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scramble shRNA Citations (483)

Plasmid Article: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM Science 2005 Feb 18;307(5712):1098-101.
PubMed Journal

Articles Citing scramble shRNA

Articles
Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Proc Natl Acad Sci U S A. 2006 Sep 19. 103(38):14182-7. PubMed
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. Wang L, Harris TE, Roth RA, Lawrence JC. J Biol Chem. 2007 Jul 6. 282(27):20036-44. PubMed

Associated Plasmids

mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 2007 Dec 15. 67(24):11712-20. PubMed
The interferon response inhibits HIV particle production by induction of TRIM22. Barr SD, Smiley JR, Bushman FD. PLoS Pathog. 2008 Feb 29;4(2):e1000007. doi: 10.1371/journal.ppat.1000007. PubMed
XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Kulkarni A, McNeill DR, Gleichmann M, Mattson MP, Wilson DM 3rd. Nucleic Acids Res. 2008 Sep;36(15):5111-21. doi: 10.1093/nar/gkn480. Epub 2008 Aug 5. PubMed
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Baryawno N, Sveinbjornsson B, Eksborg S, Orrego A, Segerstrom L, Oqvist CO, Holm S, Gustavsson B, Kagedal B, Kogner P, Johnsen JI. Neuro Oncol. 2008 Oct;10(5):661-74. doi: 10.1215/15228517-2008-035. Epub 2008 Aug 20. PubMed
COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. Kato S, Ding J, Pisck E, Jhala US, Du K. J Biol Chem. 2008 Dec 19;283(51):35464-73. doi: 10.1074/jbc.M801011200. Epub 2008 Sep 24. PubMed
Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication. Urtishak KA, Smith KD, Chanoux RA, Greenberg RA, Johnson FB, Brown EJ. J Biol Chem. 2009 Mar 27;284(13):8777-85. doi: 10.1074/jbc.M806103200. Epub 2008 Dec 28. PubMed
A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. PubMed
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR. Blood. 2009 Apr 2;113(14):3172-81. doi: 10.1182/blood-2008-07-170035. Epub 2009 Jan 30. PubMed
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Copp J, Manning G, Hunter T. Cancer Res. 2009 Mar 1. 69(5):1821-7. PubMed
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB. J Biol Chem. 2009 Apr 17;284(16):10334-42. doi: 10.1074/jbc.M808848200. Epub 2009 Feb 24. PubMed
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barila D, Lahti JM, Schlaepfer D, Stupack DG. Cancer Res. 2009 May 1;69(9):3755-63. doi: 10.1158/0008-5472.CAN-08-3937. Epub 2009 Apr 21. PubMed
In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Ballif BA, Fingar DC. Mol Cell Biol. 2009 Jun 1. ():. PubMed
Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. Su WC, Liu WL, Cheng CW, Chou YB, Hung KH, Huang WH, Wu CL, Li YT, Shiau AL, Lai MY. FEBS Lett. 2009 Sep 3;583(17):2793-8. doi: 10.1016/j.febslet.2009.07.027. Epub 2009 Jul 18. PubMed
Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors. Allington TM, Galliher-Beckley AJ, Schiemann WP. FASEB J. 2009 Dec;23(12):4231-43. doi: 10.1096/fj.09-138412. Epub 2009 Aug 18. PubMed
Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. Snyder CM, Shroff EH, Liu J, Chandel NS. PLoS One. 2009 Sep 21;4(9):e7059. doi: 10.1371/journal.pone.0007059. PubMed
G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W. J Biol Chem. 2009 Dec 11. 284(50):35040-8. PubMed
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. Smith KD, Fu MA, Brown EJ. J Cell Biol. 2009 Oct 5. 187(1):15-23. PubMed
Rab5 mediates caspase-8-promoted cell motility and metastasis. Torres VA, Mielgo A, Barbero S, Hsiao R, Wilkins JA, Stupack DG. Mol Biol Cell. 2010 Jan 15;21(2):369-76. doi: 10.1091/mbc.E09-09-0769. Epub 2009 Nov 18. PubMed
Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Biochem Biophys Res Commun. 2010 Apr 2. 394(2):418-23. PubMed
Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, Simon MC. J Biol Chem. 2010 May 14;285(20):15587-98. doi: 10.1074/jbc.M109.081687. Epub 2010 Mar 15. PubMed
Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression. Liu J, Uygur B, Zhang Z, Shao L, Romero D, Vary C, Ding Q, Wu WS. Prostate. 2010 Dec 1;70(16):1768-77. doi: 10.1002/pros.21213. PubMed
The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage. Mao FJ, Sidorova JM, Lauper JM, Emond MJ, Monnat RJ. Cancer Res. 2010 Aug 15;70(16):6548-55. doi: 10.1158/0008-5472.CAN-10-0475. Epub 2010 Jul 27. PubMed
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor. Hoang B, Frost P, Shi Y, Belanger E, Benavides A, Pezeshkpour G, Cappia S, Guglielmelli T, Gera J, Lichtenstein A. Blood. 2010 Nov 25;116(22):4560-8. doi: 10.1182/blood-2010-05-285726. Epub 2010 Aug 4. PubMed
Long-term IGF-I exposure decreases autophagy and cell viability. Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, Lorenzini A, Hrelia S, Ikeno Y, Matzko ME, McCarter R, Sell C. PLoS One. 2010 Sep 7;5(9):e12592. doi: 10.1371/journal.pone.0012592. PubMed
Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. PubMed
Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation. Lin FY, Chang CW, Cheong ML, Chen HC, Lee DY, Chang GD, Chen H. Nucleic Acids Res. 2011 Feb;39(3):848-61. doi: 10.1093/nar/gkq838. Epub 2010 Sep 19. PubMed
Ku80 facilitates chromatin binding of the telomere binding protein, TRF2. Fink LS, Lerner CA, Torres PF, Sell C. Cell Cycle. 2010 Sep 15;9(18):3798-806. Epub 2010 Sep 25. PubMed
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. Vinciguerra P, Godinho SA, Parmar K, Pellman D, D'Andrea AD. J Clin Invest. 2010 Nov;120(11):3834-42. doi: 10.1172/JCI43391. PubMed
A WD-repeat protein stabilizes ORC binding to chromatin. Shen Z, Sathyan KM, Geng Y, Zheng R, Chakraborty A, Freeman B, Wang F, Prasanth KV, Prasanth SG. Mol Cell. 2010 Oct 8;40(1):99-111. doi: 10.1016/j.molcel.2010.09.021. PubMed
In vitro genetic analysis of an erythrocyte determinant of malaria infection. Bei AK, Brugnara C, Duraisingh MT. J Infect Dis. 2010 Dec 1;202(11):1722-7. doi: 10.1086/657157. Epub 2010 Oct 19. PubMed
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS. Am J Respir Crit Care Med. 2011 Apr 15;183(8):1043-54. doi: 10.1164/rccm.201002-0181OC. Epub 2010 Oct 19. PubMed
Podoplanin associates with CD44 to promote directional cell migration. Martin-Villar E, Fernandez-Munoz B, Parsons M, Yurrita MM, Megias D, Perez-Gomez E, Jones GE, Quintanilla M. Mol Biol Cell. 2010 Dec;21(24):4387-99. doi: 10.1091/mbc.E10-06-0489. Epub 2010 Oct 20. PubMed
Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. Takahashi Y, Meyerkord CL, Hori T, Runkle K, Fox TE, Kester M, Loughran TP, Wang HG. Autophagy. 2011 Jan . 7(1):61-73. PubMed
Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation. Iftikhar M, Hurtado P, Bais MV, Wigner N, Stephens DN, Gerstenfeld LC, Trackman PC. J Biol Chem. 2011 Jan 14;286(2):909-18. doi: 10.1074/jbc.M110.155622. Epub 2010 Nov 11. PubMed
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nowak U, Matthews AJ, Zheng S, Chaudhuri J. Nat Immunol. 2011 Feb;12(2):160-6. doi: 10.1038/ni.1977. Epub 2010 Dec 26. PubMed
Cullin-4A.DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. Jiang L, Rong R, Sheikh MS, Huang Y. J Biol Chem. 2011 Mar 4;286(9):6971-8. doi: 10.1074/jbc.M110.186494. Epub 2011 Jan 4. PubMed
Scavenger receptor WC1 contributes to the gammadelta T cell response to Leptospira. Wang F, Herzig CT, Chen C, Hsu H, Baldwin CL, Telfer JC. Mol Immunol. 2011 Mar;48(6-7):801-9. doi: 10.1016/j.molimm.2010.12.001. Epub 2011 Jan 11. PubMed
Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA. Oncogene. 2011 Apr 14;30(15):1812-21. doi: 10.1038/onc.2010.556. Epub 2011 Jan 17. PubMed
Therapy mediated by mitophagy abrogates tumor progression. Gargini R, Garcia-Escudero V, Izquierdo M. Autophagy. 2011 May;7(5):466-76. Epub 2011 May 1. PubMed
ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma. Sampson N, Koziel R, Zenzmaier C, Bubendorf L, Plas E, Jansen-Durr P, Berger P. Mol Endocrinol. 2011 Mar;25(3):503-15. doi: 10.1210/me.2010-0340. Epub 2011 Jan 27. PubMed
The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Ranahan WP, Han Z, Smith-Kinnaman W, Nabinger SC, Heller B, Herbert BS, Chan R, Wells CD. Cancer Res. 2011 Mar 15;71(6):2203-11. doi: 10.1158/0008-5472.CAN-10-1995. Epub 2011 Feb 1. PubMed
JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed
SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Bell EL, Emerling BM, Ricoult SJ, Guarente L. Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28. PubMed
Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells. Zlatic SA, Tornieri K, L'Hernault SW, Faundez V. Mol Biol Cell. 2011 May 15;22(10):1699-715. doi: 10.1091/mbc.E10-10-0799. Epub 2011 Mar 16. PubMed
Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Jakel H, Weinl C, Hengst L. Oncogene. 2011 Aug 11;30(32):3502-12. doi: 10.1038/onc.2011.68. Epub 2011 Mar 21. PubMed
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed
Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells. Alekseev OM, Richardson RT, Tsuruta JK, O'Rand MG. Reprod Biol Endocrinol. 2011 Apr 16;9:50. doi: 10.1186/1477-7827-9-50. PubMed
Phosphoproteomic screen identifies potential therapeutic targets in melanoma. Tworkoski K, Singhal G, Szpakowski S, Zito CI, Bacchiocchi A, Muthusamy V, Bosenberg M, Krauthammer M, Halaban R, Stern DF. Mol Cancer Res. 2011 Jun;9(6):801-12. doi: 10.1158/1541-7786.MCR-10-0512. Epub 2011 Apr 26. PubMed
The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. Oteiza A, Mechti N. J Virol. 2011 Jul;85(13):6480-91. doi: 10.1128/JVI.00036-11. Epub 2011 Apr 27. PubMed
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16. PubMed
Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Kazi AA, Hong-Brown L, Lang SM, Lang CH. Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19. PubMed
Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM. EMBO J. 2011 May 24;30(13):2662-74. doi: 10.1038/emboj.2011.159. PubMed

Associated Plasmids

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1. Glauser L, Sonnay S, Stafa K, Moore DJ. J Neurochem. 2011 Aug;118(4):636-45. doi: 10.1111/j.1471-4159.2011.07318.x. Epub 2011 Jun 6. PubMed
Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP. Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ. Oncogene. 2012 Jan 12;31(2):238-50. doi: 10.1038/onc.2011.224. Epub 2011 Jun 13. PubMed

Associated Plasmids

Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation. Benhaddou A, Keime C, Ye T, Morlon A, Michel I, Jost B, Mengus G, Davidson I. Cell Death Differ. 2012 Feb;19(2):220-31. doi: 10.1038/cdd.2011.87. Epub 2011 Jun 24. PubMed
Peroxisome-proliferator-activated receptor gamma coactivator 1 alpha contributes to dysmyelination in experimental models of Huntington's disease. Xiang Z, Valenza M, Cui L, Leoni V, Jeong HK, Brilli E, Zhang J, Peng Q, Duan W, Reeves SA, Cattaneo E, Krainc D. J Neurosci. 2011 Jun 29;31(26):9544-53. doi: 10.1523/JNEUROSCI.1291-11.2011. PubMed
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5. PubMed
The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG, Koh TL, Yu Q, Chng WJ. Blood. 2011 Sep 8;118(10):2830-9. doi: 10.1182/blood-2010-07-294827. Epub 2011 Jul 6. PubMed
A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion. Chang CW, Chang GD, Chen H. Mol Cell Biol. 2011 Sep;31(18):3820-31. doi: 10.1128/MCB.05582-11. Epub 2011 Jul 26. PubMed
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Kofoed EM, Vance RE. Nature. 2011 Aug 28;477(7366):592-5. doi: 10.1038/nature10394. PubMed

Associated Plasmids

Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state. Zenzmaier C, Hermann M, Hengster P, Berger P. Int J Oncol. 2012 Jan;40(1):40-6. doi: 10.3892/ijo.2011.1180. Epub 2011 Aug 29. PubMed
Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features. Bernemann C, Greber B, Ko K, Sterneckert J, Han DW, Arauzo-Bravo MJ, Scholer HR. Stem Cells. 2011 Oct;29(10):1496-503. doi: 10.1002/stem.709. PubMed
53BP1 contributes to a robust genomic stability in human fibroblasts. Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, Lorenzini A, Sell C. Aging (Albany NY). 2011 Sep;3(9):836-45. PubMed
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes. Potts RC, Zhang P, Wurster AL, Precht P, Mughal MR, Wood WH 3rd, Zhang Y, Becker KG, Mattson MP, Pazin MJ. PLoS One. 2011;6(9):e24515. doi: 10.1371/journal.pone.0024515. Epub 2011 Sep 13. PubMed
FOSL1 is integral to establishing the maternal-fetal interface. Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. Mol Cell Biol. 2011 Dec;31(23):4801-13. doi: 10.1128/MCB.05780-11. Epub 2011 Sep 26. PubMed
Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1. Huang S, Yang ZJ, Yu C, Sinicrope FA. J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23. PubMed
c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells. Waldron T, De Dominici M, Soliera AR, Audia A, Iacobucci I, Lonetti A, Martinelli G, Zhang Y, Martinez R, Hyslop T, Bender TP, Calabretta B. Leukemia. 2012 Apr;26(4):644-53. doi: 10.1038/leu.2011.264. Epub 2011 Sep 30. PubMed
O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, Simon MC. Mol Cell Biol. 2012 Jan;32(1):36-49. doi: 10.1128/MCB.05857-11. Epub 2011 Oct 17. PubMed
Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM. Chem Biol. 2011 Oct 28;18(10):1300-11. doi: 10.1016/j.chembiol.2011.07.020. PubMed
SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis. Uygur B, Wu WS. Mol Cancer. 2011 Nov 10;10:139. doi: 10.1186/1476-4598-10-139. PubMed
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Nature. 2011 Nov 9;480(7378):534-7. doi: 10.1038/nature10606. PubMed

Associated Plasmids

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. Orthwein A, Zahn A, Methot SP, Godin D, Conticello SG, Terada K, Di Noia JM. EMBO J. 2012 Feb 1;31(3):679-91. doi: 10.1038/emboj.2011.417. Epub 2011 Nov 15. PubMed
FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed
Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. PubMed
Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag. Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD. Retrovirology. 2011 Nov 17;8:95. doi: 10.1186/1742-4690-8-95. PubMed
Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Gu B, Watanabe K, Dai X. Cell Cycle. 2012 Jan 1;11(1):79-87. doi: 10.4161/cc.11.1.18402. Epub 2012 Jan 1. PubMed
Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. Hwang SY, Putney JW. FASEB J. 2012 Apr;26(4):1484-92. doi: 10.1096/fj.11-194399. Epub 2011 Dec 23. PubMed
LRRK2 inhibition attenuates microglial inflammatory responses. Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. J Neurosci. 2012 Feb 1;32(5):1602-11. doi: 10.1523/JNEUROSCI.5601-11.2012. PubMed
Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes. Guo C, Gow CH, Li Y, Gardner A, Khan S, Zhang J. J Biol Chem. 2012 Apr 6;287(15):12111-20. doi: 10.1074/jbc.M111.327023. Epub 2012 Feb 15. PubMed
Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Xing L, Yao X, Williams KR, Bassell GJ. Mol Biol Cell. 2012 Apr;23(8):1500-9. doi: 10.1091/mbc.E11-10-0867. Epub 2012 Feb 22. PubMed
The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish. Li Z, Wang Y, Zhang M, Xu P, Huang H, Wu D, Meng A. J Biol Chem. 2012 Apr 13;287(16):13005-15. doi: 10.1074/jbc.M112.347419. Epub 2012 Feb 23. PubMed
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J, Sharma AK, Amin S, Hu CD, Zhang J, Kester M, Wang HG. J Biol Chem. 2012 Apr 6;287(15):12455-68. doi: 10.1074/jbc.M111.309104. Epub 2012 Feb 23. PubMed
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. Stafa K, Trancikova A, Webber PJ, Glauser L, West AB, Moore DJ. PLoS Genet. 2012;8(2):e1002526. doi: 10.1371/journal.pgen.1002526. Epub 2012 Feb 9. PubMed
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1. Gokhale A, Larimore J, Werner E, So L, Moreno-De-Luca A, Lese-Martin C, Lupashin VV, Smith Y, Faundez V. J Neurosci. 2012 Mar 14;32(11):3697-711. doi: 10.1523/JNEUROSCI.5640-11.2012. PubMed
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. Sonveaux P, Copetti T, De Saedeleer CJ, Vegran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frerart F, Gallez B, Ribeiro A, Michiels C, Dewhirst MW, Feron O. PLoS One. 2012;7(3):e33418. doi: 10.1371/journal.pone.0033418. Epub 2012 Mar 13. PubMed
Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY. Neuron. 2012 Apr 12;74(1):179-92. doi: 10.1016/j.neuron.2012.01.033. PubMed
Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons. Diez H, Garrido JJ, Wandosell F. PLoS One. 2012;7(4):e32715. doi: 10.1371/journal.pone.0032715. Epub 2012 Apr 11. PubMed
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. PubMed
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Ahmed M, Xu J, Xu PX. Development. 2012 Jun;139(11):1965-77. doi: 10.1242/dev.071670. Epub 2012 Apr 18. PubMed
LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation. Malek M, Guillaumot P, Huber AL, Lebeau J, Petrilli V, Kfoury A, Mikaelian I, Renno T, Manie SN. Cell Death Dis. 2012 Apr 19;3:e300. doi: 10.1038/cddis.2012.39. PubMed
Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors. Gunsalus KT, Wagoner MP, Meyer K, Potter WB, Schoenike B, Kim S, Alexander CM, Friedl A, Roopra A. Cancer Res. 2012 Jul 1;72(13):3207-16. doi: 10.1158/0008-5472.CAN-11-1639. Epub 2012 Apr 24. PubMed
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR. RNA. 2012 Jun;18(6):1186-96. doi: 10.1261/rna.031369.111. Epub 2012 Apr 27. PubMed

Associated Plasmids

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Singh DK, Popuri V, Kulikowicz T, Shevelev I, Ghosh AK, Ramamoorthy M, Rossi ML, Janscak P, Croteau DL, Bohr VA. Nucleic Acids Res. 2012 Aug;40(14):6632-48. doi: 10.1093/nar/gks349. Epub 2012 Apr 28. PubMed
KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Moleirinho S, Chang N, Sims AH, Tilston-Lunel AM, Angus L, Steele A, Boswell V, Barnett SC, Ormandy C, Faratian D, Gunn-Moore FJ, Reynolds PA. Oncogene. 2012 May 21. doi: 10.1038/onc.2012.196. PubMed

Associated Plasmids

Recruitment and retention dynamics of RECQL5 at DNA double strand break sites. Popuri V, Ramamoorthy M, Tadokoro T, Singh DK, Karmakar P, Croteau DL, Bohr VA. DNA Repair (Amst). 2012 Jul 1;11(7):624-35. doi: 10.1016/j.dnarep.2012.05.001. Epub 2012 May 24. PubMed
Activation of canonical WNT/beta-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Kahlert UD, Maciaczyk D, Doostkam S, Orr BA, Simons B, Bogiel T, Reithmeier T, Prinz M, Schubert J, Niedermann G, Brabletz T, Eberhart CG, Nikkhah G, Maciaczyk J. Cancer Lett. 2012 Dec 1;325(1):42-53. doi: 10.1016/j.canlet.2012.05.024. Epub 2012 May 28. PubMed
Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis. Lo YH, Ho PC, Wang SC. J Biol Chem. 2012 Aug 3;287(32):27148-57. doi: 10.1074/jbc.M112.388843. Epub 2012 Jun 12. PubMed
EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance. Robin TP, Smith A, McKinsey E, Reaves L, Jedlicka P, Ford HL. Mol Cancer Res. 2012 Aug;10(8):1098-108. doi: 10.1158/1541-7786.MCR-12-0086. Epub 2012 Jun 20. PubMed
Glutaminolysis activates Rag-mTORC1 signaling. Duran RV, Oppliger W, Robitaille AM, Heiserich L, Skendaj R, Gottlieb E, Hall MN. Mol Cell. 2012 Aug 10;47(3):349-58. doi: 10.1016/j.molcel.2012.05.043. Epub 2012 Jun 29. PubMed
Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM. J Biol Chem. 2012 Aug 24;287(35):29861-72. doi: 10.1074/jbc.M112.391961. Epub 2012 Jul 13. PubMed
Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EH, Wang JS, Hong CY. Rheumatology (Oxford). 2012 Nov;51(11):1953-65. doi: 10.1093/rheumatology/kes174. Epub 2012 Jul 28. PubMed
Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Cell Metab. 2012 Aug 8;16(2):189-201. PubMed
Phosphodiesterase type 5 inhibition reverts prostate fibroblast-to-myofibroblast trans-differentiation. Zenzmaier C, Kern J, Sampson N, Heitz M, Plas E, Untergasser G, Berger P. Endocrinology. 2012 Nov;153(11):5546-55. doi: 10.1210/en.2012-1431. Epub 2012 Sep 4. PubMed
The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli. Hagemeier SR, Barlow EA, Meng Q, Kenney SC. J Virol. 2012 Dec;86(24):13360-70. doi: 10.1128/JVI.01850-12. Epub 2012 Sep 26. PubMed
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap. Nguyen HB, Babcock JT, Wells CD, Quilliam LA. Oncogene. 2013 Aug 29;32(35):4100-9. doi: 10.1038/onc.2012.431. Epub 2012 Oct 1. PubMed
Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M, Gottlieb E. Nature. 2012 Nov 15;491(7424):458-62. doi: 10.1038/nature11540. Epub 2012 Oct 14. PubMed
Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P. PLoS One. 2012;7(10):e46571. doi: 10.1371/journal.pone.0046571. Epub 2012 Oct 17. PubMed
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids. Duran RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E. Oncogene. 2013 Sep 19;32(38):4549-56. doi: 10.1038/onc.2012.465. Epub 2012 Oct 22. PubMed
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-theta and reactive oxygen species. Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP. Nat Med. 2012 Nov;18(11):1693-8. doi: 10.1038/nm.2960. Epub 2012 Oct 21. PubMed
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Popuri V, Croteau DL, Brosh RM Jr, Bohr VA. Cell Cycle. 2012 Nov 15;11(22):4252-65. doi: 10.4161/cc.22581. Epub 2012 Oct 24. PubMed
Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro. Kahlert UD, Maciaczyk D, Dai F, Claus R, Firat E, Doostkam S, Bogiel T, Carro MS, Dobrossy M, Herold-Mende C, Niedermann G, Prinz M, Nikkhah G, Maciaczyk J. J Neuropathol Exp Neurol. 2012 Dec;71(12):1086-99. doi: 10.1097/NEN.0b013e3182772d83. PubMed
Hypoxia-inducible factor 1-alpha induces miR-210 in normoxic differentiating myoblasts. Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, Ambrosino V, Antonini A, Capogrossi MC, Gaetano C, Piaggio G, Martelli F. J Biol Chem. 2012 Dec 28;287(53):44761-71. doi: 10.1074/jbc.M112.421255. Epub 2012 Nov 12. PubMed
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase. Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau DL, Bohr VA. Nucleic Acids Res. 2013 Jan;41(2):881-99. doi: 10.1093/nar/gks1134. Epub 2012 Nov 23. PubMed
The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Sun J, Karoulia Z, Wong EY, Ahmed M, Itoh K, Xu PX. Mol Cell Biol. 2013 Mar;33(5):927-36. doi: 10.1128/MCB.01516-12. Epub 2012 Dec 21. PubMed
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity. Dutta D, Xu J, Kim JS, Dunn WA Jr, Leeuwenburgh C. Autophagy. 2013 Mar;9(3):328-44. doi: 10.4161/auto.22971. Epub 2013 Jan 8. PubMed
Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. Xu J, Zhu W, Xu W, Yao W, Zhang B, Xu Y, Ji S, Liu C, Long J, Ni Q, Yu X. Curr Mol Med. 2013 Mar;13(3):387-400. PubMed
Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer. Burns TF, Dobromilskaya I, Murphy SC, Gajula RP, Thiyagarajan S, Chatley SN, Aziz K, Cho YJ, Tran PT, Rudin CM. Mol Cancer Res. 2013 Apr;11(4):329-38. doi: 10.1158/1541-7786.MCR-12-0456. Epub 2013 Jan 30. PubMed
Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons. Lafourcade CA, Lin TV, Feliciano DM, Zhang L, Hsieh LS, Bordey A. J Neurosci. 2013 Feb 6;33(6):2419-31. doi: 10.1523/JNEUROSCI.1840-12.2013. PubMed
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. Cell. 2013 Feb 14;152(4):778-90. doi: 10.1016/j.cell.2013.01.023. Epub 2013 Feb 7. PubMed
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. Condon KH, Ho J, Robinson CG, Hanus C, Ehlers MD. J Neurosci. 2013 Feb 27;33(9):3799-814. doi: 10.1523/JNEUROSCI.1930-11.2013. PubMed
Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Zinn RL, Gardner EE, Dobromilskaya I, Murphy S, Marchionni L, Hann CL, Rudin CM. Mol Cancer. 2013 Mar 2;12:16. doi: 10.1186/1476-4598-12-16. PubMed
Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadkari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L. Mol Cell Biol. 2013 May;33(9):1845-58. doi: 10.1128/MCB.01124-12. Epub 2013 Mar 4. PubMed
The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex. Feldman DE, Chen C, Punj V, Machida K. PLoS One. 2013;8(2):e57312. doi: 10.1371/journal.pone.0057312. Epub 2013 Feb 27. PubMed
Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Kuroda K, Kuang S, Taketo MM, Rudnicki MA. Skelet Muscle. 2013 Mar 5;3(1):5. doi: 10.1186/2044-5040-3-5. PubMed
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Klauke K, Radulovic V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. Nat Cell Biol. 2013 Apr;15(4):353-62. doi: 10.1038/ncb2701. Epub 2013 Mar 17. PubMed
PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Wang Q, Moore MJ, Adelmant G, Marto JA, Silver PA. Genes Dev. 2013 Mar 15;27(6):615-26. doi: 10.1101/gad.212308.112. PubMed
Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth. Adler JJ, Heller BL, Bringman LR, Ranahan WP, Cocklin RR, Goebl MG, Oh M, Lim HS, Ingham RJ, Wells CD. J Biol Chem. 2013 May 24;288(21):15181-93. doi: 10.1074/jbc.M112.446534. Epub 2013 Apr 5. PubMed
Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Xu J, Zhu W, Xu W, Cui X, Chen L, Ji S, Qin Y, Yao W, Liu L, Liu C, Long J, Li M, Yu X. Int J Oncol. 2013 Jun;42(6):2046-52. doi: 10.3892/ijo.2013.1901. Epub 2013 Apr 16. PubMed
mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy. Kim EJ, Jeong JH, Bae S, Kang S, Kim CH, Lim YB. J Cell Biochem. 2013 Jun;114(6):1248-56. doi: 10.1002/jcb.24465. PubMed
Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro. Garcia P, Leal P, Ili C, Brebi P, Alvarez H, Roa JC. Int J Exp Pathol. 2013 Jun;94(3):195-202. doi: 10.1111/iep.12023. Epub 2013 Apr 18. PubMed
Cadherin-17 interacts with alpha2beta1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis. Bartolome RA, Barderas R, Torres S, Fernandez-Acenero MJ, Mendes M, Garcia-Foncillas J, Lopez-Lucendo M, Casal JI. Oncogene. 2014 Mar 27;33(13):1658-69. doi: 10.1038/onc.2013.117. Epub 2013 Apr 22. PubMed
Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013 Apr 19. PubMed
MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL. Tworkoski KA, Platt JT, Bacchiocchi A, Bosenberg M, Boggon TJ, Stern DF. Pigment Cell Melanoma Res. 2013 Jul;26(4):527-41. doi: 10.1111/pcmr.12110. Epub 2013 May 21. PubMed
Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation. Rybak AP, Ingram AJ, Tang D. PLoS One. 2013 Apr 19;8(4):e61716. doi: 10.1371/journal.pone.0061716. Print 2013. PubMed
HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. Zhao H, Zhang X, Frazao JB, Condino-Neto A, Newburger PE. J Cell Biochem. 2013 Oct;114(10):2375-83. doi: 10.1002/jcb.24586. PubMed
RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion. Wang CC, Lo HF, Lin SY, Chen H. Biochem J. 2013 Jul 15;453(2):201-8. doi: 10.1042/BJ20130175. PubMed
Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Brault ME, Lauzon C, Autexier C. Hum Mol Genet. 2013 Sep 1;22(17):3498-507. doi: 10.1093/hmg/ddt204. Epub 2013 May 8. PubMed
Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Chen QK, Lee K, Radisky DC, Nelson CM. Differentiation. 2013 Oct;86(3):126-32. doi: 10.1016/j.diff.2013.03.003. Epub 2013 May 6. PubMed
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIalpha. Ryder PV, Vistein R, Gokhale A, Seaman MN, Puthenveedu MA, Faundez V. Mol Biol Cell. 2013 Jul;24(14):2269-84. doi: 10.1091/mbc.E13-02-0088. Epub 2013 May 15. PubMed
The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. Raver RM, Panfil AR, Hagemeier SR, Kenney SC. J Virol. 2013 Jul;87(14):8053-63. doi: 10.1128/JVI.00546-13. Epub 2013 May 15. PubMed
Overexpression of miR-26a-2 in human liposarcoma is correlated with poor patient survival. Lee DH, Amanat S, Goff C, Weiss LM, Said JW, Doan NB, Sato-Otsubo A, Ogawa S, Forscher C, Koeffler HP. Oncogenesis. 2013 May 20;2:e47. doi: 10.1038/oncsis.2013.10. PubMed
Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E183-93. doi: 10.1152/ajpendo.00541.2012. Epub 2013 May 21. PubMed
Rapid assessment of RNAi-mediated protein depletion by selected reaction monitoring mass spectrometry. Glukhova VA, Tomazela DM, Findlay GD, Monnat RJ Jr, MacCoss MJ. J Proteome Res. 2013 Jul 5;12(7):3246-54. doi: 10.1021/pr400067k. Epub 2013 Jun 10. PubMed
The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA. Carcinogenesis. 2013 Oct;34(10):2218-30. doi: 10.1093/carcin/bgt183. Epub 2013 May 28. PubMed
Src-inducible association of CrkL with procaspase-8 promotes cell migration. Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D. Cell Adh Migr. 2013 Jul-Aug;7(4):362-9. doi: 10.4161/cam.25284. Epub 2013 Jun 10. PubMed
Dickkopf-related protein 3 promotes pathogenic stromal remodeling in benign prostatic hyperplasia and prostate cancer. Zenzmaier C, Sampson N, Plas E, Berger P. Prostate. 2013 Sep;73(13):1441-52. doi: 10.1002/pros.22691. Epub 2013 Jun 14. PubMed
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. PubMed
Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts. Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, Torres C, Sell C. Aging Cell. 2013 Dec;12(6):966-77. doi: 10.1111/acel.12122. Epub 2013 Jul 30. PubMed
The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration. Giri A, Bajpai S, Trenton N, Jayatilaka H, Longmore GD, Wirtz D. FASEB J. 2013 Oct;27(10):4089-99. doi: 10.1096/fj.12-224352. Epub 2013 Jun 24. PubMed
Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. Trinh AT, Kim SH, Chang HY, Mastrocola AS, Tibbetts RS. J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27. PubMed
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. PubMed
RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD, Chen J. PLoS One. 2013 Jul 2;8(7):e68068. doi: 10.1371/journal.pone.0068068. Print 2013. PubMed
LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Mao XG, Hutt-Cabezas M, Orr BA, Weingart M, Taylor I, Rajan AK, Odia Y, Kahlert U, Maciaczyk J, Nikkhah G, Eberhart CG, Raabe EH. Oncotarget. 2013 Jul;4(7):1050-64. PubMed
The telomere deprotection response is functionally distinct from the genomic DNA damage response. Cesare AJ, Hayashi MT, Crabbe L, Karlseder J. Mol Cell. 2013 Jul 25;51(2):141-55. doi: 10.1016/j.molcel.2013.06.006. Epub 2013 Jul 11. PubMed
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Eisinger-Mathason TS, Zhang M, Qiu Q, Skuli N, Nakazawa MS, Karakasheva T, Mucaj V, Shay JE, Stangenberg L, Sadri N, Pure E, Yoon SS, Kirsch DG, Simon MC. Cancer Discov. 2013 Oct;3(10):1190-205. doi: 10.1158/2159-8290.CD-13-0118. Epub 2013 Aug 1. PubMed
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. Salloum S, Wang H, Ferguson C, Parton RG, Tai AW. PLoS Pathog. 2013;9(8):e1003513. doi: 10.1371/journal.ppat.1003513. Epub 2013 Aug 1. PubMed
Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. Kwun HJ, Shuda M, Feng H, Camacho CJ, Moore PS, Chang Y. Cell Host Microbe. 2013 Aug 14;14(2):125-35. doi: 10.1016/j.chom.2013.06.008. PubMed
An isoform of C/EBPbeta, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. Park BH, Kook S, Lee S, Jeong JH, Brufsky A, Lee BC. J Biol Chem. 2013 Oct 4;288(40):28656-67. doi: 10.1074/jbc.M113.509505. Epub 2013 Aug 21. PubMed
Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95. Jiang H, Lu X, Shimada M, Dou Y, Tang Z, Roeder RG. Nat Struct Mol Biol. 2013 Oct;20(10):1156-63. doi: 10.1038/nsmb.2656. Epub 2013 Sep 1. PubMed
SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells. Rybak AP, Tang D. Cell Signal. 2013 Dec;25(12):2734-42. doi: 10.1016/j.cellsig.2013.08.041. Epub 2013 Sep 13. PubMed
Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways. Gow CH, Guo C, Wang D, Hu Q, Zhang J. Nucleic Acids Res. 2014 Jan;42(1):137-52. doi: 10.1093/nar/gkt855. Epub 2013 Sep 24. PubMed
Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. Cheng Y, Cheung AK, Ko JM, Phoon YP, Chiu PM, Lo PH, Waterman ML, Lung ML. BMC Cell Biol. 2013 Sep 27;14:44. doi: 10.1186/1471-2121-14-44. PubMed
Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism. Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M. Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27. PubMed
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. Corum DG, Tsichlis PN, Muise-Helmericks RC. FASEB J. 2014 Jan;28(1):395-407. doi: 10.1096/fj.13-235382. Epub 2013 Sep 30. PubMed
Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts. Khosravi R, Sodek KL, Faibish M, Trackman PC. Bone. 2014 Jan;58:33-41. doi: 10.1016/j.bone.2013.10.001. Epub 2013 Oct 10. PubMed
Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Li Z, Dong L, Dean E, Yang LV. Int J Mol Sci. 2013 Oct 11;14(10):20236-55. doi: 10.3390/ijms141020236. PubMed
Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration. De Saedeleer CJ, Porporato PE, Copetti T, Perez-Escuredo J, Payen VL, Brisson L, Feron O, Sonveaux P. Oncogene. 2014 Jul 31;33(31):4060-8. doi: 10.1038/onc.2013.454. Epub 2013 Oct 28. PubMed
Lappaol F, a novel anticancer agent isolated from plant arctium Lappa L. Sun Q, Liu K, Shen X, Jin W, Jiang L, Saeed Sheikh M, Hu Y, Huang Y. Mol Cancer Ther. 2014 Jan;13(1):49-59. doi: 10.1158/1535-7163.MCT-13-0552. Epub 2013 Nov 12. PubMed
Targeting SOD1 reduces experimental non-small-cell lung cancer. Glasauer A, Sena LA, Diebold LP, Mazar AP, Chandel NS. J Clin Invest. 2014 Jan;124(1):117-28. PubMed
DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Simoes-Correia J, Silva DI, Melo S, Figueiredo J, Caldeira J, Pinto MT, Girao H, Pereira P, Seruca R. Hum Mol Genet. 2014 Apr 15;23(8):2094-105. doi: 10.1093/hmg/ddt602. Epub 2013 Nov 29. PubMed
Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions. Park M, Ohana E, Choi SY, Lee MS, Park JH, Muallem S. J Biol Chem. 2014 Jan 24;289(4):1993-2001. doi: 10.1074/jbc.M113.503466. Epub 2013 Dec 3. PubMed
A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. Munkley J, Rajan P, Lafferty NP, Dalgliesh C, Jackson RM, Robson CN, Leung HY, Elliott DJ. Oncotarget. 2014 Jan 15;5(1):131-9. PubMed
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Pancreatic cancer counterattack: MUC4 mediates Fas-independent apoptosis of antigen-specific cytotoxic T lymphocyte. Zhu Y, Zhang JJ, Liang WB, Zhu R, Wang B, Miao Y, Xu ZK. Oncol Rep. 2014 Apr;31(4):1768-76. doi: 10.3892/or.2014.3016. Epub 2014 Feb 10. PubMed
Control of gene expression using a red- and far-red light-responsive bi-stable toggle switch. Muller K, Zurbriggen MD, Weber W. Nat Protoc. 2014 Mar;9(3):622-32. doi: 10.1038/nprot.2014.038. Epub 2014 Feb 20. PubMed
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The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRalpha and PDGFRalpha D842V. Noel LA, Arts FA, Montano-Almendras CP, Cox L, Gielen O, Toffalini F, Marbehant CY, Cools J, Demoulin JB. Mol Oncol. 2014 May;8(3):728-40. doi: 10.1016/j.molonc.2014.02.003. Epub 2014 Feb 17. PubMed
Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion. Diaz J, Mendoza P, Ortiz R, Diaz N, Leyton L, Stupack D, Quest AF, Torres VA. J Cell Sci. 2014 Jun 1;127(Pt 11):2401-6. doi: 10.1242/jcs.141689. Epub 2014 Mar 21. PubMed
Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Crawley SW, Shifrin DA Jr, Grega-Larson NE, McConnell RE, Benesh AE, Mao S, Zheng Y, Zheng QY, Nam KT, Millis BA, Kachar B, Tyska MJ. Cell. 2014 Apr 10;157(2):433-46. doi: 10.1016/j.cell.2014.01.067. PubMed
AAG8 promotes carcinogenesis by activating STAT3. Sun B, Kawahara M, Ehata S, Nagamune T. Cell Signal. 2014 Sep;26(9):1863-9. doi: 10.1016/j.cellsig.2014.04.001. Epub 2014 Apr 12. PubMed
Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kogel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bahr O. PLoS One. 2014 Apr 17;9(4):e94921. doi: 10.1371/journal.pone.0094921. eCollection 2014. PubMed
The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway. Coomans de Brachene A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos KE, Burgering BM, Coffer PJ, Essaghir A, Demoulin JB. Biochem J. 2014 May 15;460(1):25-34. doi: 10.1042/BJ20131467. PubMed
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. PubMed
Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta. Alcaraz LB, Exposito JY, Chuvin N, Pommier RM, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U. J Cell Biol. 2014 May 12;205(3):409-28. doi: 10.1083/jcb.201308031. PubMed
Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. Zhang X, Weissman SM, Newburger PE. RNA Biol. 2014;11(6):777-87. Epub 2014 Apr 24. PubMed
Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis. de Renty C, DePamphilis ML, Ullah Z. PLoS One. 2014 May 21;9(5):e97434. doi: 10.1371/journal.pone.0097434. eCollection 2014. PubMed
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG. J Biol Chem. 2014 Aug 1;289(31):21694-705. doi: 10.1074/jbc.M114.550038. Epub 2014 Jun 16. PubMed
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Interactions between E6, FAK, and GIT1 at paxillin LD4 are necessary for transformation by bovine papillomavirus 1 E6. Brimer N, Wade R, Vande Pol S. J Virol. 2014 Sep 1;88(17):9927-33. doi: 10.1128/JVI.00552-14. Epub 2014 Jun 18. PubMed
Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs. Nguyen GH, Tang W, Robles AI, Beyer RP, Gray LT, Welsh JA, Schetter AJ, Kumamoto K, Wang XW, Hickson ID, Maizels N, Monnat RJ Jr, Harris CC. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9905-10. doi: 10.1073/pnas.1404807111. Epub 2014 Jun 23. PubMed
CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility. Kim Y, Kumar S. Mol Cancer Res. 2014 Oct;12(10):1416-29. doi: 10.1158/1541-7786.MCR-13-0629. Epub 2014 Jun 24. PubMed
A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia. Khosravi R, Sodek KL, Xu WP, Bais MV, Saxena D, Faibish M, Trackman PC. PLoS One. 2014 Jun 27;9(6):e100669. doi: 10.1371/journal.pone.0100669. eCollection 2014. PubMed
ATG4B promotes colorectal cancer growth independent of autophagic flux. Liu PF, Leung CM, Chang YH, Cheng JS, Chen JJ, Weng CJ, Tsai KW, Hsu CJ, Liu YC, Hsu PC, Pan HW, Shu CW. Autophagy. 2014 Aug;10(8):1454-65. doi: 10.4161/auto.29556. Epub 2014 Jun 12. PubMed
Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells. Bieler J, Cannavo R, Gustafson K, Gobet C, Gatfield D, Naef F. Mol Syst Biol. 2014 Jul 15;10:739. doi: 10.15252/msb.20145218. PubMed
Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Qian J, Wu C, Chen X, Li X, Ying G, Jin L, Ma Q, Li G, Shi Y, Zhang G, Zhou N. Cell Signal. 2014 Nov;26(11):2412-23. doi: 10.1016/j.cellsig.2014.07.019. Epub 2014 Jul 16. PubMed
PDK1-mediated activation of MRCKalpha regulates directional cell migration and lamellipodia retraction. Gagliardi PA, di Blasio L, Puliafito A, Seano G, Sessa R, Chianale F, Leung T, Bussolino F, Primo L. J Cell Biol. 2014 Aug 4;206(3):415-34. doi: 10.1083/jcb.201312090. PubMed
Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1alpha axis. Yao W, Ji S, Qin Y, Yang J, Xu J, Zhang B, Xu W, Liu J, Shi S, Liu L, Liu C, Long J, Ni Q, Li M, Yu X. Mol Cancer. 2014 Aug 7;13:187. doi: 10.1186/1476-4598-13-187. PubMed
PGE2-induced colon cancer growth is mediated by mTORC1. Dufour M, Faes S, Dormond-Meuwly A, Demartines N, Dormond O. Biochem Biophys Res Commun. 2014 Sep 5;451(4):587-91. doi: 10.1016/j.bbrc.2014.08.032. Epub 2014 Aug 13. PubMed
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2. Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J. Mol Cell Biol. 2014 Nov;34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18. PubMed
The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Yang Z, Augustin J, Chang C, Hu J, Shah K, Chang CW, Townes T, Jiang H. Blood. 2014 Sep 25;124(13):2025-33. doi: 10.1182/blood-2014-01-549220. Epub 2014 Aug 18. PubMed
Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein. Ye JS, Kim N, Lee KJ, Nam YR, Lee U, Joo CH. J Virol. 2014 Nov;88(21):12765-76. doi: 10.1128/JVI.02037-14. Epub 2014 Aug 20. PubMed
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Yang CS, Matsuura K, Huang NJ, Robeson AC, Huang B, Zhang L, Kornbluth S. Oncogene. 2014 Aug 25. doi: 10.1038/onc.2014.271. PubMed
The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo. Baskin R, Park SO, Keseru GM, Bisht KS, Wamsley HL, Sayeski PP. PLoS One. 2014 Aug 27;9(8):e105568. doi: 10.1371/journal.pone.0105568. eCollection 2014. PubMed
A secreted tyrosine kinase acts in the extracellular environment. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. Cell. 2014 Aug 28;158(5):1033-44. doi: 10.1016/j.cell.2014.06.048. PubMed
mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma. Bailey ST, Zhou B, Damrauer JS, Krishnan B, Wilson HL, Smith AM, Li M, Yeh JJ, Kim WY. PLoS One. 2014 Sep 2;9(9):e104413. doi: 10.1371/journal.pone.0104413. eCollection 2014. PubMed
Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells. Tripathi R, Ash D, Shaha C. J Cell Mol Med. 2014 Nov;18(11):2275-86. doi: 10.1111/jcmm.12386. Epub 2014 Sep 11. PubMed
Rb suppresses human cone-precursor-derived retinoblastoma tumours. Xu XL, Singh HP, Wang L, Qi DL, Poulos BK, Abramson DH, Jhanwar SC, Cobrinik D. Nature. 2014 Oct 16;514(7522):385-8. doi: 10.1038/nature13813. Epub 2014 Sep 24. PubMed
Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus. Liu B, Li NL, Wang J, Shi PY, Wang T, Miller MA, Li K. J Virol. 2014 Dec;88(23):13821-35. doi: 10.1128/JVI.02505-14. Epub 2014 Sep 24. PubMed
BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo. Shao Q, Kannan A, Lin Z, Stack BC Jr, Suen JY, Gao L. Cancer Res. 2014 Dec 1;74(23):7090-102. doi: 10.1158/0008-5472.CAN-14-0305. Epub 2014 Oct 2. PubMed
PDGF-D expression is down-regulated by TGFbeta in fibroblasts. Charni Chaabane S, Coomans de Brachene A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB. PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014. PubMed
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. Soncini D, Caffa I, Zoppoli G, Cea M, Cagnetta A, Passalacqua M, Mastracci L, Boero S, Montecucco F, Sociali G, Lasiglie D, Damonte P, Grozio A, Mannino E, Poggi A, D'Agostino VG, Monacelli F, Provenzani A, Odetti P, Ballestrero A, Bruzzone S, Nencioni A. J Biol Chem. 2014 Dec 5;289(49):34189-204. doi: 10.1074/jbc.M114.594721. Epub 2014 Oct 20. PubMed
Functional analysis of prognostic gene expression network genes in metastatic breast cancer models. Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW. PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014. PubMed
Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia. Tan YS, Kim M, Kingsbury TJ, Civin CI, Cheng WC. PLoS One. 2014 Nov 4;9(11):e111777. doi: 10.1371/journal.pone.0111777. eCollection 2014. PubMed
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters. Reusch JA, Nawandar DM, Wright KL, Kenney SC, Mertz JE. J Virol. 2015 Feb;89(3):1731-43. doi: 10.1128/JVI.02781-14. Epub 2014 Nov 19. PubMed
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Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M. Autophagy. 2014;10(11):1989-2005. doi: 10.4161/auto.36184. PubMed
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An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST. Cargnin F, Nechiporuk T, Mullendorff K, Stumpo DJ, Blackshear PJ, Ballas N, Mandel G. J Neurosci. 2014 Dec 10;34(50):16650-61. doi: 10.1523/JNEUROSCI.1650-14.2014. PubMed
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ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres. Kahlert UD, Suwala AK, Raabe EH, Siebzehnrubl FA, Suarez MJ, Orr BA, Bar EE, Maciaczyk J, Eberhart CG. Brain Pathol. 2014 Dec 17. doi: 10.1111/bpa.12240. PubMed
A Regulatory Network Involving beta-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling. Huang TS, Li L, Moalim-Nour L, Jia D, Bai J, Yao Z, Bennett SA, Figeys D, Wang L. Stem Cells. 2015 May;33(5):1419-33. doi: 10.1002/stem.1944. PubMed
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase zeta. Tomida J, Takata K, Lange SS, Schibler AC, Yousefzadeh MJ, Bhetawal S, Dent SY, Wood RD. Nucleic Acids Res. 2015 Jan;43(2):1000-11. doi: 10.1093/nar/gku1385. Epub 2015 Jan 7. PubMed

Associated Plasmids

NUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells. Gordon CA, Gulzar ZG, Brooks JD. Prostate. 2015 Apr 1;75(5):517-26. doi: 10.1002/pros.22938. Epub 2015 Jan 13. PubMed
Hypoxia/HIF1alpha induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2. Karakashev SV, Reginato MJ. Oncotarget. 2015 Feb 10;6(4):1967-80. PubMed
Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes. Niemeyer BF, Parrish JK, Spoelstra NS, Joyal T, Richer JK, Jedlicka P. PLoS One. 2015 Jan 20;10(1):e0116895. doi: 10.1371/journal.pone.0116895. eCollection 2015. PubMed
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. Bruserud O, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F. Oncotarget. 2015 Feb 20;6(5):2794-811. PubMed
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis. Lunardi A, Varmeh S, Chen M, Taulli R, Guarnerio J, Ala U, Seitzer N, Ishikawa T, Carver BS, Hobbs RM, Quarantotti V, Ng C, Berger AH, Nardella C, Poliseno L, Montironi R, Castillo-Martin M, Cordon-Cardo C, Signoretti S, Pandolfi PP. Cancer Discov. 2015 May;5(5):550-63. doi: 10.1158/2159-8290.CD-13-1050. Epub 2015 Feb 4. PubMed
A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. Shah M, Rennoll SA, Raup-Konsavage WM, Yochum GS. Cell Cycle. 2015;14(3):323-32. doi: 10.4161/15384101.2014.980643. PubMed
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. PubMed
p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling. Li X, Gu S, Ling Y, Shen C, Cao X, Xie R. Brain Res. 2015 Apr 24;1605:31-8. doi: 10.1016/j.brainres.2015.02.009. Epub 2015 Feb 12. PubMed
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, Chiao PJ, Xu J, Ni Q, Gao D, Yu X. Cell Res. 2015 May;25(5):561-73. doi: 10.1038/cr.2015.30. Epub 2015 Mar 10. PubMed
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA. Elife. 2015 Mar 10;4. doi: 10.7554/eLife.04883. PubMed
The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis. Spring K, Fournier P, Lapointe L, Chabot C, Roussy J, Pommey S, Stagg J, Royal I. Oncogene. 2015 Mar 16. doi: 10.1038/onc.2015.9. PubMed
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Polarized activities of AMPK and BRSK in primary hippocampal neurons. Sample V, Ramamurthy S, Gorshkov K, Ronnett GV, Zhang J. Mol Biol Cell. 2015 May 15;26(10):1935-46. doi: 10.1091/mbc.E14-02-0764. Epub 2015 Mar 18. PubMed

Associated Plasmids

A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma. Ip JC, Ko JM, Yu VZ, Chan KW, Lam AK, Law S, Tong DK, Lung ML. Biomed Res Int. 2015;2015:910715. doi: 10.1155/2015/910715. Epub 2015 Mar 5. PubMed
siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, Lam W, Hannus M, Sonnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Ed Dami T, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC. Nat Chem Biol. 2015 May;11(5):347-54. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6. PubMed
Proteasome inhibition enhances the killing effect of BikDD gene therapy. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Am J Transl Res. 2015 Feb 15;7(2):319-27. eCollection 2015. PubMed
An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors. Carvalho S, Lindzen M, Lauriola M, Shirazi N, Sinha S, Abdul-Hai A, Levanon K, Korach J, Barshack I, Cohen Y, Onn A, Mills G, Yarden Y. Oncogene. 2016 Jan 28;35(4):438-47. doi: 10.1038/onc.2015.93. Epub 2015 Apr 27. PubMed
Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. Mishra DR, Chaudhary S, Krishna BM, Mishra SK. PLoS One. 2015 Apr 29;10(4):e0124864. doi: 10.1371/journal.pone.0124864. eCollection 2015. PubMed
Leukemia stem cells in T-ALL require active Hif1alpha and Wnt signaling. Giambra V, Jenkins CE, Lam SH, Hoofd C, Belmonte M, Wang X, Gusscott S, Gracias D, Weng AP. Blood. 2015 Jun 18;125(25):3917-27. doi: 10.1182/blood-2014-10-609370. Epub 2015 May 1. PubMed
Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma. Sengupta D, Kannan A, Kern M, Moreno MA, Vural E, Stack B Jr, Suen JY, Tackett AJ, Gao L. Epigenetics. 2015;10(6):460-6. doi: 10.1080/15592294.2015.1034416. Epub 2015 May 5. PubMed
Dysregulation of astrocyte extracellular signaling in Costello syndrome. Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM. Sci Transl Med. 2015 May 6;7(286):286ra66. doi: 10.1126/scitranslmed.aaa5645. PubMed
MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells. Zhou J, Xie M, Shi Y, Luo B, Gong G, Li J, Wang J, Zhao W, Zi Y, Wu X, Wen J. Oncol Rep. 2015 Jul;34(1):111-20. doi: 10.3892/or.2015.3952. Epub 2015 May 5. PubMed
Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA. Zheng S, Vuong BQ, Vaidyanathan B, Lin JY, Huang FT, Chaudhuri J. Cell. 2015 May 7;161(4):762-73. doi: 10.1016/j.cell.2015.03.020. PubMed
Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation. Lei X, Callaway M, Zhou H, Yang Y, Chen W. Mol Cell Endocrinol. 2015 Aug 15;411:207-13. doi: 10.1016/j.mce.2015.05.001. Epub 2015 May 6. PubMed
PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma. Cheung AK, Ip JC, Chu AC, Cheng Y, Leong MM, Ko JM, Shuen WH, Lung HL, Lung ML. Oncotarget. 2015 May 30;6(15):13434-47. PubMed
Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Paran CW, Verkerke AR, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Obesity (Silver Spring). 2015 Jul;23(7):1440-9. doi: 10.1002/oby.21123. Epub 2015 May 13. PubMed
The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. Gokhale A, Mullin AP, Zlatic SA, Easley CA 4th, Merritt ME, Raj N, Larimore J, Gordon DE, Peden AA, Sanyal S, Faundez V. J Neurosci. 2015 May 13;35(19):7643-53. doi: 10.1523/JNEUROSCI.4724-14.2015. PubMed
NF-kappaB p65 Subunit Is Modulated by Latent Transforming Growth Factor-beta Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells. Kan R, Shuen WH, Lung HL, Cheung AK, Dai W, Kwong DL, Ng WT, Lee AW, Yau CC, Ngan RK, Tung SY, Lung ML. PLoS One. 2015 May 14;10(5):e0127239. doi: 10.1371/journal.pone.0127239. eCollection 2015. PubMed
Regulation of autophagic cell death by glycogen synthase kinase-3beta in adult hippocampal neural stem cells following insulin withdrawal. Ha S, Ryu HY, Chung KM, Baek SH, Kim EK, Yu SW. Mol Brain. 2015 May 19;8:30. doi: 10.1186/s13041-015-0119-9. PubMed
TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption. Witwicka H, Jia H, Kutikov A, Reyes-Gutierrez P, Li X, Odgren PR. PLoS One. 2015 May 19;10(5):e0127537. doi: 10.1371/journal.pone.0127537. eCollection 2015. PubMed

Associated Plasmids

WNT/beta-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-kappaB target genes. Ma B, Fey M, Hottiger MO. J Cell Sci. 2015 Jul 15;128(14):2430-6. doi: 10.1242/jcs.168542. Epub 2015 May 28. PubMed
Role of EGFR expression levels in the regulation of integrin function by EGF. Vial D, McKeown-Longo PJ. Mol Carcinog. 2015 Jun 4. doi: 10.1002/mc.22346. PubMed
Lentiviral Vector Mediated Claudin1 Silencing Inhibits Epithelial to Mesenchymal Transition in Breast Cancer Cells. Zhao X, Zou Y, Gu Q, Zhao G, Gray H, Pfeffer LM, Yue J. Viruses. 2015 Jun 10;7(6):2965-79. doi: 10.3390/v7062755. PubMed
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed
KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells. Wang Y, Yang C, Gu Q, Sims M, Gu W, Pfeffer LM, Yue J. PLoS One. 2015 Jun 15;10(6):e0130341. doi: 10.1371/journal.pone.0130341. eCollection 2015. PubMed
IGF1R/IRS1 signaling confers pathogenic activity on breast tumor cells lacking REST. Meyer K, Albaugh B, Schoenike B, Roopra A. Mol Cell Biol. 2015 Jun 22. pii: MCB.01149-14. PubMed
cAMP-Dependent Protein Kinase A (PKA)-Mediated c-Myc Degradation Is Dependent on the Relative Proportion of PKA-I and PKA-II Isozymes. Liu Q, Nguyen E, Doskeland S, Segal-Bendirdjian E. Mol Pharmacol. 2015 Sep;88(3):469-76. doi: 10.1124/mol.115.097915. Epub 2015 Jun 23. PubMed
Cell death during crisis is mediated by mitotic telomere deprotection. Hayashi MT, Cesare AJ, Rivera T, Karlseder J. Nature. 2015 Jun 25;522(7557):492-6. doi: 10.1038/nature14513. PubMed
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. Taylor IC, Hutt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J, Chang HT, Warren KE, Eberhart CG, Raabe EH. J Neuropathol Exp Neurol. 2015 Aug;74(8):778-90. doi: 10.1097/NEN.0000000000000216. PubMed
Dynamic Regulation of AP-1 Transcriptional Complexes Directs Trophoblast Differentiation. Kubota K, Kent LN, Rumi MA, Roby KF, Soares MJ. Mol Cell Biol. 2015 Sep;35(18):3163-77. doi: 10.1128/MCB.00118-15. Epub 2015 Jul 6. PubMed
Down-regulation of poly (ADP-ribose) polymerase-1 by a viral processivity factor facilitates gammaherpesvirus lytic replication. Cheong WC, Park JH, Kang HR, Song MJ. J Virol. 2015 Jul 8. pii: JVI.00559-15. PubMed
Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir. Hui KF, Cheung AK, Choi CK, Yeung PL, Middeldorp JM, Lung ML, Tsao SW, Chiang AK. Int J Cancer. 2016 Jan 1;138(1):125-36. doi: 10.1002/ijc.29698. Epub 2015 Aug 11. PubMed
Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Kruse C, Kurz AR, Palfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23. PubMed
Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas. Lee DH, Forscher C, Di Vizio D, Koeffler HP. Sci Rep. 2015 Jul 29;5:12580. doi: 10.1038/srep12580. PubMed
Specific inhibition of mTOR pathway induces anti-proliferative effect and decreases the hormone secretion in cultured pituitary adenoma cells. Xie R, He WQ, Shen M, Shou XF, Wang YF, Bao WM, Zhao Y. J Neurooncol. 2015 Oct;125(1):79-89. doi: 10.1007/s11060-015-1895-x. Epub 2015 Aug 22. PubMed
Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed
Prolactin/Jak2 directs apical/basal polarization and luminal linage maturation of mammary epithelial cells through regulation of the Erk1/2 pathway. Liu F, Pawliwec A, Feng Z, Yasruel Z, Lebrun JJ, Ali S. Stem Cell Res. 2015 Sep;15(2):376-83. doi: 10.1016/j.scr.2015.08.001. Epub 2015 Aug 11. PubMed
p53-regulated autophagy is controlled by glycolysis and determines cell fate. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. Oncotarget. 2015 Sep 15;6(27):23135-56. PubMed
Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed
LDL suppresses angiogenesis through disruption of the HIF pathway via NF-kappaB inhibition which is reversed by the proteasome inhibitor BSc2118. Yao G, Zhang Q, Doeppner TR, Niu F, Li Q, Yang Y, Kuckelkorn U, Hagemann N, Li W, Hermann DM, Dai Y, Zhou W, Jin F. Oncotarget. 2015 Oct 6;6(30):30251-62. doi: 10.18632/oncotarget.4943. PubMed
BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation. Carey TS, Cao Z, Choi I, Ganguly A, Wilson CA, Paul S, Knott JG. Mol Cell Biol. 2015 Dec 15;35(24):4158-69. doi: 10.1128/MCB.00546-15. Epub 2015 Sep 28. PubMed
Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames. Janich P, Arpat AB, Castelo-Szekely V, Lopes M, Gatfield D. Genome Res. 2015 Dec;25(12):1848-59. doi: 10.1101/gr.195404.115. Epub 2015 Oct 20. PubMed
Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function. Birket MJ, Ribeiro MC, Kosmidis G, Ward D, Leitoguinho AR, van de Pol V, Dambrot C, Devalla HD, Davis RP, Mastroberardino PG, Atsma DE, Passier R, Mummery CL. Cell Rep. 2015 Oct 27;13(4):733-45. doi: 10.1016/j.celrep.2015.09.025. Epub 2015 Oct 17. PubMed
OVO-like 1 regulates progenitor cell fate in human trophoblast development. Renaud SJ, Chakraborty D, Mason CW, Rumi MA, Vivian JL, Soares MJ. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6175-84. doi: 10.1073/pnas.1507397112. Epub 2015 Oct 26. PubMed
Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Diabetes. 2016 Feb;65(2):358-70. doi: 10.2337/db15-0659. Epub 2015 Oct 28. PubMed
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. Zucal C, D'Agostino VG, Casini A, Mantelli B, Thongon N, Soncini D, Caffa I, Cea M, Ballestrero A, Quattrone A, Indraccolo S, Nencioni A, Provenzani A. BMC Cancer. 2015 Nov 5;15:855. doi: 10.1186/s12885-015-1845-1. PubMed
Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function. D'Agostino VG, Lal P, Mantelli B, Tiedje C, Zucal C, Thongon N, Gaestel M, Latorre E, Marinelli L, Seneci P, Amadio M, Provenzani A. Sci Rep. 2015 Nov 10;5:16478. doi: 10.1038/srep16478. PubMed
Decreased expression of SOX9 indicates a better prognosis and inhibits the growth of glioma cells by inducing cell cycle arrest. Gao J, Zhang JY, Li YH, Ren F. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10130-8. eCollection 2015. PubMed
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells. Perez-Escuredo J, Dadhich RK, Dhup S, Cacace A, Van Hee VF, De Saedeleer CJ, Sboarina M, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P. Cell Cycle. 2016;15(1):72-83. doi: 10.1080/15384101.2015.1120930. PubMed
Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. Foss KM, Robeson AC, Kornbluth S, Zhang L. Cell Cycle. 2016;15(2):225-33. doi: 10.1080/15384101.2015.1121331. PubMed
Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF-kappaB Pathway-Mediated Epithelial-Mesenchymal Transition after Resection. Wu TJ, Chang SS, Li CW, Hsu YH, Chen TC, Lee WC, Yeh CT, Hung MC. Clin Cancer Res. 2015 Dec 11. PubMed
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells. Roberts JL, He B, Erickson A, Moreau R. Biochim Biophys Acta. 2016 Mar;1861(3):166-76. doi: 10.1016/j.bbalip.2015.12.001. Epub 2015 Dec 8. PubMed
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. Shan Y, Cortopassi G. Mitochondrion. 2015 Dec 17. pii: S1567-7249(15)30042-8. doi: 10.1016/j.mito.2015.12.005. PubMed
CD44 promotes chemoresistance in T-ALL by increased drug efflux. Hoofd C, Wang X, Lam S, Jenkins C, Wood B, Giambra V, Weng AP. Exp Hematol. 2015 Dec 18. pii: S0301-472X(15)00798-5. doi: 10.1016/j.exphem.2015.12.001. PubMed
Lrp5 serves a Wnt-independent role in glucose uptake and growth for mammary epithelial cells. Chin EN, Martin JA, Kim S, Fakhraldeen SA, Alexander CM. Mol Cell Biol. 2015 Dec 28. pii: MCB.00800-15. PubMed
BMI1 Regulation of Self-Renewal and Multipotency in Human Mesenchymal Stem Cells. Jung Y, Nolta JA. Curr Stem Cell Res Ther. 2016;11(2):131-40. PubMed
Effect of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against human Merkel cell carcinoma MKL-1 cells. Lin Z, Mei H, Fan J, Yin Z, Wu G. Oncol Lett. 2015 Dec;10(6):3663-3667. Epub 2015 Oct 12. PubMed
ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Crawley SW, Weck ML, Grega-Larson NE, Shifrin DA Jr, Tyska MJ. Dev Cell. 2016 Jan 25;36(2):190-200. doi: 10.1016/j.devcel.2015.12.022. PubMed
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. He Y, Zeng MY, Yang D, Motro B, Nunez G. Nature. 2016 Feb 18;530(7590):354-7. doi: 10.1038/nature16959. Epub 2016 Jan 27. PubMed
miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer. Zhao G, Guo Y, Chen Z, Wang Y, Yang C, Dudas A, Du Z, Liu W, Zou Y, Szabo E, Lee SC, Sims M, Gu W, Tillmanns T, Pfeffer LM, Tigyi G, Yue J. J Cancer Sci Ther. 2015;7(2):34-43. PubMed
Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance. Gall BJ, Wilson A, Schroer AB, Gross JD, Stoilov P, Setola V, Watkins CM, Siderovski DP. Genes Immun. 2016 Jan 28. doi: 10.1038/gene.2016.3. PubMed
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Llanos S, Garcia-Pedrero JM, Morgado-Palacin L, Rodrigo JP, Serrano M. Nat Commun. 2016 Feb 2;7:10438. doi: 10.1038/ncomms10438. PubMed
Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin. Piotrowski-Daspit AS, Tien J, Nelson CM. Integr Biol (Camb). 2016 Mar 14;8(3):319-31. doi: 10.1039/c5ib00282f. PubMed
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, Oya M, Sabe H. Nat Commun. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656. PubMed
ALDOA functions as an oncogene in the highly metastatic pancreatic cancer. Ji S, Zhang B, Liu J, Qin Y, Liang C, Shi S, Jin K, Liang D, Xu W, Xu H, Wang W, Wu C, Liu L, Liu C, Xu J, Ni Q, Yu X. Cancer Lett. 2016 Apr 28;374(1):127-35. doi: 10.1016/j.canlet.2016.01.054. Epub 2016 Feb 12. PubMed
The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP. J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9. PubMed
ERbeta decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function. Bado I, Nikolos F, Rajapaksa G, Gustafsson JA, Thomas C. Oncotarget. 2016 Mar 22;7(12):13599-611. doi: 10.18632/oncotarget.7300. PubMed
CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Wright HJ, Arulmoli J, Motazedi M, Nelson LJ, Heinemann FS, Flanagan LA, Razorenova OV. Oncogene. 2016 Feb 15. doi: 10.1038/onc.2016.7. PubMed
Possible involvement of miRNAs in tropism of Parvovirus B19. Anbarlou A, AkhavanRahnama M, Atashi A, Soleimani M, Arefian E, Gallinella G. Mol Biol Rep. 2016 Mar;43(3):175-81. doi: 10.1007/s11033-016-3952-8. Epub 2016 Feb 15. PubMed
CITED2 modulation of trophoblast cell differentiation: insights from global transcriptome analysis. Imakawa K, Dhakal P, Kubota K, Kusama K, Chakraborty D, Karim Rumi MA, J Soares M. Reproduction. 2016 May;151(5):509-16. doi: 10.1530/REP-15-0555. Epub 2016 Feb 25. PubMed
Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes. Yalley A, Schill D, Hatta M, Johnson N, Cirillo LA. J Biol Chem. 2016 Apr 15;291(16):8848-61. doi: 10.1074/jbc.M115.677583. Epub 2016 Feb 29. PubMed
Live imaging of transforming growth factor-beta activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid. Takaoka S, Kamioka Y, Takakura K, Baba A, Shime H, Seya T, Matsuda M. Cancer Sci. 2016 May;107(5):644-52. doi: 10.1111/cas.12923. Epub 2016 Apr 27. PubMed
Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. Shi RL, Qu N, Liao T, Wang YL, Wang Y, Sun GH, Ji QH. Int J Oncol. 2016 May;48(5):2055-62. doi: 10.3892/ijo.2016.3412. Epub 2016 Mar 2. PubMed
The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs. Takahashi Y, Tsotakos N, Liu Y, Young MM, Serfass J, Tang Z, Abraham T, Wang HG. Oncotarget. 2016 Mar 10. doi: 10.18632/oncotarget.8028. PubMed
The GSK3beta inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level. Thongon N, Castiglioni I, Zucal C, Latorre E, D'Agostino V, Bauer I, Pancher M, Ballestrero A, Feldmann G, Nencioni A, Provenzani A. Oncotarget. 2016 Mar 28. doi: 10.18632/oncotarget.8437. PubMed
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, Asano K, Litchfield D, Larsson O, Topisirovic I. Nat Commun. 2016 Apr 4;7:11127. doi: 10.1038/ncomms11127. PubMed
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H. J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4. PubMed
Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Feehan RP, Shantz LM. Cell Signal. 2016 Aug;28(8):798-809. doi: 10.1016/j.cellsig.2016.03.013. Epub 2016 Apr 4. PubMed
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S. Exp Cell Res. 2016 May 15;344(1):67-75. doi: 10.1016/j.yexcr.2016.04.014. Epub 2016 Apr 20. PubMed
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis. Silva P, Mendoza P, Rivas S, Diaz J, Moraga C, Quest AF, Torres VA. Oncotarget. 2016 Apr 18. doi: 10.18632/oncotarget.8794. PubMed
Activation of AMP-activated kinase modulates sensitivity of glioma cells against epidermal growth factor receptor inhibition. Hartel I, Ronellenfitsch M, Wanka C, Wolking S, Steinbach JP, Rieger J. Int J Oncol. 2016 Jul;49(1):173-80. doi: 10.3892/ijo.2016.3498. Epub 2016 Apr 25. PubMed
The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. LeNoue-Newton ML, Wadzinski BE, Spiller BW. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. PubMed
Loss of ARID1A activates ANXA1, which serves as a predictive biomarker for trastuzumab resistance. Berns K, Sonnenblick A, Gennissen A, Brohee S, Hijmans ME, Evers B, Fumagalli D, Desmedt C, Loibl S, Denkert C, Neven P, Guo W, Zhang F, Knijnenburg TA, Bosse T, van der Heijden MS, Hindriksen S, Nijkamp W, Wessels LF, Joensuu H, Mills GB, Beijersbergen RL, Sotiriou C, Bernards R. Clin Cancer Res. 2016 May 12. pii: clincanres.2996.2015. PubMed
Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. Tilston-Lunel AM, Haley KE, Schlecht NF, Wang Y, Chatterton AL, Moleirinho S, Watson A, Hundal HS, Prystowsky MB, Gunn-Moore FJ, Reynolds PA. J Mol Cell Biol. 2016 Apr 18. pii: mjw020. PubMed
Rictor/mTORC2 drives progression and therapeutic resistance of HER2-amplified breast cancers. Morrison-Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS. Cancer Res. 2016 Apr 25. pii: canres.3393.2015. PubMed
Tissue Factor Induced by Epithelial-Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells. Bourcy M, Suarez-Carmona M, Lambert J, Francart ME, Schroeder H, Delierneux C, Skrypek N, Thompson EW, Jerusalem G, Berx G, Thiry M, Blacher S, Hollier BG, Noel A, Oury C, Polette M, Gilles C. Cancer Res. 2016 May 24. PubMed
MicroRNA-214 Reduces Insulin-like Growth Factor-1 (IGF-1) Receptor Expression and Downstream mTORC1 Signaling in Renal Carcinoma Cells. Das F, Dey N, Bera A, Kasinath BS, Ghosh-Choudhury N, Choudhury GG. J Biol Chem. 2016 Jul 8;291(28):14662-76. doi: 10.1074/jbc.M115.694331. Epub 2016 May 13. PubMed
Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutte E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J. Cancer Res. 2016 Aug 1;76(15):4481-92. doi: 10.1158/0008-5472.CAN-15-3376. Epub 2016 Jun 14. PubMed
Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model. Gall BJ, Schroer AB, Gross JD, Setola V, Siderovski DP. Genes Immun. 2016 Jun 16. doi: 10.1038/gene.2016.26. PubMed
Regulation of Laminin gamma2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation. Coskun M, Soendergaard C, Joergensen S, Dahlgaard K, Riis LB, Nielsen OH, Sandelin A, Troelsen JT. J Cell Biochem. 2016 Jun 23. doi: 10.1002/jcb.25636. PubMed
Agonist-Activated Bombyx Corazonin Receptor Is Internalized via an Arrestin-Dependent and Clathrin-Independent Pathway. Yang J, Shen Z, Jiang X, Yang H, Huang H, Jin L, Chen Y, Shi L, Zhou N. Biochemistry. 2016 Jul 19;55(28):3874-87. doi: 10.1021/acs.biochem.6b00250. Epub 2016 Jul 8. PubMed
Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. Li Q, Qin Y, Wei P, Lian P, Li Y, Xu Y, Li X, Li D, Cai S. Mol Cancer Res. 2016 Sep;14(9):830-40. doi: 10.1158/1541-7786.MCR-16-0032. Epub 2016 Jul 11. PubMed
Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells. Yan J, Fei Y, Han Y, Lu S. Cell Biol Int. 2016 Oct;40(10):1033-40. doi: 10.1002/cbin.10644. Epub 2016 Jul 28. PubMed
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. Martin KA, Lupey LN, Tempera I. J Virol. 2016 Sep 12;90(19):8520-30. doi: 10.1128/JVI.01180-16. Print 2016 Oct 1. PubMed
IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. Gusscott S, Jenkins CE, Lam SH, Giambra V, Pollak M, Weng AP. PLoS One. 2016 Aug 17;11(8):e0161158. doi: 10.1371/journal.pone.0161158. eCollection 2016. PubMed
Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer. Li J, Yu H, Xi M, Lu X. J Ovarian Res. 2016 Aug 17;9(1):49. doi: 10.1186/s13048-016-0258-3. PubMed
IKKbeta promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. Genes Dev. 2016 Aug 15;30(16):1837-51. doi: 10.1101/gad.287235.116. Epub 2016 Sep 1. PubMed
ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance. Hashimoto A, Hashimoto S, Sugino H, Yoshikawa A, Onodera Y, Handa H, Oikawa T, Sabe H. Oncogenesis. 2016 Sep 12;5(9):e259. doi: 10.1038/oncsis.2016.60. PubMed
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed
IL-1beta-Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human beta-Defensin 2. Wang B, McHugh BJ, Qureshi A, Campopiano DJ, Clarke DJ, Fitzgerald JR, Dorin JR, Weller R, Davidson DJ. J Invest Dermatol. 2017 Jan;137(1):95-105. doi: 10.1016/j.jid.2016.08.025. Epub 2016 Oct 1. PubMed
MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis. Vasconcelos FF, Sessa A, Laranjeira C, Raposo AA, Teixeira V, Hagey DW, Tomaz DM, Muhr J, Broccoli V, Castro DS. Cell Rep. 2016 Oct 4;17(2):469-483. doi: 10.1016/j.celrep.2016.09.024. PubMed
HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells. Jorgensen S, Coskun M, Homburg KM, Pedersen OB, Troelsen JT. PLoS One. 2016 Oct 18;11(10):e0164555. doi: 10.1371/journal.pone.0164555. eCollection 2016. PubMed
Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. Kawakami H, Huang S, Pal K, Dutta SK, Mukhopadhyay D, Sinicrope FA. Mol Cancer Ther. 2016 Dec;15(12):3015-3027. Epub 2016 Oct 7. PubMed
MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway. Chen W, Xu Y, Zhong J, Wang H, Weng M, Cheng Q, Wu Q, Sun Z, Jiang H, Zhu M, Ren Y, Xu P, Chen J, Miao C. Oncotarget. 2016 Nov 29;7(48):78726-78735. doi: 10.18632/oncotarget.12807. PubMed
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV. Oncogene. 2016 Nov 14. doi: 10.1038/onc.2016.272. PubMed
SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491. PubMed
Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Perez-Diaz S, Garcia-Rodriguez B, Gonzalez-Irazabal Y, Valero M, Lagos-Lizan J, Arbones-Mainar JM. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C83-C91. doi: 10.1152/ajpcell.00246.2016. Epub 2016 Nov 16. PubMed
Both bulk and cancer stem cell subpopulations in triple-negative breast cancer are susceptible to Wnt, HDAC, and ERalpha coinhibition. Sulaiman A, Sulaiman B, Khouri L, McGarry S, Nessim C, Arnaout A, Li X, Addison C, Dimitroulakos J, Wang L. FEBS Lett. 2016 Dec;590(24):4606-4616. doi: 10.1002/1873-3468.12496. Epub 2016 Dec 9. PubMed
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Demartines N, Dormond O. Mol Cancer. 2016 Dec 5;15(1):78. PubMed
The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse. Gokhale A, Hartwig C, Freeman AH, Das R, Zlatic SA, Vistein R, Burch A, Carrot G, Lewis AF, Nelms S, Dickman DK, Puthenveedu MA, Cox DN, Faundez V. J Neurosci. 2016 Dec 7;36(49):12393-12411. PubMed
CCT complex restricts neuropathogenic protein aggregation via autophagy. Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC. Nat Commun. 2016 Dec 8;7:13821. doi: 10.1038/ncomms13821. PubMed
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Gollner S, Oellerich T, Agrawal-Singh S, Schenk T, Klein HU, Rohde C, Pabst C, Sauer T, Lerdrup M, Tavor S, Stolzel F, Herold S, Ehninger G, Kohler G, Pan KT, Urlaub H, Serve H, Dugas M, Spiekermann K, Vick B, Jeremias I, Berdel WE, Hansen K, Zelent A, Wickenhauser C, Muller LP, Thiede C, Muller-Tidow C. Nat Med. 2017 Jan;23(1):69-78. doi: 10.1038/nm.4247. Epub 2016 Dec 12. PubMed
Intravital Forster resonance energy transfer imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli. Kamioka Y, Takakura K, Sumiyama K, Matsuda M. Cancer Sci. 2017 Feb;108(2):226-235. doi: 10.1111/cas.13132. PubMed
Radiosynthesis and validation of (+/-)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. Van Hee VF, Labar D, Dehon G, Grasso D, Gregoire V, Muccioli GG, Frederick R, Sonveaux P. Oncotarget. 2017 Apr 11;8(15):24415-24428. doi: 10.18632/oncotarget.14705. PubMed
Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30. PubMed
Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated alpha-Synuclein-selective Autophagic Degradation. Dahmene M, Berard M, Oueslati A. J Biol Chem. 2017 Mar 3;292(9):3919-3928. doi: 10.1074/jbc.M116.759373. Epub 2017 Jan 30. PubMed
Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK-p90RSK-mTOR Signaling Network. Chatterjee S, Huang EH, Christie I, Kurland BF, Burns TF. Mol Cancer Ther. 2017 May;16(5):793-804. doi: 10.1158/1535-7163.MCT-16-0677. Epub 2017 Feb 6. PubMed
The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. Walters BJ, Mercaldo V, Gillon CJ, Yip M, Neve RL, Boyce FM, Frankland PW, Josselyn SA. Neuropsychopharmacology. 2017 Jun;42(7):1502-1510. doi: 10.1038/npp.2017.31. Epub 2017 Feb 16. PubMed
Genomic instability and proliferation/survival pathways in RB1-deficient malignancies. Pappas L, Xu XL, Abramson DH, Jhanwar SC. Adv Biol Regul. 2017 May;64:20-32. doi: 10.1016/j.jbior.2017.01.002. Epub 2017 Feb 8. PubMed
PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. Coomans de Brachene A, Dif N, de Rocca Serra A, Bonnineau C, Velghe AI, Larondelle Y, Tyteca D, Demoulin JB. FEBS Open Bio. 2017 Feb 2;7(3):414-423. doi: 10.1002/2211-5463.12194. eCollection 2017 Mar. PubMed
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T. Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15. PubMed

Associated Plasmids

The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis. Sechler M, Parrish JK, Birks DK, Jedlicka P. Oncogene. 2017 Jul 20;36(29):4150-4160. doi: 10.1038/onc.2017.44. Epub 2017 Mar 20. PubMed
The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner. Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H. PLoS One. 2017 Mar 20;12(3):e0173713. doi: 10.1371/journal.pone.0173713. eCollection 2017. PubMed
Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Biochim Biophys Acta. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. PubMed
A novel autophagy modulator 6-Bio ameliorates SNCA/alpha-synuclein toxicity. Suresh SN, Chavalmane AK, Dj V, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R. Autophagy. 2017 Jul 3;13(7):1221-1234. doi: 10.1080/15548627.2017.1302045. Epub 2017 Mar 28. PubMed
Differential autophagic effects of vital dyes in retinal pigment epithelial ARPE-19 and photoreceptor 661W cells. Sheu SJ, Chen JL, Bee YS, Chen YA, Lin SH, Shu CW. PLoS One. 2017 Mar 30;12(3):e0174736. doi: 10.1371/journal.pone.0174736. eCollection 2017. PubMed
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl1 pathway. Qu N, Hu JQ, Liu L, Zhang TT, Sun GH, Shi RL, Ji QH. Int J Oncol. 2017 May;50(5):1683-1692. doi: 10.3892/ijo.2017.3951. Epub 2017 Apr 5. PubMed
NUSAP1 promotes invasion and metastasis of prostate cancer. Gordon CA, Gong X, Ganesh D, Brooks JD. Oncotarget. 2017 May 2;8(18):29935-29950. doi: 10.18632/oncotarget.15604. PubMed
Erythropoietin drives breast cancer progression by activation of its receptor EPOR. Chan KK, Matchett KB, Coulter JA, Yuen HF, McCrudden CM, Zhang SD, Irwin GW, Davidson MA, Rulicke T, Schober S, Hengst L, Jaekel H, Platt-Higgins A, Rudland PS, Mills KI, Maxwell P, El-Tanani M, Lappin TR. Oncotarget. 2017 Jun 13;8(24):38251-38263. doi: 10.18632/oncotarget.16368. PubMed
Polyglutamine tracts regulate beclin 1-dependent autophagy. Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC. Nature. 2017 May 4;545(7652):108-111. doi: 10.1038/nature22078. Epub 2017 Apr 26. PubMed
PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Lupey-Green LN, Moquin SA, Martin KA, McDevitt SM, Hulse M, Caruso LB, Pomerantz RT, Miranda JL, Tempera I. Virology. 2017 Jul;507:220-230. doi: 10.1016/j.virol.2017.04.006. Epub 2017 Apr 26. PubMed
Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ, VanderVorst K, Rowson-Hodel A, Angelastro JM, Sweeney C, Carraway KL Rd. Oncogene. 2017 Sep 7;36(36):5158-5167. doi: 10.1038/onc.2017.126. Epub 2017 May 8. PubMed
Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF Jr, Cooper MP. Sci Rep. 2017 May 17;7(1):2013. doi: 10.1038/s41598-017-01879-x. PubMed
MiR-193b, downregulated in Ewing Sarcoma, targets the ErbB4 oncogene to inhibit anchorage-independent growth. Moore C, Parrish JK, Jedlicka P. PLoS One. 2017 May 18;12(5):e0178028. doi: 10.1371/journal.pone.0178028. eCollection 2017. PubMed
Reactivation of the p90RSK-CDC25C pathway leads to bypass of the ganetespib induced G2/M arrest and mediates acquired resistance to ganetespib in KRAS mutant NSCLC. Chatterjee S, Huang EH, Christie I, Burns TF. Mol Cancer Ther. 2017 May 31. pii: molcanther.0114.2017. doi: 10.1158/1535-7163.MCT-17-0114. PubMed
Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun;5(11). pii: 5/11/e13299. doi: 10.14814/phy2.13299. PubMed
Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PubMed
A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling. Gatliff J, East DA, Singh A, Alvarez MS, Frison M, Matic I, Ferraina C, Sampson N, Turkheimer F, Campanella M. Cell Death Dis. 2017 Jun 22;8(6):e2896. doi: 10.1038/cddis.2017.186. PubMed
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22. PubMed
CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer. Binothman N, Hachim IY, Lebrun JJ, Ali S. EBioMedicine. 2017 Jul;21:65-78. doi: 10.1016/j.ebiom.2017.06.023. Epub 2017 Jun 24. PubMed
Accumulation of autophagosomes confers cytotoxicity. Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. J Biol Chem. 2017 Jul 3. pii: jbc.M117.782276. doi: 10.1074/jbc.M117.782276. PubMed
miR-302/367/LATS2/YAP pathway is essential for prostate tumor-propagating cells and promotes the development of castration resistance. Guo Y, Cui J, Ji Z, Cheng C, Zhang K, Zhang C, Chu M, Zhao Q, Yu Z, Zhang Y, Fang YX, Gao WQ, Zhu HH. Oncogene. 2017 Nov 9;36(45):6336-6347. doi: 10.1038/onc.2017.240. Epub 2017 Jul 24. PubMed
Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781. doi: 10.1073/pnas.1704955114. Epub 2017 Jul 27. PubMed
Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis. Hertig V, Matos-Nieves A, Garg V, Villeneuve L, Mamarbachi M, Caland L, Calderone A. J Cell Physiol. 2018 Apr;233(4):3218-3229. doi: 10.1002/jcp.26165. Epub 2017 Sep 27. PubMed
Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Gallagher LE, Radhi OA, Abdullah MO, McCluskey AG, Boyd M, Chan EYW. Cell Death Dis. 2017 Aug 24;8(8):e3014. doi: 10.1038/cddis.2017.416. PubMed
Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting. Kwun HJ, Wendzicki JA, Shuda Y, Moore PS, Chang Y. Oncogene. 2017 Dec 7;36(49):6784-6792. doi: 10.1038/onc.2017.277. Epub 2017 Aug 28. PubMed
AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells. Lee D, Yu EJ, Ham IH, Hur H, Kim YS. Onco Targets Ther. 2017 Aug 22;10:4153-4159. doi: 10.2147/OTT.S139664. eCollection 2017. PubMed
Ffar2 expression regulates leukaemic cell growth in vivo. Bindels LB, Porporato PE, Ducastel S, Sboarina M, Neyrinck AM, Dewulf EM, Feron O, Lestavel S, Cani PD, Staels B, Sonveaux P, Delzenne NM. Br J Cancer. 2017 Oct 24;117(9):1336-1340. doi: 10.1038/bjc.2017.307. Epub 2017 Sep 5. PubMed
Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ. Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004. PubMed
TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression. Godse NR, Khan N, Yochum ZA, Gomez-Casal R, Kemp C, Shiwarski DJ, Seethala RS, Kulich S, Seshadri M, Burns TF, Duvvuri U. Clin Cancer Res. 2017 Dec 1;23(23):7324-7332. doi: 10.1158/1078-0432.CCR-17-1561. Epub 2017 Sep 12. PubMed
KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition. Wong KY, Liu J, Chan KW. Oncotarget. 2017 Apr 26;8(33):54558-54571. doi: 10.18632/oncotarget.17421. eCollection 2017 Aug 15. PubMed
The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18. PubMed
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. Nature. 2017 Sep 20;549(7673):548-552. doi: 10.1038/nature24023. PubMed

Associated Plasmids

Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death. Thiepold AL, Lorenz NI, Foltyn M, Engel AL, Dive I, Urban H, Heller S, Bruns I, Hofmann U, Drose S, Harter PN, Mittelbronn M, Steinbach JP, Ronellenfitsch MW. Brain. 2017 Oct 1;140(10):2623-2638. doi: 10.1093/brain/awx196. PubMed
Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-beta Induction. Kim JE, Kim YE, Stinski MF, Ahn JH, Song YJ. Front Microbiol. 2017 Sep 26;8:1854. doi: 10.3389/fmicb.2017.01854. eCollection 2017. PubMed
CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas. Venkataramani V, Kuffer S, Cheung KCP, Jiang X, Trumper L, Wulf GG, Strobel P. Clin Cancer Res. 2018 Jan 15;24(2):460-473. doi: 10.1158/1078-0432.CCR-17-1778. Epub 2017 Oct 30. PubMed
EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration. Jayatilaka H, Giri A, Karl M, Aifuwa I, Trenton NJ, Phillip JM, Khatau S, Wirtz D. FASEB J. 2018 Mar;32(3):1207-1221. doi: 10.1096/fj.201700444RR. Epub 2018 Jan 3. PubMed
Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration. Mendoza PA, Silva P, Diaz J, Arriagada C, Canales J, Cerda O, Torres VA. Cell Adh Migr. 2017 Nov 3:1-10. doi: 10.1080/19336918.2017.1377388. PubMed
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A, Beltran H, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Cancer Cell. 2017 Dec 11;32(6):792-806.e7. doi: 10.1016/j.ccell.2017.10.008. Epub 2017 Nov 16. PubMed
MRCKalpha is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion. Gagliardi PA, Somale D, Puliafito A, Chiaverina G, di Blasio L, Oneto M, Bianchini P, Bussolino F, Primo L. J Cell Biol. 2018 Jan 2;217(1):231-249. doi: 10.1083/jcb.201703044. Epub 2017 Nov 21. PubMed
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. PubMed
Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Jafferali MH, Figueroa RA, Hasan M, Hallberg E. Sci Rep. 2017 Nov 30;7(1):16655. doi: 10.1038/s41598-017-16746-y. PubMed
Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph(+) Acute Lymphoblastic Leukemia. De Dominici M, Porazzi P, Soliera AR, Mariani SA, Addya S, Fortina P, Peterson LF, Spinelli O, Rambaldi A, Martinelli G, Ferrari A, Iacobucci I, Calabretta B. Cancer Res. 2018 Feb 15;78(4):1097-1109. doi: 10.1158/0008-5472.CAN-17-2644. Epub 2017 Dec 12. PubMed
Extracellular vesicles from KSHV-infected endothelial cells activate the complement system. Jeon H, Yoo SM, Choi HS, Mun JY, Kang HG, Lee J, Park J, Gao SJ, Lee MS. Oncotarget. 2017 Oct 9;8(59):99841-99860. doi: 10.18632/oncotarget.21668. eCollection 2017 Nov 21. PubMed
FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR. Zhang Y, Zhu T, Liu J, Liu J, Gao D, Su T, Zhao R. Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):164-170. doi: 10.1093/abbs/gmx135. PubMed
HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation. Bollaert E, Johanns M, Herinckx G, de Rocca Serra A, Vandewalle VA, Havelange V, Rider MH, Vertommen D, Demoulin JB. Cell Signal. 2018 Apr;44:158-170. doi: 10.1016/j.cellsig.2018.01.014. Epub 2018 Feb 16. PubMed
Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1. Roilo M, Kullmann MK, Hengst L. Nucleic Acids Res. 2018 Apr 6;46(6):3198-3210. doi: 10.1093/nar/gkx1317. PubMed
Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer. Liu R, Zhang T, Zhu G, Xing M. Nat Commun. 2018 Feb 8;9(1):579. doi: 10.1038/s41467-018-03033-1. PubMed
A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira II, Brittain EL, Wolfgang MJ, Jurczak MJ, Fessel JP, Finkel T. Mol Cell. 2018 Feb 15;69(4):689-698.e7. doi: 10.1016/j.molcel.2018.01.010. Epub 2018 Feb 8. PubMed
RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Qi ZH, Xu HX, Zhang SR, Xu JZ, Li S, Gao HL, Jin W, Wang WQ, Wu CT, Ni QX, Yu XJ, Liu L. Int J Oncol. 2018 Apr;52(4):1105-1116. doi: 10.3892/ijo.2018.4269. Epub 2018 Feb 7. PubMed
Inhibition of Nox4-dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal-mediated protumorigenic interactions. Sampson N, Brunner E, Weber A, Puhr M, Schafer G, Szyndralewiez C, Klocker H. Int J Cancer. 2018 Jul 15;143(2):383-395. doi: 10.1002/ijc.31316. Epub 2018 Mar 1. PubMed
Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration. Creus-Muncunill J, Rue L, Alcala-Vida R, Badillos-Rodriguez R, Romani-Aumedes J, Marco S, Alberch J, Perez-Otano I, Malagelada C, Perez-Navarro E. Mol Neurobiol. 2018 Oct;55(10):7728-7742. doi: 10.1007/s12035-018-0956-5. Epub 2018 Feb 19. PubMed
Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer. Lee MS, Lee J, Lee S, Yoo SM, Kim JH, Kim WT, Kim WJ, Park J. Oncotarget. 2018 Jan 8;9(8):7961-7974. doi: 10.18632/oncotarget.24091. eCollection 2018 Jan 30. PubMed
Most bicarbonate secretion by Calu-3 cells is mediated by CFTR and independent of pendrin. Huang J, Kim D, Shan J, Abu-Arish A, Luo Y, Hanrahan JW. Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13641. PubMed
p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism. Pappas B, Yang Y, Wang Y, Kim K, Chung HJ, Cheung M, Ngo K, Shinn A, Chan WK. Biochem Pharmacol. 2018 Jun;152:34-44. doi: 10.1016/j.bcp.2018.03.015. Epub 2018 Mar 17. PubMed
Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1. Han S, Pang MF, Nelson CM. J Cell Sci. 2018 Apr 23;131(8). pii: jcs.210476. doi: 10.1242/jcs.210476. PubMed
The mTOR cell signaling pathway is crucial to the long-term protective effects of ischemic postconditioning against stroke. Wang P, Xie R, Cheng M, Sapolsky R, Ji X, Zhao H. Neurosci Lett. 2018 May 29;676:58-65. doi: 10.1016/j.neulet.2018.03.062. Epub 2018 Mar 29. PubMed
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