pMJ806 Citations (34)
Originally described in: A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity.Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28. PubMed Journal
Articles Citing pMJ806
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Efficient genome editing in zebrafish using a CRISPR-Cas system.
Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK.
Nat Biotechnol. 2013 Jan 29. doi: 10.1038/nbt.2501.
PubMed
Associated Plasmids |
RNA-guided gene activation by CRISPR-Cas9-based transcription factors.
Perez-Pinera P, Kocak DD, Vockley CM, Adler AF, Kabadi AM, Polstein LR, Thakore PI, Glass KA, Ousterout DG, Leong KW, Guilak F, Crawford GE, Reddy TE, Gersbach CA.
Nat Methods. 2013 Jul 25. doi: 10.1038/nmeth.2600.
PubMed
Associated Plasmids |
| Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Hruscha A, Krawitz P, Rechenberg A, Heinrich V, Hecht J, Haass C, Schmid B. Development. 2013 Dec;140(24):4982-7. doi: 10.1242/dev.099085. Epub 2013 Nov 20. PubMed |
| A CRISPR method for genome engineering. Wilkinson R, Wiedenheft B. F1000Prime Rep. 2014 Jan 2;6:3. doi: 10.12703/P6-3. eCollection 2014. PubMed |
| Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins. Menoret S, De Cian A, Tesson L, Remy S, Usal C, Boule JB, Boix C, Fontaniere S, Creneguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I. Sci Rep. 2015 Oct 7;5:14410. doi: 10.1038/srep14410. PubMed |
| Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements. Karvelis T, Gasiunas G, Young J, Bigelyte G, Silanskas A, Cigan M, Siksnys V. Genome Biol. 2015 Nov 19;16(1):253. doi: 10.1186/s13059-015-0818-7. PubMed |
| Overcoming doxorubicin resistance of cancer cells by Cas9-mediated gene disruption. Ha JS, Byun J, Ahn DR. Sci Rep. 2016 Mar 10;6:22847. doi: 10.1038/srep22847. PubMed |
| Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Anders C, Bargsten K, Jinek M. Mol Cell. 2016 Mar 17;61(6):895-902. doi: 10.1016/j.molcel.2016.02.020. PubMed |
| Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling. Vazquez Reyes C, Tangprasertchai NS, Yogesha SD, Nguyen RH, Zhang X, Rajan R, Qin PZ. Cell Biochem Biophys. 2016 Jun 24. PubMed |
| Cas9 in Genetically Modified Food Is Unlikely to Cause Food Allergy. Nakajima O, Nishimaki-Mogami T, Kondo K. Biol Pharm Bull. 2016;39(11):1876-1880. PubMed |
| Cas9-mediated genome editing in the methanogenic archaeon Methanosarcina acetivorans. Nayak DD, Metcalf WW. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2976-2981. doi: 10.1073/pnas.1618596114. Epub 2017 Mar 6. PubMed |
| Tubulin isotype substitution revealed that isotype combination modulates microtubule dynamics in C. elegans embryos. Honda Y, Tsuchiya K, Sumiyoshi E, Haruta N, Sugimoto A. J Cell Sci. 2017 May 1;130(9):1652-1661. doi: 10.1242/jcs.200923. Epub 2017 Mar 16. PubMed |
Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.
Savic N, Ringnalda FC, Lindsay H, Berk C, Bargsten K, Li Y, Neri D, Robinson MD, Ciaudo C, Hall J, Jinek M, Schwank G.
Elife. 2018 May 29;7. pii: 33761. doi: 10.7554/eLife.33761.
PubMed
Associated Plasmids |
| Straightforward Delivery of Linearized Double-Stranded DNA Encoding sgRNA and Donor DNA for the Generation of Single Nucleotide Variants Based on the CRISPR/Cas9 System. Jun S, Lim H, Jang H, Lee W, Ahn J, Lee JH, Bang D. ACS Synth Biol. 2018 Jul 20;7(7):1651-1659. doi: 10.1021/acssynbio.7b00345. Epub 2018 Jul 2. PubMed |
| Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ. Mol Cell. 2018 Jul 5;71(1):42-55.e8. doi: 10.1016/j.molcel.2018.06.005. PubMed |
| Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla. Uribe RV, van der Helm E, Misiakou MA, Lee SW, Kol S, Sommer MOA. Cell Host Microbe. 2019 Feb 13;25(2):233-241.e5. doi: 10.1016/j.chom.2019.01.003. Epub 2019 Feb 5. PubMed |
| The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection. Zhang R, Varela M, Vallentgoed W, Forn-Cuni G, van der Vaart M, Meijer AH. PLoS Pathog. 2019 Feb 28;15(2):e1007329. doi: 10.1371/journal.ppat.1007329. eCollection 2019 Feb. PubMed |
| RNA-guided endonuclease - in situ labelling (RGEN-ISL): a fast CRISPR/Cas9-based method to label genomic sequences in various species. Ishii T, Schubert V, Khosravi S, Dreissig S, Metje-Sprink J, Sprink T, Fuchs J, Meister A, Houben A. New Phytol. 2019 May;222(3):1652-1661. doi: 10.1111/nph.15720. Epub 2019 Mar 8. PubMed |
| A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dancik V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A. Cell. 2019 May 2;177(4):1067-1079.e19. doi: 10.1016/j.cell.2019.04.009. PubMed |
CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites.
Jayavaradhan R, Pillis DM, Goodman M, Zhang F, Zhang Y, Andreassen PR, Malik P.
Nat Commun. 2019 Jun 28;10(1):2866. doi: 10.1038/s41467-019-10735-7.
PubMed
Associated Plasmids |
| Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9. Zhu X, Clarke R, Puppala AK, Chittori S, Merk A, Merrill BJ, Simonovic M, Subramaniam S. Nat Struct Mol Biol. 2019 Aug;26(8):679-685. doi: 10.1038/s41594-019-0258-2. Epub 2019 Jul 8. PubMed |
| Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome. Forsberg KJ, Bhatt IV, Schmidtke DT, Javanmardi K, Dillard KE, Stoddard BL, Finkelstein IJ, Kaiser BK, Malik HS. Elife. 2019 Sep 10;8. pii: 46540. doi: 10.7554/eLife.46540. PubMed |
| Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish. Sommer F, Torraca V, Kamel SM, Lombardi A, Meijer AH. J Leukoc Biol. 2020 Feb;107(2):185-203. doi: 10.1002/JLB.2HI0119-006R. Epub 2019 Sep 17. PubMed |
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs.
Kulcsar PI, Talas A, Toth E, Nyeste A, Ligeti Z, Welker Z, Welker E.
Nat Commun. 2020 Mar 6;11(1):1223. doi: 10.1038/s41467-020-15021-5.
PubMed
Associated Plasmids
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| Application of Tris-HCl Allows the Specific Labeling of Regularly Prepared Chromosomes by CRISPR-FISH. Potlapalli BP, Schubert V, Metje-Sprink J, Liehr T, Houben A. Cytogenet Genome Res. 2020;160(3):156-165. doi: 10.1159/000506720. Epub 2020 Mar 21. PubMed |
| Systematic in vitro specificity profiling reveals nicking defects in natural and engineered CRISPR-Cas9 variants. Murugan K, Suresh SK, Seetharam AS, Severin AJ, Sashital DG. Nucleic Acids Res. 2021 Apr 19;49(7):4037-4053. doi: 10.1093/nar/gkab163. PubMed |
| The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity. Forsberg KJ, Schmidtke DT, Werther R, Uribe RV, Hausman D, Sommer MOA, Stoddard BL, Kaiser BK, Malik HS. PLoS Biol. 2021 Oct 13;19(10):e3001428. doi: 10.1371/journal.pbio.3001428. eCollection 2021 Oct. PubMed |
| Probing the stability of the SpCas9-DNA complex after cleavage. Aldag P, Welzel F, Jakob L, Schmidbauer A, Rutkauskas M, Fettes F, Grohmann D, Seidel R. Nucleic Acids Res. 2021 Dec 2;49(21):12411-12421. doi: 10.1093/nar/gkab1072. PubMed |
| Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences. Krysler AR, Cromwell CR, Tu T, Jovel J, Hubbard BP. Nat Commun. 2022 Mar 25;13(1):1617. doi: 10.1038/s41467-022-29202-x. PubMed |
| Thermodynamic Swings: How Ideal Complex of Cas9-RNA/DNA Forms. Zhdanova PV, Lomzov AA, Prokhorova DV, Stepanov GA, Chernonosov AA, Koval VV. Int J Mol Sci. 2022 Aug 10;23(16):8891. doi: 10.3390/ijms23168891. PubMed |
| Natural Nucleoside Modifications in Guide RNAs Can Modulate the Activity of the CRISPR-Cas9 System In Vitro. Prokhorova DV, Vokhtantsev IP, Tolstova PO, Zhuravlev ES, Kulishova LM, Zharkov DO, Stepanov GA. CRISPR J. 2022 Dec;5(6):799-812. doi: 10.1089/crispr.2022.0069. Epub 2022 Nov 9. PubMed |
| Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage. Sun R, Zhao Y, Wang W, Liu JG, Chen C. Chem Sci. 2023 Mar 10;14(14):3839-3851. doi: 10.1039/d2sc05463a. eCollection 2023 Apr 5. PubMed |
A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets.
Kulcsar PI, Talas A, Ligeti Z, Toth E, Rakvacs Z, Bartos Z, Krausz SL, Welker A, Vegi VL, Huszar K, Welker E.
Nat Commun. 2023 Sep 16;14(1):5746. doi: 10.1038/s41467-023-41393-5.
PubMed
Associated Plasmids |
| Cas9 is mostly orthogonal to human systems of DNA break sensing and repair. Maltseva EA, Vasil'eva IA, Moor NA, Kim DV, Dyrkheeva NS, Kutuzov MM, Vokhtantsev IP, Kulishova LM, Zharkov DO, Lavrik OI. PLoS One. 2023 Nov 29;18(11):e0294683. doi: 10.1371/journal.pone.0294683. eCollection 2023. PubMed |
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