Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.
Hansen SK, Parrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T
J Clin Invest. 2002 Sep;110(6):827-33. PubMed Article
Hansen SK, Parrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T
J Clin Invest. 2002 Sep;110(6):827-33. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 60324 | pGL2 HNF4A P2 wt | HNF4A P2 promoter cloned into the pGL2-basic backbone. |
| 60325 | pGL2 HNF4A P2 mut | Mutated HNF4A P2 promoter region cloned into the pGL2-basic backbone. The -181 G to A mutation is in a HNF1alpha binding site and cosegregates with MODY. |