pPlatTET-gRNA2 Citations (23)
Originally described in: Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I Nat Biotechnol. 2016 Aug 29. doi: 10.1038/nbt.3658. PubMed Journal
Articles Citing pPlatTET-gRNA2
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| Editing of DNA Methylation Using dCas9-Peptide Repeat and scFv-TET1 Catalytic Domain Fusions. Morita S, Horii T, Hatada I. Methods Mol Biol. 2018;1767:419-428. doi: 10.1007/978-1-4939-7774-1_23. PubMed |
| Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Xiong L, Wu F, Wu Q, Xu L, Cheung OK, Kang W, Mok MT, Szeto LLM, Lun CY, Lung RW, Zhang J, Yu KH, Lee SD, Huang G, Wang CM, Liu J, Yu Z, Yu DY, Chou JL, Huang WH, Feng B, Cheung YS, Lai PB, Tan P, Wong N, Chan MW, Huang TH, Yip KY, Cheng AS, To KF. Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z. PubMed |
| Targeted demethylation of the SARI promotor impairs colon tumour growth. Wang Q, Dai L, Wang Y, Deng J, Lin Y, Wang Q, Fang C, Ma Z, Wang H, Shi G, Cheng L, Liu Y, Chen S, Li J, Dong Z, Su X, Yang L, Zhang S, Jiang M, Huang M, Yang Y, Yu D, Zhou Z, Wei Y, Deng H. Cancer Lett. 2019 Apr 28;448:132-143. doi: 10.1016/j.canlet.2019.01.040. Epub 2019 Feb 14. PubMed |
| Transposable elements drive widespread expression of oncogenes in human cancers. Jang HS, Shah NM, Du AY, Dailey ZZ, Pehrsson EC, Godoy PM, Zhang D, Li D, Xing X, Kim S, O'Donnell D, Gordon JI, Wang T. Nat Genet. 2019 Apr;51(4):611-617. doi: 10.1038/s41588-019-0373-3. Epub 2019 Mar 29. PubMed |
| Sequence-specific m6A demethylation in RNA by FTO fused to RCas9. Rau K, Roesner L, Rentmeister A. RNA. 2019 Jul 1. pii: rna.070706.119. doi: 10.1261/rna.070706.119. PubMed |
| Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome. Horii T, Morita S, Hino S, Kimura M, Hino Y, Kogo H, Nakao M, Hatada I. Genome Biol. 2020 Apr 1;21(1):77. doi: 10.1186/s13059-020-01991-8. PubMed |
| Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity. Dahlet T, Argueso Lleida A, Al Adhami H, Dumas M, Bender A, Ngondo RP, Tanguy M, Vallet J, Auclair G, Bardet AF, Weber M. Nat Commun. 2020 Jun 19;11(1):3153. doi: 10.1038/s41467-020-16919-w. PubMed |
| Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer. Dong Z, Dai L, Zhang Y, Fang C, Shi G, Chen Y, Li J, Wang Q, Fu J, Yu Y, Wang W, Cheng L, Liu Y, Lin Y, Wang Y, Wang Q, Wang H, Zhang H, Zhang Y, Su X, Zhang S, Wang F, Qiu M, Zhou Z, Deng H. PLoS Genet. 2020 Nov 11;16(11):e1009159. doi: 10.1371/journal.pgen.1009159. eCollection 2020 Nov. PubMed |
| Genomic Targeting of TET Activity for Targeted Demethylation Using CRISPR/Cas9. Nguyen TV, Lister R. Methods Mol Biol. 2021;2272:181-194. doi: 10.1007/978-1-0716-1294-1_10. PubMed |
| Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells. Hagihara Y, Asada S, Maeda T, Nakano T, Yamaguchi S. PLoS Genet. 2021 Jun 24;17(6):e1009646. doi: 10.1371/journal.pgen.1009646. eCollection 2021 Jun. PubMed |
| Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex. Koike Y, Sugai A, Hara N, Ito J, Yokoseki A, Ishihara T, Yamagishi T, Tsuboguchi S, Tada M, Ikeuchi T, Kakita A, Onodera O. Commun Biol. 2021 Sep 21;4(1):1107. doi: 10.1038/s42003-021-02621-0. PubMed |
Sequential enhancer state remodelling defines human germline competence and specification.
Tang WWC, Castillo-Venzor A, Gruhn WH, Kobayashi T, Penfold CA, Morgan MD, Sun D, Irie N, Surani MA.
Nat Cell Biol. 2022 Apr;24(4):448-460. doi: 10.1038/s41556-022-00878-z. Epub 2022 Apr 11.
PubMed
Associated Plasmids |
| Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression. Li Y, Liu B, Yin X, Jiang Z, Fang C, Chen N, Zhang B, Dai L, Yin Y. Clin Epigenetics. 2022 Jul 20;14(1):92. doi: 10.1186/s13148-022-01308-5. PubMed |
| Timing of MeCP2 Expression Determines Midbrain Dopamine Neuron Phenotype Specification. He XB, Guo F, Li K, Yan J, Lee SH. Stem Cells. 2022 Nov 29;40(11):1043-1055. doi: 10.1093/stmcls/sxac061. PubMed |
| mir152 hypomethylation as a mechanism for non-syndromic cleft lip and palate. Alvizi L, Brito LA, Kobayashi GS, Bischain B, da Silva CBF, Ramos SLG, Wang J, Passos-Bueno MR. Epigenetics. 2022 Dec;17(13):2278-2295. doi: 10.1080/15592294.2022.2115606. Epub 2022 Sep 1. PubMed |
| In Vivo Tissue-Specific DNA Demethylation in Mouse Liver Through a Hydrodynamic Tail Vein Injection. Hashimoto K, Hanzawa N. Methods Mol Biol. 2023;2577:269-277. doi: 10.1007/978-1-0716-2724-2_19. PubMed |
| Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system. Horii T, Morita S, Kimura M, Hatada I. Epigenetics Chromatin. 2022 Dec 16;15(1):40. doi: 10.1186/s13072-022-00474-3. PubMed |
| THOR is a targetable epigenetic biomarker with clinical implications in breast cancer. Apolonio JD, Dias JS, Fernandes MT, Komosa M, Lipman T, Zhang CH, Leao R, Lee D, Nunes NM, Maia AT, Morera JL, Vicioso L, Tabori U, Castelo-Branco P. Clin Epigenetics. 2022 Dec 18;14(1):178. doi: 10.1186/s13148-022-01396-3. PubMed |
| Unveiling the epigenomic mechanisms of acquired platinum-resistance in high-grade serous ovarian cancer. Silva R, Glennon K, Metoudi M, Moran B, Salta S, Slattery K, Treacy A, Martin T, Shaw J, Doran P, Lynch L, Jeronimo C, Perry AS, Brennan DJ. Int J Cancer. 2023 Jul 1;153(1):120-132. doi: 10.1002/ijc.34496. Epub 2023 Mar 20. PubMed |
| Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth. Yang B, Tang H, Wang N, Gu J, Wang Q. Cell Death Dis. 2023 Mar 25;14(3):210. doi: 10.1038/s41419-023-05743-x. PubMed |
| Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer. Yang L, Chen X, Lee C, Shi J, Lawrence EB, Zhang L, Li Y, Gao N, Jung SY, Creighton CJ, Li JJ, Cui Y, Arimura S, Lei Y, Li W, Shen L. J Exp Clin Cancer Res. 2023 May 4;42(1):113. doi: 10.1186/s13046-023-02689-y. PubMed |
| Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction. Alvizi L, Nani D, Brito LA, Kobayashi GS, Passos-Bueno MR, Mayor R. Nat Commun. 2023 May 24;14(1):2868. doi: 10.1038/s41467-023-38526-1. PubMed |
| DCAF1/VprBP triggers melanomagenic gene silencing through histone H2A phosphorylation. Shin Y, Kim S, Liang G, Ulmer TS, An W. Res Sq. 2023 May 25:rs.3.rs-2950076. doi: 10.21203/rs.3.rs-2950076/v1. Preprint. PubMed |
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