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pLKO.1-blast Citations (55)

Originally described in: A molecular network for de novo generation of the apical surface and lumen.
Bryant DM, Datta A, Rodriguez-Fraticelli AE, Peranen J, Martin-Belmonte F, Mostov KE Nat Cell Biol. 2010 Oct 3. ():.
PubMed Journal

Articles Citing pLKO.1-blast

Articles
PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed
Antileukemic Activity of 2-Deoxy-d-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations. Larrue C, Saland E, Vergez F, Serhan N, Delabesse E, Mansat-De Mas V, Hospital MA, Tamburini J, Manenti S, Sarry JE, Recher C. Mol Cancer Ther. 2015 Oct;14(10):2364-73. doi: 10.1158/1535-7163.MCT-15-0163. Epub 2015 Jul 23. PubMed
Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells. Larrue C, Saland E, Boutzen H, Vergez F, David M, Joffre C, Hospital MA, Tamburini J, Delabesse E, Manenti S, Sarry JE, Recher C. Blood. 2015 Aug 18. pii: blood-2015-05-646497. PubMed
Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness. Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF. Nat Commun. 2016 May 3;7:11246. doi: 10.1038/ncomms11246. PubMed
An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR. Meredith EK, Balas MM, Sindy K, Haislop K, Johnson AM. RNA. 2016 Jul;22(7):995-1010. doi: 10.1261/rna.055830.115. Epub 2016 May 4. PubMed
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66. doi: 10.1073/pnas.1608319113. Epub 2016 Jul 18. PubMed
Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia. Lam SS, Ho ES, He BL, Wong WW, Cher CY, Ng NK, Man CH, Gill H, Cheung AM, Ip HW, So CC, Tamburini J, So CW, Ho DN, Au CH, Chan TL, Ma ES, Liang R, Kwong YL, Leung AY. Sci Transl Med. 2016 Oct 5;8(359):359ra129. PubMed
SIKs control osteocyte responses to parathyroid hormone. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176. PubMed
PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y. Stem Cell Reports. 2016 Dec 13;7(6):1072-1086. doi: 10.1016/j.stemcr.2016.10.007. Epub 2016 Nov 17. PubMed
G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer. Yim CY, Bikorimana E, Khan E, Warzecha JM, Shin L, Rodriguez J, Dmitrovsky E, Freemantle SJ, Spinella MJ. Cell Cycle. 2017;16(21):2146-2155. doi: 10.1080/15384101.2017.1371884. Epub 2017 Sep 14. PubMed
Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Feng YX, Jin DX, Sokol ES, Reinhardt F, Miller DH, Gupta PB. Nat Commun. 2017 Oct 20;8(1):1079. doi: 10.1038/s41467-017-01052-y. PubMed
Hoxa9 and Hoxa10 induce CML myeloid blast crisis development through activation of Myb expression. Negi V, Vishwakarma BA, Chu S, Oakley K, Han Y, Bhatia R, Du Y. Oncotarget. 2017 Oct 24;8(58):98853-98864. doi: 10.18632/oncotarget.22008. eCollection 2017 Nov 17. PubMed
The concerted roles of FANCM and Rad52 in the protection of common fragile sites. Wang H, Li S, Oaks J, Ren J, Li L, Wu X. Nat Commun. 2018 Jul 18;9(1):2791. doi: 10.1038/s41467-018-05066-y. PubMed
RAP2 mediates mechanoresponses of the Hippo pathway. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22. PubMed
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed
Role of PDGF receptor-alpha during human cytomegalovirus entry into fibroblasts. Wu K, Oberstein A, Wang W, Shenk T. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9889-E9898. doi: 10.1073/pnas.1806305115. Epub 2018 Oct 1. PubMed
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma. Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H. Sci Rep. 2018 Oct 23;8(1):15674. doi: 10.1038/s41598-018-33852-7. PubMed
DNA polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. Wang Z, Song Y, Li S, Kurian S, Xiang R, Chiba T, Wu X. J Biol Chem. 2019 Mar 15;294(11):3909-3919. doi: 10.1074/jbc.RA118.005188. Epub 2019 Jan 17. PubMed
The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer. Rampias T, Karagiannis D, Avgeris M, Polyzos A, Kokkalis A, Kanaki Z, Kousidou E, Tzetis M, Kanavakis E, Stravodimos K, Manola KN, Pantelias GE, Scorilas A, Klinakis A. EMBO Rep. 2019 Mar;20(3). pii: embr.201846821. doi: 10.15252/embr.201846821. Epub 2019 Jan 21. PubMed
L1 drives IFN in senescent cells and promotes age-associated inflammation. De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beausejour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. PubMed
ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures. Li S, Lu H, Wang Z, Hu Q, Wang H, Xiang R, Chiba T, Wu X. iScience. 2019 Jun 28;16:63-78. doi: 10.1016/j.isci.2019.05.017. Epub 2019 May 16. PubMed
DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction. Marivin A, Garcia-Marcos M. Mol Biol Cell. 2019 Jul 22;30(16):1900-1910. doi: 10.1091/mbc.E19-02-0091. Epub 2019 Jul 3. PubMed
Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. Pringle ES, Robinson CA, McCormick C. J Virol. 2019 Oct 15;93(21). pii: JVI.00854-19. doi: 10.1128/JVI.00854-19. Print 2019 Nov 1. PubMed
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed
Kaposi's Sarcoma-Associated Herpesvirus ORF66 Is Essential for Late Gene Expression and Virus Production via Interaction with ORF34. Watanabe T, Nishimura M, Izumi T, Kuriyama K, Iwaisako Y, Hosokawa K, Takaori-Kondo A, Fujimuro M. J Virol. 2020 Jan 6;94(2). pii: JVI.01300-19. doi: 10.1128/JVI.01300-19. Print 2020 Jan 6. PubMed
Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. Watson ZL, Yamamoto TM, McMellen A, Kim H, Hughes CJ, Wheeler LJ, Post MD, Behbakht K, Bitler BG. Clin Epigenetics. 2019 Nov 27;11(1):165. doi: 10.1186/s13148-019-0758-2. PubMed
Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. You E, Ko P, Jeong J, Keum S, Kim JW, Seo YJ, Song WK, Rhee S. Cell Mol Life Sci. 2020 Jan 7. pii: 10.1007/s00018-019-03412-x. doi: 10.1007/s00018-019-03412-x. PubMed
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation. Raffeiner P, Hart JR, Garcia-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6571-6579. doi: 10.1073/pnas.1921786117. Epub 2020 Mar 10. PubMed
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability. Che N, Ng KY, Wong TL, Tong M, Kau PW, Chan LH, Lee TK, Huen MS, Yun JP, Ma S. Cancer Lett. 2021 Mar 31;501:247-262. doi: 10.1016/j.canlet.2020.11.002. Epub 2020 Nov 11. PubMed
Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus. Markiewicz L, Uspienski T, Baran B, Niedziolka SM, Niewiadomski P. Cell Signal. 2021 Apr;80:109907. doi: 10.1016/j.cellsig.2020.109907. Epub 2020 Dec 28. PubMed
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. J Clin Invest. 2021 Feb 1;131(3). pii: 140105. doi: 10.1172/JCI140105. PubMed
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J. Elife. 2021 May 26;10. pii: 67624. doi: 10.7554/eLife.67624. PubMed
Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Ko P, Choi JH, Song S, Keum S, Jeong J, Hwang YE, Kim JW, Rhee S. Int J Mol Sci. 2021 Jun 2;22(11). pii: ijms22116018. doi: 10.3390/ijms22116018. PubMed
Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies. Castle EL, Robinson CA, Douglas P, Rinker KD, Corcoran JA. Mol Cell Biol. 2021 Oct 26;41(11):e0039921. doi: 10.1128/MCB.00399-21. Epub 2021 Sep 13. PubMed
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN. Nat Commun. 2021 Nov 1;12(1):6271. doi: 10.1038/s41467-021-26571-7. PubMed
A targetable LIFR-NF-kappaB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L. Nat Commun. 2021 Dec 17;12(1):7333. doi: 10.1038/s41467-021-27452-9. PubMed
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain. Dai J, Cimino PJ, Gouin KH 3rd, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A, Schulte V, Clegg N, Pisarsky L, Lyden D, Bissell MJ, Knott S, Welm AL, Bielas JH, Hansen KC, Winkler F, Holland EC, Ghajar CM. Nat Cancer. 2022 Jan;3(1):25-42. doi: 10.1038/s43018-021-00297-3. Epub 2021 Dec 24. PubMed
Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing. Segelle A, Nunez-Alvarez Y, Oldfield AJ, Webb KM, Voigt P, Luco RF. Cell Rep. 2022 Feb 15;38(7):110357. doi: 10.1016/j.celrep.2022.110357. PubMed
Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells. Bristol JA, Brand J, Ohashi M, Eichelberg MR, Casco A, Nelson SE, Hayes M, Romero-Masters JC, Baiu DC, Gumperz JE, Johannsen EC, Dinh HQ, Kenney SC. PLoS Pathog. 2022 Apr 26;18(4):e1010453. doi: 10.1371/journal.ppat.1010453. eCollection 2022 Apr. PubMed
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Nat Commun. 2022 Apr 29;13(1):2350. doi: 10.1038/s41467-022-29730-6. PubMed
Post-translational control of beige fat biogenesis by PRDM16 stabilization. Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S. Nature. 2022 Sep;609(7925):151-158. doi: 10.1038/s41586-022-05067-4. Epub 2022 Aug 17. PubMed
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells. Porman AM, Roberts JT, Duncan ED, Chrupcala ML, Levine AA, Kennedy MA, Williams MM, Richer JK, Johnson AM. PLoS Biol. 2022 Nov 28;20(11):e3001885. doi: 10.1371/journal.pbio.3001885. eCollection 2022 Nov. PubMed
DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells. Liu S, Wang Z, Shah SB, Chang CY, Ai M, Nguyen T, Xiang R, Wu X. J Biol Chem. 2023 Jan;299(1):102770. doi: 10.1016/j.jbc.2022.102770. Epub 2022 Dec 5. PubMed
Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies. Robinson CA, Singh GK, Kleer M, Katsademas T, Castle EL, Boudreau BQ, Corcoran JA. PLoS Pathog. 2023 Jan 12;19(1):e1011080. doi: 10.1371/journal.ppat.1011080. eCollection 2023 Jan. PubMed
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. Patel PS, Algouneh A, Krishnan R, Reynolds JJ, Nixon KCJ, Hao J, Lee J, Feng Y, Fozil C, Stanic M, Yerlici T, Su P, Soares F, Liedtke E, Prive G, Baider GD, Pujana MA, Mekhail K, He HH, Hakem A, Stewart GS, Hakem R. Nucleic Acids Res. 2023 May 22;51(9):4341-4362. doi: 10.1093/nar/gkad172. PubMed
DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer. Miller AL, Perurena N, Gardner A, Hinoue T, Loi P, Laird PW, Cichowski K. Cancer Res. 2023 Jun 2;83(11):1800-1814. doi: 10.1158/0008-5472.CAN-22-0370. PubMed
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer. Wong TL, Loh JJ, Lu S, Yan HHN, Siu HC, Xi R, Chan D, Kam MJF, Zhou L, Tong M, Copland JA, Chen L, Yun JP, Leung SY, Ma S. Nat Commun. 2023 May 19;14(1):2861. doi: 10.1038/s41467-023-38581-8. PubMed
KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2. Chen L, Li Y, Chen Y. iScience. 2023 May 19;26(6):106914. doi: 10.1016/j.isci.2023.106914. eCollection 2023 Jun 16. PubMed
Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA. Sci Adv. 2023 Jul 7;9(27):eadf6621. doi: 10.1126/sciadv.adf6621. Epub 2023 Jul 5. PubMed
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. Krishnan R, Lapierre M, Gautreau B, Nixon KCJ, El Ghamrasni S, Patel PS, Hao J, Yerlici VT, Guturi KKN, St-Germain J, Mateo F, Saad A, Algouneh A, Earnshaw R, Shili D, Seitova A, Miller J, Khosraviani N, Penn A, Ho B, Sanchez O, Hande MP, Masson JY, Brown GW, Alaoui-Jamali M, Reynolds JJ, Arrowsmith C, Raught B, Pujana MA, Mekhail K, Stewart GS, Hakem A, Hakem R. Nucleic Acids Res. 2023 Oct 27;51(19):10484-10505. doi: 10.1093/nar/gkad733. PubMed
Increased expression of BRD4 isoforms long (BRD4-L) and short (BRD4-S) promotes chemotherapy resistance in high-grade serous ovarian carcinoma. Drumond-Bock AL, Wang L, Wang L, Cybula M, Rostworowska M, Kinter M, Bieniasz M. Genes Cancer. 2023 Sep 12;14:56-76. doi: 10.18632/genesandcancer.233. eCollection 2023. PubMed
Hypoxia stabilizes SETDB1 to maintain genome stability. Park S, Cho JH, Kim JH, Park M, Park S, Kim SY, Kim SK, Kim K, Park SG, Park BC, Moon JH, Lee G, Kim S, Kim JA, Kim JH. Nucleic Acids Res. 2023 Nov 10;51(20):11178-11196. doi: 10.1093/nar/gkad796. PubMed
Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection. Adamoski D, Dias MM, Quesnay JEN, Yang Z, Zagoriy I, Steyer AM, Rodrigues CT, da Silva Bastos AC, da Silva BN, Costa RKE, de Abreu FMO, Islam Z, Cassago A, van Heel MG, Consonni SR, Mattei S, Mahamid J, Portugal RV, Ambrosio ALB, Dias SMG. Nat Struct Mol Biol. 2023 Dec;30(12):1902-1912. doi: 10.1038/s41594-023-01118-0. Epub 2023 Oct 19. PubMed

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