Cas9m4-VP64 Citations (13)
Originally described in: CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering.Mali P, Aach J, Stranges PB, Esvelt KM, Moosburner M, Kosuri S, Yang L, Church GM Nat Biotechnol. 2013 Aug 1. doi: 10.1038/nbt.2675. PubMed Journal
Articles Citing Cas9m4-VP64
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| Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Gao X, Tsang JC, Gaba F, Wu D, Lu L, Liu P. Nucleic Acids Res. 2014 Nov 10;42(20):e155. doi: 10.1093/nar/gku836. Epub 2014 Sep 15. PubMed |
Highly efficient Cas9-mediated transcriptional programming.
Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.
Nat Methods. 2015 Mar 2. doi: 10.1038/nmeth.3312.
PubMed
Associated Plasmids |
| Engineering Synthetic Gene Circuits in Living Cells with CRISPR Technology. Jusiak B, Cleto S, Perez-Pinera P, Lu TK. Trends Biotechnol. 2016 Jan 22. pii: S0167-7799(15)00274-7. doi: 10.1016/j.tibtech.2015.12.014. PubMed |
Comparison of Cas9 activators in multiple species.
Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G.
Nat Methods. 2016 May 23. doi: 10.1038/nmeth.3871.
PubMed
Associated Plasmids |
| Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs. Ferry QR, Lyutova R, Fulga TA. Nat Commun. 2017 Mar 3;8:14633. doi: 10.1038/ncomms14633. PubMed |
Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo.
Williams RM, Senanayake U, Artibani M, Taylor G, Wells D, Ahmed AA, Sauka-Spengler T.
Development. 2018 Feb 23;145(4). pii: dev.160333. doi: 10.1242/dev.160333.
PubMed
Associated Plasmids |
| Aptazyme-mediated direct modulation of post-transcriptional sgRNA level for conditional genome editing and gene expression. Chen H, Li Y, Du C, Li Y, Zhao J, Zheng X, Mao Q, Xia H. J Biotechnol. 2018 Dec 20;288:23-29. doi: 10.1016/j.jbiotec.2018.10.011. Epub 2018 Nov 1. PubMed |
| dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice. Colasante G, Lignani G, Brusco S, Di Berardino C, Carpenter J, Giannelli S, Valassina N, Bido S, Ricci R, Castoldi V, Marenna S, Church T, Massimino L, Morabito G, Benfenati F, Schorge S, Leocani L, Kullmann DM, Broccoli V. Mol Ther. 2020 Jan 8;28(1):235-253. doi: 10.1016/j.ymthe.2019.08.018. Epub 2019 Sep 3. PubMed |
| In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy. Colasante G, Qiu Y, Massimino L, Di Berardino C, Cornford JH, Snowball A, Weston M, Jones SP, Giannelli S, Lieb A, Schorge S, Kullmann DM, Broccoli V, Lignani G. Brain. 2020 Mar 1;143(3):891-905. doi: 10.1093/brain/awaa045. PubMed |
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
Bohm S, Splith V, Riedmayr LM, Rotzer RD, Gasparoni G, Nordstrom KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E.
Sci Adv. 2020 Aug 19;6(34):eaba5614. doi: 10.1126/sciadv.aba5614. eCollection 2020 Aug.
PubMed
Associated Plasmids |
| Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Velazquez JJ, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore JC, Hislop J, Liu S, Cats D, Chuva de Sousa Lopes SM, Plaisier C, Cahan P, Kiani S, Ebrahimkhani MR. Cell Syst. 2021 Jan 20;12(1):41-55.e11. doi: 10.1016/j.cels.2020.11.002. Epub 2020 Dec 7. PubMed |
| Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells. Honda T, Nishikawa Y, Nishimura K, Teng D, Takemoto K, Ueda K. Sci Rep. 2020 Dec 17;10(1):22136. doi: 10.1038/s41598-020-79197-y. PubMed |
| Modular cytosine base editing promotes epigenomic and genomic modifications. Weischedel J, Higgins L, Rogers S, Gramalla-Schmitz A, Wyrzykowska P, Borgoni S, MacCarthy T, Chahwan R. Nucleic Acids Res. 2024 Jan 25;52(2):e8. doi: 10.1093/nar/gkad1118. PubMed |
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