19-05-0291. Epub 2019 Jun 12. PubMed |
| DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Jun 22;38(1):273. doi: 10.1186/s13046-019-1220-1. PubMed |
| Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells. Cheng YP, Li S, Chuang WL, Li CH, Chen GJ, Chang CC, Or CR, Lin PY, Chang CC. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133366. doi: 10.3390/ijms20133366. PubMed |
| Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Pettersen IKN, Tusubira D, Ashrafi H, Dyrstad SE, Hansen L, Liu XZ, Nilsson LIH, Lovsletten NG, Berge K, Wergedahl H, Bjorndal B, Fluge O, Bruland O, Rustan AC, Halberg N, Rosland GV, Berge RK, Tronstad KJ. Mitochondrion. 2019 Nov;49:97-110. doi: 10.1016/j.mito.2019.07.009. Epub 2019 Jul 25. PubMed |
| Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance. Pelullo M, Nardozza F, Zema S, Quaranta R, Nicoletti C, Besharat ZM, Felli MP, Cerbelli B, d'Amati G, Palermo R, Capalbo C, Talora C, Di Marcotullio L, Giannini G, Checquolo S, Screpanti I, Bellavia D. Cancer Res. 2019 Nov 1;79(21):5575-5586. doi: 10.1158/0008-5472.CAN-19-0145. Epub 2019 Sep 10. PubMed |
| DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1beta-Ser88. Legartova S, Lochmanova G, Zdrahal Z, Kozubek S, Sponer J, Krepl M, Pokorna P, Bartova E. Cells. 2019 Sep 17;8(9). pii: cells8091097. doi: 10.3390/cells8091097. PubMed |
| The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. Dibley MG, Formosa LE, Lyu B, Reljic B, McGann D, Muellner-Wong L, Kraus F, Sharpe AJ, Stroud DA, Ryan MT. Mol Cell Proteomics. 2020 Jan;19(1):65-77. doi: 10.1074/mcp.RA119.001784. Epub 2019 Oct 30. PubMed |
| Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. Zhang Y, Wu X, Kai Y, Lee CH, Cheng F, Li Y, Zhuang Y, Ghaemmaghami J, Chuang KH, Liu Z, Meng Y, Keswani M, Gough NR, Wu X, Zhu W, Tzatsos A, Peng W, Seto E, Sotomayor EM, Zheng X. JCI Insight. 2019 Dec 19;4(24). pii: 129344. doi: 10.1172/jci.insight.129344. PubMed |
| Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Escoll M, Lastra D, Pajares M, Robledinos-Anton N, Rojo AI, Fernandez-Gines R, Mendiola M, Martinez-Marin V, Esteban I, Lopez-Larrubia P, Gargini R, Cuadrado A. Redox Biol. 2020 Feb;30:101425. doi: 10.1016/j.redox.2019.101425. Epub 2020 Jan 2. PubMed |
| Targeting the EphB4 receptor tyrosine kinase sensitizes HER2-positive breast cancer cells to Lapatinib. Ding J, Yao Y, Huang G, Wang X, Yi J, Zhang N, Liu C, Wang K, Zhang Y, Wang M, Liu P, Ye M, Li M, Cheng H. Cancer Lett. 2020 Apr 10;475:53-64. doi: 10.1016/j.canlet.2020.01.032. Epub 2020 Jan 29. PubMed |
| Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells. Kumazaki M, Shimomura I, Kiyono T, Ochiya T, Yamamoto Y. Biochem Biophys Res Commun. 2020 Apr 30;525(2):483-490. doi: 10.1016/j.bbrc.2020.02.113. Epub 2020 Feb 25. PubMed |
| Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. Loregger A, Raaben M, Nieuwenhuis J, Tan JME, Jae LT, van den Hengel LG, Hendrix S, van den Berg M, Scheij S, Song JY, Huijbers IJ, Kroese LJ, Ottenhoff R, van Weeghel M, van de Sluis B, Brummelkamp T, Zelcer N. Nat Commun. 2020 Feb 28;11(1):1128. doi: 10.1038/s41467-020-14811-1. PubMed |
| ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, Bank T, Cotler SJ, Dhanarajan A, Denning MF, Ding X, Breslin P, Qiang W, Li J, Koleske AJ, Qiu W. Gastroenterology. 2020 Jul;159(1):289-305.e16. doi: 10.1053/j.gastro.2020.03.013. Epub 2020 Jun 24. PubMed |
| Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome. Mao X, Bharti P, Thaivalappil A, Cao K. Aging (Albany NY). 2020 Mar 18;12(6):5195-5208. doi: 10.18632/aging.102941. Epub 2020 Mar 18. PubMed |
| HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV. Hock DH, Reljic B, Ang CS, Muellner-Wong L, Mountford HS, Compton AG, Ryan MT, Thorburn DR, Stroud DA. Mol Cell Proteomics. 2020 Jul;19(7):1145-1160. doi: 10.1074/mcp.RA120.002076. Epub 2020 Apr 21. PubMed |
| Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD. Nat Commun. 2020 May 11;11(1):2332. doi: 10.1038/s41467-020-16243-3. PubMed |
| Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V. Nat Commun. 2020 May 12;11(1):2376. doi: 10.1038/s41467-020-16050-w. PubMed |
| Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer. Lu CS, Shiau AL, Su BH, Hsu TS, Wang CT, Su YC, Tsai MS, Feng YH, Tseng YL, Yen YT, Wu CL, Shieh GS. J Hematol Oncol. 2020 Jun 1;13(1):62. doi: 10.1186/s13045-020-00887-1. PubMed |
| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
| Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport. Andersen JP, Zhang J, Sun H, Liu X, Liu J, Nie J, Shi Y. Mol Metab. 2020 Dec;42:101055. doi: 10.1016/j.molmet.2020.101055. Epub 2020 Jul 29. PubMed |
| Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells. Han B, Lee-Okada HC, Ishimine M, Orita H, Nishikawa K, Takagaki T, Kajino K, Yokomizo T, Hino O, Kobayashi T. FEBS Open Bio. 2020 Nov;10(11):2375-2387. doi: 10.1002/2211-5463.12985. Epub 2020 Oct 5. PubMed |
| SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. Mangosh TL, Awadallah WN, Grabowska MM, Taylor DJ. Mol Cancer Res. 2021 Feb;19(2):301-316. doi: 10.1158/1541-7786.MCR-20-0314. Epub 2020 Nov 13. PubMed |
| Sorting nexin 5 mediates virus-induced autophagy and immunity. Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B. Nature. 2021 Jan;589(7842):456-461. doi: 10.1038/s41586-020-03056-z. Epub 2020 Dec 16. PubMed |
| The 14-3-3sigma protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway. Song J, Liu Y, Liu F, Zhang L, Li G, Yuan C, Yu C, Lu X, Liu Q, Chen X, Liang H, Ding Z, Zhang B. Theranostics. 2021 Jan 1;11(3):996-1015. doi: 10.7150/thno.51646. eCollection 2021. PubMed |
| CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2. Zhang Y, Gan H, Zhao F, Ma X, Xie X, Huang R, Zhao J. Front Pharmacol. 2021 Jan 13;11:600994. doi: 10.3389/fphar.2020.600994. eCollection 2020. PubMed |
| Laser Micro-Irradiation to Study DNA Recruitment During S Phase. Miwatani-Minter B, Rona G. J Vis Exp. 2021 Apr 16;(170). doi: 10.3791/62466. PubMed |
| Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. Eisele BS, Luka Z, Wu AJ, Yang F, Hale AT, York JD. J Biol Chem. 2021 Nov;297(5):101293. doi: 10.1016/j.jbc.2021.101293. Epub 2021 Oct 8. PubMed |
| YAP1-mediated regulation of mitochondrial dynamics in IDH1 mutant gliomas. Patrick S, Gowda P, Lathoria K, Suri V, Sen E. J Cell Sci. 2021 Nov 15;134(22). pii: 273515. doi: 10.1242/jcs.259188. Epub 2021 Nov 24. PubMed |
| In Vitro Replication Inhibitory Activity of Xanthorrhizol against Severe Acute Respiratory Syndrome Coronavirus 2. Kim M, Cho H, Ahn DG, Jung HG, Seo HY, Kim JS, Lee YJ, Choi JY, Park IH, Shin JS, Kim SJ, Oh JW. Biomedicines. 2021 Nov 19;9(11):1725. doi: 10.3390/biomedicines9111725. PubMed |
| Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO. Nat Chem Biol. 2022 Apr;18(4):360-367. doi: 10.1038/s41589-021-00900-9. Epub 2021 Dec 2. PubMed |
| Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells. Sun Y, Lin X, Liu B, Zhang Y, Li W, Zhang S, He F, Tian H, Zhu X, Liu X, Wu J, Cai J, Li M. Sci Adv. 2021 Dec 24;7(52):eabj6877. doi: 10.1126/sciadv.abj6877. Epub 2021 Dec 22. PubMed |
| Restoration of mitophagy ameliorates cardiomyopathy in Barth syndrome. Zhang J, Liu X, Nie J, Shi Y. Autophagy. 2022 Sep;18(9):2134-2149. doi: 10.1080/15548627.2021.2020979. Epub 2022 Jan 5. PubMed |
| Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes. Yoon S, Bogdanov K, Wallach D. Cell Death Differ. 2022 Feb;29(2):306-322. doi: 10.1038/s41418-021-00924-7. Epub 2022 Jan 9. PubMed |
| CDK6 increases glycolysis and suppresses autophagy by mTORC1-HK2 pathway activation in cervical cancer cells. Zhang X, Sun Y, Cheng S, Yao Y, Hua X, Shi Y, Jin X, Pan J, Hu MG, Ying P, Hou X, Xia D. Cell Cycle. 2022 May;21(9):984-1002. doi: 10.1080/15384101.2022.2039981. Epub 2022 Feb 15. PubMed |
| Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Qi M, Xia Y, Wu Y, Zhang Z, Wang X, Lu L, Dai C, Song Y, Xu K, Ji W, Zhan L. Nat Commun. 2022 Feb 16;13(1):897. doi: 10.1038/s41467-022-28438-x. PubMed |
| MESH1 knockdown triggers proliferation arrest through TAZ repression. Sun T, Ding CC, Zhang Y, Zhang Y, Lin CC, Wu J, Setayeshpour Y, Coggins S, Shepard C, Macias E, Kim B, Zhou P, Gordan R, Chi JT. Cell Death Dis. 2022 Mar 10;13(3):221. doi: 10.1038/s41419-022-04663-6. PubMed |
| Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1. Garcia-Dominguez DJ, Hajji N, Lopez-Alemany R, Sanchez-Molina S, Figuerola-Bou E, Moron Civanto FJ, Rello-Varona S, Andres-Leon E, Benito A, Keun HC, Mora J, Tirado OM, de Alava E, Hontecillas-Prieto L. Oncogene. 2022 Apr;41(18):2638-2650. doi: 10.1038/s41388-022-02279-w. Epub 2022 Mar 30. PubMed |
| De novo labeling and trafficking of individual lipid species in live cells. Zhang J, Nie J, Sun H, Li J, Andersen JP, Shi Y. Mol Metab. 2022 Jul;61:101511. doi: 10.1016/j.molmet.2022.101511. Epub 2022 May 2. PubMed |
| Cystathionine-beta-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. Zhu H, Chan KT, Huang X, Cerra C, Blake S, Trigos AS, Anderson D, Creek DJ, De Souza DP, Wang X, Fu C, Jana M, Sanij E, Pearson RB, Kang J. Elife. 2022 Jun 27;11. pii: 71929. doi: 10.7554/eLife.71929. PubMed |
| Tumor suppressive functions of WNT5A in rhabdomyosarcoma. Ragab N, Bauer J, Uhmann A, Marx A, Hahn H, Simon-Keller K. Int J Oncol. 2022 Sep;61(3). pii: 102. doi: 10.3892/ijo.2022.5392. Epub 2022 Jul 7. PubMed |
| Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer. Mughal MJ, Chan KI, Mahadevappa R, Wong SW, Wai KC, Kwok HF. Int J Biol Sci. 2022 May 29;18(9):3827-3844. doi: 10.7150/ijbs.69344. eCollection 2022. PubMed |
| Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming. von Joest M, Chen C, Douche T, Chantrel J, Chiche A, Gianetto QG, Matondo M, Li H. Cell Rep. 2022 Jul 12;40(2):111074. doi: 10.1016/j.celrep.2022.111074. PubMed |
| Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells. Palazzo A, Hernandez-Vargas H, Goehrig D, Medard JJ, Vindrieux D, Flaman JM, Bernard D. Cancer Lett. 2022 Oct 10;546:215850. doi: 10.1016/j.canlet.2022.215850. Epub 2022 Aug 1. PubMed |
| Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis. Sabate-Perez A, Romero M, Sanchez-Fernandez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martinez-Cristobal P, Villena JA, Virtue S, Vidal-Puig A, Palacin M, Testar X, Zorzano A. Autophagy. 2023 Mar;19(3):904-925. doi: 10.1080/15548627.2022.2111081. Epub 2022 Aug 25. PubMed |
| Protocol to use TopNet for gene regulatory network modeling using gene expression data from perturbation experiments. McMurray HR, Stern HA, Ambeskovic A, Land H, McCall MN. STAR Protoc. 2022 Dec 16;3(4):101737. doi: 10.1016/j.xpro.2022.101737. Epub 2022 Sep 30. PubMed |
| A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering. Sloat SR, Hoppins S. Life Sci Alliance. 2022 Oct 13;6(1):e202101305. doi: 10.26508/lsa.202101305. Print 2023 Jan. PubMed |
| Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisozu A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. PubMed |
| Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature. Coll-Bonfill N, Mahajan U, Shashkova EV, Lin CJ, Mecham RP, Gonzalo S. Geroscience. 2023 Apr;45(2):965-982. doi: 10.1007/s11357-022-00694-1. Epub 2022 Dec 9. PubMed |
| Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer. Dharavath B, Butle A, Pal A, Desai S, Upadhyay P, Rane A, Khandelwal R, Manavalan S, Thorat R, Sonawane K, Vaish R, Gera P, Bal M, D'Cruz AK, Nair S, Dutt A. Commun Biol. 2023 Jan 17;6(1):57. doi: 10.1038/s42003-023-04437-6. PubMed |
| BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer. Rose MM, Espinoza VL, Hoff KJ, Pike LA, Sharma V, Hofmann MC, Tan AC, Pozdeyev N, Schweppe RE. Cancers (Basel). 2023 Jan 6;15(2):378. doi: 10.3390/cancers15020378. PubMed |
| Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation. Perrone C, Pomella S, Cassandri M, Pezzella M, Giuliani S, Gasperi T, Porrazzo A, Alisi A, Pastore A, Codenotti S, Fanzani A, Barillari G, Conti LA, De Angelis B, Quintarelli C, Mariottini P, Locatelli F, Marampon F, Rota R, Cervelli M. Front Cell Dev Biol. 2023 Jan 23;11:1061570. doi: 10.3389/fcell.2023.1061570. eCollection 2023. PubMed |
| A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation. Su S, Xue Y, Lee SK, Zhang Y, Fan J, De S, Sharov A, Wang W. Nucleic Acids Res. 2023 Mar 21;51(5):2415-2433. doi: 10.1093/nar/gkad086. PubMed |
| Corruption of DNA end-joining in mammalian chromosomes by progerin expression. Joudeh LA, DiCintio AJ, Ries MR, Gasperson AS, Griffin KE, Robbins VP, Bonner M, Nolan S, Black E, Waldman AS. DNA Repair (Amst). 2023 Jun;126:103491. doi: 10.1016/j.dnarep.2023.103491. Epub 2023 Mar 31. PubMed |
| FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung. Tomoshige K, Stuart WD, Fink-Baldauf IM, Ito M, Tsuchiya T, Nagayasu T, Yamatsuji T, Okada M, Fukazawa T, Guo M, Maeda Y. Cancer Res. 2023 May 2;83(9):1443-1458. doi: 10.1158/0008-5472.CAN-22-2805. PubMed |
| Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars. Martinez-Zamudio RI, Stefa A, Nabuco Leva Ferreira Freitas JA, Vasilopoulos T, Simpson M, Dore G, Roux PF, Galan MA, Chokshi RJ, Bischof O, Herbig U. Cell Genom. 2023 Apr 5;3(4):100293. doi: 10.1016/j.xgen.2023.100293. eCollection 2023 Apr 12. PubMed |
| Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression. Xiong YX, Zhang XC, Zhu JH, Zhang YX, Pan YL, Wu Y, Zhao JP, Liu JJ, Lu YX, Liang HF, Zhang ZG, Zhang WG. Cell Death Differ. 2023 Jul;30(7):1648-1665. doi: 10.1038/s41418-023-01166-5. Epub 2023 Apr 28. PubMed |
| Deregulated expression of the 14q32 miRNA cluster in clear cell renal cancer cells. Chhabra R, Guergues J, Wohlfahrt J, Rockfield S, Espinoza Gonzalez P, Rego S, Park MA, Berglund AE, Stevens SM Jr, Nanjundan M. Front Oncol. 2023 Apr 17;13:1048419. doi: 10.3389/fonc.2023.1048419. eCollection 2023. PubMed |
| Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Healy MD, McNally KE, Butkovic R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ. Cell. 2023 May 11;186(10):2219-2237.e29. doi: 10.1016/j.cell.2023.04.003. PubMed |
| Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD. Abenza JF, Rossetti L, Mouelhi M, Burgues J, Andreu I, Kennedy K, Roca-Cusachs P, Marco S, Garcia-Ojalvo J, Trepat X. J Cell Biol. 2023 Sep 4;222(9):e202209120. doi: 10.1083/jcb.202209120. Epub 2023 Jun 28. PubMed |
| Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC). Richards CE, Elamin YY, Carr A, Gately K, Rafee S, Cremona M, Hanrahan E, Smyth R, Ryan D, Morgan RK, Kennedy S, Hudson L, Fay J, O'Byrne K, Hennessy BT, Toomey S. Int J Mol Sci. 2023 Jun 23;24(13):10545. doi: 10.3390/ijms241310545. PubMed |
A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion.
Li J, Krause GJ, Gui Q, Kaushik S, Rona G, Zhang Q, Liang FX, Dhabaria A, Anerillas C, Martindale JL, Vasilyev N, Askenazi M, Ueberheide B, Nudler E, Gorospe M, Cuervo AM, Pagano M.
Sci Adv. 2023 Oct 13;9(41):eadh1134. doi: 10.1126/sciadv.adh1134. Epub 2023 Oct 13.
PubMed
Associated Plasmids |
| Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Zhang J, Keibler MA, Dong W, Ghelfi J, Cordes T, Kanashova T, Pailot A, Linster CL, Dittmar G, Metallo CM, Lautenschlaeger T, Hiller K, Stephanopoulos G. Biomedicines. 2023 Oct 19;11(10):2842. doi: 10.3390/biomedicines11102842. PubMed |
| LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport. Sun H, Zhang J, Ye Q, Jiang T, Liu X, Zhang X, Zeng F, Li J, Zheng Y, Han X, Su C, Shi Y. Cell Rep. 2023 Nov 28;42(11):113214. doi: 10.1016/j.celrep.2023.113214. Epub 2023 Nov 2. PubMed |
| Akt enhances the vulnerability of cancer cells to VCP/p97 inhibition-mediated paraptosis. Lee DM, Kim IY, Lee HJ, Seo MJ, Cho MY, Lee HI, Yoon G, Ji JH, Park SS, Jeong SY, Choi EK, Choi YH, Yun CO, Yeo M, Kim E, Choi KS. Cell Death Dis. 2024 Jan 13;15(1):48. doi: 10.1038/s41419-024-06434-x. PubMed |
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