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Susan Lindquist Lab Plasmids

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The Susan Lindquist Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a non-profit plasmid repository dedicated to improving life science research.

Learn more about research in the Susan Lindquist Lab.

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Title	Authors
Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.	McLellan et al
TorsinA and the TorsinA-Interacting Protein Printor Have No Impact on Endoplasmic Reticulum Stress or Protein Trafficking in Yeast.	Valastyan et al
Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice.	Jackson et al
Chaperone-dependent amyloid assembly protects cells from prion toxicity.	Douglas et al
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.	Gitler et al
Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions.	Dong et al
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.	Dai et al
Prion recognition elements govern nucleation, strain specificity and species barriers.	Tessier et al
Flanking sequences profoundly alter polyglutamine toxicity in yeast.	Duennwald et al
A network of protein interactions determines polyglutamine toxicity.	Duennwald et al
Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.	Cowen et al
Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits.	True et al
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers.	Shorter et al
Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region.	Schirmer et al
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+].	Liu et al
Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein.	Cashikar et al
Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation.	Ma et al
The role of conformational flexibility in prion propagation and maintenance for Sup35p.	Scheibel et al
Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae.	Jensen et al
Bidirectional amyloid fiber growth for a yeast prion determinant.	Scheibel et al
Subunit interactions influence the biochemical and biological properties of Hsp104.	Schirmer et al
Rnq1: an epigenetic modifier of protein function in yeast.	Sondheimer et al
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins.	Krobitsch et al
Creating a protein-based element of inheritance.	Li et al
De novo generation of a PrPSc-like conformation in living cells.	Ma et al
Oligopeptide-repeat expansions modulate 'protein-only' inheritance in yeast.	Liu et al
Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation.	Nathan et al
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.	Xu et al
Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins.	Glover et al
Multiple effects of trehalose on protein folding in vitro and in vivo.	Singer et al
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone.	Nathan et al
Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae.	Glover et al
In vivo analysis of the Hsp90 cochaperone Sti1 (p60).	Chang et al
Support for the prion hypothesis for inheritance of a phenotypic trait in yeast.	Patino et al
Protein disaggregation mediated by heat-shock protein Hsp104.	Parsell et al
Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae.	Chang et al
Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase.	Nathan et al
Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways.	Kimura et al
Reduced levels of hsp90 compromise steroid receptor action in vivo.	Picard et al
S cerevisiae Advanced Gateway Destination Vectors