pUC57-sgRNA expression vector Citations (100)
Originally described in: Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC Nat Methods. 2014 Mar 2. doi: 10.1038/nmeth.2857. PubMed Journal
Articles Citing pUC57-sgRNA expression vector
| Articles |
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| An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S, Tian Y. Sci Rep. 2014 Sep 19;4:6420. doi: 10.1038/srep06420. PubMed |
Mouse Genome Editing Using the CRISPR/Cas System.
Harms DW, Quadros RM, Seruggia D, Ohtsuka M, Takahashi G, Montoliu L, Gurumurthy CB.
Curr Protoc Hum Genet. 2014 Oct 1;83:15.7.1-15.7.27. doi: 10.1002/0471142905.hg1507s83.
PubMed
Associated Plasmids |
| Insertion of sequences at the original provirus integration site of mouse ROSA26 locus using the CRISPR/Cas9 system. Quadros RM, Harms DW, Ohtsuka M, Gurumurthy CB. FEBS Open Bio. 2015 Mar 10;5:191-7. doi: 10.1016/j.fob.2015.03.003. eCollection 2015. PubMed |
| GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice. Takahashi G, Gurumurthy CB, Wada K, Miura H, Sato M, Ohtsuka M. Sci Rep. 2015 Jun 22;5:11406. doi: 10.1038/srep11406. PubMed |
| CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA. Miura H, Gurumurthy CB, Sato T, Sato M, Ohtsuka M. Sci Rep. 2015 Aug 5;5:12799. doi: 10.1038/srep12799. PubMed |
| Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System. Bao D, Ma Y, Zhang X, Guan F, Chen W, Gao K, Qin C, Zhang L. Sci Rep. 2015 Nov 5;5:15942. doi: 10.1038/srep15942. PubMed |
| Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling. Miao R, Lu Y, Xing X, Li Y, Huang Z, Zhong H, Huang Y, Chen AF, Tang X, Li H, Cai J, Yuan H. Hypertension. 2016 Jan;67(1):86-98. doi: 10.1161/HYPERTENSIONAHA.115.05957. Epub 2015 Nov 16. PubMed |
| Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy. He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J. Hypertension. 2016 Jun;67(6):1237-48. doi: 10.1161/HYPERTENSIONAHA.116.07392. Epub 2016 Apr 4. PubMed |
| Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy. Huang J, Chen L, Yao Y, Tang C, Ding J, Fu C, Li H, Ma G. Hypertension. 2016 Jun;67(6):1228-36. doi: 10.1161/HYPERTENSIONAHA.115.06877. Epub 2016 Apr 18. PubMed |
| Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein. Ma Y, Chen W, Zhang X, Yu L, Dong W, Pan S, Gao S, Huang X, Zhang L. RNA Biol. 2016 Jul 2;13(7):605-612. Epub 2016 May 10. PubMed |
| Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK-ERK1/2 signalling pathway. Li Y, Tang XH, Li XH, Dai HJ, Miao RJ, Cai JJ, Huang ZJ, Chen AF, Xing XW, Lu Y, Yuan H. Basic Res Cardiol. 2016 Jul;111(4):47. doi: 10.1007/s00395-016-0566-1. Epub 2016 Jun 13. PubMed |
| Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system. Bevacqua RJ, Fernandez-Martin R, Savy V, Canel NG, Gismondi MI, Kues WA, Carlson DF, Fahrenkrug SC, Niemann H, Taboga OA, Ferraris S, Salamone DF. Theriogenology. 2016 Nov;86(8):1886-1896.e1. doi: 10.1016/j.theriogenology.2016.06.010. Epub 2016 Jun 15. PubMed |
| Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling. Ying X, Zhao Y, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J, He B. Hypertension. 2016 Nov;68(5):1160-1170. doi: 10.1161/HYPERTENSIONAHA.116.07562. Epub 2016 Aug 29. PubMed |
| Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload. Li WM, Zhao YF, Zhu GF, Peng WH, Zhu MY, Yu XJ, Chen W, Xu DC, Xu YW. Clin Sci (Lond). 2017 Jan 1;131(2):141-154. doi: 10.1042/CS20160664. Epub 2016 Oct 4. PubMed |
| Smad Nuclear Interacting Protein 1 Acts as a Protective Regulator of Pressure Overload-Induced Pathological Cardiac Hypertrophy. Lu YY, Xu DC, Zhao YF, Zhu GF, Zhu MY, Liu WJ, Yu XJ, Chen W, Liu Z, Xu YW. J Am Heart Assoc. 2016 Oct 26;5(11). pii: e003943. PubMed |
| Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection. Li Z, Zhou C, Tan L, Chen P, Cao Y, Li C, Li X, Yan J, Zeng H, Wang DW, Wang DW. Sci China Life Sci. 2017 Jan;60(1):57-65. doi: 10.1007/s11427-016-0333-3. Epub 2016 Dec 13. PubMed |
| ZNF307 (Zinc Finger Protein 307) Acts as a Negative Regulator of Pressure Overload-Induced Cardiac Hypertrophy. Yu CJ, Liang C, Li YX, Hu QQ, Zheng WW, Niu N, Yang X, Wang ZR, Yu XD, Zhang BL, Song BL, Zhang ZR. Hypertension. 2017 Apr;69(4):615-624. doi: 10.1161/HYPERTENSIONAHA.116.08500. Epub 2017 Feb 21. PubMed |
| Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy. Tang K, Zhao Y, Li H, Zhu M, Li W, Liu W, Zhu G, Xu D, Peng W, Xu YW. J Am Heart Assoc. 2017 Apr 21;6(4). pii: e004346. doi: 10.1161/JAHA.116.004346. PubMed |
| RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Jiang L, Li T, Zhang X, Zhang B, Yu C, Li Y, Fan S, Jiang X, Khan T, Hao Q, Xu P, Nadano D, Huleihel M, Lunenfeld E, Wang PJ, Zhang Y, Shi Q. Curr Biol. 2017 May 22;27(10):1498-1505.e6. doi: 10.1016/j.cub.2017.04.017. Epub 2017 May 11. PubMed |
| Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response. Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, Hu Y, Wu J, Cao X. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8620-8625. doi: 10.1073/pnas.1700917114. Epub 2017 Jul 24. PubMed |
| CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing. Ma Y, Yu L, Pan S, Gao S, Chen W, Zhang X, Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L, Zhang L. FEBS J. 2017 Oct;284(19):3262-3277. doi: 10.1111/febs.14188. Epub 2017 Sep 19. PubMed |
| Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis. Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C. Cell Res. 2017 Sep;27(9):1115-1127. doi: 10.1038/cr.2017.99. Epub 2017 Aug 15. PubMed |
| Building Cre Knockin Rat Lines Using CRISPR/Cas9. Ma Y, Zhang L, Huang X. Methods Mol Biol. 2017;1642:37-52. doi: 10.1007/978-1-4939-7169-5_3. PubMed |
| MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction. Chen X, Zhou L, Peng N, Yu H, Li M, Cao Z, Lin Y, Wang X, Li Q, Wang J, She Y, Zhu C, Lu M, Zhu Y, Liu S. J Biol Chem. 2017 Dec 29;292(52):21291-21303. doi: 10.1074/jbc.M117.805937. Epub 2017 Oct 18. PubMed |
| Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis. Pan L, Sheng M, Huang Z, Zhu Z, Xu C, Teng L, He L, Gu C, Yi C, Li J. PLoS One. 2017 Oct 24;12(10):e0186635. doi: 10.1371/journal.pone.0186635. eCollection 2017. PubMed |
| i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases. Ohtsuka M, Sato M, Miura H, Takabayashi S, Matsuyama M, Koyano T, Arifin N, Nakamura S, Wada K, Gurumurthy CB. Genome Biol. 2018 Feb 26;19(1):25. doi: 10.1186/s13059-018-1400-x. PubMed |
| Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice. Liu YM, Liu W, Jia JS, Chen BZ, Chen HW, Liu Y, Bie YN, Gu P, Sun Y, Xiao D, Gu WW. J Transl Med. 2018 May 25;16(1):141. doi: 10.1186/s12967-018-1512-9. PubMed |
| The transcription factor SOX30 is a key regulator of mouse spermiogenesis. Zhang D, Xie D, Lin X, Ma L, Chen J, Zhang D, Wang Y, Duo S, Feng Y, Zheng C, Jiang B, Ning Y, Han C. Development. 2018 May 30;145(11). pii: 145/11/dev164723. doi: 10.1242/dev.164723. PubMed |
| Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S. Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. PubMed |
| Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, Cheng L, Tan H, Liu X, Guo Y, Zhang Y, Xie J, He W, Wang Y, Feng H, Xin C, Zhang J, Lin M, Shen B, Sun Z, Guo X, Zheng K, Ye L. Development. 2018 Jul 4;145(13). pii: dev.164855. doi: 10.1242/dev.164855. PubMed |
Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing.
Liu Z, Lu Z, Yang G, Huang S, Li G, Feng S, Liu Y, Li J, Yu W, Zhang Y, Chen J, Sun Q, Huang X.
Nat Commun. 2018 Jun 14;9(1):2338. doi: 10.1038/s41467-018-04768-7.
PubMed
Associated Plasmids |
| Glycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy. Tokuhiro K, Dean J. Dev Cell. 2018 Sep 10;46(5):627-640.e5. doi: 10.1016/j.devcel.2018.07.020. Epub 2018 Aug 16. PubMed |
| Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos. Zeng Y, Li J, Li G, Huang S, Yu W, Zhang Y, Chen D, Chen J, Liu J, Huang X. Mol Ther. 2018 Nov 7;26(11):2631-2637. doi: 10.1016/j.ymthe.2018.08.007. Epub 2018 Aug 14. PubMed |
| CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure. Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP. J Biol Chem. 2018 Nov 2;293(44):17291-17305. doi: 10.1074/jbc.RA118.004554. Epub 2018 Sep 6. PubMed |
| Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage. Bai L, Shi G, Ma Y, Zhang L, Guan F, Zhang X, Xu Y, Chen H, Zhang L. Sci Rep. 2018 Sep 27;8(1):14457. doi: 10.1038/s41598-018-32780-w. PubMed |
| Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. Wang L, Sun ZS, Xiang B, Wei CJ, Wang Y, Sun K, Chen G, Lan MS, Carmona GN, Notkins AL, Cai T. J Transl Med. 2018 Oct 25;16(1):297. doi: 10.1186/s12967-018-1665-6. PubMed |
| m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1. Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T. Nature. 2018 Nov;563(7730):249-253. doi: 10.1038/s41586-018-0666-1. Epub 2018 Oct 31. PubMed |
| Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells. Zhang T, Chen P, Li W, Sha S, Wang Y, Yuan Z, Shen B, Chen L. Glia. 2019 Apr;67(4):688-702. doi: 10.1002/glia.23565. Epub 2018 Nov 28. PubMed |
| Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development. Lee YS, Kim TY, Kim Y, Lee SH, Kim S, Kang SW, Yang JY, Baek IJ, Sung YH, Park YY, Hwang SW, O E, Kim KS, Liu S, Kamada N, Gao N, Kweon MN. Cell Host Microbe. 2018 Dec 12;24(6):833-846.e6. doi: 10.1016/j.chom.2018.11.002. PubMed |
| PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA. Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30. PubMed |
| Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy. Xu D, Zhao Y, Weng X, Lu Y, Li W, Tang K, Chen W, Liu Z, Qi X, Zheng J, Fassett J, Zhang Y, Xu Y. J Mol Cell Cardiol. 2019 Mar;128:105-116. doi: 10.1016/j.yjmcc.2019.01.025. Epub 2019 Jan 29. PubMed |
| Label-Free LC-MS/MS Proteomics Analyses Reveal Proteomic Changes Accompanying MSTN KO in C2C12 Cells. Wang L, Huang Y, Wang X, Chen Y. Biomed Res Int. 2019 Apr 3;2019:7052456. doi: 10.1155/2019/7052456. eCollection 2019. PubMed |
| Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase. Yuan Z, Chen P, Zhang T, Shen B, Chen L. Cells. 2019 Jun 6;8(6). pii: cells8060552. doi: 10.3390/cells8060552. PubMed |
| Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair. Li G, Zhou S, Li C, Cai B, Yu H, Ma B, Huang Y, Ding Y, Liu Y, Ding Q, He C, Zhou J, Wang Y, Zhou G, Li Y, Yan Y, Hua J, Petersen B, Jiang Y, Sonstegard T, Huang X, Chen Y, Wang X. FEBS J. 2019 Jul 5. doi: 10.1111/febs.14983. PubMed |
| Efficient Generation of Pathogenic A-to-G Mutations in Human Tripronuclear Embryos via ABE-Mediated Base Editing. Li G, Liu X, Huang S, Zeng Y, Yang G, Lu Z, Zhang Y, Ma X, Wang L, Huang X, Liu J. Mol Ther Nucleic Acids. 2019 Jun 5;17:289-296. doi: 10.1016/j.omtn.2019.05.021. PubMed |
| P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed |
| Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. Wang D, Zheng X, Fu B, Nian Z, Qian Y, Sun R, Tian Z, Wei H. EBioMedicine. 2019 Aug;46:119-132. doi: 10.1016/j.ebiom.2019.07.058. Epub 2019 Jul 30. PubMed |
| Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors. Liu X, Li G, Zhou X, Qiao Y, Wang R, Tang S, Liu J, Wang L, Huang X. Mol Ther Nucleic Acids. 2019 Sep 6;17:626-635. doi: 10.1016/j.omtn.2019.06.024. Epub 2019 Jul 12. PubMed |
| Roles of the hypoximir microRNA-424/322 in acute hypoxia and hypoxia-induced pulmonary vascular leakage. Tsai SH, Huang PH, Tsai HY, Hsu YJ, Chen YW, Wang JC, Chen YH, Lin SJ. FASEB J. 2019 Nov;33(11):12565-12575. doi: 10.1096/fj.201900564RR. Epub 2019 Aug 28. PubMed |
| Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex. Chen P, Zhang T, Yuan Z, Shen B, Chen L. Mol Brain. 2019 Aug 28;12(1):74. doi: 10.1186/s13041-019-0496-6. PubMed |
| Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization. Roesler MK, Lombino FL, Freitag S, Schweizer M, Hermans-Borgmeyer I, Schwarz JR, Kneussel M, Wagner W. Front Cell Neurosci. 2019 Aug 13;13:330. doi: 10.3389/fncel.2019.00330. eCollection 2019. PubMed |
| A DNAH17 missense variant causes flagella destabilization and asthenozoospermia. Zhang B, Ma H, Khan T, Ma A, Li T, Zhang H, Gao J, Zhou J, Li Y, Yu C, Bao J, Ali A, Murtaza G, Yin H, Gao Q, Jiang X, Zhang F, Liu C, Khan I, Zubair M, Hussain HMJ, Khan R, Yousaf A, Yuan L, Lu Y, Xu X, Wang Y, Tao Q, Hao Q, Fang H, Cheng H, Zhang Y, Shi Q. J Exp Med. 2020 Feb 3;217(2). pii: jem.20182365. doi: 10.1084/jem.20182365. PubMed |
| Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. Utsunomiya A, Chino T, Utsunomiya N, Luong VH, Tokuriki A, Naganuma T, Arita M, Higashi K, Saito K, Suzuki N, Ohara A, Sugai M, Sugawara K, Tsuruta D, Oyama N, Hasegawa M. J Invest Dermatol. 2019 Oct 25. pii: S0022-202X(19)33303-2. doi: 10.1016/j.jid.2019.09.011. PubMed |
| Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y, Fan Z. J Exp Med. 2020 Feb 3;217(2). pii: jem.20190974. doi: 10.1084/jem.20190974. PubMed |
| Diurnal oscillations of endogenous H2O2 sustained by p66(Shc) regulate circadian clocks. Pei JF, Li XK, Li WQ, Gao Q, Zhang Y, Wang XM, Fu JQ, Cui SS, Qu JH, Zhao X, Hao DL, Ju D, Liu N, Carroll KS, Yang J, Zhang EE, Cao JM, Chen HZ, Liu DP. Nat Cell Biol. 2019 Dec;21(12):1553-1564. doi: 10.1038/s41556-019-0420-4. Epub 2019 Nov 25. PubMed |
| Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys. Luo X, He Y, Zhang C, He X, Yan L, Li M, Hu T, Hu Y, Jiang J, Meng X, Ji W, Zhao X, Zheng P, Xu S, Su B. Nat Commun. 2019 Dec 4;10(1):5525. doi: 10.1038/s41467-019-13481-y. PubMed |
| CD47 Deficiency Attenuates Isoproterenol-Induced Cardiac Remodeling in Mice. Zuo Z, Ji MY, Zhao K, Su ZP, Li P, Hou DR, Li Y. Oxid Med Cell Longev. 2019 Nov 19;2019:7121763. doi: 10.1155/2019/7121763. eCollection 2019. PubMed |
| CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains. Lleres D, Moindrot B, Pathak R, Piras V, Matelot M, Pignard B, Marchand A, Poncelet M, Perrin A, Tellier V, Feil R, Noordermeer D. Genome Biol. 2019 Dec 12;20(1):272. doi: 10.1186/s13059-019-1896-8. PubMed |
| Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation. Wang X, Liu Z, Li G, Dang L, Huang S, He L, Ma Y, Li C, Liu M, Yang G, Huang X, Zhou F, Ma X. Mol Ther. 2020 Feb 5;28(2):431-440. doi: 10.1016/j.ymthe.2019.11.022. Epub 2019 Nov 29. PubMed |
| Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis. Rolvien T, Yorgan TA, Kornak U, Hermans-Borgmeyer I, Mundlos S, Schmidt T, Niemeier A, Schinke T, Amling M, Oheim R. Osteoarthritis Cartilage. 2020 Mar;28(3):334-343. doi: 10.1016/j.joca.2019.12.011. Epub 2020 Jan 17. PubMed |
| CRLS1 ameliorates nonalcoholic steatohepatitis through ATF3 transcriptional inactivation. Tu C, Xiong H, Hu Y, Wang W, Mei G, Wang H, Li Y, Zhou Z, Meng F, Zhang P, Mei Z. Hepatology. 2020 Feb 25. doi: 10.1002/hep.31202. PubMed |
| Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator. Yang N, Smyllie NJ, Morris H, Goncalves CF, Dudek M, Pathiranage DRJ, Chesham JE, Adamson A, Spiller DG, Zindy E, Bagnall J, Humphreys N, Hoyland J, Loudon ASI, Hastings MH, Meng QJ. PLoS Genet. 2020 Apr 30;16(4):e1008729. doi: 10.1371/journal.pgen.1008729. eCollection 2020 Apr. PubMed |
| Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss. Oka A, Takagi A, Komiyama E, Yoshihara N, Mano S, Hosomichi K, Suzuki S, Haida Y, Motosugi N, Hatanaka T, Kimura M, Ueda MT, Nakagawa S, Miura H, Ohtsuka M, Tanaka M, Komiyama T, Otomo A, Hadano S, Mabuchi T, Beck S, Inoko H, Ikeda S. EBioMedicine. 2020 Jul;57:102810. doi: 10.1016/j.ebiom.2020.102810. Epub 2020 Jun 21. PubMed |
| Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis. Bottiglione F, Dee CT, Lea R, Zeef LAH, Badrock AP, Wane M, Bugeon L, Dallman MJ, Allen JE, Hurlstone AFL. J Immunol. 2020 Aug 15;205(4):994-1008. doi: 10.4049/jimmunol.2000372. Epub 2020 Jul 8. PubMed |
| NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity. Zhang X, Lei F, Wang XM, Deng KQ, Ji YX, Zhang Y, Li H, Zhang XD, Lu Z, Zhang P. J Am Heart Assoc. 2020 Aug 18;9(16):e016419. doi: 10.1161/JAHA.120.016419. Epub 2020 Aug 4. PubMed |
| A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis. Li ZG, Fu XM, Chai CY, Sun FF, Xiao FF, Huang YX, Yao K, Chen JP, Hou Y. Chin Med J (Engl). 2020 Aug 20;133(16):1943-1951. doi: 10.1097/CM9.0000000000000934. PubMed |
| Congestive heart failure in COX2 deficient rats. Wan Q, Kong D, Liu Q, Guo S, Wang C, Zhao Y, Ke ZJ, Yu Y. Sci China Life Sci. 2020 Sep 14. pii: 10.1007/s11427-020-1792-5. doi: 10.1007/s11427-020-1792-5. PubMed |
| FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. Hui X, Hu F, Liu J, Li C, Yang Y, Shu S, Liu P, Wang F, Li S. J Mol Cell Cardiol. 2021 Feb;151:31-43. doi: 10.1016/j.yjmcc.2020.09.008. Epub 2020 Sep 22. PubMed |
| MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancydagger. Bian X, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X, Wang YL. Biol Reprod. 2021 Feb 11;104(2):418-429. doi: 10.1093/biolre/ioaa187. PubMed |
| A Cas-embedding strategy for minimizing off-target effects of DNA base editors. Liu Y, Zhou C, Huang S, Dang L, Wei Y, He J, Zhou Y, Mao S, Tao W, Zhang Y, Yang H, Huang X, Chi T. Nat Commun. 2020 Nov 27;11(1):6073. doi: 10.1038/s41467-020-19690-0. PubMed |
| Multiplex gene targeting in the mouse embryo using a Cas9-Cpf1 hybrid guide RNA. Oh SH, Lee HJ, Ahn MK, Jeon MY, Yoon JS, Jung YJ, Kim GN, Baek IJ, Kim I, Kim KM, Sung YH. Biochem Biophys Res Commun. 2021 Feb 5;539:48-55. doi: 10.1016/j.bbrc.2020.12.072. Epub 2021 Jan 6. PubMed |
| A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. Liu C, Gao J, Cui X, Li Z, Chen L, Yuan Y, Zhang Y, Mei L, Zhao L, Cai D, Hu M, Zhou B, Li Z, Qin T, Si H, Li G, Lin Z, Xu Y, Zhu C, Yin Y, Zhang C, Xu W, Li Q, Wang K, Gilbert MTP, Heller R, Wang W, Huang J, Qiu Q. Sci Adv. 2021 Mar 17;7(12). pii: 7/12/eabe9459. doi: 10.1126/sciadv.abe9459. Print 2021 Mar. PubMed |
| LITAF acts as a novel regulator for pathological cardiac hypertrophy. Xiang M, Yang F, Zhou Y, Li W, Zou Y, Ye P, Zhu L, Wang PX, Chen M. J Mol Cell Cardiol. 2021 Jul;156:82-94. doi: 10.1016/j.yjmcc.2021.03.012. Epub 2021 Apr 3. PubMed |
| Mutations in RNA Methyltransferase Gene NSUN5 Confer High Risk of Outflow Tract Malformation. Wang Y, Jiang T, Xu J, Gu Y, Zhou Y, Lin Y, Wu Y, Li W, Wang C, Shen B, Mo X, Wang X, Zhou B, Ding C, Hu Z. Front Cell Dev Biol. 2021 Apr 21;9:623394. doi: 10.3389/fcell.2021.623394. eCollection 2021. PubMed |
| Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes. Liu X, Zhou X, Li G, Huang S, Sun W, Sun Q, Li L, Huang X, Liu J, Wang L. CRISPR J. 2021 Oct;4(5):710-727. doi: 10.1089/crispr.2021.0036. PubMed |
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