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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM
Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
72592pRK5-FLAG-Sestrin3overexpression, codon optimized for mammalian expression
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72593pRK5-HA-Sestrin2overexpression, codon optimized for mammalian expression
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72594pRK5-FLAG-Sestrin1 isoform1overexpression, codon optimized for mammalian expression
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72595pRK5-FLAG-Sestrin2overexpression
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Antibodies from Article