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PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.
Ilic N, Utermark T, Widlund HR, Roberts TM
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E699-708. Epub 2011 Aug 29.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
33252pBabe puro-eIF4E
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33253pBabe puro-HA-PIK3CA(H1047R;I848V)
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33254pBabe puro-HA-PIK3CA(H1047R;G320E)
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33255pBabe puro-HA-PIK3CA(H1047R;F486S;del)
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Antibodies from Article