pcDNA3/Flag-METTL3 Citations (22)
Originally described in: A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C Nat Chem Biol. 2014 Feb;10(2):93-5. doi: 10.1038/nchembio.1432. Epub 2013 Dec 6. PubMed Journal
Articles Citing pcDNA3/Flag-METTL3
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| m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells. Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, He C, Shi Y. Cell Rep. 2017 Mar 14;18(11):2622-2634. doi: 10.1016/j.celrep.2017.02.059. PubMed |
| Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millan-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T. Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27. PubMed |
| Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus. Rodriguez Pulido M, Sanchez-Aparicio MT, Martinez-Salas E, Garcia-Sastre A, Sobrino F, Saiz M. PLoS Pathog. 2018 Jun 29;14(6):e1007135. doi: 10.1371/journal.ppat.1007135. eCollection 2018 Jun. PubMed |
| Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site. Selberg S, Blokhina D, Aatonen M, Koivisto P, Siltanen A, Mervaala E, Kankuri E, Karelson M. Cell Rep. 2019 Mar 26;26(13):3762-3771.e5. doi: 10.1016/j.celrep.2019.02.100. PubMed |
| Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed |
| mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation. Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J. Mol Cell. 2021 May 20;81(10):2064-2075.e8. doi: 10.1016/j.molcel.2021.03.010. Epub 2021 Mar 22. PubMed |
| mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis. Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. Mol Cell. 2021 May 20;81(10):2076-2093.e9. doi: 10.1016/j.molcel.2021.03.009. Epub 2021 Mar 22. PubMed |
| m(6)A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R. Nat Cell Biol. 2021 Apr;23(4):355-365. doi: 10.1038/s41556-021-00656-3. Epub 2021 Apr 1. PubMed |
| METTL3mediated m6A modification of Bcl2 mRNA promotes nonsmall cell lung cancer progression. Zhang Y, Liu S, Zhao T, Dang C. Oncol Rep. 2021 Aug;46(2). pii: 163. doi: 10.3892/or.2021.8114. Epub 2021 Jun 16. PubMed |
| Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Su X, Shen Y, Jin Y, Kim IM, Weintraub NL, Tang Y. Front Pharmacol. 2021 Aug 3;12:654316. doi: 10.3389/fphar.2021.654316. eCollection 2021. PubMed |
| METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events. Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X. Mol Neurodegener. 2021 Sep 30;16(1):70. doi: 10.1186/s13024-021-00484-x. PubMed |
| Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression. He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX. Cancer Cell Int. 2021 Nov 22;21(1):616. doi: 10.1186/s12935-021-02288-x. PubMed |
| Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease. Sebastian-delaCruz M, Olazagoitia-Garmendia A, Gonzalez-Moro I, Santin I, Garcia-Etxebarria K, Castellanos-Rubio A. Epigenomes. 2020 Aug 3;4(3):16. doi: 10.3390/epigenomes4030016. PubMed |
| Epitranscriptomic regulation of HIV-1 full-length RNA packaging. Pereira-Montecinos C, Toro-Ascuy D, Ananias-Saez C, Gaete-Argel A, Rojas-Fuentes C, Riquelme-Barrios S, Rojas-Araya B, Garcia-de-Gracia F, Aguilera-Cortes P, Chnaiderman J, Acevedo ML, Valiente-Echeverria F, Soto-Rifo R. Nucleic Acids Res. 2022 Feb 28;50(4):2302-2318. doi: 10.1093/nar/gkac062. PubMed |
| Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation. Han D, Longhini AP, Zhang X, Hoang V, Wilson MZ, Kosik KS. PLoS Biol. 2022 Feb 10;20(2):e3001535. doi: 10.1371/journal.pbio.3001535. eCollection 2022 Feb. PubMed |
| METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis. Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J. Nat Cell Biol. 2022 Feb;24(2):205-216. doi: 10.1038/s41556-021-00835-2. Epub 2022 Feb 10. PubMed |
| Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing. Cui X, Nilsson K, Kajitani N, Schwartz S. Virus Genes. 2022 Apr;58(2):98-112. doi: 10.1007/s11262-022-01889-6. Epub 2022 Feb 21. PubMed |
| APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly. Wang Q, Chen C, Xu X, Shu C, Cao C, Wang Z, Fu Y, Xu L, Xu K, Xu J, Xia A, Wang B, Xu G, Zou X, Su R, Kang W, Xue Y, Mo R, Sun B, Wang S. Adv Sci (Weinh). 2022 Oct;9(28):e2201889. doi: 10.1002/advs.202201889. Epub 2022 Aug 17. PubMed |
| RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis. Li Y, Wang NX, Yin C, Jiang SS, Li JC, Yang SY. Int J Mol Sci. 2022 Aug 25;23(17):9656. doi: 10.3390/ijms23179656. PubMed |
| Mettl3-mediated m(6)A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration. Jiang FQ, Liu K, Chen JX, Cao Y, Chen WY, Zhao WL, Song GH, Liang CQ, Zhou YM, Huang HL, Huang RJ, Zhao H, Park KS, Ju Z, Cai D, Qi XF. Elife. 2022 Nov 18;11:e77014. doi: 10.7554/eLife.77014. PubMed |
The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells.
Leoni C, Bataclan M, Ito-Kureha T, Heissmeyer V, Monticelli S.
Nat Commun. 2023 Jun 29;14(1):3862. doi: 10.1038/s41467-023-39614-y.
PubMed
Associated Plasmids |
| Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma. Guo S, Chen F, Li L, Dou S, Li Q, Huang Y, Li Z, Liu W, Zhang G. J Adv Res. 2023 Aug 22:S2090-1232(23)00229-1. doi: 10.1016/j.jare.2023.08.014. PubMed |
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