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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.
Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B
Nat Cell Biol. 2020 Apr;22(4):476-486. doi: 10.1038/s41556-020-0496-x. Epub 2020 Mar 30.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
161818lentiCRISPR v2-sgSLC7A11/xCT-1knock out SLC7A11/xCT in mammalian cells
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161819lentiCRISPR v2-sgSLC7A11/xCT-2knock out SLC7A11/xCT in mammalian cells
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Antibodies from Article