pLX302 Citations (40)
Originally described in: A public genome-scale lentiviral expression library of human ORFs.Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, Hieronymus H, Balcha D, Fan C, Lin C, Ghamsari L, Vidal M, Hahn WC, Hill DE, Root DE Nat Methods. 2011 Jun 26. ():. PubMed Journal
Articles Citing pLX302
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| Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration. Drivas TG, Holzbaur EL, Bennett J. J Clin Invest. 2013 Oct;123(10):4525-39. doi: 10.1172/JCI69448. Epub 2013 Sep 24. PubMed |
| LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. Schwarz LJ, Fox EM, Balko JM, Garrett JT, Kuba MG, Estrada MV, Gonzalez-Angulo AM, Mills GB, Red-Brewer M, Mayer IA, Abramson V, Rizzo M, Kelley MC, Meszoely IM, Arteaga CL. J Clin Invest. 2014 Dec;124(12):5490-502. doi: 10.1172/JCI72573. Epub 2014 Nov 17. PubMed |
| CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis. Rizzardi LF, Coleman KE, Varma D, Matson JP, Oh S, Cook JG. J Biol Chem. 2015 Jan 2;290(1):556-67. doi: 10.1074/jbc.M114.614701. Epub 2014 Nov 19. PubMed |
| The role of frataxin in doxorubicin-mediated cardiac hypertrophy. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. PubMed |
| RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors. Loi S, Dushyanthen S, Beavis PA, Salgado R, Denkert C, Savas P, Combs S, Rimm DL, Giltnane JM, Estrada MV, Sanchez V, Sanders ME, Cook RS, Pilkinton MA, Mallal SA, Wang K, Miller VA, Stephens PJ, Yelensky R, Doimi FD, Gomez H, Ryzhov SV, Darcy PK, Arteaga CL, Balko JM. Clin Cancer Res. 2016 Mar 15;22(6):1499-509. doi: 10.1158/1078-0432.CCR-15-1125. Epub 2015 Oct 29. PubMed |
| Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS. Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8. PubMed |
| Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies. Hellner K, Miranda F, Fotso Chedom D, Herrero-Gonzalez S, Hayden DM, Tearle R, Artibani M, KaramiNejadRanjbar M, Williams R, Gaitskell K, Elorbany S, Xu R, Laios A, Buiga P, Ahmed K, Dhar S, Zhang RY, Campo L, Myers KA, Lozano M, Ruiz-Miro M, Gatius S, Mota A, Moreno-Bueno G, Matias-Guiu X, Benitez J, Witty L, McVean G, Leedham S, Tomlinson I, Drmanac R, Cazier JB, Klein R, Dunne K, Bast RC Jr, Kennedy SH, Hassan B, Lise S, Garcia MJ, Peters BA, Yau C, Sauka-Spengler T, Ahmed AA. EBioMedicine. 2016 Aug;10:137-49. doi: 10.1016/j.ebiom.2016.06.048. Epub 2016 Jul 2. PubMed |
| Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. Duffy S, Fam HK, Wang YK, Styles EB, Kim JH, Ang JS, Singh T, Larionov V, Shah SP, Andrews B, Boerkoel CF, Hieter P. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9967-76. doi: 10.1073/pnas.1611839113. Epub 2016 Aug 22. PubMed |
| A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. Vijai J, Topka S, Villano D, Ravichandran V, Maxwell KN, Maria A, Thomas T, Gaddam P, Lincoln A, Kazzaz S, Wenz B, Carmi S, Schrader KA, Hart SN, Lipkin SM, Neuhausen SL, Walsh MF, Zhang L, Lejbkowicz F, Rennert H, Stadler ZK, Robson M, Weitzel JN, Domchek S, Daly MJ, Couch FJ, Nathanson KL, Norton L, Rennert G, Offit K. Cancer Discov. 2016 Nov;6(11):1267-1275. Epub 2016 Sep 21. PubMed |
| Human papillomavirus regulates HER3 expression in head and neck cancer: implications for targeted HER3 therapy in HPV(+) patients. Brand TM, Hartmann S, Bhola NE, Peyser ND, Li H, Zeng Y, Isaacson Wechsler E, Ranall MV, Bandyopadhyay S, Duvvuri U, LaVallee TM, Jordan RC, Johnson DE, Grandis JR. Clin Cancer Res. 2016 Dec 16. pii: clincanres.2203.2016. doi: 10.1158/1078-0432.CCR-16-2203. PubMed |
| Delete_Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA. Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S244-S262. doi: 10.1074/mcp.O116.063487. Epub 2017 Feb 7. PubMed |
| Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kalpha-selective Inhibitors in Breast Cancer. Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH. Theranostics. 2017 Feb 23;7(4):974-986. doi: 10.7150/thno.17830. eCollection 2017. PubMed |
| Deletion of the Vaccinia Virus I2 Protein Interrupts Virion Morphogenesis, Leading to Retention of the Scaffold Protein and Mislocalization of Membrane-Associated Entry Proteins. Hyun SI, Weisberg A, Moss B. J Virol. 2017 Jul 12;91(15). pii: e00558-17. doi: 10.1128/JVI.00558-17. Print 2017 Aug 1. PubMed |
| Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases. Merilahti JAM, Ojala VK, Knittle AM, Pulliainen AT, Elenius K. Mol Biol Cell. 2017 Nov 1;28(22):3123-3131. doi: 10.1091/mbc.E17-04-0261. Epub 2017 Sep 13. PubMed |
| Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR. Cancer Res. 2018 May 1;78(9):2383-2395. doi: 10.1158/0008-5472.CAN-17-1672. Epub 2018 Feb 12. PubMed |
| CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. Lin CC, Kitagawa M, Tang X, Hou MH, Wu J, Qu DC, Srinivas V, Liu X, Thompson JW, Mathey-Prevot B, Yao TP, Lee SH, Chi JT. Nat Commun. 2018 Mar 12;9(1):1039. doi: 10.1038/s41467-018-03422-6. PubMed |
| Engineering a Protein Binder Specific for p38alpha with Interface Expansion. Hussain M, Angus SP, Kuhlman B. Biochemistry. 2018 Jul 31;57(30):4526-4535. doi: 10.1021/acs.biochem.8b00408. Epub 2018 Jul 19. PubMed |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway. Li Z, Razavi P, Li Q, Toy W, Liu B, Ping C, Hsieh W, Sanchez-Vega F, Brown DN, Da Cruz Paula AF, Morris L, Selenica P, Eichenberger E, Shen R, Schultz N, Rosen N, Scaltriti M, Brogi E, Baselga J, Reis-Filho JS, Chandarlapaty S. Cancer Cell. 2018 Dec 10;34(6):893-905.e8. doi: 10.1016/j.ccell.2018.11.006. PubMed |
| EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity. Kaibori Y, Saito Y, Nakayama Y. FASEB J. 2019 Apr;33(4):5334-5349. doi: 10.1096/fj.201801519RR. Epub 2019 Jan 22. PubMed |
| Mir-17 approximately 92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration. Tung YT, Peng KC, Chen YC, Yen YP, Chang M, Thams S, Chen JA. Cell Stem Cell. 2019 Aug 1;25(2):193-209.e7. doi: 10.1016/j.stem.2019.04.016. Epub 2019 May 30. PubMed |
| Oncogenic Biogenesis of pri-miR-17 approximately 92 Reveals Hierarchy and Competition among Polycistronic MicroRNAs. Donayo AO, Johnson RM, Tseng HW, Izreig S, Gariepy A, Mayya VK, Wu E, Alam R, Lussier C, Jones RG, Duchaine TF. Mol Cell. 2019 Jul 25;75(2):340-356.e10. doi: 10.1016/j.molcel.2019.05.033. Epub 2019 Jun 26. PubMed |
| Resistance to TRK inhibition mediated by convergent MAPK pathway activation. Cocco E, Schram AM, Kulick A, Misale S, Won HH, Yaeger R, Razavi P, Ptashkin R, Hechtman JF, Toska E, Cownie J, Somwar R, Shifman S, Mattar M, Selcuklu SD, Samoila A, Guzman S, Tuch BB, Ebata K, de Stanchina E, Nagy RJ, Lanman RB, Houck-Loomis B, Patel JA, Berger MF, Ladanyi M, Hyman DM, Drilon A, Scaltriti M. Nat Med. 2019 Sep;25(9):1422-1427. doi: 10.1038/s41591-019-0542-z. Epub 2019 Aug 12. PubMed |
| MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X, Wang X, Shen J, Zhang Y, Lang JY. EBioMedicine. 2019 Oct;48:289-300. doi: 10.1016/j.ebiom.2019.10.003. Epub 2019 Oct 21. PubMed |
| Interstitial serum albumin empowers osteosarcoma cells with FAIM2 transcription to obtain viability via dedifferentiation. Pan Y, Zhang Y, Tang W, Zhang Y. In Vitro Cell Dev Biol Anim. 2020 Feb;56(2):129-144. doi: 10.1007/s11626-019-00421-9. Epub 2020 Jan 15. PubMed |
| Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers. Ying Z, Beronja S. Cell Stem Cell. 2020 Mar 5;26(3):403-419.e4. doi: 10.1016/j.stem.2020.01.009. Epub 2020 Feb 13. PubMed |
| MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Ding CC, Rose J, Sun T, Wu J, Chen PH, Lin CC, Yang WH, Chen KY, Lee H, Xu E, Tian S, Akinwuntan J, Zhao J, Guan Z, Zhou P, Chi JT. Nat Metab. 2020 Mar;2(3):270-277. doi: 10.1038/s42255-020-0181-1. Epub 2020 Mar 9. PubMed |
| Hedgehog signaling promotes multidrug resistance by regulation of ABC transporters in oral squamous cell carcinoma. Lu X, Wang Z, Huang H, Wang H. J Oral Pathol Med. 2020 Jun 8. doi: 10.1111/jop.13050. PubMed |
| Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress. Cai EY, Kufeld MN, Schuster S, Arora S, Larkin M, Germanos AA, Hsieh AC, Beronja S. Cell Stem Cell. 2020 Aug 6;27(2):270-283.e7. doi: 10.1016/j.stem.2020.05.007. Epub 2020 Jun 8. PubMed |
| Fragmentation of Small-Cell Lung Cancer Regulatory States in Heterotypic Microenvironments. Schaff DL, Singh S, Kim KB, Sutcliffe MD, Park KS, Janes KA. Cancer Res. 2021 Apr 1;81(7):1853-1867. doi: 10.1158/0008-5472.CAN-20-1036. Epub 2021 Feb 2. PubMed |
| Mapping proteolytic neo-N termini at the surface of living cells. Weeks AM, Byrnes JR, Lui I, Wells JA. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8). pii: 2018809118. doi: 10.1073/pnas.2018809118. PubMed |
| DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. Lin CC, Yang WH, Lin YT, Tang X, Chen PH, Ding CC, Qu DC, Alvarez JV, Chi JT. Oncogene. 2021 Mar;40(11):2018-2034. doi: 10.1038/s41388-021-01676-x. Epub 2021 Feb 18. PubMed |
| Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Lopacinski AB, Sweatt AJ, Smolko CM, Gray-Gaillard E, Borgman CA, Shah M, Janes KA. Cell Syst. 2021 Apr 21;12(4):304-323.e13. doi: 10.1016/j.cels.2021.02.004. Epub 2021 Mar 18. PubMed |
| Upregulation of the ErbB family by EZH2 in hepatocellular carcinoma confers resistance to FGFR inhibitor. Prawira A, Le TBU, Ho RZW, Huynh H. J Cancer Res Clin Oncol. 2021 Oct;147(10):2955-2968. doi: 10.1007/s00432-021-03703-6. Epub 2021 Jun 22. PubMed |
| Editorial: Novel Insights Into Ferroptosis. Setayeshpour Y, Chi JT. Front Cell Dev Biol. 2021 Oct 7;9:754160. doi: 10.3389/fcell.2021.754160. eCollection 2021. PubMed |
| MESH1 knockdown triggers proliferation arrest through TAZ repression. Sun T, Ding CC, Zhang Y, Zhang Y, Lin CC, Wu J, Setayeshpour Y, Coggins S, Shepard C, Macias E, Kim B, Zhou P, Gordan R, Chi JT. Cell Death Dis. 2022 Mar 10;13(3):221. doi: 10.1038/s41419-022-04663-6. PubMed |
| The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation. Ladewig E, Michelini F, Jhaveri K, Castel P, Carmona J, Fairchild L, Zuniga AG, Arruabarrena-Aristorena A, Cocco E, Blawski R, Kittane S, Zhang Y, Sallaku M, Baldino L, Hristidis V, Chandarlapaty S, Abdel-Wahab O, Leslie C, Scaltriti M, Toska E. Cancer Res. 2022 Jun 15;82(12):2269-2280. doi: 10.1158/0008-5472.CAN-22-0446. PubMed |
| Control of cell state transitions. Rukhlenko OS, Halasz M, Rauch N, Zhernovkov V, Prince T, Wynne K, Maher S, Kashdan E, MacLeod K, Carragher NO, Kolch W, Kholodenko BN. Nature. 2022 Sep;609(7929):975-985. doi: 10.1038/s41586-022-05194-y. Epub 2022 Sep 14. PubMed |
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.
Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B.
Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6.
PubMed
Associated Plasmids |
| TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, Patel FP, Zammit WH, Gali-Moya J, Hazime KS, Jones KL, Rey C, Jonjic S, Rovis TL, Tannahill GM, Cruz De Matos GDS, Waight JD, Davis DM. Nat Commun. 2023 Aug 18;14(1):5016. doi: 10.1038/s41467-023-40755-3. PubMed |
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