pcDNA3-FLAG-MTOR-S2215Y Citations (6)
Originally described in: A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. PubMed Journal
Articles Citing pcDNA3-FLAG-MTOR-S2215Y
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| Negative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate. Kadoya M, Sasai N. Front Neurosci. 2019 Sep 25;13:1022. doi: 10.3389/fnins.2019.01022. eCollection 2019. PubMed |
| mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, Klingmuller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PubMed |
| Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors in Patients With De Novo EGFR(T790M)-Mutant NSCLC. Park HR, Kim TM, Lee Y, Kim S, Park S, Ju YS, Kim M, Keam B, Jeon YK, Kim DW, Heo DS. J Thorac Oncol. 2021 Jul 6. pii: S1556-0864(21)02254-1. doi: 10.1016/j.jtho.2021.06.013. PubMed |
| The transglutaminase 2 cancer cell survival factor maintains mTOR activity to drive an aggressive cancer phenotype. Chen X, Adhikary G, Newland JJ, Xu W, Ma E, Naselsky W, Eckert RL. Mol Carcinog. 2023 Jan;62(1):90-100. doi: 10.1002/mc.23446. Epub 2022 Jul 18. PubMed |
| mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Liu HJ, Du H, Khabibullin D, Zarei M, Wei K, Freeman GJ, Kwiatkowski DJ, Henske EP. Nat Commun. 2023 Mar 3;14(1):1214. doi: 10.1038/s41467-023-36881-7. PubMed |
| The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. Nguyen LH, Xu Y, Nair M, Bordey A. bioRxiv [Preprint]. 2024 Jan 6:2023.08.11.553034. doi: 10.1101/2023.08.11.553034. PubMed |
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