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Flag-Bcl2 Citations (22)

Originally described in: Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death.
Wang NS, Unkila MT, Reineks EZ, Distelhorst CW J Biol Chem. 2001 Nov 23. 276(47):44117-28. PubMed Journal

Articles Citing Flag-Bcl2

Articles
Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Ren SX, Cheng AS, To KF, Tong JH, Li MS, Shen J, Wong CC, Zhang L, Chan RL, Wang XJ, Ng SS, Chiu LC, Marquez VE, Gallo RL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH. Cancer Res. 2012 Dec 15;72(24):6512-23. doi: 10.1158/0008-5472.CAN-12-2359. Epub 2012 Oct 24. PubMed
Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. Fei B, Yu S, Geahlen RL. Biochim Biophys Acta. 2013 Oct;1833(10):2153-64. doi: 10.1016/j.bbamcr.2013.05.010. Epub 2013 May 16. PubMed
FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. Ren SX, Shen J, Cheng AS, Lu L, Chan RL, Li ZJ, Wang XJ, Wong CC, Zhang L, Ng SS, Chan FL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH. PLoS One. 2013 May 20;8(5):e63641. doi: 10.1371/journal.pone.0063641. Print 2013. PubMed
A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI. Mol Cell Biol. 2013 Oct;33(20):4051-67. doi: 10.1128/MCB.00021-13. Epub 2013 Aug 19. PubMed
Interaction of Leukocyte Elastase Inhibitor/L-DNase II with BCL-2 and BAX. Jaadane I, Nagbou A, Behar-Cohen F, Torriglia A. Biochim Biophys Acta. 2014 Dec;1843(12):2807-15. doi: 10.1016/j.bbamcr.2014.08.007. Epub 2014 Aug 16. PubMed
The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Rui YN, Xu Z, Chen Z, Zhang S. Autophagy. 2015;11(5):812-32. doi: 10.1080/15548627.2015.1034402. PubMed
A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells. Mughal W, Nguyen L, Pustylnik S, da Silva Rosa SC, Piotrowski S, Chapman D, Du M, Alli NS, Grigull J, Halayko AJ, Aliani M, Topham MK, Epand RM, Hatch GM, Pereira TJ, Kereliuk S, McDermott JC, Rampitsch C, Dolinsky VW, Gordon JW. Cell Death Dis. 2015 Oct 29;6:e1944. doi: 10.1038/cddis.2015.306. PubMed

Associated Plasmids
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J. Autophagy. 2016 Aug 2;12(8):1340-54. doi: 10.1080/15548627.2016.1187365. Epub 2016 May 31. PubMed
Aspirin induces Beclin-1-dependent autophagy of human hepatocellular carcinoma cell. Huang Z, Fang W, Liu W, Wang L, Liu B, Liu S, Liu S. Eur J Pharmacol. 2018 Mar 15;823:58-64. doi: 10.1016/j.ejphar.2018.01.031. Epub 2018 Feb 4. PubMed
A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop. Wu DW, Wang YC, Wang L, Chen CY, Lee H. Theranostics. 2018 Feb 2;8(5):1256-1269. doi: 10.7150/thno.22048. eCollection 2018. PubMed
Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition. Mughal W, Martens M, Field J, Chapman D, Huang J, Rattan S, Hai Y, Cheung KG, Kereliuk S, West AR, Cole LK, Hatch GM, Diehl-Jones W, Keijzer R, Dolinsky VW, Dixon IM, Parmacek MS, Gordon JW. Cell Death Differ. 2018 Mar 6. pii: 10.1038/s41418-018-0073-z. doi: 10.1038/s41418-018-0073-z. PubMed

Associated Plasmids
BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy. Oing C, Tennstedt P, Simon R, Volquardsen J, Borgmann K, Bokemeyer C, Petersen C, Dikomey E, Rothkamm K, Mansour WY. Cancer Lett. 2018 Jun 1;423:60-70. doi: 10.1016/j.canlet.2018.03.007. Epub 2018 Mar 8. PubMed
MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2. Chen MJ, Wu DW, Wang GC, Wang YC, Chen CY, Lee H. Oncotarget. 2018 Feb 9;9(17):13758-13767. doi: 10.18632/oncotarget.24474. eCollection 2018 Mar 2. PubMed
MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. Proc Natl Acad Sci U S A. 2018 May 29;115(22):5768-5773. doi: 10.1073/pnas.1721650115. Epub 2018 May 14. PubMed
Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress. Field JT, Martens MD, Mughal W, Hai Y, Chapman D, Hatch GM, Ivanco TL, Diehl-Jones W, Gordon JW. Cell Death Discov. 2018 Sep 21;4:37. doi: 10.1038/s41420-018-0104-z. eCollection 2018. PubMed

Associated Plasmids
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. PubMed
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. PubMed
MITOL promotes cell survival by degrading Parkin during mitophagy. Shiiba I, Takeda K, Nagashima S, Ito N, Tokuyama T, Yamashita SI, Kanki T, Komatsu T, Urano Y, Fujikawa Y, Inatome R, Yanagi S. EMBO Rep. 2021 Mar 3;22(3):e49097. doi: 10.15252/embr.201949097. Epub 2021 Feb 10. PubMed
Hepatitis B virus X Protein Promotes Liver Cancer Progression through Autophagy Induction in Response to TLR4 Stimulation. Son J, Kim MJ, Lee JS, Kim JY, Chun E, Lee KY. Immune Netw. 2021 Oct 26;21(5):e37. doi: 10.4110/in.2021.21.e37. eCollection 2021 Oct. PubMed
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D. Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x. PubMed
iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Dulloo I, Atakpa-Adaji P, Yeh YC, Levet C, Muliyil S, Lu F, Taylor CW, Freeman M. Nat Commun. 2022 Mar 10;13(1):1257. doi: 10.1038/s41467-022-28930-4. PubMed
mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer. Kumari A, Gesumaria L, Liu YJ, Hughitt VK, Zhang X, Ceribelli M, Wilson KM, Klumpp-Thomas C, Chen L, McKnight C, Itkin Z, Thomas CJ, Mock BA, Schrump DS, Chen H. JCI Insight. 2023 Mar 8;8(5):e156657. doi: 10.1172/jci.insight.156657. PubMed

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