Addgene - David Sabatini Lab Plasmids

The David Sabatini Lab has deposited plasmids at Addgene for distribution to academic researchers. Addgene is a non-profit plasmid repository dedicated to improving life science research.

Learn more about research in the David Sabatini Lab.

Browse by Plasmid

Title	Authors
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase.	Zoncu et al
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway.	Peterson et al
Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo.	Sheen et al
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.	Sancak et al
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival.	Peterson et al
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.	Thoreen et al
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.	Sancak et al
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.	Sancak et al
mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s.	Frias et al
Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.	Ali et al
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	Sarbassov et al
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.	Sarbassov et al
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.	Kim et al
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.	Kim et al
myc mTOR kinase dead
Unpublished plasmid
pLJM1-Flag