AAV:ITR-U6-sgRNA(backbone)-hSyn-Cre-2A-EGFP-KASH-WPRE-shortPA-ITR Citations (15)
Originally described in: CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F Cell. 2014 Sep 24. pii: S0092-8674(14)01163-5. doi: 10.1016/j.cell.2014.09.014. PubMed Journal
Articles Citing AAV:ITR-U6-sgRNA(backbone)-hSyn-Cre-2A-EGFP-KASH-WPRE-shortPA-ITR
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The Development of a Viral Mediated CRISPR/Cas9 System with Doxycycline Dependent gRNA Expression for Inducible In vitro and In vivo Genome Editing.
de Solis CA, Ho A, Holehonnur R, Ploski JE.
Front Mol Neurosci. 2016 Aug 18;9:70. doi: 10.3389/fnmol.2016.00070. eCollection 2016.
PubMed
Associated Plasmids |
| Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y, Fan Z. J Hepatol. 2018 Oct;69(4):861-872. doi: 10.1016/j.jhep.2018.03.029. Epub 2018 Apr 11. PubMed |
| LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z. Nat Cell Biol. 2018 Oct;20(10):1134-1144. doi: 10.1038/s41556-018-0194-0. Epub 2018 Sep 17. PubMed |
| CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice. Nishitani N, Ohmura Y, Nagayasu K, Shibui N, Kaneko S, Ohashi A, Yoshida T, Yamanaka A, Yoshioka M. Brain Res. 2019 Sep 15;1719:243-252. doi: 10.1016/j.brainres.2019.06.009. Epub 2019 Jun 10. PubMed |
Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.
Gao Y, Hisey E, Bradshaw TWA, Erata E, Brown WE, Courtland JL, Uezu A, Xiang Y, Diao Y, Soderling SH.
Neuron. 2019 Aug 21;103(4):583-597.e8. doi: 10.1016/j.neuron.2019.05.047. Epub 2019 Jul 1.
PubMed
Associated Plasmids |
| LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y, Fan Z. EMBO J. 2019 Sep 2;38(17):e101110. doi: 10.15252/embj.2018101110. Epub 2019 Jul 23. PubMed |
| Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. Gantz SC, Moussawi K, Hake HS. Elife. 2020 Apr 1;9. pii: 56054. doi: 10.7554/eLife.56054. PubMed |
| Differential Impact of Inhibitory G-Protein Signaling Pathways in Ventral Tegmental Area Dopamine Neurons on Behavioral Sensitivity to Cocaine and Morphine. DeBaker MC, Marron Fernandez de Velasco E, McCall NM, Lee AM, Wickman K. eNeuro. 2021 Mar 26;8(2). pii: ENEURO.0081-21.2021. doi: 10.1523/ENEURO.0081-21.2021. Print 2021 Mar-Apr. PubMed |
| Transgenic mice for in vivo epigenome editing with CRISPR-based systems. Gemberling MP, Siklenka K, Rodriguez E, Tonn-Eisinger KR, Barrera A, Liu F, Kantor A, Li L, Cigliola V, Hazlett MF, Williams CA, Bartelt LC, Madigan VJ, Bodle JC, Daniels H, Rouse DC, Hilton IB, Asokan A, Ciofani M, Poss KD, Reddy TE, West AE, Gersbach CA. Nat Methods. 2021 Aug;18(8):965-974. doi: 10.1038/s41592-021-01207-2. Epub 2021 Aug 2. PubMed |
| Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses. Feng B, Freitas AE, Gorodetski L, Wang J, Tian R, Lee YR, Grewal AS, Zou Y. Sci Adv. 2021 Aug 18;7(34). pii: 7/34/eabh2307. doi: 10.1126/sciadv.abh2307. Print 2021 Aug. PubMed |
| N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z. Nat Commun. 2021 Nov 2;12(1):6314. doi: 10.1038/s41467-021-26718-6. PubMed |
| Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum. Liu Z, Jiang M, Liakath-Ali K, Sclip A, Ko J, Zhang RS, Sudhof TC. Elife. 2022 Apr 14;11. pii: 70664. doi: 10.7554/eLife.70664. PubMed |
| Somatic genetics analysis of sleep in adult mice. Wang G, Li Q, Xu J, Zhao S, Zhou R, Chen Z, Jiang W, Gao X, Zhou S, Chen Z, Sun Q, Ma C, Chen L, Shi B, Guo Y, Wang H, Wang X, Li H, Cai T, Wang Y, Chen Z, Wang F, Liu Q. J Neurosci. 2022 Jun 3. pii: JNEUROSCI.0089-22.2022. doi: 10.1523/JNEUROSCI.0089-22.2022. PubMed |
| RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice. DeBaker MC, Mitten EH, Rose TR, Marron Fernandez de Velasco E, Gao R, Lee AM, Wickman K. Br J Pharmacol. 2023 Aug;180(16):2140-2155. doi: 10.1111/bph.16071. Epub 2023 Apr 13. PubMed |
Transcriptional linkage analysis with in vivo AAV-Perturb-seq.
Santinha AJ, Klingler E, Kuhn M, Farouni R, Lagler S, Kalamakis G, Lischetti U, Jabaudon D, Platt RJ.
Nature. 2023 Oct;622(7982):367-375. doi: 10.1038/s41586-023-06570-y. Epub 2023 Sep 20.
PubMed
Associated Plasmids |
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