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BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons.
Vierock J, Rodriguez-Rozada S, Dieter A, Pieper F, Sims R, Tenedini F, Bergs ACF, Bendifallah I, Zhou F, Zeitzschel N, Ahlbeck J, Augustin S, Sauter K, Papagiakoumou E, Gottschalk A, Soba P, Emiliani V, Engel AK, Hegemann P, Wiegert JS
Nat Commun. 2021 Jul 26;12(1):4527. doi: 10.1038/s41467-021-24759-5.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
154944hSyn-BiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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154945hSyn-somBiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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154946mDlx-BiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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154948CaMKII-somBiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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154949Ef1a-DIO-BiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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154950hSyn-DIO-BiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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154951hSyn-DIO-somBiPOLES-mCeruleanOptogenetic tool for blue-light inhibition and red-light excitation of neurons
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192580hSyn-GtACR2-ChRmine-tandem-eYFPAAV-vector for bidirectional optogenetic manipulation of neurons
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Antibodies from Article