ptfLC3 Citations (285)
Originally described in: Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3.Kimura S, Noda T, Yoshimori T Autophagy. 2007;3(5):452-60. PubMed Journal
Articles Citing ptfLC3
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| Identification of PTPsigma as an autophagic phosphatase. Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu CL, Tremblay ML, Xu HE, MacKeigan JP. J Cell Sci. 2011 Mar 1;124(Pt 5):812-9. doi: 10.1242/jcs.080341. Epub 2011 Feb 8. PubMed |
| A role for autophagy during hepatic stellate cell activation. Thoen LF, Guimaraes EL, Dolle L, Mannaerts I, Najimi M, Sokal E, van Grunsven LA. J Hepatol. 2011 Dec;55(6):1353-60. doi: 10.1016/j.jhep.2011.07.010. Epub 2011 Jul 29. PubMed |
| Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Tumbarello DA, Waxse BJ, Arden SD, Bright NA, Kendrick-Jones J, Buss F. Nat Cell Biol. 2012 Oct;14(10):1024-35. doi: 10.1038/ncb2589. Epub 2012 Sep 30. PubMed |
| Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells. Funakoshi T, Aki T, Unuma K, Uemura K. Brain Res. 2013 Jan 15;1490:9-22. doi: 10.1016/j.brainres.2012.10.056. Epub 2012 Nov 2. PubMed |
| Delphinidin induces autolysosome as well as autophagosome formation and delphinidin-induced autophagy exerts a cell protective role. Tsuyuki S, Fukui S, Watanabe A, Akune S, Tanabe M, Yoshida K. J Biochem Mol Toxicol. 2012 Nov;26(11):445-53. doi: 10.1002/jbt.21443. Epub 2012 Nov 5. PubMed |
| Computational model for autophagic vesicle dynamics in single cells. Martin KR, Barua D, Kauffman AL, Westrate LM, Posner RG, Hlavacek WS, Mackeigan JP. Autophagy. 2013 Jan;9(1):74-92. doi: 10.4161/auto.22532. Epub 2012 Nov 29. PubMed |
| Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Yu KN, Yoon TJ, Minai-Tehrani A, Kim JE, Park SJ, Jeong MS, Ha SW, Lee JK, Kim JS, Cho MH. Toxicol In Vitro. 2013 Jun;27(4):1187-95. doi: 10.1016/j.tiv.2013.02.010. Epub 2013 Feb 28. PubMed |
| The thiazole derivative CPTH6 impairs autophagy. Ragazzoni Y, Desideri M, Gabellini C, De Luca T, Carradori S, Secci D, Nescatelli R, Candiloro A, Condello M, Meschini S, Del Bufalo D, Trisciuoglio D. Cell Death Dis. 2013 Mar 7;4:e524. doi: 10.1038/cddis.2013.53. PubMed |
| Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth. Trisciuoglio D, De Luca T, Desideri M, Passeri D, Gabellini C, Scarpino S, Liang C, Orlandi A, Del Bufalo D. Neoplasia. 2013 Mar;15(3):315-27. PubMed |
| Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. Martin S, Harper CB, May LM, Coulson EJ, Meunier FA, Osborne SL. PLoS One. 2013;8(3):e60152. doi: 10.1371/journal.pone.0060152. Epub 2013 Mar 27. PubMed |
| Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita TK, Wang HG, Bhalla KN. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6841-6. doi: 10.1073/pnas.1217692110. Epub 2013 Apr 8. PubMed |
| Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS). Korvatska O, Strand NS, Berndt JD, Strovas T, Chen DH, Leverenz JB, Kiianitsa K, Mata IF, Karakoc E, Greenup JL, Bonkowski E, Chuang J, Moon RT, Eichler EE, Nickerson DA, Zabetian CP, Kraemer BC, Bird TD, Raskind WH. Hum Mol Genet. 2013 Aug 15;22(16):3259-68. doi: 10.1093/hmg/ddt180. Epub 2013 Apr 16. PubMed |
| Spatiotemporally controlled induction of autophagy-mediated lysosome turnover. Hung YH, Chen LM, Yang JY, Yang WY. Nat Commun. 2013;4:2111. doi: 10.1038/ncomms3111. PubMed |
| Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells. Balmer D, Emery M, Andreux P, Auwerx J, Ginet V, Puyal J, Schorderet DF, Roduit R. PLoS One. 2013 Sep 16;8(9):e74162. doi: 10.1371/journal.pone.0074162. eCollection 2013. PubMed |
| The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Qiao S, Tao S, Rojo de la Vega M, Park SL, Vonderfecht AA, Jacobs SL, Zhang DD, Wondrak GT. Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8. PubMed |
| Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells. Bruntz RC, Taylor HE, Lindsley CW, Brown HA. J Biol Chem. 2014 Jan 10;289(2):600-16. doi: 10.1074/jbc.M113.532978. Epub 2013 Nov 20. PubMed |
| Autophagy activation reduces renal tubular injury induced by urinary proteins. Liu WJ, Luo MN, Tan J, Chen W, Huang LZ, Yang C, Pan Q, Li B, Liu HF. Autophagy. 2014 Feb;10(2):243-56. doi: 10.4161/auto.27004. Epub 2013 Nov 26. PubMed |
| Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress. He H, Liu X, Lv L, Liang H, Leng B, Zhao D, Zhang Y, Du Z, Chen X, Li S, Lu Y, Shan H. Cell Death Dis. 2014 Jan 16;5:e997. doi: 10.1038/cddis.2013.533. PubMed |
| Involvement of autophagy in hypoxic-excitotoxic neuronal death. Ginet V, Spiehlmann A, Rummel C, Rudinskiy N, Grishchuk Y, Luthi-Carter R, Clarke PG, Truttmann AC, Puyal J. Autophagy. 2014 May;10(5):846-60. doi: 10.4161/auto.28264. Epub 2014 Mar 11. PubMed |
| Antagonism of tumoral prolactin receptor promotes autophagy-related cell death. Wen Y, Zand B, Ozpolat B, Szczepanski MJ, Lu C, Yuca E, Carroll AR, Alpay N, Bartholomeusz C, Tekedereli I, Kang Y, Rupaimoole R, Pecot CV, Dalton HJ, Hernandez A, Lokshin A, Lutgendorf SK, Liu J, Hittelman WN, Chen WY, Lopez-Berestein G, Szajnik M, Ueno NT, Coleman RL, Sood AK. Cell Rep. 2014 Apr 24;7(2):488-500. doi: 10.1016/j.celrep.2014.03.009. Epub 2014 Apr 3. PubMed |
| Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA. Cell. 2014 May 8;157(4):882-96. doi: 10.1016/j.cell.2014.03.026. PubMed |
| Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Goodall ML, Wang T, Martin KR, Kortus MG, Kauffman AL, Trent JM, Gately S, MacKeigan JP. Autophagy. 2014 Jun;10(6):1120-36. doi: 10.4161/auto.28594. PubMed |
| FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR. Autophagy. 2014 Oct 1;10(10):1749-60. doi: 10.4161/auto.29640. Epub 2014 Jul 22. PubMed |
| Abeta1-42 monomers or oligomers have different effects on autophagy and apoptosis. Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E. Autophagy. 2014 Oct 1;10(10):1827-43. doi: 10.4161/auto.30001. Epub 2014 Aug 12. PubMed |
| WW domain of BAG3 is required for the induction of autophagy in glioma cells. Merabova N, Sariyer IK, Saribas AS, Knezevic T, Gordon J, Turco MC, Rosati A, Weaver M, Landry J, Khalili K. J Cell Physiol. 2015 Apr;230(4):831-41. doi: 10.1002/jcp.24811. PubMed |
| Nutrient-sensing nuclear receptors coordinate autophagy. Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nature. 2014 Dec 4;516(7529):112-5. doi: 10.1038/nature13961. Epub 2014 Nov 12. PubMed |
| Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Wen Y, Graybill WS, Previs RA, Hu W, Ivan C, Mangala LS, Zand B, Nick AM, Jennings NB, Dalton HJ, Sehgal V, Ram P, Lee JS, Vivas-Mejia PE, Coleman RL, Sood AK. Clin Cancer Res. 2015 Jan 15;21(2):448-59. doi: 10.1158/1078-0432.CCR-14-1578. Epub 2014 Nov 21. PubMed |
| Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Lefort S, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F. Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788. PubMed |
| Autophagic flux without a block differentiates varicella-zoster virus infection from herpes simplex virus infection. Buckingham EM, Carpenter JE, Jackson W, Zerboni L, Arvin AM, Grose C. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):256-61. doi: 10.1073/pnas.1417878112. Epub 2014 Dec 22. PubMed |
| FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection. Xu Y, Tian C, Sun J, Zhang J, Ren K, Fan XY, Wang K, Wang H, Yan YE, Chen C, Shi Q, Dong XP. Mol Neurobiol. 2015 Jan 13. PubMed |
| beta-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease. Tamura A, Yui N. J Biol Chem. 2015 Apr 10;290(15):9442-54. doi: 10.1074/jbc.M115.636803. Epub 2015 Feb 24. PubMed |
| The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing. Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A. Sci Rep. 2015 Mar 17;5:9149. doi: 10.1038/srep09149. PubMed |
| Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia. Haslip M, Dostanic I, Huang Y, Zhang Y, Russell KS, Jurczak MJ, Mannam P, Giordano F, Erzurum SC, Lee PJ. Arterioscler Thromb Vasc Biol. 2015 May;35(5):1166-78. doi: 10.1161/ATVBAHA.114.304865. Epub 2015 Mar 26. PubMed |
| Autophagy induction by silibinin positively contributes to its anti-metastatic capacity via AMPK/mTOR pathway in renal cell carcinoma. Li F, Ma Z, Guan Z, Chen Y, Wu K, Guo P, Wang X, He D, Zeng J. Int J Mol Sci. 2015 Apr 15;16(4):8415-29. doi: 10.3390/ijms16048415. PubMed |
| Proximity Ligation In situ Assay is a Powerful Tool to Monitor Specific ATG Protein Interactions following Autophagy Induction. Gauthier T, Claude-Taupin A, Delage-Mourroux R, Boyer-Guittaut M, Hervouet E. PLoS One. 2015 Jun 2;10(6):e0128701. doi: 10.1371/journal.pone.0128701. eCollection 2015. PubMed |
| AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia. Ruozi G, Bortolotti F, Falcione A, Dal Ferro M, Ukovich L, Macedo A, Zentilin L, Filigheddu N, Gortan Cappellari G, Baldini G, Zweyer M, Barazzoni R, Graziani A, Zacchigna S, Giacca M. Nat Commun. 2015 Jun 11;6:7388. doi: 10.1038/ncomms8388. PubMed |
| Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. Huang SP, Chien JY, Tsai RK. Dis Model Mech. 2015 Aug 1;8(8):977-87. doi: 10.1242/dmm.019737. Epub 2015 Jun 18. PubMed |
| The Cytotoxicity of Elderberry Ribosome-Inactivating Proteins Is Not Solely Determined by Their Protein Translation Inhibition Activity. Shang C, Chen Q, Dell A, Haslam SM, De Vos WH, Van Damme EJ. PLoS One. 2015 Jul 6;10(7):e0132389. doi: 10.1371/journal.pone.0132389. eCollection 2015. PubMed |
| Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. Dever SM, Rodriguez M, Lapierre J, Costin BN, El-Hage N. Front Microbiol. 2015 Jul 6;6:653. doi: 10.3389/fmicb.2015.00653. eCollection 2015. PubMed |
| KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation. Brooks CR, Yeung MY, Brooks YS, Chen H, Ichimura T, Henderson JM, Bonventre JV. EMBO J. 2015 Oct 1;34(19):2441-64. doi: 10.15252/embj.201489838. Epub 2015 Aug 17. PubMed |
| G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma. Li F, Zeng J, Gao Y, Guan Z, Ma Z, Shi Q, Du C, Jia J, Xu S, Wang X, Chang L, He D, Guo P. PLoS One. 2015 Sep 23;10(9):e0138390. doi: 10.1371/journal.pone.0138390. eCollection 2015. PubMed |
| Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates. Maulucci G, Chiarpotto M, Papi M, Samengo D, Pani G, De Spirito M. Autophagy. 2015 Oct 3;11(10):1905-16. doi: 10.1080/15548627.2015.1084455. PubMed |
| MicroRNA 17-5p regulates autophagy in Mycobacterium tuberculosis-infected macrophages by targeting Mcl-1 and STAT3. Kumar R, Sahu SK, Kumar M, Jana K, Gupta P, Gupta UD, Kundu M, Basu J. Cell Microbiol. 2015 Oct 29. doi: 10.1111/cmi.12540. PubMed |
| Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1alpha-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ. Oncotarget. 2015 Dec 22;6(41):43911-26. doi: 10.18632/oncotarget.6084. PubMed |
| Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells. Ullio C, Brunk UT, Urani C, Melchioretto P, Bonelli G, Baccino FM, Autelli R. Autophagy. 2015;11(12):2184-98. doi: 10.1080/15548627.2015.1106662. PubMed |
| Deficiency of Neuronal p38alpha MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1. Schnoder L, Hao W, Qin Y, Liu S, Tomic I, Liu X, Fassbender K, Liu Y. J Biol Chem. 2016 Jan 29;291(5):2067-79. doi: 10.1074/jbc.M115.695916. Epub 2015 Dec 9. PubMed |
| 2,2'-dipyridyl induces pexophagy. Jin A, Lee JN, Kim MS, Kwak S, Kim SJ, Song K, Choe SK, Park R. Biochem Biophys Res Commun. 2016 Jan 22;469(4):941-7. doi: 10.1016/j.bbrc.2015.12.098. Epub 2015 Dec 23. PubMed |
| Imaging organelle transport in primary hippocampal neurons treated with amyloid-beta oligomers. Gan KJ, Silverman MA. Methods Cell Biol. 2016;131:425-51. doi: 10.1016/bs.mcb.2015.06.012. Epub 2015 Sep 2. PubMed |
| Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A. Kim N, Kim MJ, Sung PS, Bae YC, Shin EC, Yoo JY. Nat Commun. 2016 Feb 12;7:10631. doi: 10.1038/ncomms10631. PubMed |
| C/EBPbeta regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion. Barakat DJ, Mendonca J, Barberi T, Zhang J, Kachhap SK, Paz-Priel I, Friedman AD. Cancer Lett. 2016 May 28;375(1):152-61. doi: 10.1016/j.canlet.2016.03.005. Epub 2016 Mar 8. PubMed |
| Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate. Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS. Cell. 2016 Apr 7;165(2):410-20. doi: 10.1016/j.cell.2016.02.014. Epub 2016 Mar 24. PubMed |
| Autophagy-related cell death by pan-histone deacetylase inhibition in liver cancer. Di Fazio P, Waldegger P, Jabari S, Lingelbach S, Montalbano R, Ocker M, Slater EP, Bartsch DK, Illig R, Neureiter D, Wissniowski TT. Oncotarget. 2016 Apr 5. doi: 10.18632/oncotarget.8585. PubMed |
| Skeletal muscle action of estrogen receptor alpha is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815. PubMed |
| Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Livingston MJ, Ding HF, Huang S, Hill JA, Yin XM, Dong Z. Autophagy. 2016 Jun 2;12(6):976-98. doi: 10.1080/15548627.2016.1166317. Epub 2016 Apr 28. PubMed |
| Role of TFEB-driven autophagy regulation in pancreatic cancer treatment. Klein K, Werner K, Teske C, Schenk M, Giese T, Weitz J, Welsch T. Int J Oncol. 2016 Jul;49(1):164-72. doi: 10.3892/ijo.2016.3505. Epub 2016 May 5. PubMed |
| TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. Ra EA, Lee TA, Won Kim S, Park A, Choi HJ, Jang I, Kang S, Hee Cheon J, Cho JW, Eun Lee J, Lee S, Park B. Nat Commun. 2016 May 24;7:11726. doi: 10.1038/ncomms11726. PubMed |
| Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway. Wang R, Zhang Q, Peng X, Zhou C, Zhong Y, Chen X, Qiu Y, Jin M, Gong M, Kong D. Sci Rep. 2016 May 31;6:27071. doi: 10.1038/srep27071. PubMed |
| Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells. Li X, Zhu F, Jiang J, Sun C, Zhong Q, Shen M, Wang X, Tian R, Shi C, Xu M, Peng F, Guo X, Hu J, Ye D, Wang M, Qin R. Autophagy. 2016 Sep;12(9):1521-37. doi: 10.1080/15548627.2016.1191722. Epub 2016 Jun 16. PubMed |
| Rab7 induces clearance of alpha-synuclein aggregates. Dinter E, Saridaki T, Nippold M, Plum S, Diederichs L, Komnig D, Fensky L, May C, Marcus K, Voigt A, Schulz JB, Falkenburger BH. J Neurochem. 2016 Sep;138(5):758-74. doi: 10.1111/jnc.13712. Epub 2016 Aug 4. PubMed |
| Cocaine induces astrocytosis through ER stress-mediated activation of autophagy. Periyasamy P, Guo ML, Buch S. Autophagy. 2016 Aug 2;12(8):1310-29. doi: 10.1080/15548627.2016.1183844. Epub 2016 Jun 23. PubMed |
| Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines. Peng J, Zhu S, Hu L, Ye P, Wang Y, Tian Q, Mei M, Chen H, Guo X. Autophagy. 2016 Oct 2;12(10):1704-1720. Epub 2016 Jul 27. PubMed |
| Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Bartlett JJ, Trivedi PC, Yeung P, Kienesberger PC, Pulinilkunnil T. Biochem J. 2016 Nov 1;473(21):3769-3789. Epub 2016 Aug 3. PubMed |
| Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Brisson L, Banski P, Sboarina M, Dethier C, Danhier P, Fontenille MJ, Van Hee VF, Vazeille T, Tardy M, Falces J, Bouzin C, Porporato PE, Frederick R, Michiels C, Copetti T, Sonveaux P. Cancer Cell. 2016 Sep 12;30(3):418-431. doi: 10.1016/j.ccell.2016.08.005. PubMed |
| LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes. Hubert V, Peschel A, Langer B, Groger M, Rees A, Kain R. Biol Open. 2016 Oct 15;5(10):1516-1529. doi: 10.1242/bio.018648. PubMed |
| Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation. Del Grosso A, Antonini S, Angella L, Tonazzini I, Signore G, Cecchini M. J Neurosci Res. 2016 Nov;94(11):1246-60. doi: 10.1002/jnr.23910. PubMed |
| Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism. Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK. Osteoarthritis Cartilage. 2017 Feb;25(2):287-296. doi: 10.1016/j.joca.2016.09.017. Epub 2016 Sep 29. PubMed |
| Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA. Biochem Biophys Res Commun. 2016 Nov 18;480(3):461-467. doi: 10.1016/j.bbrc.2016.10.072. Epub 2016 Oct 20. PubMed |
| Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity. Xiong J, Kong Q, Dai L, Ma H, Cao X, Liu L, Ding Z. J Cell Mol Med. 2016 Nov 15. doi: 10.1111/jcmm.13003. PubMed |
| ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernandez-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sanchez-Madrid F. Nat Commun. 2016 Nov 24;7:13588. doi: 10.1038/ncomms13588. PubMed |
| Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM. Cell Death Dis. 2016 Dec 8;7(12):e2513. doi: 10.1038/cddis.2016.374. PubMed |
| SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM. Autophagy. 2016 Dec 8:1-17. doi: 10.1080/15548627.2016.1261238. PubMed |
| PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K. Autophagy. 2017 Mar 4;13(3):486-505. doi: 10.1080/15548627.2016.1263781. Epub 2017 Jan 19. PubMed |
| Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells. Lin Z, Zhang Z, Jiang X, Kou X, Bao Y, Liu H, Sun F, Ling S, Qin N, Jiang L, Yang Y. Oncotarget. 2017 Mar 14;8(11):17833-17848. doi: 10.18632/oncotarget.14868. PubMed |
| The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. FASEB J. 2017 Feb;31(2):598-609. doi: 10.1096/fj.201600915R. Epub 2016 Oct 25. PubMed |
| Viability of primary cultured podocytes is associated with extracellular high glucose-dependent autophagy downregulation. Audzeyenka I, Rogacka D, Piwkowska A, Angielski S, Jankowski M. Mol Cell Biochem. 2017 Jun;430(1-2):11-19. doi: 10.1007/s11010-017-2949-5. Epub 2017 Feb 24. PubMed |
| Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells. Tang ZH, Cao WX, Su MX, Chen X, Lu JJ. Toxicol Appl Pharmacol. 2017 Apr 15;321:18-26. doi: 10.1016/j.taap.2017.02.017. Epub 2017 Feb 22. PubMed |
| Intra-articular lentivirus-mediated gene therapy targeting CRACM1 for the treatment of collagen-induced arthritis. Liu S, Kiyoi T, Takemasa E, Maeyama K. J Pharmacol Sci. 2017 Mar;133(3):130-138. doi: 10.1016/j.jphs.2017.02.001. Epub 2017 Feb 11. PubMed |
| Prototype foamy virus elicits complete autophagy involving the ER stress-related UPR pathway. Yuan P, Dong L, Cheng Q, Wang S, Li Z, Sun Y, Han S, Yin J, Peng B, He X, Liu W. Retrovirology. 2017 Mar 7;14(1):16. doi: 10.1186/s12977-017-0341-x. PubMed |
| A novel autophagy modulator 6-Bio ameliorates SNCA/alpha-synuclein toxicity. Suresh SN, Chavalmane AK, Dj V, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R. Autophagy. 2017 Jul 3;13(7):1221-1234. doi: 10.1080/15548627.2017.1302045. Epub 2017 Mar 28. PubMed |
| Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Basit F, van Oppen LM, Schockel L, Bossenbroek HM, van Emst-de Vries SE, Hermeling JC, Grefte S, Kopitz C, Heroult M, Hgm Willems P, Koopman WJ. Cell Death Dis. 2017 Mar 30;8(3):e2716. doi: 10.1038/cddis.2017.133. PubMed |
| Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. Serfass JM, Takahashi Y, Zhou Z, Kawasawa YI, Liu Y, Tsotakos N, Young MM, Tang Z, Yang L, Atkinson JM, Chroneos ZC, Wang HG. J Biol Chem. 2017 Jun 16;292(24):10097-10111. doi: 10.1074/jbc.M117.792747. Epub 2017 Apr 28. PubMed |
| p62/sequestosome 1 in human colorectal carcinoma as a potent prognostic predictor associated with cell proliferation. Nakayama S, Karasawa H, Suzuki T, Yabuuchi S, Takagi K, Aizawa T, Onodera Y, Nakamura Y, Watanabe M, Fujishima F, Yoshida H, Morikawa T, Sase T, Naitoh T, Unno M, Sasano H. Cancer Med. 2017 Jun;6(6):1264-1274. doi: 10.1002/cam4.1093. Epub 2017 May 23. PubMed |
| Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda-Andoh T, Okano H, Nakashima K. Stem Cell Reports. 2017 Jun 6;8(6):1743-1756. doi: 10.1016/j.stemcr.2017.05.001. PubMed |
| AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy. Chen M, Liu J, Yang L, Ling W. FEBS Open Bio. 2017 May 11;7(6):811-820. doi: 10.1002/2211-5463.12221. eCollection 2017 Jun. PubMed |
| Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy. Wang Y, Wang Q, Zhang L, Ke Z, Zhao Y, Wang D, Chen H, Jiang X, Gu M, Fan S, Huang C. Biochem Biophys Res Commun. 2017 Aug 19;490(2):231-238. doi: 10.1016/j.bbrc.2017.06.027. Epub 2017 Jun 9. PubMed |
| A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Hein LK, Apaja PM, Hattersley K, Grose RH, Xie J, Proud CG, Sargeant TJ. Biochim Biophys Acta. 2017 Jun 19;1864(10):1554-1565. doi: 10.1016/j.bbamcr.2017.06.011. PubMed |
| Accumulation of autophagosomes confers cytotoxicity. Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. J Biol Chem. 2017 Jul 3. pii: jbc.M117.782276. doi: 10.1074/jbc.M117.782276. PubMed |
| Chromatographic HPV-16 E6/E7 plasmid vaccine purification employing L-histidine and 1-benzyl-L-histidine affinity ligands. Amorim LFA, Gaspar R, Pereira PC, Cernigoj U, Sousa F, Queiroz JA, Sousa A. Electrophoresis. 2017 Jul 6. doi: 10.1002/elps.201700147. PubMed |
| Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-kappaB-Dependent Autophagy. Piao X, Liu B, Guo L, Meng F, Gao L. Oxid Med Cell Longev. 2017;2017:7085709. doi: 10.1155/2017/7085709. Epub 2017 Jun 21. PubMed |
| Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells. Sun MY, Zhu JY, Zhang CY, Zhang M, Song YN, Rahman K, Zhang LJ, Zhang H. Biotechnol Lett. 2017 Oct;39(10):1477-1484. doi: 10.1007/s10529-017-2392-4. Epub 2017 Jul 18. PubMed |
| Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms. Mishra P, Dauphinee AN, Ward C, Sarkar S, Gunawardena AHLAN, Manjithaya R. Autophagy. 2017 Sep 2;13(9):1556-1572. doi: 10.1080/15548627.2017.1339002. Epub 2017 Aug 9. PubMed |
| Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis. Tang Z, Takahashi Y, Chen C, Liu Y, He H, Tsotakos N, Serfass JM, Gebru MT, Chen H, Young MM, Wang HG. Cell Death Differ. 2017 Dec;24(12):2127-2138. doi: 10.1038/cdd.2017.133. Epub 2017 Aug 11. PubMed |
| Rapamycin-induced autophagy restricts porcine epidemic diarrhea virus infectivity in porcine intestinal epithelial cells. Ko S, Gu MJ, Kim CG, Kye YC, Lim Y, Lee JE, Park BC, Chu H, Han SH, Yun CH. Antiviral Res. 2017 Oct;146:86-95. doi: 10.1016/j.antiviral.2017.08.010. Epub 2017 Aug 24. PubMed |
| VPS34 stimulation of p62 phosphorylation for cancer progression. Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, Qian Z, Lin Z, Li X, Liu X, Jiang L, Yang Y. Oncogene. 2017 Dec 14;36(50):6850-6862. doi: 10.1038/onc.2017.295. Epub 2017 Aug 28. PubMed |
| Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways. Liu L, Jin X, Hu CF, Li R, Zhou Z, Shen CX. Cell Physiol Biochem. 2017;43(1):52-68. doi: 10.1159/000480317. Epub 2017 Aug 25. PubMed |
| Identification of novel small molecule Beclin 1 mimetics activating autophagy. Yu J, Lan L, Lewin SJ, Rogers SA, Roy A, Wu X, Gao P, Karanicolas J, Aube J, Sun B, Xu L. Oncotarget. 2017 May 18;8(31):51355-51369. doi: 10.18632/oncotarget.17977. eCollection 2017 Aug 1. PubMed |
| The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. Han X, Chen H, Zhou J, Tai H, Gong H, Wang X, Huang N, Qin J, Fang T, Wang F, Xiao H. J Cell Physiol. 2018 May;233(5):3945-3954. doi: 10.1002/jcp.26169. Epub 2017 Sep 28. PubMed |
| The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Zhao YG, Chen Y, Miao G, Zhao H, Qu W, Li D, Wang Z, Liu N, Li L, Chen S, Liu P, Feng D, Zhang H. Mol Cell. 2017 Sep 21;67(6):974-989.e6. doi: 10.1016/j.molcel.2017.08.005. Epub 2017 Sep 7. PubMed |
| Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. Shetty R, Sharma A, Pahuja N, Chevour P, Padmajan N, Dhamodaran K, Jayadev C, M M A Nuijts R, Ghosh A, Nallathambi J. PLoS One. 2017 Sep 13;12(9):e0184628. doi: 10.1371/journal.pone.0184628. eCollection 2017. PubMed |
| PI3K-C2alpha knockdown decreases autophagy and maturation of endocytic vesicles. Merrill NM, Schipper JL, Karnes JB, Kauffman AL, Martin KR, MacKeigan JP. PLoS One. 2017 Sep 14;12(9):e0184909. doi: 10.1371/journal.pone.0184909. eCollection 2017. PubMed |
| Escherichia coli O157:H7 suppresses host autophagy and promotes epithelial adhesion via Tir-mediated and cAMP-independent activation of protein kinase A. Xue Y, Du M, Sheng H, Hovde CJ, Zhu MJ. Cell Death Discov. 2017 Oct 2;3:17055. doi: 10.1038/cddiscovery.2017.55. eCollection 2017. PubMed |
| 5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells. Dembitz V, Lalic H, Visnjic D. Cell Death Discov. 2017 Oct 2;3:17066. doi: 10.1038/cddiscovery.2017.66. eCollection 2017. PubMed |
| Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Tang ZH, Cao WX, Guo X, Dai XY, Lu JH, Chen X, Zhu H, Lu JJ. Cancer Lett. 2018 Jan 1;412:1-9. doi: 10.1016/j.canlet.2017.10.001. Epub 2017 Oct 9. PubMed |
| N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux. Ranieri R, Ciaglia E, Amodio G, Picardi P, Proto MC, Gazzerro P, Laezza C, Remondelli P, Bifulco M, Pisanti S. Cell Death Differ. 2018 Feb;25(2):353-367. doi: 10.1038/cdd.2017.165. Epub 2017 Oct 13. PubMed |
| Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways. Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y. Redox Biol. 2018 May;15:115-124. doi: 10.1016/j.redox.2017.09.007. Epub 2017 Sep 20. PubMed |
| Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes. Xie YY, Li Y, Zhou RP, Dai BB, Qian YJ, Wu XS, Ge JF, Hu W, Chen FH. Mol Cell Biochem. 2017 Dec 22. pii: 10.1007/s11010-017-3223-6. doi: 10.1007/s11010-017-3223-6. PubMed |
| Morphine-Mediated Brain Region-Specific Astrocytosis Involves the ER Stress-Autophagy Axis. Sil S, Periyasamy P, Guo ML, Callen S, Buch S. Mol Neurobiol. 2018 Aug;55(8):6713-6733. doi: 10.1007/s12035-018-0878-2. Epub 2018 Jan 17. PubMed |
| Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic beta-cell apoptosis. Lambelet M, Terra LF, Fukaya M, Meyerovich K, Labriola L, Cardozo AK, Allagnat F. Cell Death Dis. 2018 Jan 24;9(2):96. doi: 10.1038/s41419-017-0121-5. PubMed |
| Estrogen receptor alpha protects pancreatic beta-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29. PubMed |
| Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK. Bhattacharjee A, Hasanain M, Kathuria M, Singh A, Datta D, Sarkar J, Mitra K. Sci Rep. 2018 Feb 2;8(1):2303. doi: 10.1038/s41598-018-20541-8. PubMed |
| A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3. Fu R, Deng Q, Zhang H, Hu X, Li Y, Liu Y, Hu J, Luo Q, Zhang Y, Jiang X, Li L, Yang C, Gao N. Cell Death Dis. 2018 Feb 14;9(2):243. doi: 10.1038/s41419-018-0276-8. PubMed |
| Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis. Singh N, Kansal P, Ahmad Z, Baid N, Kushwaha H, Khatri N, Kumar A. Autophagy. 2018;14(6):972-991. doi: 10.1080/15548627.2018.1436936. Epub 2018 May 10. PubMed |
| A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism. Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. Autophagy. 2018;14(1):38-52. doi: 10.1080/15548627.2017.1389822. Epub 2018 Feb 20. PubMed |
| Identification of the Functional Autophagy-Regulatory Domain in HCLS1-Associated Protein X-1 That Resists Against Oxidative Stress. Li YL, Cai WF, Wang L, Liu GS, Paul C, Jiang L, Wang B, Gao X, Wang Y, Wu SZ. DNA Cell Biol. 2018 May;37(5):432-441. doi: 10.1089/dna.2017.3873. Epub 2018 Feb 20. PubMed |
| Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells. Liu J, Livingston MJ, Dong G, Tang C, Su Y, Wu G, Yin XM, Dong Z. Cell Death Dis. 2018 Feb 23;9(3):322. doi: 10.1038/s41419-018-0374-7. PubMed |
| Differentiation by nerve growth factor (NGF) involves mechanisms of crosstalk between energy homeostasis and mitochondrial remodeling. Martorana F, Gaglio D, Bianco MR, Aprea F, Virtuoso A, Bonanomi M, Alberghina L, Papa M, Colangelo AM. Cell Death Dis. 2018 Mar 9;9(3):391. doi: 10.1038/s41419-018-0429-9. PubMed |
| Taurine is an amino acid with the ability to activate autophagy in adipocytes. Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y. Amino Acids. 2018 May;50(5):527-535. doi: 10.1007/s00726-018-2550-6. Epub 2018 Mar 9. PubMed |
| Hemodynamic shear stress induces protective autophagy in HeLa cells through lipid raft-mediated mechanotransduction. Das J, Maji S, Agarwal T, Chakraborty S, Maiti TK. Clin Exp Metastasis. 2018 Mar;35(3):135-148. doi: 10.1007/s10585-018-9887-9. Epub 2018 Mar 13. PubMed |
| The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis. Zhao YG, Liu N, Miao G, Chen Y, Zhao H, Zhang H. Curr Biol. 2018 Apr 23;28(8):1234-1245.e4. doi: 10.1016/j.cub.2018.03.002. Epub 2018 Apr 5. PubMed |
| Autophagy inhibition attenuates hyperoxaluria-induced renal tubular oxidative injury and calcium oxalate crystal depositions in the rat kidney. Duan X, Kong Z, Mai X, Lan Y, Liu Y, Yang Z, Zhao Z, Deng T, Zeng T, Cai C, Li S, Zhong W, Wu W, Zeng G. Redox Biol. 2018 Jun;16:414-425. doi: 10.1016/j.redox.2018.03.019. Epub 2018 Apr 2. PubMed |
| Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRalpha Is Neuroprotective. Suresh SN, Chavalmane AK, Pillai M, Ammanathan V, Vidyadhara DJ, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R. Front Mol Neurosci. 2018 Apr 9;11:109. doi: 10.3389/fnmol.2018.00109. eCollection 2018. PubMed |
| Mangiferin Enhanced Autophagy via Inhibiting mTORC1 Pathway to Prevent High Glucose-Induced Cardiomyocyte Injury. Hou J, Zheng D, Xiao W, Li D, Ma J, Hu Y. Front Pharmacol. 2018 Apr 17;9:383. doi: 10.3389/fphar.2018.00383. eCollection 2018. PubMed |
| Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy. Shumin C, Wei X, Yunfeng L, Jiangshui L, Youguang G, Zhongqing C, Tao L. Cell Death Discov. 2018 May 9;4:52. doi: 10.1038/s41420-018-0057-2. eCollection 2018. PubMed |
| Monitoring and Measuring Mammalian Autophagy. Bhutia SK, Praharaj PP, Bhol CS, Panigrahi DP, Mahapatra KK, Patra S, Saha S, Das DN, Mukhopadhyay S, Sinha N, Panda PK, Naik PP. Methods Mol Biol. 2019;1854:209-222. doi: 10.1007/7651_2018_159. PubMed |
| Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy. Yu M, Liu T, Chen Y, Li Y, Li W. J Exp Clin Cancer Res. 2018 Jun 4;37(1):114. doi: 10.1186/s13046-018-0779-2. PubMed |
| HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Thangaraj A, Periyasamy P, Liao K, Bendi VS, Callen S, Pendyala G, Buch S. Autophagy. 2018;14(9):1596-1619. doi: 10.1080/15548627.2018.1476810. Epub 2018 Jul 26. PubMed |
| Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes. Sil S, Niu F, Tom E, Liao K, Periyasamy P, Buch S. Mol Neurobiol. 2018 Aug 27. pii: 10.1007/s12035-018-1325-0. doi: 10.1007/s12035-018-1325-0. PubMed |
| Enhanced autophagy contributes to excitotoxic lesions in a rat model of preterm brain injury. Descloux C, Ginet V, Rummel C, Truttmann AC, Puyal J. Cell Death Dis. 2018 Aug 28;9(9):853. doi: 10.1038/s41419-018-0916-z. PubMed |
| PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes. Negoita F, Blomdahl J, Wasserstrom S, Winberg ME, Osmark P, Larsson S, Stenkula KG, Ekstedt M, Kechagias S, Holm C, Jones HA. J Cell Biochem. 2019 Jan;120(1):343-356. doi: 10.1002/jcb.27378. Epub 2018 Sep 1. PubMed |
| Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, van Wijk SJL, Kogel D, Fulda S. Cell Death Dis. 2018 Sep 24;9(10):994. doi: 10.1038/s41419-018-1003-1. PubMed |
| Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway. Zhang Y, Fan Y, Huang S, Wang G, Han R, Lei F, Luo A, Jing X, Zhao L, Gu S, Zhao X. Cancer Sci. 2018 Dec;109(12):3865-3873. doi: 10.1111/cas.13808. Epub 2018 Oct 28. PubMed |
| ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKKbeta/ERK signaling pathway. Wang Y, Sun Y, Zuo L, Wang Y, Huang Y. Toxicol Lett. 2019 Jan;300:1-9. doi: 10.1016/j.toxlet.2018.10.003. Epub 2018 Oct 3. PubMed |
| miR4673 improves fitness profile of neoplastic cells by induction of autophagy. Dokumcu K, Simonian M, Farahani RM. Cell Death Dis. 2018 Oct 19;9(11):1068. doi: 10.1038/s41419-018-1088-6. PubMed |
| IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen. Barreiro-Pineiro N, Lostale-Seijo I, Varela-Calvino R, Benavente J, Martinez-Costas JM. Sci Rep. 2018 Nov 2;8(1):16286. doi: 10.1038/s41598-018-34488-3. PubMed |
| Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases. Kochetkova EY, Blinova GI, Bystrova OA, Martynova MG, Pospelov VA, Pospelova TV. Aging (Albany NY). 2018 Nov 27;10(11):3574-3589. doi: 10.18632/aging.101686. PubMed |
| GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation. Meng Q, Xu J, Liang C, Liu J, Hua J, Zhang Y, Ni Q, Shi S, Yu X. Cell Death Dis. 2018 Dec 11;9(12):1187. doi: 10.1038/s41419-018-1244-z. PubMed |
| Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome-autophagosome fusion. Mohan N, Sorokina EM, Verdeny IV, Alvarez AS, Lakadamyali M. J Cell Biol. 2019 Feb 4;218(2):632-643. doi: 10.1083/jcb.201807124. Epub 2018 Dec 19. PubMed |
| N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes. Huber K, Hofer DC, Trefely S, Pelzmann HJ, Madreiter-Sokolowski C, Duta-Mare M, Schlager S, Trausinger G, Stryeck S, Graier WF, Kolb D, Magnes C, Snyder NW, Prokesch A, Kratky D, Madl T, Wellen KE, Bogner-Strauss JG. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):337-348. doi: 10.1016/j.bbamcr.2018.08.017. Epub 2018 Aug 31. PubMed |
| RNA Binding Protein HuR Promotes Autophagosome Formation by Regulating Expression of Autophagy-Related Proteins 5, 12, and 16 in Human Hepatocellular Carcinoma Cells. Ji E, Kim C, Kang H, Ahn S, Jung M, Hong Y, Tak H, Lee S, Kim W, Lee EK. Mol Cell Biol. 2019 Mar 1;39(6). pii: MCB.00508-18. doi: 10.1128/MCB.00508-18. Print 2019 Mar 15. PubMed |
| Autophagy-lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease. Adams J, Feuerborn M, Molina JA, Wilden AR, Adhikari B, Budden T, Lee SY. Sci Rep. 2019 Jan 17;9(1):151. doi: 10.1038/s41598-018-36379-z. PubMed |
| Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. Zhuang H, Wu F, Wei W, Dang Y, Yang B, Ma X, Han F, Li Y. Cell Death Dis. 2019 Feb 25;10(3):192. doi: 10.1038/s41419-019-1446-z. PubMed |
| Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy. Hsieh CW, Yang WY. Nat Commun. 2019 Feb 27;10(1):969. doi: 10.1038/s41467-019-08924-5. PubMed |
| CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor. Shoemaker CJ, Huang TQ, Weir NR, Polyakov NJ, Schultz SW, Denic V. PLoS Biol. 2019 Apr 1;17(4):e2007044. doi: 10.1371/journal.pbio.2007044. eCollection 2019 Apr. PubMed |
| Concomitant Inhibition of Cytoprotective Autophagy Augments the Efficacy of Withaferin A in Hepatocellular Carcinoma. Siddharth S, Muniraj N, Saxena NK, Sharma D. Cancers (Basel). 2019 Mar 30;11(4). pii: cancers11040453. doi: 10.3390/cancers11040453. PubMed |
| Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation. Catanese A, Olde Heuvel F, Mulaw M, Demestre M, Higelin J, Barbi G, Freischmidt A, Weishaupt JH, Ludolph AC, Roselli F, Boeckers TM. Autophagy. 2019 Oct;15(10):1719-1737. doi: 10.1080/15548627.2019.1589257. Epub 2019 Apr 2. PubMed |
| Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy. Zhang Z, Wang X, Ma C, Li Z, Chen H, Zhang Z, Li T. Int Immunopharmacol. 2019 Jul;72:21-30. doi: 10.1016/j.intimp.2019.03.052. Epub 2019 Apr 5. PubMed |
| Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Thangaraj A, Periyasamy P, Guo ML, Chivero ET, Callen S, Buch S. Autophagy. 2020 Feb;16(2):289-312. doi: 10.1080/15548627.2019.1607686. Epub 2019 Apr 28. PubMed |
| Keratin 6a mutations lead to impaired mitochondrial quality control. Lehmann SM, Leube RE, Schwarz N. Br J Dermatol. 2019 Apr 20. doi: 10.1111/bjd.18014. PubMed |
| Glycan sulfation patterns define autophagy flux at axon tip via PTPRsigma-cortactin axis. Sakamoto K, Ozaki T, Ko YC, Tsai CF, Gong Y, Morozumi M, Ishikawa Y, Uchimura K, Nadanaka S, Kitagawa H, Zulueta MML, Bandaru A, Tamura JI, Hung SC, Kadomatsu K. Nat Chem Biol. 2019 Jul;15(7):699-709. doi: 10.1038/s41589-019-0274-x. Epub 2019 May 6. PubMed |
| Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Livingston MJ, Wang J, Zhou J, Wu G, Ganley IG, Hill JA, Yin XM, Dong Z. Autophagy. 2019 May 22:1-21. doi: 10.1080/15548627.2019.1615822. PubMed |
| Activation of the macroautophagy pathway by Yersinia enterocolitica promotes intracellular multiplication and egress of yersiniae from epithelial cells. Valencia Lopez MJ, Schimmeck H, Gropengiesser J, Middendorf L, Quitmann M, Schneider C, Holstermann B, Wacker R, Heussler V, Reimer R, Aepfelbacher M, Ruckdeschel K. Cell Microbiol. 2019 May 17:e13046. doi: 10.1111/cmi.13046. PubMed |
| A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Vats S, Manjithaya R. Mol Biol Cell. 2019 Aug 1;30(17):2283-2295. doi: 10.1091/mbc.E18-08-0482. Epub 2019 Jun 12. PubMed |
| LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer. Zhang X, Kumstel S, Jiang K, Meng S, Gong P, Vollmar B, Zechner D. J Adv Res. 2019 Apr 24;20:9-21. doi: 10.1016/j.jare.2019.04.006. eCollection 2019 Nov. PubMed |
| Mitochondrial Stress Response in Neural Stem Cells Exposed to Electronic Cigarettes. Zahedi A, Phandthong R, Chaili A, Leung S, Omaiye E, Talbot P. iScience. 2019 Jun 28;16:250-269. doi: 10.1016/j.isci.2019.05.034. Epub 2019 May 28. PubMed |
| Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. Jung S, Choe S, Woo H, Jeong H, An HK, Moon H, Ryu HY, Yeo BK, Lee YW, Choi H, Mun JY, Sun W, Choe HK, Kim EK, Yu SW. Autophagy. 2019 Jun 24:1-19. doi: 10.1080/15548627.2019.1630222. PubMed |
| BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells. Li F, Yang C, Zhang HB, Ma J, Jia J, Tang X, Zeng J, Chong T, Wang X, He D, Guo P. Cancer Med. 2019 Jun 28. doi: 10.1002/cam4.2385. PubMed |
| Histone Deacetylase Inhibitors Reduce Cysts by Activating Autophagy in Polycystic Kidney Disease. Sun L, Hu C, Zhang X. Kidney Dis (Basel). 2019 Jun;5(3):163-172. doi: 10.1159/000499368. Epub 2019 May 10. PubMed |
| Hepatitis C virus infection increases autophagosome stability by suppressing lysosomal fusion through an Arl8b-dependent mechanism. Jones-Jamtgaard KN, Wozniak AL, Koga H, Ralston R, Weinman SA. J Biol Chem. 2019 Sep 27;294(39):14257-14266. doi: 10.1074/jbc.RA119.008229. Epub 2019 Aug 5. PubMed |
| Neuroprotective effects of memantine via enhancement of autophagy. Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N. Biochem Biophys Res Commun. 2019 Oct 8;518(1):161-170. doi: 10.1016/j.bbrc.2019.08.025. Epub 2019 Aug 17. PubMed |
| Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction. Zhou C, Wang M, Yang J, Xiong H, Wang Y, Tang J. Cell Commun Signal. 2019 Aug 22;17(1):105. doi: 10.1186/s12964-019-0422-7. PubMed |
| The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation. Zhang W, Zhuang N, Liu X, He L, He Y, Mahinthichaichan P, Zhang H, Kang Y, Lu Y, Wu Q, Xu D, Shi L. Cell Mol Immunol. 2019 Aug 29. pii: 10.1038/s41423-019-0281-6. doi: 10.1038/s41423-019-0281-6. PubMed |
| Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. Panda PK, Patra S, Naik PP, Praharaj PP, Mukhopadhyay S, Meher BR, Gupta PK, Verma RS, Maiti TK, Bhutia SK. J Cell Physiol. 2020 Mar;235(3):2776-2791. doi: 10.1002/jcp.29182. Epub 2019 Sep 23. PubMed |
| Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction. Tripathi A, Thangaraj A, Chivero ET, Periyasamy P, Callen S, Burkovetskaya ME, Guo ML, Buch S. Cells. 2019 Sep 28;8(10). pii: cells8101168. doi: 10.3390/cells8101168. PubMed |
| BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. Lin TY, Chan HH, Chen SH, Sarvagalla S, Chen PS, Coumar MS, Cheng SM, Chang YC, Lin CH, Leung E, Cheung CHA. Autophagy. 2019 Oct 15:1-18. doi: 10.1080/15548627.2019.1671643. PubMed |
| Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, Rai S, Paul A, Yarreiphang H, Pillai MS, Giridharan M, Clement JP, Alladi PA, Saiyed T, Manjithaya R. EBioMedicine. 2019 Dec;50:260-273. doi: 10.1016/j.ebiom.2019.10.036. Epub 2019 Nov 11. PubMed |
| Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy. Ammanathan V, Mishra P, Chavalmane AK, Muthusamy S, Jadhav V, Siddamadappa C, Manjithaya R. Autophagy. 2019 Nov 19:1-14. doi: 10.1080/15548627.2019.1689770. PubMed |
| Protective role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP) in curcumin-induced cancer cell death. Boldbaatar J, Gunarta IK, Suzuki R, Erdenebaatar P, Davaakhuu G, Hohjoh H, Yoshioka K. Biochem Biophys Res Commun. 2020 Feb 12;522(3):697-703. doi: 10.1016/j.bbrc.2019.11.154. Epub 2019 Nov 28. PubMed |
| CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. An HK, Chung KM, Park H, Hong J, Gim JE, Choi H, Lee YW, Choi J, Mun JY, Yu SW. Autophagy. 2019 Dec 10:1-20. doi: 10.1080/15548627.2019.1695398. PubMed |
| SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mosbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Muller-Myhsok B, Drosten C, Muller MA, Rein T. Nat Commun. 2019 Dec 18;10(1):5770. doi: 10.1038/s41467-019-13659-4. PubMed |
| Mitochondrial Ca(2+) Uptake Relieves Palmitate-Induced Cytosolic Ca(2+) Overload in MIN6 Cells. Ly LD, Ly DD, Nguyen NT, Kim JH, Yoo H, Chung J, Lee MS, Cha SK, Park KS. Mol Cells. 2020 Jan 31;43(1):66-75. doi: 10.14348/molcells.2019.0223. PubMed |
| Critical roles of conventional dendritic cells in autoimmune hepatitis via autophagy regulation. Fan X, Men R, Huang C, Shen M, Wang T, Ghnewa Y, Ma Y, Ye T, Yang L. Cell Death Dis. 2020 Jan 13;11(1):23. doi: 10.1038/s41419-019-2217-6. PubMed |
| STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. Kinzler MN, Zielke S, Kardo S, Meyer N, Kogel D, van Wijk SJL, Fulda S. Sci Rep. 2020 Jan 20;10(1):687. doi: 10.1038/s41598-019-56990-y. PubMed |
| Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma. Valli F, Garcia Vior MC, Roguin LP, Marino J. Free Radic Biol Med. 2020 May 20;152:743-754. doi: 10.1016/j.freeradbiomed.2020.01.018. Epub 2020 Jan 18. PubMed |
| The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K. Liu Y, Fan D. Nutrients. 2020 Jan 18;12(1). pii: nu12010246. doi: 10.3390/nu12010246. PubMed |
| Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, Peng J, Jiang DS, Mu X, Wang C, Peng T, Guan JL, Wang Y, Jegga A, Huang K, Fan GC. Redox Biol. 2020 May;32:101453. doi: 10.1016/j.redox.2020.101453. Epub 2020 Feb 6. PubMed |
| Dimethyloxaloylglycine induces pexophagy in a HIF-2alpha dependent manner involving autophagy receptor p62. Mu Y, Maharjan Y, Dutta RK, Kim H, Wei X, Kim JH, Kim D, Park C, Park R. Biochem Biophys Res Commun. 2020 Feb 16. pii: S0006-291X(20)30319-3. doi: 10.1016/j.bbrc.2020.02.051. PubMed |
| Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block. Sharma V, Makhdoomi M, Singh L, Kumar P, Khan N, Singh S, Verma HN, Luthra K, Sarkar S, Kumar D. Autophagy. 2020 Feb 20:1-20. doi: 10.1080/15548627.2020.1725374. PubMed |
| Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibition. Kwon M, Jang M, Kim GH, Oh T, Ryoo IJ, Ryu HW, Oh SR, Kim BY, Jang JH, Ko SK, Ahn JS. Biochem Pharmacol. 2020 May;175:113861. doi: 10.1016/j.bcp.2020.113861. Epub 2020 Feb 17. PubMed |
| MitoBlue as a tool to analyze the mitochondria-lysosome communication. Sanchez MI, Vida Y, Perez-Inestrosa E, Mascarenas JL, Vazquez ME, Sugiura A, Martinez-Costas J. Sci Rep. 2020 Feb 26;10(1):3528. doi: 10.1038/s41598-020-60573-7. PubMed |
| Translational read-through promotes aggregation and shapes stop codon identity. Kramarski L, Arbely E. Nucleic Acids Res. 2020 Apr 17;48(7):3747-3760. doi: 10.1093/nar/gkaa136. PubMed |
| Par-4 regulates autophagic cell death in human cancer cells via upregulating p53 and BNIP3. Thayyullathil F, Cheratta AR, Pallichankandy S, Subburayan K, Tariq S, Rangnekar VM, Galadari S. Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118692. doi: 10.1016/j.bbamcr.2020.118692. Epub 2020 Mar 2. PubMed |
| The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington's disease. Nobrega C, Conceicao A, Costa RG, Koppenol R, Sequeira RL, Nunes R, Carmo-Silva S, Marcelo A, Matos CA, Betuing S, Caboche J, Cartier N, Alves S. BMC Res Notes. 2020 Apr 10;13(1):210. doi: 10.1186/s13104-020-05053-x. PubMed |
| Phanginin R Induces Cytoprotective Autophagy via JNK/c-Jun Signaling Pathway in Non-Small Cell Lung Cancer A549 Cells. Zhang LL, Bao H, Xu YL, Jiang XM, Li W, Zou L, Lin LG, Lu JJ. Anticancer Agents Med Chem. 2020;20(8):982-988. doi: 10.2174/1871520620666200414095828. PubMed |
| ATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death. Hwang SH, Yeom H, Lee M. Korean J Physiol Pharmacol. 2020 May 1;24(3):233-240. doi: 10.4196/kjpp.2020.24.3.233. PubMed |
| High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways. Song SB, Hwang ES. Biomolecules. 2020 May 13;10(5). pii: biom10050761. doi: 10.3390/biom10050761. PubMed |
| Saikosaponin D inhibits autophagosomelysosome fusion and induces autophagyindependent apoptosis in MDAMB231 breast cancer cells. Fu R, Zhang L, Li Y, Li B, Ming Y, Li Z, Xing H, Chen J. Mol Med Rep. 2020 Aug;22(2):1026-1034. doi: 10.3892/mmr.2020.11155. Epub 2020 May 18. PubMed |
| Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS. Wen X, An P, Li H, Zhou Z, Sun Y, Wang J, Ma L, Lu B. Neurosci Bull. 2020 Jun 4. pii: 10.1007/s12264-020-00518-2. doi: 10.1007/s12264-020-00518-2. PubMed |
| Autophagosome biogenesis and human health. Kawabata T, Yoshimori T. Cell Discov. 2020 Jun 2;6:33. doi: 10.1038/s41421-020-0166-y. eCollection 2020. PubMed |
| TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes. Wetzel L, Blanchard S, Rama S, Beier V, Kaufmann A, Wollert T. Nat Commun. 2020 Jun 12;11(1):2993. doi: 10.1038/s41467-020-16689-5. PubMed |
| LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13. Chu Y, Kang Y, Yan C, Yang C, Zhang T, Huo H, Liu Y. Autophagy. 2021 Jul;17(7):1684-1699. doi: 10.1080/15548627.2020.1781393. Epub 2020 Jun 26. PubMed |
| Hepatic autophagy fluctuates during the development of non-alcoholic fatty liver disease. Ding H, Ge G, Tseng Y, Ma Y, Zhang J, Liu J. Ann Hepatol. 2020 Jun 15. pii: S1665-2681(20)30055-7. doi: 10.1016/j.aohep.2020.06.001. PubMed |
| SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation. Richard P, Feng S, Tsai YL, Li W, Rinchetti P, Muhith U, Irizarry-Cole J, Stolz K, Sanz LA, Hartono S, Hoque M, Tadesse S, Seitz H, Lotti F, Hirano M, Chedin F, Tian B, Manley JL. Autophagy. 2021 Aug;17(8):1889-1906. doi: 10.1080/15548627.2020.1796292. Epub 2020 Aug 7. PubMed |
| Ursolic acid inhibits pigmentation by increasing melanosomal autophagy in B16F1 cells. Park HJ, Jo DS, Choi DS, Bae JE, Park NY, Kim JB, Chang JH, Shin JJ, Cho DH. Biochem Biophys Res Commun. 2020 Oct 15;531(2):209-214. doi: 10.1016/j.bbrc.2020.07.125. Epub 2020 Aug 11. PubMed |
| Melasolv induces melanosome autophagy to inhibit pigmentation in B16F1 cells. Park HJ, Jo DS, Choi H, Bae JE, Park NY, Kim JB, Choi JY, Kim YH, Oh GS, Chang JH, Kim HJ, Cho DH. PLoS One. 2020 Sep 17;15(9):e0239019. doi: 10.1371/journal.pone.0239019. eCollection 2020. PubMed |
| Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment. Muniraj N, Siddharth S, Shriver M, Nagalingam A, Parida S, Woo J, Elsey J, Gabrielson K, Gabrielson E, Arbiser JL, Saxena NK, Sharma D. Cell Death Discov. 2020 Sep 6;6:81. doi: 10.1038/s41420-020-00315-w. eCollection 2020. PubMed |
| N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction. Tripathi A, Thangaraj A, Chivero ET, Periyasamy P, Burkovetskaya ME, Niu F, Guo ML, Buch S. Front Neurol. 2020 Sep 4;11:840. doi: 10.3389/fneur.2020.00840. eCollection 2020. PubMed |
| SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy. Yang C, Chen XC, Li ZH, Wu HL, Jing KP, Huang XR, Ye L, Wei B, Lan HY, Liu HF. Autophagy. 2021 Sep;17(9):2325-2344. doi: 10.1080/15548627.2020.1824694. Epub 2020 Oct 12. PubMed |
| Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death. Matrood S, de Prisco N, Wissniowski T, Wiese D, Jabari S, Griesmann H, Wanzel M, Stiewe T, Neureiter D, Klieser E, Mintziras I, Buchholz M, Bartsch DK, Gennarino V, Di Fazio P. Neuroendocrinology. 2020 Oct 27. pii: 000512567. doi: 10.1159/000512567. PubMed |
| PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation. Chou HY, Lee YT, Lin YJ, Wen JK, Peng WH, Hsieh PL, Lin SY, Hung CC, Chen GC. Autophagy. 2020 Oct 28:1-16. doi: 10.1080/15548627.2020.1838117. PubMed |
| Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes. Mohamud Y, Shi J, Tang H, Xiang P, Xue YC, Liu H, Ng CS, Luo H. Sci Rep. 2020 Nov 4;10(1):19068. doi: 10.1038/s41598-020-76227-7. PubMed |
| The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells. Prieto K, Lozano MP, Uruena C, Almeciga-Diaz CJ, Fiorentino S, Barreto A. Apoptosis. 2020 Dec;25(11-12):875-888. doi: 10.1007/s10495-020-01643-z. Epub 2020 Nov 6. PubMed |
| Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes. Kobayashi M, Yasukawa H, Arikawa T, Deguchi Y, Mizushima N, Sakurai M, Onishi S, Tagawa R, Sudo Y, Okita N, Higashi K, Higami Y. FEBS Open Bio. 2021 Jan;11(1):185-194. doi: 10.1002/2211-5463.13055. Epub 2020 Dec 13. PubMed |
| The apple dihydrochalcone phloretin suppresses growth and improves chemosensitivity of breast cancer cells via inhibition of cytoprotective autophagy. Chen M, Gowd V, Wang M, Chen F, Cheng KW. Food Funct. 2021 Jan 7;12(1):177-190. doi: 10.1039/d0fo02362k. Epub 2020 Dec 8. PubMed |
| HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation. Zhan Y, Wang H, Zhang L, Pei F, Chen Z. Front Cell Dev Biol. 2020 Nov 26;8:605609. doi: 10.3389/fcell.2020.605609. eCollection 2020. PubMed |
| Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy. Huang Y, Li S, Jia Z, Zhao W, Zhou C, Zhang R, Ali DW, Michalak M, Chen XZ, Tang J. Front Oncol. 2020 Dec 4;10:573127. doi: 10.3389/fonc.2020.573127. eCollection 2020. PubMed |
| BIX-01294, a G9a inhibitor, suppresses cell proliferation by inhibiting autophagic flux in nasopharyngeal carcinoma cells. Li Q, Wang L, Ji D, Bao X, Tan G, Liang X, Deng P, Pi H, Lu Y, Chen C, He M, Zhang L, Zhou Z, Yu Z, Deng A. Invest New Drugs. 2021 Jun;39(3):686-696. doi: 10.1007/s10637-020-01053-7. Epub 2021 Jan 2. PubMed |
| Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Thayyullathil F, Cheratta AR, Alakkal A, Subburayan K, Pallichankandy S, Hannun YA, Galadari S. Cell Death Dis. 2021 Jan 7;12(1):26. doi: 10.1038/s41419-020-03297-w. PubMed |
| ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, Bi Y, Wang P, Zhang H. Dev Cell. 2021 Feb 22;56(4):427-442.e5. doi: 10.1016/j.devcel.2020.12.010. Epub 2020 Dec 16. PubMed |
| Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition. Yeom H, Hwang SH, Han BI, Lee M. Biomol Ther (Seoul). 2021 Jul 1;29(4):434-444. doi: 10.4062/biomolther.2020.203. PubMed |
| Molecular imaging of the kinetics of hyperactivated ERK1/2-mediated autophagy during acquirement of chemoresistance. Bishnu A, Phadte P, Dhadve A, Sakpal A, Rekhi B, Ray P. Cell Death Dis. 2021 Feb 8;12(2):161. doi: 10.1038/s41419-021-03451-y. PubMed |
| PRKAA/AMPKalpha phosphorylation switches the role of RASAL2 from a suppressor to an activator of autophagy. Bao Y, Qian C, Liu MY, Jiang F, Jiang X, Liu H, Zhang Z, Sun F, Fu N, Hou Z, Ke Y, Li Y, Qian ZM. Autophagy. 2021 Nov;17(11):3607-3621. doi: 10.1080/15548627.2021.1886767. Epub 2021 Feb 24. PubMed |
| Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. Khundadze M, Ribaudo F, Hussain A, Stahlberg H, Brocke-Ahmadinejad N, Franzka P, Varga RE, Zarkovic M, Pungsrinont T, Kokal M, Ganley IG, Beetz C, Sylvester M, Hubner CA. Autophagy. 2021 Mar 9:1-17. doi: 10.1080/15548627.2021.1891848. PubMed |
| beta-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells. Ji C, Zhao H, Chen D, Zhang H, Zhao YG. Curr Biol. 2021 Apr 26;31(8):1666-1677.e6. doi: 10.1016/j.cub.2021.01.081. Epub 2021 Feb 25. PubMed |
| Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction. Lee M, Nam HY, Kang HB, Lee WH, Lee GH, Sung GJ, Han MW, Cho KJ, Chang EJ, Choi KC, Kim SW, Kim SY. Cell Death Dis. 2021 Mar 5;12(3):250. doi: 10.1038/s41419-021-03539-5. PubMed |
| The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death. Guo W, Wang Q, Pan S, Li J, Wang Y, Shu Y, Chen J, Wang Q, Zhang S, Zhang X, Yue J. J Cell Physiol. 2021 Oct;236(10):6932-6947. doi: 10.1002/jcp.30354. Epub 2021 Mar 8. PubMed |
| Sarco/Endoplasmic Reticulum Ca(2+) Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells. Peng J, Ran Y, Xie H, Deng L, Li C, Ling C. J Virol. 2021 Mar 10. pii: JVI.00217-21. doi: 10.1128/JVI.00217-21. PubMed |
| MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. Zhou J, Singh BK, Ho JP, Lim A, Bruinstroop E, Ohba K, Sinha RA, Yen PM. Autophagy. 2021 Mar 18:1-19. doi: 10.1080/15548627.2021.1899691. PubMed |
| Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy. Fujiwara N, Shibutani S, Ohama T, Sato K. Biochem Biophys Res Commun. 2021 May 7;552:191-195. doi: 10.1016/j.bbrc.2021.02.136. Epub 2021 Mar 20. PubMed |
| Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca(2+) Homeostasis and Associated Apoptosis. Chen J, Li L, Bai X, Xiao L, Shangguan J, Zhang W, Zhang X, Wang S, Liu G. Front Pharmacol. 2021 Mar 8;12:620812. doi: 10.3389/fphar.2021.620812. eCollection 2021. PubMed |
| The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD. Kim DH, Park JS, Choi HI, Kim CS, Bae EH, Ma SK, Kim SW. Cell Death Dis. 2021 Mar 25;12(4):320. doi: 10.1038/s41419-021-03620-z. PubMed |
| Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells. Lai M, La Rocca V, Amato R, Freer G, Costa M, Spezia PG, Quaranta P, Lombardo G, Piomelli D, Pistello M. Int J Mol Sci. 2021 Mar 23;22(6). pii: ijms22063247. doi: 10.3390/ijms22063247. PubMed |
| Autophagy Triggers Tamoxifen Resistance in Human Breast Cancer Cells by Preventing Drug-Induced Lysosomal Damage. Actis C, Muzio G, Autelli R. Cancers (Basel). 2021 Mar 12;13(6). pii: cancers13061252. doi: 10.3390/cancers13061252. PubMed |
| Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C. Roney JC, Li S, Farfel-Becker T, Huang N, Sun T, Xie Y, Cheng XT, Lin MY, Platt FM, Sheng ZH. Dev Cell. 2021 May 17;56(10):1452-1468.e8. doi: 10.1016/j.devcel.2021.03.032. Epub 2021 Apr 19. PubMed |
| BNIP3 promotes HIF-1alpha-driven melanoma growth by curbing intracellular iron homeostasis. Vara-Perez M, Rossi M, Van den Haute C, Maes H, Sassano ML, Venkataramani V, Michalke B, Romano E, Rillaerts K, Garg AD, Schepkens C, Bosisio FM, Wouters J, Oliveira AI, Vangheluwe P, Annaert W, Swinnen JV, Colet JM, van den Oord JJ, Fendt SM, Mazzone M, Agostinis P. EMBO J. 2021 May 17;40(10):e106214. doi: 10.15252/embj.2020106214. Epub 2021 May 1. PubMed |
| Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like disease. Sofou K, Meier K, Sanderson LE, Kaminski D, Montoliu-Gaya L, Samuelsson E, Blomqvist M, Agholme L, Gartner J, Muhlhausen C, Darin N, Barakat TS, Schlotawa L, van Ham T, Asin Cayuela J, Sterky FH. EMBO Mol Med. 2021 May 7;13(5):e13376. doi: 10.15252/emmm.202013376. Epub 2021 May 3. PubMed |
| Maturing Autophagosomes are Transported Towards the Cell Periphery. Hilverling A, Szego EM, Dinter E, Cozma D, Saridaki T, Falkenburger BH. Cell Mol Neurobiol. 2021 Jun 9. pii: 10.1007/s10571-021-01116-0. doi: 10.1007/s10571-021-01116-0. PubMed |
| Mammalian cells use the autophagy process to restrict avian influenza virus replication. Liu S, Mok BW, Deng S, Liu H, Wang P, Song W, Chen P, Huang X, Zheng M, Lau SY, Cremin CJ, Tam CY, Li B, Jiang L, Chen Y, Yuen KY, Chen H. Cell Rep. 2021 Jun 8;35(10):109213. doi: 10.1016/j.celrep.2021.109213. PubMed |
| Rabies Virus-Induced Autophagy Is Dependent on Viral Load in BV2 Cells. Wang Y, He H, Li J, Chen L, Luo J, Kuang Y, Lv Z, Fan R, Zhang B, Luo Y, Guo X. Front Microbiol. 2021 May 25;12:595678. doi: 10.3389/fmicb.2021.595678. eCollection 2021. PubMed |
| ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK. Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6. Epub 2021 May 17. PubMed |
| SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals. Gassen NC, Papies J, Bajaj T, Emanuel J, Dethloff F, Chua RL, Trimpert J, Heinemann N, Niemeyer C, Weege F, Honzke K, Aschman T, Heinz DE, Weckmann K, Ebert T, Zellner A, Lennarz M, Wyler E, Schroeder S, Richter A, Niemeyer D, Hoffmann K, Meyer TF, Heppner FL, Corman VM, Landthaler M, Hocke AC, Morkel M, Osterrieder N, Conrad C, Eils R, Radbruch H, Giavalisco P, Drosten C, Muller MA. Nat Commun. 2021 Jun 21;12(1):3818. doi: 10.1038/s41467-021-24007-w. PubMed |
| (V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells. Jimenez-Mora E, Gallego B, Diaz-Gago S, Lasa M, Baquero P, Chiloeches A. Int J Mol Sci. 2021 Jun 3;22(11). pii: ijms22116033. doi: 10.3390/ijms22116033. PubMed |
| Degradation of lipid droplets by chimeric autophagy-tethering compounds. Fu Y, Chen N, Wang Z, Luo S, Ding Y, Lu B. Cell Res. 2021 Sep;31(9):965-979. doi: 10.1038/s41422-021-00532-7. Epub 2021 Jul 8. PubMed |
| Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells. Chen Y, Li P, Peng Y, Xie X, Zhang Y, Jiang Y, Li T, Qin X, Li S, Yang H, Wu C, Zheng C, Zhu J, You F, Liu Y. Free Radic Biol Med. 2021 Aug 20;172:590-603. doi: 10.1016/j.freeradbiomed.2021.07.005. Epub 2021 Jul 6. PubMed |
| Inhibition of autophagy by YC-1 promotes gefitinib induced apoptosis by targeting FOXO1 in gefitinib-resistant NSCLC cells. Hu H, Zhang XW, Li L, Hu MN, Hu WQ, Zhang JY, Miao XK, Yang WL, Mou LY. Eur J Pharmacol. 2021 Oct 5;908:174346. doi: 10.1016/j.ejphar.2021.174346. Epub 2021 Jul 13. PubMed |
| Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease. Guo W, Zhong W, Hao L, Dong H, Sun X, Yue R, Li T, Zhou Z. Cell Mol Gastroenterol Hepatol. 2021;12(5):1599-1615. doi: 10.1016/j.jcmgh.2021.07.002. Epub 2021 Jul 17. PubMed |
| The Novel Antitumor Compound HCA Promotes Glioma Cell Death by Inducing Endoplasmic Reticulum Stress and Autophagy. Beteta-Gobel R, Fernandez-Diaz J, Arbona-Gonzalez L, Rodriguez-Lorca R, Torres M, Busquets X, Fernandez-Garcia P, Escriba PV, Llado V. Cancers (Basel). 2021 Aug 26;13(17). pii: cancers13174290. doi: 10.3390/cancers13174290. PubMed |
| Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, Coffey M, Topiwala D, Gomes C, Ozbek B, Jones T, Rosen M, Dong L, Wiens S, Brennen WN, Isaacs JT, De Marzo AM, Markowski MC, Antonarakis ES, Qian DZ, Pienta KJ, Pardoll DM, Carducci MA, Denmeade SR, Kachhap SK. Cancer Res. 2021 Dec 1;81(23):5948-5962. doi: 10.1158/0008-5472.CAN-20-3607. Epub 2021 Oct 13. PubMed |
| Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease. Guo W, Zhong W, Hao L, Sun X, Zhou Z. Cells. 2021 Oct 13;10(10). pii: cells10102730. doi: 10.3390/cells10102730. PubMed |
| Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis. Shu S, Wang H, Zhu J, Liu Z, Yang D, Wu W, Cai J, Chen A, Tang C, Dong Z. Cell Death Dis. 2021 Oct 29;12(11):1016. doi: 10.1038/s41419-021-04274-7. PubMed |
| SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores. Lee JE, Kim N, Jung M, Mun JY, Yoo JY. Autophagy. 2022 Jul;18(7):1613-1628. doi: 10.1080/15548627.2021.1994297. Epub 2021 Oct 31. PubMed |
| Genome-wide association studies identify the role of caspase-9 in kidney disease. Doke T, Huang S, Qiu C, Sheng X, Seasock M, Liu H, Ma Z, Palmer M, Susztak K. Sci Adv. 2021 Nov 5;7(45):eabi8051. doi: 10.1126/sciadv.abi8051. Epub 2021 Nov 5. PubMed |
| Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy. Marcelo A, Afonso IT, Afonso-Reis R, Brito DVC, Costa RG, Rosa A, Alves-Cruzeiro J, Ferreira B, Henriques C, Nobre RJ, Matos CA, de Almeida LP, Nobrega C. Cell Death Dis. 2021 Nov 29;12(12):1117. doi: 10.1038/s41419-021-04404-1. PubMed |
| MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans. Jung Y, Artan M, Kim N, Yeom J, Hwang AB, Jeong DE, Altintas O, Seo K, Seo M, Lee D, Hwang W, Lee Y, Sohn J, Kim EJE, Ju S, Han SK, Nam HJ, Adams L, Ryu Y, Moon DJ, Kang C, Yoo JY, Park SK, Ha CM, Hansen M, Kim S, Lee C, Park SY, Lee SV. Sci Adv. 2021 Dec 3;7(49):eabj8156. doi: 10.1126/sciadv.abj8156. Epub 2021 Dec 3. PubMed |
| STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Remy J, Linder B, Weirauch U, Day BW, Stringer BW, Herold-Mende C, Aigner A, Krohn K, Kogel D. Cancers (Basel). 2022 Jan 11;14(2). pii: cancers14020339. doi: 10.3390/cancers14020339. PubMed |
| Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells. Yeom H, Hwang SH, Kim HG, Lee M. Toxicol Res. 2021 Oct 11;38(1):35-44. doi: 10.1007/s43188-021-00109-x. eCollection 2022 Jan. PubMed |
| Tri-2-Hydroxyarachidonein Induces Cytocidal Autophagy in Pancreatic Ductal Adenocarcinoma Cancer Cell Models. Fernandez-Diaz J, Beteta-Gobel R, Torres M, Cabot J, Fernandez-Garcia P, Llado V, Escriba PV, Busquets X. Front Physiol. 2022 Jan 20;12:782525. doi: 10.3389/fphys.2021.782525. eCollection 2021. PubMed |
| Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma. Nath LR, Swetha M, Vijayakurup V, Thangarasu AK, Haritha NH, Shabna A, Aiswarya SU, Rayginia TP, Keerthana CK, Kalimuthu K, Sundaram S, Lankalapalli RS, Pillai S, Towner R, Isakov N, Anto RJ. Front Oncol. 2022 Feb 8;12:812598. doi: 10.3389/fonc.2022.812598. eCollection 2022. PubMed |
| The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Khan SY, Ali M, Kabir F, Na CH, Delannoy M, Ma Y, Qiu C, Costello MJ, Hejtmancik JF, Riazuddin SA. Autophagy. 2022 Sep;18(9):2198-2215. doi: 10.1080/15548627.2022.2025570. Epub 2022 Mar 28. PubMed |
| Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. Wang Y, Wang Y, Li F, Zou J, Li X, Xu M, Yu D, Ma Y, Huang W, Sun X, Zhang Y. Cells. 2022 Mar 22;11(7). pii: cells11071067. doi: 10.3390/cells11071067. PubMed |
| Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Ke PY, Chang CW, Hsiao YC. Cells. 2022 Mar 28;11(7). pii: cells11071132. doi: 10.3390/cells11071132. PubMed |
| P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition. Chadet S, Allard J, Brisson L, Lopez-Charcas O, Lemoine R, Heraud A, Lerondel S, Guibon R, Fromont G, Le Pape A, Angoulvant D, Jiang LH, Murrell-Lagnado R, Roger S. Oncogene. 2022 May;41(21):2920-2931. doi: 10.1038/s41388-022-02297-8. Epub 2022 Apr 11. PubMed |
| Dyskerin Downregulation Can Induce ER Stress and Promote Autophagy via AKT-mTOR Signaling Deregulation. Maiello D, Varone M, Vicidomini R, Belli V, De Rosa M, Dama P, Furia M, Turano M. Biomedicines. 2022 May 8;10(5). pii: biomedicines10051092. doi: 10.3390/biomedicines10051092. PubMed |
| Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease. Fao L, Coelho P, Duarte L, Vilaca R, Hayden MR, Mota SI, Rego AC. Antioxid Redox Signal. 2022 Aug 5. doi: 10.1089/ars.2022.0001. PubMed |
| Blocking autophagy with chloroquine aggravates lipid accumulation and reduces intracellular energy synthesis in hepatocellular carcinoma cells, both contributing to its anti-proliferative effect. Xu F, Tautenhahn HM, Dirsch O, Dahmen U. J Cancer Res Clin Oncol. 2022 Jun 13. pii: 10.1007/s00432-022-04074-2. doi: 10.1007/s00432-022-04074-2. PubMed |
| Persistent Activation of Autophagy After Cisplatin Nephrotoxicity Promotes Renal Fibrosis and Chronic Kidney Disease. Fu Y, Xiang Y, Wu W, Cai J, Tang C, Dong Z. Front Pharmacol. 2022 May 30;13:918732. doi: 10.3389/fphar.2022.918732. eCollection 2022. PubMed |
| Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway. Zhao L, Lan Z, Peng L, Wan L, Liu D, Tan X, Tang C, Chen G, Liu H. Cell Prolif. 2022 Sep;55(9):e13278. doi: 10.1111/cpr.13278. Epub 2022 Jun 22. PubMed |
| AXL Promotes Metformin-Induced Apoptosis Through Mediation of Autophagy by Activating ROS-AMPK-ULK1 Signaling in Human Esophageal Adenocarcinoma. Hong J, Maacha S, Pidkovka N, Bates A, Salaria SN, Washington MK, Belkhiri A. Front Oncol. 2022 Jul 22;12:903874. doi: 10.3389/fonc.2022.903874. eCollection 2022. PubMed |
| Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy. Wang S, Wang G, Wu W, Xu Z, Yang J, Cao M, Wang Q, Wang J, Yang C, Zhang W. Front Immunol. 2022 Aug 1;13:968686. doi: 10.3389/fimmu.2022.968686. eCollection 2022. PubMed |
| MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer. Panigrahi DP, Patra S, Behera BP, Behera PK, Patil S, Patro BS, Rout L, Sarangi I, Bhutia SK. Free Radic Biol Med. 2022 Sep;190:307-319. doi: 10.1016/j.freeradbiomed.2022.08.019. Epub 2022 Aug 17. PubMed |
| Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia. Vantaggiato C, Orso G, Guarato G, Brivio F, Napoli B, Panzeri E, Masotti S, Santorelli FM, Lamprou M, Gumeni S, Clementi E, Bassi MT. Brain. 2023 Mar 1;146(3):1103-1120. doi: 10.1093/brain/awac308. PubMed |
| Impairment of Neuronal Mitochondrial Quality Control in Prion-Induced Neurodegeneration. Kim MJ, Kim HJ, Jang B, Kim HJ, Mostafa MN, Park SJ, Kim YS, Choi EK. Cells. 2022 Sep 2;11(17):2744. doi: 10.3390/cells11172744. PubMed |
| Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells. Hwang SH, Kim HG, Lee M. BMC Cancer. 2022 Sep 10;22(1):969. doi: 10.1186/s12885-022-10053-0. PubMed |
| In human astrocytes neurotropic flaviviruses increase autophagy, yet their replication is autophagy-independent. Tavcar Verdev P, Potokar M, Korva M, Resman Rus K, Kolenc M, Avsic Zupanc T, Zorec R, Jorgacevski J. Cell Mol Life Sci. 2022 Oct 25;79(11):566. doi: 10.1007/s00018-022-04578-7. PubMed |
| Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS. Alan P, Vandevoorde KR, Joshi B, Cardoen B, Gao G, Mohammadzadeh Y, Hamarneh G, Nabi IR. Cell Mol Life Sci. 2022 Oct 25;79(11):565. doi: 10.1007/s00018-022-04585-8. PubMed |
| Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion. Maharjan Y, Dutta RK, Son J, Wei X, Park C, Kwon HM, Park R. Cell Commun Signal. 2022 Nov 25;20(1):189. doi: 10.1186/s12964-022-00942-z. PubMed |
| ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy. Sanchez-Martin P, Kriegenburg F, Alves L, Adam J, Elsaesser J, Babic R, Mancilla H, Licheva M, Tascher G, Munch C, Eimer S, Kraft C. J Cell Sci. 2023 Feb 1;136(3):jcs260546. doi: 10.1242/jcs.260546. Epub 2023 Feb 9. PubMed |
| Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production. Pellegrini FR, De Martino S, Fianco G, Ventura I, Valente D, Fiore M, Trisciuoglio D, Degrassi F. Autophagy. 2023 Jul;19(7):2078-2093. doi: 10.1080/15548627.2023.2170962. Epub 2023 Feb 10. PubMed |
| Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. Xia Q, Li Y, Xu W, Wu C, Zheng H, Liu L, Dong L. Cell Biosci. 2023 Feb 21;13(1):37. doi: 10.1186/s13578-023-00978-9. PubMed |
| Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Wen J, Zellner A, Braun NC, Bajaj T, Gassen NC, Peitz M, Brustle O. Transl Psychiatry. 2023 May 3;13(1):143. doi: 10.1038/s41398-023-02432-3. PubMed |
| Distinct Signaling Pathways for Autophagy-Driven Cell Death and Survival in Adult Hippocampal Neural Stem Cells. Jeong SH, An HK, Ha S, Yu SW. Int J Mol Sci. 2023 May 5;24(9):8289. doi: 10.3390/ijms24098289. PubMed |
| SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing. Bhosle VK, Tan JM, Li T, Hua R, Kwon H, Li Z, Patel S, Tessier-Lavigne M, Robinson LA, Kim PK, Brumell JH. Life Sci Alliance. 2023 Jun 13;6(8):e202301964. doi: 10.26508/lsa.202301964. Print 2023 Aug. PubMed |
| Restored autophagy is protective against PAK3-induced cardiac dysfunction. Ruiz-Velasco A, Raja R, Chen X, Ganenthiran H, Kaur N, Alatawi NHO, Miller JM, Abouleisa RRE, Ou Q, Zhao X, Fonseka O, Wang X, Hille SS, Frey N, Wang T, Mohamed TMA, Muller OJ, Cartwright EJ, Liu W. iScience. 2023 May 26;26(6):106970. doi: 10.1016/j.isci.2023.106970. eCollection 2023 Jun 16. PubMed |
| The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle. Avula K, Singh B, Samantaray S, Syed GH. J Virol. 2023 Jul 27;97(7):e0018023. doi: 10.1128/jvi.00180-23. Epub 2023 Jun 20. PubMed |
| SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux. Mozzi A, Oldani M, Forcella ME, Vantaggiato C, Cappelletti G, Pontremoli C, Valenti F, Forni D, Saresella M, Biasin M, Sironi M, Fusi P, Cagliani R. iScience. 2023 Jul 21;26(7):107118. doi: 10.1016/j.isci.2023.107118. Epub 2023 Jun 14. PubMed |
| Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee PJ, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro HH, Ju H, Liao C, Tieze SM, Rigo F, Jafar-Nejad P, Lim J. J Clin Invest. 2023 Aug 15;133(16):e138207. doi: 10.1172/JCI138207. PubMed |
| Umbelliprenin induces autophagy and apoptosis while inhibits cancer cell stemness in pancreatic cancer cells. Wang H, Liu Y, Wang Y, Xu T, Xia G, Huang X. Cancer Med. 2023 Jul;12(14):15277-15288. doi: 10.1002/cam4.6170. Epub 2023 Jul 6. PubMed |
| SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells. Geng F, Zhong Y, Su H, Lefai E, Magaki S, Cloughesy TF, Yong WH, Chakravarti A, Guo D. Cell Rep. 2023 Jul 25;42(7):112790. doi: 10.1016/j.celrep.2023.112790. Epub 2023 Jul 11. PubMed |
| Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. Zhang W, Fan Y, Zhang J, Shi D, Yuan J, Ashrafizadeh M, Li W, Hu M, Abd El-Aty AM, Hacimuftuoglu A, Linnebacher M, Cheng Y, Li W, Fang S, Gong P, Zhang X. Drug Resist Updat. 2023 Nov;71:101005. doi: 10.1016/j.drup.2023.101005. Epub 2023 Aug 21. PubMed |
| Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH. Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, Ito A, Oka Y, Hidaka I, Takami T, Honda Y, Maeda M, Saito Y, Murata Y, Matozaki T, Nakajima A, Kataoka Y, Ogi T, Ogawa Y, Suganami T. J Exp Med. 2023 Nov 6;220(11):e20220681. doi: 10.1084/jem.20220681. Epub 2023 Sep 19. PubMed |
| Inhibition of autophagy can promote the apoptosis of bladder cancer cells induced by SC66 through the endoplasmic reticulum stress pathway. Wang L, Song R, Ma M, Chen Y, Jiang Y, Li J, Yang Z, Zhang L, Jing M, Wang X, Zhang M, Fan J. Chem Biol Interact. 2023 Oct 1;384:110725. doi: 10.1016/j.cbi.2023.110725. Epub 2023 Sep 21. PubMed |
| Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors. Mariner BL, Rodriguez AS, Heath OC, McCormick MA. Geroscience. 2024 Apr;46(2):1755-1773. doi: 10.1007/s11357-023-00938-8. Epub 2023 Sep 25. PubMed |
| TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1. Heo H, Park H, Lee MS, Kim J, Kim J, Jung SY, Kim SK, Lee S, Chang J. Autophagy. 2023 Nov 27:1-16. doi: 10.1080/15548627.2023.2287925. PubMed |
| Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway. Ma J, Zheng M, Zhang X, Lu J, Gu L. BMC Complement Med Ther. 2023 Dec 6;23(1):441. doi: 10.1186/s12906-023-04290-4. PubMed |
| Quantitative Analysis of Autophagy in Single Cells: Differential Response to Amino Acid and Glucose Starvation. Martin KR, Celano SL, Sheldon RD, Jones RG, MacKeigan JP. bioRxiv [Preprint]. 2023 Dec 3:2023.12.01.569679. doi: 10.1101/2023.12.01.569679. PubMed |
| Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients. Pozzi M, Vantaggiato C, Brivio F, Orso G, Bassi MT. Transl Psychiatry. 2024 Jan 8;14(1):13. doi: 10.1038/s41398-023-02686-x. PubMed |
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