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pCMV-dR8.2 dvpr Citations (273)

Originally described in: Lentivirus-delivered stable gene silencing by RNAi in primary cells.
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501.
PubMed Journal

Articles Citing pCMV-dR8.2 dvpr

Articles
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, Kirken RA, Rui H. Mol Endocrinol. 2007 Sep . 21(9):2218-32. PubMed
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 2007 Dec 15. 67(24):11712-20. PubMed
Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. Blood. 2008 Aug 1;112(3):690-8. doi: 10.1182/blood-2008-02-141382. Epub 2008 May 28. PubMed
Generation of human-induced pluripotent stem cells. Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Nat Protoc. 2008 . 3(7):1180-6. PubMed
XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Kulkarni A, McNeill DR, Gleichmann M, Mattson MP, Wilson DM 3rd. Nucleic Acids Res. 2008 Sep;36(15):5111-21. doi: 10.1093/nar/gkn480. Epub 2008 Aug 5. PubMed
A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. PubMed
Human iPS cell derivation/reprogramming. Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2009 Jan . Chapter 4():Unit 4A.1. PubMed
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB. J Biol Chem. 2009 Apr 17;284(16):10334-42. doi: 10.1074/jbc.M808848200. Epub 2009 Feb 24. PubMed
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Ballif BA, Fingar DC. Mol Cell Biol. 2009 Jun 1. ():. PubMed
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. DuPage M, Dooley AL, Jacks T. Nat Protoc. 2009;4(7):1064-72. doi: 10.1038/nprot.2009.95. Epub 2009 Jun 25. PubMed
Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Hamid R, Brandt SJ. Mol Oncol. 2009 Dec;3(5-6):451-63. doi: 10.1016/j.molonc.2009.07.004. Epub 2009 Jul 29. PubMed
TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia. Costantini JL, Cheung SM, Hou S, Li H, Kung SK, Johnston JB, Wilkins JA, Gibson SB, Marshall AJ. Blood. 2009 Nov 19;114(21):4703-12. doi: 10.1182/blood-2009-03-213058. Epub 2009 Sep 28. PubMed
Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Tran TH, Utama FE, Lin J, Yang N, Sjolund AB, Ryder A, Johnson KJ, Neilson LM, Liu C, Brill KL, Rosenberg AL, Witkiewicz AK, Rui H. Cancer Res. 2010 Feb 15;70(4):1711-21. doi: 10.1158/0008-5472.CAN-09-2314. Epub 2010 Feb 2. PubMed
Exploration of self-renewal and pluripotency in ES cells using RNAi. Schaniel C, Lee DF, Lemischka IR. Methods Enzymol. 2010;477:351-65. doi: 10.1016/S0076-6879(10)77018-X. PubMed
PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Johnson KJ, Peck AR, Liu C, Tran TH, Utama FE, Sjolund AB, Schaber JD, Witkiewicz AK, Rui H. Am J Pathol. 2010 Dec;177(6):2971-83. doi: 10.2353/ajpath.2010.090399. Epub 2010 Oct 15. PubMed
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL. Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7. PubMed

Associated Plasmids

Therapy mediated by mitophagy abrogates tumor progression. Gargini R, Garcia-Escudero V, Izquierdo M. Autophagy. 2011 May;7(5):466-76. Epub 2011 May 1. PubMed
Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Ullah Z, de Renty C, DePamphilis ML. Mol Cell Biol. 2011 Oct;31(19):4129-43. doi: 10.1128/MCB.05723-11. Epub 2011 Jul 26. PubMed
Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells. Joshi JP, Brown NE, Griner SE, Nahta R. Biochem Pharmacol. 2011 Nov 1;82(9):1090-9. doi: 10.1016/j.bcp.2011.07.082. Epub 2011 Jul 23. PubMed
Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade J, Wachsmuth M, Hufnagel L, Knop M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. PubMed
GADD45A protein plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. Zhang RP, Shao JZ, Xiang LX. J Biol Chem. 2011 Nov 25;286(47):41083-94. doi: 10.1074/jbc.M111.258715. Epub 2011 Sep 14. PubMed
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW. Clin Cancer Res. 2012 Jan 15;18(2):408-16. doi: 10.1158/1078-0432.CCR-11-0946. Epub 2011 Oct 28. PubMed
Remodeling of the epitope repertoire of a candidate idiotype vaccine by targeting to lysosomal degradation in dendritic cells. Martorelli D, Coppotelli G, Muraro E, Dolcetti R, Masucci MG. Cancer Immunol Immunother. 2012 Jun;61(6):881-92. doi: 10.1007/s00262-011-1157-5. Epub 2011 Nov 17. PubMed
Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. PubMed
Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Wanka C, Brucker DP, Bahr O, Ronellenfitsch M, Weller M, Steinbach JP, Rieger J. Oncogene. 2012 Aug 16;31(33):3764-76. doi: 10.1038/onc.2011.530. Epub 2011 Nov 28. PubMed
The role of c-FLIP splice variants in urothelial tumours. Ewald F, Ueffing N, Brockmann L, Hader C, Telieps T, Schuster M, Schulz WA, Schmitz I. Cell Death Dis. 2011 Dec 22;2:e245. doi: 10.1038/cddis.2011.131. PubMed
Peroxisome proliferator-activated receptor beta/delta induces myogenesis by modulating myostatin activity. Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, McFarlane C, Kambadur R. J Biol Chem. 2012 Apr 13;287(16):12935-51. doi: 10.1074/jbc.M111.319145. Epub 2012 Feb 23. PubMed
Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018. PubMed
The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Singh DK, Popuri V, Kulikowicz T, Shevelev I, Ghosh AK, Ramamoorthy M, Rossi ML, Janscak P, Croteau DL, Bohr VA. Nucleic Acids Res. 2012 Aug;40(14):6632-48. doi: 10.1093/nar/gks349. Epub 2012 Apr 28. PubMed
Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2012;Chapter 4:Unit4A.5. doi: 10.1002/9780470151808.sc04a05s21. PubMed
Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. Yan X, Huang Y, Zhao JX, Rogers CJ, Zhu MJ, Ford SP, Nathanielsz PW, Du M. Int J Obes (Lond). 2013 Apr;37(4):568-75. doi: 10.1038/ijo.2012.69. Epub 2012 May 22. PubMed
gamma-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Seveno C, Loussouarn D, Brechet S, Campone M, Juin P, Barille-Nion S. Breast Cancer Res. 2012 Jun 15;14(3):R96. PubMed
The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee. Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T. Osteoarthritis Cartilage. 2012 Nov;20(11):1258-67. doi: 10.1016/j.joca.2012.07.013. Epub 2012 Jul 27. PubMed
Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion. Griner SE, Joshi JP, Nahta R. Biochem Pharmacol. 2013 Jan 1;85(1):46-58. doi: 10.1016/j.bcp.2012.10.007. Epub 2012 Oct 17. PubMed
Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed
Phytochemicals attenuating aberrant activation of beta-catenin in cancer cells. Wang D, Wise ML, Li F, Dey M. PLoS One. 2012;7(12):e50508. doi: 10.1371/journal.pone.0050508. Epub 2012 Dec 3. PubMed
High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. Shin YJ, Kim MS, Kim MS, Lee J, Kang M, Jeong JH. Cancer Biol Ther. 2013 Mar;14(3):213-21. doi: 10.4161/cbt.23292. Epub 2012 Dec 19. PubMed
On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S. Neuro Oncol. 2013 Feb;15(2):198-207. doi: 10.1093/neuonc/nos302. Epub 2012 Dec 21. PubMed
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8. PubMed
Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Zhang X, He Y, Lee KH, Dubois W, Li Z, Wu X, Kovalchuk A, Zhang W, Huang J. Cell Cycle. 2013 Apr 15;12(8):1279-91. doi: 10.4161/cc.24364. Epub 2013 Mar 27. PubMed
Pseudovirus-based neuraminidase inhibition assays reveal potential H5N1 drug-resistant mutations. Lu Y, Jiang T. Protein Cell. 2013 May;4(5):356-63. doi: 10.1007/s13238-013-2125-y. Epub 2013 Apr 15. PubMed
Evidence for tankyrases as antineoplastic targets in lung cancer. Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211. PubMed
The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA. Carcinogenesis. 2013 Oct;34(10):2218-30. doi: 10.1093/carcin/bgt183. Epub 2013 May 28. PubMed
Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. Munger SC, Natarajan A, Looger LL, Ohler U, Capel B. PLoS Genet. 2013;9(7):e1003630. doi: 10.1371/journal.pgen.1003630. Epub 2013 Jul 11. PubMed
BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma. Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW. BMC Cancer. 2013 Aug 5;13:371. doi: 10.1186/1471-2407-13-371. PubMed
Generation of porcine induced pluripotent stem cells and evaluation of their major histocompatibility complex protein expression in vitro. Park KM, Cha SH, Ahn C, Woo HM. Vet Res Commun. 2013 Dec;37(4):293-301. doi: 10.1007/s11259-013-9574-x. Epub 2013 Aug 23. PubMed
Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Li Z, Dong L, Dean E, Yang LV. Int J Mol Sci. 2013 Oct 11;14(10):20236-55. doi: 10.3390/ijms141020236. PubMed
PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed
TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Busch S, Acar A, Magnusson Y, Gregersson P, Ryden L, Landberg G. Oncogene. 2015 Jan 2;34(1):27-38. doi: 10.1038/onc.2013.527. Epub 2013 Dec 16. PubMed
Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R. J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. PubMed
All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. Cancer Biol Ther. 2014 Apr;15(4):463-72. doi: 10.4161/cbt.27821. Epub 2014 Feb 4. PubMed
Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed
Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. Iempridee T, Reusch JA, Riching A, Johannsen EC, Dovat S, Kenney SC, Mertz JE. J Virol. 2014 May;88(9):4811-27. doi: 10.1128/JVI.03706-13. Epub 2014 Feb 12. PubMed
Anoctamin 6 regulates C2C12 myoblast proliferation. Zhao P, Torcaso A, Mariano A, Xu L, Mohsin S, Zhao L, Han R. PLoS One. 2014 Mar 24;9(3):e92749. doi: 10.1371/journal.pone.0092749. eCollection 2014. PubMed

Associated Plasmids

Regulation of fibulin-2 gene expression by integrin alpha3beta1 contributes to the invasive phenotype of transformed keratinocytes. Missan DS, Chittur SV, DiPersio CM. J Invest Dermatol. 2014 Sep;134(9):2418-27. doi: 10.1038/jid.2014.166. Epub 2014 Apr 2. PubMed
Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kogel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bahr O. PLoS One. 2014 Apr 17;9(4):e94921. doi: 10.1371/journal.pone.0094921. eCollection 2014. PubMed
Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis. Wutka A, Palagani V, Barat S, Chen X, El Khatib M, Gotze J, Belahmer H, Zender S, Bozko P, Malek NP, Plentz RR. PLoS One. 2014 Apr 18;9(4):e95605. doi: 10.1371/journal.pone.0095605. eCollection 2014. PubMed
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F. Am J Hum Genet. 2014 May 1;94(5):790-7. doi: 10.1016/j.ajhg.2014.04.005. PubMed

Associated Plasmids

Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Cell. 2014 Aug 14;158(4):889-902. doi: 10.1016/j.cell.2014.07.021. PubMed
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Transl Psychiatry. 2014 Aug 26;4:e428. doi: 10.1038/tp.2014.72. PubMed
Kruppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. Trucco LD, Andreoli V, Nunez NG, Maccioni M, Bocco JL. FASEB J. 2014 Dec;28(12):5262-76. doi: 10.1096/fj.14-251884. Epub 2014 Sep 11. PubMed
PDGF-D expression is down-regulated by TGFbeta in fibroblasts. Charni Chaabane S, Coomans de Brachene A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB. PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014. PubMed
A platform for rapid prototyping of synthetic gene networks in mammalian cells. Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R. Nucleic Acids Res. 2014 Dec 1;42(21):13440-51. doi: 10.1093/nar/gku1082. Epub 2014 Nov 5. PubMed
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters. Reusch JA, Nawandar DM, Wright KL, Kenney SC, Mertz JE. J Virol. 2015 Feb;89(3):1731-43. doi: 10.1128/JVI.02781-14. Epub 2014 Nov 19. PubMed
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed
A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20. PubMed
Loss of TGFbeta Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance. Busch S, Sims AH, Stal O, Ferno M, Landberg G. Cancer Res. 2015 Apr 1;75(7):1457-69. doi: 10.1158/0008-5472.CAN-14-1583. PubMed
Proteasome inhibition enhances the killing effect of BikDD gene therapy. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Am J Transl Res. 2015 Feb 15;7(2):319-27. eCollection 2015. PubMed
MALT1 is required for EGFR-induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression. Pan D, Jiang C, Ma Z, Blonska M, You MJ, Lin X. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. PubMed
TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption. Witwicka H, Jia H, Kutikov A, Reyes-Gutierrez P, Li X, Odgren PR. PLoS One. 2015 May 19;10(5):e0127537. doi: 10.1371/journal.pone.0127537. eCollection 2015. PubMed

Associated Plasmids

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. PLoS Genet. 2015 May 28;11(5):e1005155. doi: 10.1371/journal.pgen.1005155. eCollection 2015 May. PubMed
Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. Zhang Y, Bao M, Dai M, Wang X, He W, Tan T, Lin D, Wang W, Wen Y, Zhang R. Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z. PubMed
Tumors escape CD4+ T cell-mediated immunosurveillance by impairing the ability of infiltrating macrophages to indirectly present tumor antigens. Tveita AA, Schjesvold F, Haabeth OA, Fauskanger MH, Bogen B. Cancer Res. 2015 Jun 2. pii: canres.3640.2014. PubMed
A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. Rubtsova SN, Zhitnyak IY, Gloushankova NA. PLoS One. 2015 Jul 24;10(7):e0133578. doi: 10.1371/journal.pone.0133578. eCollection 2015. PubMed
Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Wang B, Lee CW, Witt A, Thakkar A, Ince TA. Breast Cancer Res Treat. 2015 Aug;153(1):57-66. doi: 10.1007/s10549-015-3521-1. Epub 2015 Jul 30. PubMed
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery. Wroblewska L, Kitada T, Endo K, Siciliano V, Stillo B, Saito H, Weiss R. Nat Biotechnol. 2015 Aug 3. doi: 10.1038/nbt.3301. PubMed

Associated Plasmids

Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Zagani R, El-Assaad W, Gamache I, Teodoro JG. Oncotarget. 2015 Sep 29;6(29):28282-95. doi: 10.18632/oncotarget.5061. PubMed
The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. Basak P, Dillon R, Leslie H, Raouf A, Mowat MR. BMC Cancer. 2015 Sep 9;15:630. doi: 10.1186/s12885-015-1642-x. PubMed
miR-128 represses L1 retrotransposition by binding directly to L1 RNA. Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders KJ, Pedersen IM. Nat Struct Mol Biol. 2015 Oct;22(10):824-31. doi: 10.1038/nsmb.3090. Epub 2015 Sep 14. PubMed
Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin SL, Angsutararux P, Chanthra N, Voronkova M, Chen YC, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. Oncogene. 2015 Sep 21. doi: 10.1038/onc.2015.351. PubMed
Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-beta1 (TGF-beta1) to Orchestrate Second Heart Field Development. Lewandowski SL, Janardhan HP, Trivedi CM. J Biol Chem. 2015 Nov 6;290(45):27067-89. doi: 10.1074/jbc.M115.684753. Epub 2015 Sep 29. PubMed
NRF2 regulates serine biosynthesis in non-small cell lung cancer. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Nat Genet. 2015 Dec;47(12):1475-81. doi: 10.1038/ng.3421. Epub 2015 Oct 19. PubMed
CRISPR Technology for Genome Activation and Repression in Mammalian Cells. Du D, Qi LS. Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot090175. doi: 10.1101/pdb.prot090175. PubMed
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R. Nat Commun. 2016 Jan 6;7:10243. doi: 10.1038/ncomms10243. PubMed
Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential. Luchsinger LL, de Almeida MJ, Corrigan DJ, Mumau M, Snoeck HW. Nature. 2016 Jan 28;529(7587):528-31. doi: 10.1038/nature16500. Epub 2016 Jan 20. PubMed
Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells. Chanvorachote P, Luanpitpong S. Am J Physiol Cell Physiol. 2016 May 1;310(9):C728-39. doi: 10.1152/ajpcell.00322.2015. Epub 2016 Feb 24. PubMed
Viral Packaging and Cell Culture for CRISPR-Based Screens. Wang T, Lander ES, Sabatini DM. Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090811. doi: 10.1101/pdb.prot090811. PubMed
Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates. Song HY, Park SH, Kang HJ, Vassilopoulos A. J Vis Exp. 2016 Feb 27;(108). doi: 10.3791/53563. PubMed
Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity. Bauman Y, Drayman N, Ben-Nun-Shaul O, Vitenstein A, Yamin R, Ophir Y, Oppenheim A, Mandelboim O. Oncotarget. 2016 Mar 29;7(13):15369-81. doi: 10.18632/oncotarget.8085. PubMed
Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Jahani-Asl A, Yin H, Soleimani VD, Haque T, Luchman HA, Chang NC, Sincennes MC, Puram SV, Scott AM, Lorimer IA, Perkins TJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A. Nat Neurosci. 2016 Jun;19(6):798-806. doi: 10.1038/nn.4295. Epub 2016 Apr 25. PubMed
Pias1 is essential for erythroid and vascular development in the mouse embryo. Constanzo JD, Deng M, Rindhe S, Tang KJ, Zhang CC, Scaglioni PP. Dev Biol. 2016 Jul 1;415(1):98-110. doi: 10.1016/j.ydbio.2016.04.013. Epub 2016 May 4. PubMed
Measuring IL-1beta Processing by Bioluminescence Sensors II: The iGLuc System. Bartok E, Kampes M, Hornung V. Methods Mol Biol. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ. EMBO J. 2016 Jun 22. pii: e201694401. PubMed
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Du L, Li YJ, Fakih M, Wiatrek RL, Duldulao M, Chen Z, Chu P, Garcia-Aguilar J, Chen Y. Nat Commun. 2016 Jul 28;7:12326. doi: 10.1038/ncomms12326. PubMed
RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Eckfeldt CE, Pomeroy EJ, Lee RD, Hazen KS, Lee LA, Moriarity BS, Largaespada DA. Oncotarget. 2016 Oct 4;7(40):65147-65156. doi: 10.18632/oncotarget.11431. PubMed
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD. Stem Cell Reports. 2016 Sep 13;7(3):355-69. doi: 10.1016/j.stemcr.2016.07.018. Epub 2016 Aug 25. PubMed
Orphan G protein-coupled receptor GPRC5A modulates integrin beta1-mediated epithelial cell adhesion. Bulanova DR, Akimov YA, Rokka A, Laajala TD, Aittokallio T, Kouvonen P, Pellinen T, Kuznetsov SG. Cell Adh Migr. 2016 Oct 7:0. PubMed
Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice. Zhang Y, Fang X, Dai M, Cao Q, Tan T, He W, Huang Y, Chu L, Bao M. Obesity (Silver Spring). 2016 Dec;24(12):2533-2543. doi: 10.1002/oby.21665. Epub 2016 Nov 2. PubMed
PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y. Stem Cell Reports. 2016 Dec 13;7(6):1072-1086. doi: 10.1016/j.stemcr.2016.10.007. Epub 2016 Nov 17. PubMed
Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation. Marmisolle I, Martinez J, Liu J, Mastrogiovanni M, Fergusson MM, Rovira II, Castro L, Trostchansky A, Moreno M, Cao L, Finkel T, Quijano C. Arch Biochem Biophys. 2017 Jan 1;613:12-22. doi: 10.1016/j.abb.2016.10.016. Epub 2016 Oct 27. PubMed
Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Pomeroy EJ, Lee LA, Lee RD, Schirm DK, Temiz NA, Ma J, Gruber TA, Diaz-Flores E, Moriarity BS, Downing JR, Shannon KM, Largaespada DA, Eckfeldt CE. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.471. PubMed
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33. PubMed
A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity. Riddick G, Kotliarova S, Rodriguez V, Kim HS, Linkous A, Storaska AJ, Ahn S, Walling J, Belova G, Fine HA. Sci Rep. 2017 Mar 3;7:43605. doi: 10.1038/srep43605. PubMed
Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kalpha-selective Inhibitors in Breast Cancer. Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH. Theranostics. 2017 Feb 23;7(4):974-986. doi: 10.7150/thno.17830. eCollection 2017. PubMed
Lysine-specific demethylase-1 (LSD1) depletion disrupts monogenic and monoallelic odorant receptor (OR) expression in an olfactory neuronal cell line. Vyas RN, Meredith D, Lane RP. Mol Cell Neurosci. 2017 Jul;82:1-11. doi: 10.1016/j.mcn.2017.04.005. Epub 2017 Apr 13. PubMed
beta-catenin promotes intracellular bacterial killing via suppression of Pseudomonas aeruginosa-triggered macrophage autophagy. Fu Q, Chen K, Zhu Q, Wang W, Huang F, Miao L, Wu X. J Int Med Res. 2017 Apr;45(2):556-569. doi: 10.1177/0300060517692147. Epub 2017 Mar 21. PubMed
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. Quiros PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J. J Cell Biol. 2017 Jul 3;216(7):2027-2045. doi: 10.1083/jcb.201702058. Epub 2017 May 31. PubMed
Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells. Jaiswal A, Peddinti G, Akimov Y, Wennerberg K, Kuznetsov S, Tang J, Aittokallio T. Genome Med. 2017 Jun 1;9(1):51. doi: 10.1186/s13073-017-0440-2. PubMed
SOD2 Facilitates the Antiviral Innate Immune Response by Scavenging Reactive Oxygen Species. Wang W, Jin Y, Zeng N, Ruan Q, Qian F. Viral Immunol. 2017 Jun 2. doi: 10.1089/vim.2017.0043. PubMed
A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer. Zhao X, Wang X, Fang L, Lan C, Zheng X, Wang Y, Zhang Y, Han X, Liu S, Cheng K, Zhao Y, Shi J, Guo J, Hao J, Ren H, Nie G. Cancer Lett. 2017 Aug 28;402:61-70. doi: 10.1016/j.canlet.2017.05.015. Epub 2017 May 30. PubMed
Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PubMed
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK. Dev Cell. 2017 Jul 10;42(1):22-36.e12. doi: 10.1016/j.devcel.2017.05.016. Epub 2017 Jun 15. PubMed
RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. Carlson SM, Soulette CM, Yang Z, Elias JE, Brooks AN, Gozani O. J Biol Chem. 2017 Jun 27. pii: jbc.M117.784371. doi: 10.1074/jbc.M117.784371. PubMed
KIBRA attains oncogenic activity by repressing RASSF1A. Anuj, Arivazhagan L, Surabhi RP, Kanakarajan A, Sundaram S, Pitani RS, Mudduwa L, Kremerskothen J, Venkatraman G, Rayala SK. Br J Cancer. 2017 Jun 29. pii: bjc2017192. doi: 10.1038/bjc.2017.192. PubMed
DeltaNp73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report. Sakil HAM, Stantic M, Wolfsberger J, Brage SE, Hansson J, Wilhelm MT. Cell Oncol (Dordr). 2017 Dec;40(6):631-638. doi: 10.1007/s13402-017-0340-x. Epub 2017 Jul 4. PubMed
miR-151a induces partial EMT by regulating E-cadherin in NSCLC cells. Daugaard I, Sanders KJ, Idica A, Vittayarukskul K, Hamdorf M, Krog JD, Chow R, Jury D, Hansen LL, Hager H, Lamy P, Choi CL, Agalliu D, Zisoulis DG, Pedersen IM. Oncogenesis. 2017 Jul 31;6(7):e366. doi: 10.1038/oncsis.2017.66. PubMed
Identification of novel ALK2 inhibitors and their effect on cancer cells. Kim M, Choi O, Pyo S, Choi SU, Park CH. Biochem Biophys Res Commun. 2017 Oct 7;492(1):121-127. doi: 10.1016/j.bbrc.2017.08.016. Epub 2017 Aug 4. PubMed
Creating a RAW264.7 CRISPR-Cas9 Genome Wide Library. Napier BA, Monack DM. Bio Protoc. 2017 May 20;7(10). doi: 10.21769/BioProtoc.2320. PubMed
Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma. Luanpitpong S, Angsutararux P, Samart P, Chanthra N, Chanvorachote P, Issaragrisil S. Sci Rep. 2017 Sep 6;7(1):10607. doi: 10.1038/s41598-017-10886-x. PubMed
WNT/beta-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4. Hennig KM, Fass DM, Zhao WN, Sheridan SD, Fu T, Erdin S, Stortchevoi A, Lucente D, Cody JD, Sweetser D, Gusella JF, Talkowski ME, Haggarty SJ. Mol Neuropsychiatry. 2017 Jul;3(1):53-71. doi: 10.1159/000475666. Epub 2017 Jul 14. PubMed
Tethering IL2 to Its Receptor IL2Rbeta Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Jounaidi Y, Cotten JF, Miller KW, Forman SA. Cancer Res. 2017 Nov 1;77(21):5938-5951. doi: 10.1158/0008-5472.CAN-17-1007. Epub 2017 Sep 15. PubMed
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death. Thiepold AL, Lorenz NI, Foltyn M, Engel AL, Dive I, Urban H, Heller S, Bruns I, Hofmann U, Drose S, Harter PN, Mittelbronn M, Steinbach JP, Ronellenfitsch MW. Brain. 2017 Oct 1;140(10):2623-2638. doi: 10.1093/brain/awx196. PubMed
MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM. J Biol Chem. 2017 Dec 15;292(50):20494-20508. doi: 10.1074/jbc.M117.807677. Epub 2017 Oct 3. PubMed
Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Kraniak JM, Chalasani A, Wallace MR, Mattingly RR. Exp Neurol. 2018 Jan;299(Pt B):289-298. doi: 10.1016/j.expneurol.2017.10.012. Epub 2017 Oct 19. PubMed
Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential. Kidan N, Khamaisie H, Ruimi N, Roitman S, Eshel E, Dally N, Ruthardt M, Mahajna J. J Cancer. 2017 Oct 23;8(19):3952-3968. doi: 10.7150/jca.19633. eCollection 2017. PubMed
Live-cell measurements of kinase activity in single cells using translocation reporters. Kudo T, Jeknic S, Macklin DN, Akhter S, Hughey JJ, Regot S, Covert MW. Nat Protoc. 2018 Jan;13(1):155-169. doi: 10.1038/nprot.2017.128. Epub 2017 Dec 21. PubMed

Associated Plasmids

Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway. Fink DM, Sun MR, Heyne GW, Everson JL, Chung HM, Park S, Sheets MD, Lipinski RJ. Cell Signal. 2018 Apr;44:1-9. doi: 10.1016/j.cellsig.2017.12.007. Epub 2017 Dec 26. PubMed
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, Shao C, Zhang X, Hu J, Li H, He S, Zhou Y, Abdel-Wahab O, Zhang DE, Fu XD. Mol Cell. 2018 Feb 1;69(3):412-425.e6. doi: 10.1016/j.molcel.2017.12.029. Epub 2018 Jan 27. PubMed
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. Kim HK, Kang MA, Kim MS, Shin YJ, Chi SG, Jeong JH. Mol Cells. 2018 Apr 30;41(4):362-372. doi: 10.14348/molcells.2018.2291. Epub 2018 Feb 28. PubMed
Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice. Sakabe T, Sakai K, Maeda T, Sunaga A, Furuta N, Schweitzer R, Sasaki T, Sakai T. J Biol Chem. 2018 Apr 20;293(16):5766-5780. doi: 10.1074/jbc.RA118.001987. Epub 2018 Mar 5. PubMed
miR-128 inhibits telomerase activity by targeting TERT mRNA. Guzman H, Sanders K, Idica A, Bochnakian A, Jury D, Daugaard I, Zisoulis DG, Pedersen IM. Oncotarget. 2018 Jan 19;9(17):13244-13253. doi: 10.18632/oncotarget.24284. eCollection 2018 Mar 2. PubMed
Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed
Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. Bui N, Huang JK, Bojorquez-Gomez A, Licon K, Sanchez KS, Tang SN, Beckett AN, Wang T, Zhang W, Shen JP, Kreisberg JF, Ideker T. Mol Cancer Ther. 2018 Jul;17(7):1585-1594. doi: 10.1158/1535-7163.MCT-17-0937. Epub 2018 Apr 10. PubMed
Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma. Chan KK, Wong OG, Wong ES, Chan KK, Ip PP, Tse KY, Cheung AN. Int J Cancer. 2018 Sep 15;143(6):1456-1469. doi: 10.1002/ijc.31535. Epub 2018 May 2. PubMed
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-kappaB p65. Li P, Jin Y, Qi F, Wu F, Luo S, Cheng Y, Montgomery RR, Qian F. Front Cell Infect Microbiol. 2018 Apr 9;8:113. doi: 10.3389/fcimb.2018.00113. eCollection 2018. PubMed
Employing CRISPR/Cas9 genome engineering to dissect the molecular requirements for mitosis. McKinley KL. Methods Cell Biol. 2018;144:75-105. doi: 10.1016/bs.mcb.2018.03.003. Epub 2018 Apr 27. PubMed
Chimeric antigen receptors that trigger phagocytosis. Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale R. Elife. 2018 Jun 4;7. pii: 36688. doi: 10.7554/eLife.36688. PubMed

Associated Plasmids

Regulation of miR-34b/c-targeted gene expression program by SUMOylation. Li YJ, Du L, Aldana-Masangkay G, Wang X, Urak R, Forman SJ, Rosen ST, Chen Y. Nucleic Acids Res. 2018 Aug 21;46(14):7108-7123. doi: 10.1093/nar/gky484. PubMed
Assembling the jigsaw puzzle: CBX2 isoform 2 and its targets in disorders/differences of sex development. Sproll P, Eid W, Gomes CR, Mendonca BB, Gomes NL, Costa EM, Biason-Lauber A. Mol Genet Genomic Med. 2018 Sep;6(5):785-795. doi: 10.1002/mgg3.445. Epub 2018 Jul 11. PubMed
Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation. Basson MD, Wang Q, Chaturvedi LS, More S, Vomhof-DeKrey EE, Al-Marsoummi S, Sun K, Kuhn LA, Kovalenko P, Kiupel M. Cell Physiol Biochem. 2018;48(3):1274-1290. doi: 10.1159/000492019. Epub 2018 Jul 25. PubMed
Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma. Luanpitpong S, Poohadsuan J, Samart P, Kiratipaiboon C, Rojanasakul Y, Issaragrisil S. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3739-3753. doi: 10.1016/j.bbadis.2018.09.010. Epub 2018 Sep 11. PubMed
Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin. Kim J, Alavi Naini F, Sun Y, Ma L. Am J Cancer Res. 2018 Sep 1;8(9):1823-1836. eCollection 2018. PubMed
Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Hackett JA, Huang Y, Gunesdogan U, Gretarsson KA, Kobayashi T, Surani MA. Nat Commun. 2018 Oct 16;9(1):4292. doi: 10.1038/s41467-018-06230-0. PubMed
Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma. Odabas G, Cetin M, Turhal S, Baloglu H, Sayan AE, Yagci T. Can J Gastroenterol Hepatol. 2018 Sep 19;2018:4040787. doi: 10.1155/2018/4040787. eCollection 2018. PubMed
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG. Immunity. 2018 Oct 16;49(4):764-779.e9. doi: 10.1016/j.immuni.2018.09.020. PubMed

Associated Plasmids

Discovery of Natural Compounds Promoting Cardiomyocyte Differentiation. Lee JA, An J, Kang TM, De D, Kim KK. Stem Cells Dev. 2019 Jan 1;28(1):13-27. doi: 10.1089/scd.2018.0153. Epub 2018 Dec 4. PubMed
Lentivirus-Mediated RNAi in Skeletal Myogenesis. Kim D, Reyes-Ordonez A, Chen J. Methods Mol Biol. 2019;1889:95-110. doi: 10.1007/978-1-4939-8897-6_7. PubMed
A Human Gonadal Cell Model From Induced Pluripotent Stem Cells. Rodriguez Gutierrez D, Eid W, Biason-Lauber A. Front Genet. 2018 Oct 24;9:498. doi: 10.3389/fgene.2018.00498. eCollection 2018. PubMed
MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators. Ljepoja B, Garcia-Roman J, Sommer AK, Wagner E, Roidl A. Breast. 2019 Feb;43:31-38. doi: 10.1016/j.breast.2018.10.007. Epub 2018 Oct 18. PubMed
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines. Adelmann CH, Wang T, Sabatini DM, Lander ES. Methods Mol Biol. 2019;1907:125-136. doi: 10.1007/978-1-4939-8967-6_10. PubMed
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Li YJ, Du L, Wang J, Vega R, Lee TD, Miao Y, Aldana-Masangkay G, Samuels ER, Li B, Ouyang SX, Colayco SA, Bobkova EV, Divlianska DB, Sergienko E, Chung TDY, Fakih M, Chen Y. Cell Chem Biol. 2019 Feb 21;26(2):278-288.e6. doi: 10.1016/j.chembiol.2018.10.026. Epub 2018 Dec 20. PubMed
IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway. Zheng T, Ma G, Tang M, Li Z, Xu R. Int J Mol Sci. 2018 Dec 27;20(1). pii: ijms20010098. doi: 10.3390/ijms20010098. PubMed
Genome-wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression. Eid W, Abdel-Rehim W. J Cell Biochem. 2019 Jan 10. doi: 10.1002/jcb.28169. PubMed
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11. PubMed
Exploitation of nuclear protein SFPQ by the encephalomyocarditis virus to facilitate its replication. Zhou B, Wu F, Han J, Qi F, Ni T, Qian F. Biochem Biophys Res Commun. 2019 Feb 26;510(1):65-71. doi: 10.1016/j.bbrc.2019.01.032. Epub 2019 Jan 18. PubMed
Development of a non-radioactive screening assay to detect chemicals disrupting the human sodium iodide symporter activity. Dong H, Atlas E, Wade MG. Toxicol In Vitro. 2019 Jun;57:39-47. doi: 10.1016/j.tiv.2019.01.021. Epub 2019 Feb 7. PubMed
ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses. Azimi I, Milevskiy MJG, Chalmers SB, Yapa KTDS, Robitaille M, Henry C, Baillie GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR. Cancers (Basel). 2019 Feb 11;11(2). pii: cancers11020208. doi: 10.3390/cancers11020208. PubMed
ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors. Yalim-Camci I, Balcik-Ercin P, Cetin M, Odabas G, Tokay N, Sayan AE, Yagci T. Mol Carcinog. 2019 Jun;58(6):1068-1081. doi: 10.1002/mc.22994. Epub 2019 Mar 6. PubMed
Assessment of different strategies for scalable production and proliferation of human myoblasts. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N. Cell Prolif. 2019 May;52(3):e12602. doi: 10.1111/cpr.12602. Epub 2019 Mar 19. PubMed
Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6. Chryplewicz A, Tienda SM, Nahotko DA, Peters PN, Lengyel E, Eckert MA. Sci Rep. 2019 Mar 26;9(1):5195. doi: 10.1038/s41598-019-41352-5. PubMed
Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus. Assetta B, Morris-Love J, Gee GV, Atkinson AL, O'Hara BA, Maginnis MS, Haley SA, Atwood WJ. Cell Rep. 2019 May 14;27(7):1960-1966.e6. doi: 10.1016/j.celrep.2019.04.067. PubMed
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM. Elife. 2019 May 20;8. pii: 45572. doi: 10.7554/eLife.45572. PubMed
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Cell Death Differ. 2019 May 21. pii: 10.1038/s41418-019-0352-3. doi: 10.1038/s41418-019-0352-3. PubMed
A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Liu X, Wei L, Dong Q, Liu L, Zhang MQ, Xie Z, Wang X. Aging (Albany NY). 2019 Jun 20;11(12):4011-4031. doi: 10.18632/aging.102034. PubMed
High-throughput multicolor optogenetics in microwell plates. Bugaj LJ, Lim WA. Nat Protoc. 2019 Jul;14(7):2205-2228. doi: 10.1038/s41596-019-0178-y. Epub 2019 Jun 24. PubMed
Endoplasmic reticulum stress and proteasome pathway involvement in human podocyte injury with a truncated COL4A3 mutation. Zhang HD, Huang JN, Liu YZ, Ren H, Xie JY, Chen N. Chin Med J (Engl). 2019 Aug 5;132(15):1823-1832. doi: 10.1097/CM9.0000000000000294. PubMed
The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy. Caines R, Cochrane A, Kelaini S, Vila-Gonzalez M, Yang C, Eleftheriadou M, Moez A, Stitt AW, Zeng L, Grieve DJ, Margariti A. J Cell Sci. 2019 Aug 15;132(16). pii: jcs.230276. doi: 10.1242/jcs.230276. PubMed
The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway. Gul N, Karlsson J, Tangemo C, Linsefors S, Tuyizere S, Perkins R, Ala C, Zou Z, Larsson E, Bergo MO, Lindahl P. Sci Rep. 2019 Oct 11;9(1):14667. doi: 10.1038/s41598-019-51205-w. PubMed
A rapid assay of human thyroid peroxidase activity. Dong H, Godlewska M, Wade MG. Toxicol In Vitro. 2020 Feb;62:104662. doi: 10.1016/j.tiv.2019.104662. Epub 2019 Oct 16. PubMed
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL. Nat Commun. 2019 Nov 1;10(1):5012. doi: 10.1038/s41467-019-12906-y. PubMed
CRISPR/Cas9-Based Genetic Screening to Study T-Cell Function. Shang W, Wang F, Zhu Q, Wang L, Wang H. Methods Mol Biol. 2020;2111:59-70. doi: 10.1007/978-1-0716-0266-9_5. PubMed
p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Marin Navarro A, Pronk RJ, van der Geest AT, Oliynyk G, Nordgren A, Arsenian-Henriksson M, Falk A, Wilhelm M. Cell Death Dis. 2020 Jan 23;11(1):52. doi: 10.1038/s41419-019-2208-7. PubMed
CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution. Kong W, Biddy BA, Kamimoto K, Amrute JM, Butka EG, Morris SA. Nat Protoc. 2020 Mar;15(3):750-772. doi: 10.1038/s41596-019-0247-2. Epub 2020 Feb 12. PubMed
Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis. De Fusco A, Cerullo MS, Marte A, Michetti C, Romei A, Castroflorio E, Baulac S, Benfenati F. Neurobiol Dis. 2020 Jun;139:104822. doi: 10.1016/j.nbd.2020.104822. Epub 2020 Feb 27. PubMed
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. J Exp Med. 2020 Jun 1;217(6). pii: 151572. doi: 10.1084/jem.20191689. PubMed
Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer. Nallanthighal S, Rada M, Heiserman JP, Cha J, Sage J, Zhou B, Yang W, Hu Y, Korgaonkar C, Hanos CT, Ashkavand Z, Norman K, Orsulic S, Cheon DJ. Cell Death Dis. 2020 Apr 20;11(4):258. doi: 10.1038/s41419-020-2442-z. PubMed
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitic T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A. EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192. Epub 2020 Apr 26. PubMed
Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma. Fassmannova D, Sedlak F, Sedlacek J, Spicka I, Grantz Saskova K. Cancers (Basel). 2020 Apr 25;12(5). pii: cancers12051065. doi: 10.3390/cancers12051065. PubMed
BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. Elsarraj HS, Hong Y, Limback D, Zhao R, Berger J, Bishop SC, Sabbagh A, Oppenheimer L, Harper HE, Tsimelzon A, Huang S, Hilsenbeck SG, Edwards DP, Fontes J, Fan F, Madan R, Fangman B, Ellis A, Tawfik O, Persons DL, Fields T, Godwin AK, Hagan CR, Swenson-Fields K, Coarfa C, Thompson J, Behbod F. NPJ Breast Cancer. 2020 Apr 24;6:12. doi: 10.1038/s41523-020-0157-z. eCollection 2020. PubMed
Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Morikawa K, Furuhashi K, de Sena-Tomas C, Garcia-Garcia AL, Bekdash R, Klein AD, Gallerani N, Yamamoto HE, Park SE, Collins GS, Kawano F, Sato M, Lin CS, Targoff KL, Au E, Salling MC, Yazawa M. Nat Commun. 2020 May 1;11(1):2141. doi: 10.1038/s41467-020-16030-0. PubMed
Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus. Delavallee L, Mathiah N, Cabon L, Mazeraud A, Brunelle-Navas MN, Lerner LK, Tannoury M, Prola A, Moreno-Loshuertos R, Baritaud M, Vela L, Garbin K, Garnier D, Lemaire C, Langa-Vives F, Cohen-Salmon M, Fernandez-Silva P, Chretien F, Migeotte I, Susin SA. Mol Metab. 2020 May 30;40:101027. doi: 10.1016/j.molmet.2020.101027. PubMed
Abrogation of PRRSV infectivity by CRISPR-Cas13b-mediated viral RNA cleavage in mammalian cells. Cui J, Techakriengkrai N, Nedumpun T, Suradhat S. Sci Rep. 2020 Jun 15;10(1):9617. doi: 10.1038/s41598-020-66775-3. PubMed
PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Kang YP, Falzone A, Liu M, Gonzalez-Sanchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. Cancer Metab. 2020 Jun 15;8:6. doi: 10.1186/s40170-020-00212-x. eCollection 2020. PubMed
miR-151a enhances Slug dependent angiogenesis. Jury D, Daugaard I, Sanders KJ, Hansen LL, Agalliu D, Pedersen IM. Oncotarget. 2020 Jun 9;11(23):2160-2171. doi: 10.18632/oncotarget.27331. eCollection 2020 Jun 9. PubMed
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent. Baker SJ, Cosenza SC, Athuluri-Divakar S, Reddy MVR, Vasquez-Del Carpio R, Jain R, Aggarwal AK, Reddy EP. Mol Cell. 2020 Jul 2;79(1):180-190.e4. doi: 10.1016/j.molcel.2020.05.024. PubMed
Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Perrigue PM, Rakoczy M, Pawlicka KP, Belter A, Giel-Pietraszuk M, Naskret-Barciszewska M, Barciszewski J, Figlerowicz M. Cancers (Basel). 2020 Jun 30;12(7). pii: cancers12071745. doi: 10.3390/cancers12071745. PubMed
MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. Whitlock NC, Trostel SY, Wilkinson S, Terrigino NT, Hennigan ST, Lake R, Carrabba NV, Atway R, Walton ED, Gryder BE, Capaldo BJ, Ye H, Sowalsky AG. Oncogene. 2020 Aug;39(34):5663-5674. doi: 10.1038/s41388-020-01389-7. Epub 2020 Jul 17. PubMed
SUMOylation of E2F1 Regulates Expression of EZH2. Du L, Fakih MG, Rosen ST, Chen Y. Cancer Res. 2020 Oct 1;80(19):4212-4223. doi: 10.1158/0008-5472.CAN-20-1259. Epub 2020 Aug 14. PubMed
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM. Nat Commun. 2020 Sep 4;11(1):4420. doi: 10.1038/s41467-020-18174-5. PubMed

Associated Plasmids

Tumor suppressive function of Matrin 3 in the basal-like breast cancer. Yang J, Lee SJ, Kwon Y, Ma L, Kim J. Biol Res. 2020 Sep 25;53(1):42. doi: 10.1186/s40659-020-00310-6. PubMed
PLCgamma1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnoder TM, Savic Prince S, Bubendorf L, Pinton P, A Schmid R, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G. Nat Cell Biol. 2020 Nov;22(11):1382-1395. doi: 10.1038/s41556-020-00592-8. Epub 2020 Oct 19. PubMed
RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. Duan Y, Zhang L, Angosto-Bazarra D, Pelegrin P, Nunez G, He Y. Cell Rep. 2020 Nov 17;33(7):108405. doi: 10.1016/j.celrep.2020.108405. PubMed
SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome. Zhang L, Richards A, Khalil A, Wogram E, Ma H, Young RA, Jaenisch R. bioRxiv. 2020 Dec 13. doi: 10.1101/2020.12.12.422516. PubMed
Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation. Smith M, Querido E, Chartrand P, Sfeir A. STAR Protoc. 2020 Sep 24;1(3):100112. doi: 10.1016/j.xpro.2020.100112. eCollection 2020 Dec 18. PubMed
Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM. Cell Death Dis. 2021 Jan 4;12(1):27. doi: 10.1038/s41419-020-03281-4. PubMed
Generation and Breeding of EGFP-Transgenic Marmoset Monkeys: Cell Chimerism and Implications for Disease Modeling. Drummer C, Vogt EJ, Heistermann M, Roshani B, Becker T, Matz-Rensing K, Kues WA, Kugler S, Behr R. Cells. 2021 Feb 27;10(3). pii: cells10030505. doi: 10.3390/cells10030505. PubMed
O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination. Samart P, Luanpitpong S, Rojanasakul Y, Issaragrisil S. J Exp Clin Cancer Res. 2021 Mar 16;40(1):100. doi: 10.1186/s13046-021-01876-z. PubMed
Mitofusin-2 regulates leukocyte adhesion and beta2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. J Leukoc Biol. 2022 Apr;111(4):771-791. doi: 10.1002/JLB.1A0720-471R. Epub 2021 Sep 8. PubMed
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko L, Li W, Mazur PK, Gozani O. Mol Cell. 2021 Nov 4;81(21):4481-4492.e9. doi: 10.1016/j.molcel.2021.08.034. Epub 2021 Sep 22. PubMed
Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Nat Commun. 2021 Nov 15;12(1):6591. doi: 10.1038/s41467-021-26989-z. PubMed
Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy. Yang D, Wu X, Wang W, Zhou Y, Wang Z. Adv Sci (Weinh). 2022 Jan;9(3):e2102568. doi: 10.1002/advs.202102568. Epub 2021 Nov 16. PubMed
PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers. Dellomo AJ, Abbotts R, Eberly CL, Karbowski M, Baer MR, Kingsbury TJ, Rassool FV. Transl Oncol. 2022 Jan;15(1):101283. doi: 10.1016/j.tranon.2021.101283. Epub 2021 Nov 19. PubMed
A beta-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Rappaport JA, Entezari AA, Caspi A, Caksa S, Jhaveri AV, Stanek TJ, Ertel A, Kupper J, Fortina PM, McMahon SB, Jaynes JB, Snook AE, Waldman SA. Cell Mol Gastroenterol Hepatol. 2022;13(4):1276-1296. doi: 10.1016/j.jcmgh.2021.12.014. Epub 2021 Dec 22. PubMed
SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma. Du L, Liu W, Aldana-Masangkay G, Pozhitkov A, Pichiorri F, Chen Y, Rosen ST. J Exp Clin Cancer Res. 2022 Jan 4;41(1):8. doi: 10.1186/s13046-021-02226-9. PubMed
Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy. Saliakoura M, Sebastiano MR, Nikdima I, Pozzato C, Konstantinidou G. J Exp Clin Cancer Res. 2022 Jan 8;41(1):16. doi: 10.1186/s13046-021-02231-y. PubMed
SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display. Ehling RA, Weber CR, Mason DM, Friedensohn S, Wagner B, Bieberich F, Kapetanovic E, Vazquez-Lombardi R, Di Roberto RB, Hong KL, Wagner C, Pataia M, Overath MD, Sheward DJ, Murrell B, Yermanos A, Cuny AP, Savic M, Rudolf F, Reddy ST. Cell Rep. 2022 Jan 18;38(3):110242. doi: 10.1016/j.celrep.2021.110242. Epub 2021 Dec 22. PubMed
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hallberg BM, Murrell B, McInerney GM. Nat Commun. 2022 Jan 10;13(1):155. doi: 10.1038/s41467-021-27610-z. PubMed
Distinctive Roles of YAP and TAZ in Human Endothelial Progenitor Cells Growth and Functions. Klaihmon P, Lorthongpanich C, Kheolamai P, Luanpitpong S, Issaragrisil S. Biomedicines. 2022 Jan 11;10(1):147. doi: 10.3390/biomedicines10010147. PubMed
De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Steiner S, Seleznik GM, Reding T, Stopic M, Lenggenhager D, Ten Buren E, Eshmuminov D, Endhardt K, Hagedorn C, Heidenblut AM, Bratus-Neuenschwander A, Grossmann J, Trachsel C, Jabbar KS, Hahn SA, Berg JV, Graf R, Gupta A. Oncogene. 2022 Mar;41(10):1507-1517. doi: 10.1038/s41388-022-02182-4. Epub 2022 Jan 26. PubMed
Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells. Chaki S, Alkanfari I, Roy S, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H. Front Immunol. 2022 Jan 20;12:803335. doi: 10.3389/fimmu.2021.803335. eCollection 2021. PubMed
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response. Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q. Cell Death Dis. 2022 Feb 16;13(2):156. doi: 10.1038/s41419-022-04602-5. PubMed
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer. Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM. Nat Commun. 2022 Feb 28;13(1):1090. doi: 10.1038/s41467-022-28619-8. PubMed

Associated Plasmids

TRIM24 promotes colorectal cancer cell progression via the Wnt/beta-catenin signaling pathway activation. Tian H, Zhao H, Qu B, Chu X, Xin X, Zhang Q, Li W, Yang S. Am J Transl Res. 2022 Feb 15;14(2):831-848. eCollection 2022. PubMed
Muller glia fused with adult stem cells undergo neural differentiation in human retinal models. Bonilla-Pons SA, Nakagawa S, Bahima EG, Fernandez-Blanco A, Pesaresi M, D'Antin JC, Sebastian-Perez R, Greco D, Dominguez-Sala E, Gomez-Riera R, Compte RIB, Dierssen M, Pulido NM, Cosma MP. EBioMedicine. 2022 Mar;77:103914. doi: 10.1016/j.ebiom.2022.103914. Epub 2022 Mar 9. PubMed
Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates. Castro Dopico X, Muschiol S, Grinberg NF, Aleman S, Sheward DJ, Hanke L, Ahl M, Vikstrom L, Forsell M, Coquet JM, McInerney G, Dillner J, Bogdanovic G, Murrell B, Albert J, Wallace C, Karlsson Hedestam GB. Clin Transl Immunology. 2022 Mar 2;11(3):e1379. doi: 10.1002/cti2.1379. eCollection 2022. PubMed
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R. Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16. PubMed

Associated Plasmids

Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study. Sheward DJ, Kim C, Ehling RA, Pankow A, Castro Dopico X, Dyrdak R, Martin DP, Reddy ST, Dillner J, Karlsson Hedestam GB, Albert J, Murrell B. Lancet Infect Dis. 2022 Jun;22(6):813-820. doi: 10.1016/S1473-3099(22)00129-3. Epub 2022 Mar 17. PubMed

Associated Plasmids

VIVA1: a more invasive subclone of MDA-MB-134VI invasive lobular carcinoma cells with increased metastatic potential in xenograft models. Allen V, Coulombe J, Zhao H, Kreps LM, Cook DP, Pryce B, Clemons M, Vanderhyden BC, Gray DA, Addison CL. Br J Cancer. 2022 Jul;127(1):56-68. doi: 10.1038/s41416-022-01778-7. Epub 2022 Mar 22. PubMed
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies. Hanke L, Sheward DJ, Pankow A, Vidakovics LP, Karl V, Kim C, Urgard E, Smith NL, Astorga-Wells J, Ekstrom S, Coquet JM, McInerney GM, Murrell B. Sci Adv. 2022 Mar 25;8(12):eabm0220. doi: 10.1126/sciadv.abm0220. Epub 2022 Mar 25. PubMed

Associated Plasmids

A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells. Xu DL, He YQ, Xiao B, Si Y, Shi J, Liu XA, Tian L, Ren Q, Wu YS, Zhu Y. Front Oncol. 2022 Mar 22;12:726985. doi: 10.3389/fonc.2022.726985. eCollection 2022. PubMed
When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciume G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M. Sci Adv. 2022 Apr 15;8(15):eabj3286. doi: 10.1126/sciadv.abj3286. Epub 2022 Apr 13. PubMed
Functional elements of the cis-regulatory lincRNA-p21. Winkler L, Jimenez M, Zimmer JT, Williams A, Simon MD, Dimitrova N. Cell Rep. 2022 Apr 19;39(3):110687. doi: 10.1016/j.celrep.2022.110687. PubMed
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R. Cell Stem Cell. 2022 Apr 13. pii: S1934-5909(22)00150-3. doi: 10.1016/j.stem.2022.03.015. PubMed

Associated Plasmids

A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity. Cortes-Kaplan S, Kurdieh R, Hasim MS, Kaczmarek S, Taha Z, Maznyi G, McComb S, Lee SH, Diallo JS, Ardolino M. Cancers (Basel). 2022 Jun 8;14(12). pii: cancers14122832. doi: 10.3390/cancers14122832. PubMed
Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation. Oda T, Yanagisawa H, Shinmori H, Ogawa Y, Kawamura T. Elife. 2022 Jun 27;11. pii: 79990. doi: 10.7554/eLife.79990. PubMed
Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells Through Inhibition of Human Endogenous Retrovirus Type K. Li J, Lin J, Lin JR, Farris M, Robbins L, Andrada L, Grohol B, Nong S, Liu Y. Cureus. 2022 Jul 3;14(7):e26525. doi: 10.7759/cureus.26525. eCollection 2022 Jul. PubMed
Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Sanidas I, Lee H, Rumde PH, Boulay G, Morris R, Golczer G, Stanzione M, Hajizadeh S, Zhong J, Ryan MB, Corcoran RB, Drapkin BJ, Rivera MN, Dyson NJ, Lawrence MS. Mol Cell. 2022 Sep 15;82(18):3333-3349.e9. doi: 10.1016/j.molcel.2022.07.014. Epub 2022 Aug 17. PubMed
TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype. Kim YS, Potashnikova DM, Gisina AM, Kholodenko IV, Kopylov AT, Tikhonova OV, Kurbatov LK, Saidova AA, Tvorogova AV, Kholodenko RV, Belousov PV, Vorobjev IA, Zgoda VG, Yarygin KN, Lupatov AY. Int J Mol Sci. 2022 Aug 30;23(17):9874. doi: 10.3390/ijms23179874. PubMed
Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling. Luanpitpong S, Rodboon N, Samart P, Janan M, Klaihmon P, Lorthongpanich C, U-Pratya Y, Issaragrisil S. Stem Cells. 2022 Dec 31;40(12):1078-1093. doi: 10.1093/stmcls/sxac068. PubMed
Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells. Weier AK, Homrich M, Ebbinghaus S, Juda P, Mikova E, Hauschild R, Zhang L, Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruss OJ, Hons M, Wieser S, Kiermaier E. J Cell Biol. 2022 Dec 5;221(12):e202107134. doi: 10.1083/jcb.202107134. Epub 2022 Oct 10. PubMed
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles. Faizan MI, Chaudhuri R, Sagar S, Albogami S, Chaudhary N, Azmi I, Akhtar A, Ali SM, Kumar R, Iqbal J, Joshi MC, Kharya G, Seth P, Roy SS, Ahmad T. Cells. 2022 Sep 23;11(19):2969. doi: 10.3390/cells11192969. PubMed
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses. Dacon C, Peng L, Lin TH, Tucker C, Lee CD, Cong Y, Wang L, Purser L, Cooper AJR, Williams JK, Pyo CW, Yuan M, Kosik I, Hu Z, Zhao M, Mohan D, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Murphy M, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Doranz BJ, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Mascola JR, Holbrook MR, Nemazee D, Wilson IA, Tan J. Cell Host Microbe. 2022 Nov 4. pii: S1931-3128(22)00523-6. doi: 10.1016/j.chom.2022.10.010. PubMed

Associated Plasmids

An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, Dipta P, Shmuel M, Forno F, Boukeileh S, Pahima H, Hermann J, Raab MS, Poos AM, Weinhold N, Rosenbluh C, Gatt ME, Palm W, Azab AK, Tirosh B. Cell Death Dis. 2022 Nov 18;13(11):969. doi: 10.1038/s41419-022-05421-4. PubMed
The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages. Duan Y, Wang J, Cai J, Kelley N, He Y. J Biol Chem. 2022 Dec;298(12):102717. doi: 10.1016/j.jbc.2022.102717. Epub 2022 Nov 17. PubMed
Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification. Kohler B, Dubovik S, Horterer E, Wilk U, Stockl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Frohlich T, Wagner E, Roidl A. Cancers (Basel). 2022 Nov 11;14(22):5554. doi: 10.3390/cancers14225554. PubMed
Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. Luanpitpong S, Janan M, Yosudjai J, Poohadsuan J, Chanvorachote P, Issaragrisil S. Int J Mol Sci. 2022 Nov 21;23(22):14474. doi: 10.3390/ijms232214474. PubMed
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies. Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, Hanke L, Chernyshev M, Narang S, Kim S, Fischbach J, Ekstrom S, McInerney G, Hallberg BM, Murrell B, Corcoran M, Karlsson Hedestam GB. Immunity. 2023 Jan 10;56(1):193-206.e7. doi: 10.1016/j.immuni.2022.12.005. Epub 2022 Dec 12. PubMed
Gene regulatory network reconfiguration in direct lineage reprogramming. Kamimoto K, Adil MT, Jindal K, Hoffmann CM, Kong W, Yang X, Morris SA. Stem Cell Reports. 2023 Jan 10;18(1):97-112. doi: 10.1016/j.stemcr.2022.11.010. Epub 2022 Dec 29. PubMed
A hierarchical pathway for assembly of the distal appendages that organize primary cilia. Kanie T, Love JF, Fisher SD, Gustavsson AK, Jackson PK. bioRxiv [Preprint]. 2023 Jan 10:2023.01.06.522944. doi: 10.1101/2023.01.06.522944. PubMed
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Associated Plasmids

Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy. Tarallo D, Martinez J, Leyva A, Monaco A, Perroni C, Tassano M, Gambini JP, Cappetta M, Duran R, Moreno M, Quijano C. Sci Rep. 2024 Jan 9;14(1):909. doi: 10.1038/s41598-024-51427-7. PubMed

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