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BRAIN Initiative Plasmid Collection


The Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative aims to revolutionize our knowledge of the human brain through the development and application of innovative tools enabling large-scale real-time interrogation and monitoring of brain cells and circuits during behavior. Long desired by researchers, the revolutionary dynamic picture of the brain generated through this effort will provide novel ways to treat, cure, and even prevent brain disorders.

Brain images from the BRAIN Initiative

The BRAIN Initiative supports the development of a diverse portfolio of biomolecular tools and emphasizes their rapid and broad dissemination to the research community. Browse plasmids created with support from the BRAIN Initiative below.

Plasmids

ID Plasmid Purpose PI
65417pAAV-hSyn-dF-HA-KORD-IRES-mCitrineAAV packaging vector for hSyn driven KOR DREADD expression. Roth
83894pAAV-hDlx-Flex-dTomato-Fishell_7Cre recombinase-dependent dTomato expression in forebrain GABA-ergic interneurons under the control of the hDlx enhancer element Fishell
83895pAAV-hDlx-Flex-GFP-Fishell_6Cre recombinase-dependent GFP expression in forebrain GABA-ergic interneurons under the control of the hDlx enhancer element Fishell
83896pAAV-hDlx-GiDREADD-dTomato-Fishell-5Gi-DREADD (P2A) nuclear dTomato expression in forebrain GABA-ergic interneurons under the control of the hDlx enhancer element Fishell
83897pAAV-hDlx-GqDREADD-dTomato-Fishell-4Gq-DREADD (P2A) nuclear dTomato expression in forebrain GABA-ergic interneurons under the control of the hDlx enhancer element Fishell
83898pAAV-mDlx-ChR2-mCherry-Fishell-3ChR2-mCherry fusion expression in forebrain GABA-ergic interneurons under the control of the mDlx enhancer element Fishell
83899pAAV-mDlx-GCaMP6f-Fishell-2GCaMP6f expression in forebrain GABA-ergic interneurons under the control of the mDlx enhancer element Fishell
83900pAAV-mDlx-GFP-Fishell-1GFP expression in forebrain GABA-ergic interneurons under the control of the mDlx enhancer element Fishell
869485LTR-puro-3LTRPiggyBac transposon Mitra
88910pFlpStop-attB-UAS-2.1-tdTomattB FlpStop plasmid, for insertion into MiMIC site Clandinin
89148pFlpStop-HDR-UAS-2.1-tdTomFlpStop plasmid for CRISPR/HDR. Has MCS for homology arms Clandinin
91718CaMKIIP-mEGFP-P2A-paAIP2/pAAVAAV-mediated expression of mEGFP and paAIP2 for optogenetic control of CaMKII Yasuda
91719CaMKIIP-mEGFP-P2A-paAIP2 (R5AR6A)/pAAVAAV-mediated expression of mEGFP and paAIP2 (R5AR6A), the functional mutant of paAIP2 Yasuda
98034pRVdG-4CreSecond-generation rabies viral vector genome Wickersham
98035pRVdG-4GCaMP6fSecond-generation rabies viral vector genome Wickersham
98036pRVdGL-1EGFPSecond-generation rabies viral vector genome Wickersham
98037pRVdGL-4EGFPSecond-generation rabies viral vector genome Wickersham
98038pRVdGL-1CreSecond-generation rabies viral vector genome Wickersham
98039pRVdGL-4CreSecond-generation rabies viral vector genome Wickersham
98040pRVdGL-4FlpoSecond-generation rabies viral vector genome Wickersham
99113pAAV-TRE-mTurquoise2An AAV genome with tet-inducible expression of the fluorescent protein mTurquoise2 Gradinaru
99114pAAV-TRE-mRuby2An AAV genome with tet-inducible expression of the fluorescent protein mRuby2 Gradinaru
99115pAAV-TRE-DIO-mTurquoise2An AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mTurquoise2 Gradinaru
99117pAAV-TRE-DIO-mRuby2An AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mRuby2 Gradinaru
99118pAAV-CAG-tTAAn AAV genome that ubiquitously expresses tTA from the CAG promoter Gradinaru
99119pAAV-hSyn1-tTAAn AAV genome that expresses tTA from the hSyn1 promoter Gradinaru
99120pAAV-ihSyn1-tTAAn AAV genome that expresses tTA from the hSyn1 promoter that contains a positive feedback loop for amplifed expression of the tTA Gradinaru
99121pAAV-ihSyn1-DIO-tTAAn AAV genome with Cre-dependent expression of the tTA from the hSyn1 promoter. Contains a positive feedback loop for amplifed expression of the tTA Gradinaru
99122pAAV-CAG-mTurquoise2An AAV genome that ubiquitously expresses the fluorescent protein mTurquoise2 from the CAG promoter Gradinaru
99123pAAV-CAG-mRuby2An AAV genome that ubiquitously expresses the fluorescent protein mRuby2 from the CAG promoter Gradinaru
99125pAAV-hSyn1-mTurquoise2An AAV genome that expresses the fluorescent protein mTurquoise2 from the hSyn1 promoter Gradinaru
99126pAAV-hSyn1-mRuby2An AAV genome that expresses the fluorescent protein mRuby2 from the hSyn1 promoter Gradinaru
99128pAAV-mTH-GFPAn AAV genome that expresses GFP from the mouse TH promoter Gradinaru
99129pAAV-GFAP-mKate2.5fAlso known as pAAV-GFAP-mKate2.5-f. An AAV genome that express the farnesylated fluorescent protein mKate2.5 from the GFAP promoter Gradinaru
99130pAAV-mDlx-NLS-mRuby2An AAV genome that expresses nuclear localized mRuby2 from the mouse Dlx5/6 enhancer Gradinaru
99131pAAV-TRE-mNeonGreenAn AAV genome with tet-inducible expression of the fluorescent protein mNeonGreen Gradinaru
99132pAAV-TRE-DIO-mNeonGreenAn AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mNeonGreen Gradinaru
99133pAAV-CAG-fDIO-mNeonGreenAn AAV genome with Flp recombinase-dependent expression of mNeonGreen from the CAG promoter Gradinaru
99134pAAV-CAG-mNeonGreenAn AAV genome that ubiquitously expresses the fluorescent protein mNeonGreen from the CAG promoter Gradinaru
99135pAAV-hSyn1-mNeonGreenAn AAV genome that ubiquitously expresses the fluorescent protein mNeonGreen from the hSyn1 promoter Gradinaru
100798pAAV-syn-FLEX-splitTVA-EGFP-tTAhelper virus for monosynaptic tracing; to be coinjected with pAAV-TREtight-mTagBFP2-B19G Wickersham
100799pAAV-TREtight-mTagBFP2-B19Ghelper virus for monosynaptic tracing; to be coinjected with pAAV-syn-FLEX-splitTVA-EGFP-tTA Wickersham
103002pUCmini-iCAP-PHP.Bnon-standard AAV2 rep-AAV-PHP.B cap plasmid with AAV cap expression controlled by a tTA-TRE amplifcation system Gradinaru
103003pUCmini-iCAP-PHP.B2non-standard AAV2 rep-AAV-PHP.B2 cap plasmid with AAV cap expression controlled by a tTA-TRE amplifcation system Gradinaru
103004pUCmini-iCAP-PHP.B3non-standard AAV2 rep-AAV-PHP.B3 cap plasmid with AAV cap expression controlled by a tTA-TRE amplifcation system Gradinaru
103005pUCmini-iCAP-PHP.eBnon-standard AAV2 rep-AAV-PHP.eB cap plasmid with AAV cap expression controlled by a tTA-TRE amplifcation system Gradinaru
103006pUCmini-iCAP-PHP.Snon-standard AAV2 rep-AAV-PHP.S cap plasmid with AAV cap expression controlled by a tTA-TRE amplifcation system Gradinaru
103137pcDNA3.1-GcACR_457-EYFPAnion channelrhodopsin from Geminigera cryophila (CCMP2564) for expression in mammalian cells Spudich
103138pcDNA3.1-GcACR_145-EYFPAnion channelrhodopsin from Geminigera cryophila (CCMP2564) for expression in mammalian cells Spudich
103142pcDNA3.1-GcACR_439-EYFPAnion channelrhodopsin from Geminigera cryophila (CCMP2564) for expression in mammalian cells Spudich
103143pcDNA3.1-G1ACR_203-EYFPAnion channelrhodopsin from Geminigera sp. (Caron Lab Isolate) for expression in mammalian cells Spudich
103529pcDNA3.1-PsuACR_433-EYFPAnion channelrhodopsin from Proteomonas sulcata (CCMP704) for expression in mammalian cells Spudich
103772pcDNA3.1-RsACR_995-EYFPAnion channelrhodopsin from Rhodomonas salina (CCMP1319) for expression in mammalian cells Spudich
103773pcDNA3.1-R1ACR_367-EYFPAnion channelrhodopsin from Rhodomonas sp. (CCMP768) for expression in mammalian cells Spudich
103883pcDNA3.1-R1ACR_877-EYFPAnion channelrhodopsin from Rhodomonas sp. (CCMP768) for expression in mammalian cells Spudich
103960pcDNA3.1-R1ACR_447-EYFPAnion channelrhodopsin from Rhodomonas sp. (CCMP768) for expression in mammalian cells Spudich
103961pcDNA3.1-R1ACR_741-EYFPHighly efficient anion channelrhodopsin from Rhodomonas sp. (CCMP768) for expression in mammalian cells Spudich
103962pcDNA3.1-R1ACR_799-EYFPAnion channelrhodopsin from Rhodomonas sp. (CCMP768) for expression in mammalian cells Spudich
103963pcDNA3.1-R2ACR_853-EYFPAnion channelrhodopsin from Rhodomonas sp. (CCAC1630) for expression in mammalian cells Spudich
103964pcDNA3.1-R2ACR_142-EYFPHighly efficient anion channelrhodopsin from Rhodomonas sp. (CCAC1630) for expression in mammalian cells Spudich
103965pcDNA3.1-C1ACR_887-EYFPAnion channelrhodopsin from unclassified cryptophyte (CCMP2293) for expression in mammalian cells Spudich
103966pcDNA3.1-C1ACR_023-EYFPAnion channelrhodopsin from unclassified cryptophyte (CCMP2293) for expression in mammalian cells Spudich
104052pAAV-CAG-DIO-EYFPAn AAV genome encoding Cre-dependent expression of the fluorescent protein EYFP from the CAG promoter Gradinaru
104053pAAV-GFAP-2xNLS-mTurquoise2An AAV genome encoding expression of the nuclear localized fluorescent protein mTurquoise2 from the GFAP promoter Gradinaru
104055pAAV-CAG-eYFPAn AAV genome that ubiquitously expresses the fluorescent protein eYFP from the CAG promoter Gradinaru
104056pAAV-TRE-eYFPAn AAV genome with tet-inducible expression of the fluorescent protein eYFP Gradinaru
104057pAAV-TRE-DIO-eYFP-fAn AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein eYFP with a C-terminal Hras farnesylation sequence Gradinaru
104058CAG-DIO-mRuby2AAV expression of Cre-dependent reporter mRuby2 Gradinaru
104059CAG-DIO-mTurquoise2AAV expression of Cre-dependent reporter mTurquoise2 Gradinaru
104060hSyn1-tdTomatofAlso known as hSyn1-tdTomato-f. AAV expresion of Farnylsated tdtomato for tracing Gradinaru
104061CAG-NLS-GFPAAV expression of nuclear localized GFP with SV40 NLS Gradinaru
105981pAAV.hSyn.FAPdL5-POST-T2A-dTomato.WPRE.bGHThis AAV plasmid constitutively expresses an extracellular dL5 FAP fused to the neuroligin-1 cytoplasmic domain for targeting to the synapse with a cell fill dTomato. Bruchez
105982pAAV.hSyn.FLEX.FAPdL5-POST-T2A-dTomato.FLEX.WPRE.SV40This AAV plasmid in the presence of Cre recombinase expresses an extracellular dL5 FAP fused to the neuroligin-1 cytoplasmic domain for targeting to the synapse with a cell fill dTomato. Bruchez
105983pAAV.hSyn.FLEX.SYFP2-POST-T2A-dTomato.FLEX.WPRE.SV40This AAV plasmid in the presence of Cre recombinase expresses an extracellular SYFP2 fused to the neuroligin-1 cytoplasmic domain for targeting to the synapse with a cell fill dTomato. Bruchez
107704YA1627: pAAV_hSyn-Dio-paQuasAr3-s-P2A-CheRiff-sin vivo voltage imaging Cohen
107705DRH323: pAAV_hSyn-QuasAr2in vivo voltage imaging Cohen
109378LZF40: LZF40_Fsyn_CreSynaptic transmission Cohen
111058pCMV-dLight1.5Expresses dLight1.5 in mammalian cells Tian
111067pAAV-CAG-dLight1.1To generate Adeno-Associated viruses for expression of dLight1.1 under CAG promoter Tian
111068pAAV-hSyn-dLight1.2To generate Adeno-Associated viruses for expression of dLight1.2 under synapsin promoter Tian
112008pAAV-hSynapsin1-FLEx-axon-GCaMP6s-P2A-mRuby3For cre-dependent enriched expression of GCaMP6s in axons with cytosolic expression of mRuby3 Tian
112278SLF155: AAV-syn-DO-H2B-jRGECO1aFor AAV based expression of nuclear jRGECO1a in neurons in Cre-negative neurons with FLEx switch Cohen
112280SLF045: AAV-hSyn-eTsChR-GFPAAV based broad expression of eTsChR in neurons Cohen
112281SLF091: Lenti-CaMKIIa-eTsChR-eGFPFor lentiviral or direct expression of eTsChR in excitatory neurons Cohen
112282SLF060: Lenti-CaMKIIa-jRGECO1aFor lentiviral or direct expression of cytosolic jRGECO1a in excitatory neurons Cohen
112670DRH-307Lentiviral expression of GFP under the CAMK2A promoter in mammalian cells Cohen
113049pAAV-hSyn-GRAB_DA1mexpress the genetically-encoded fluorescent dopamine(DA) sensor GRAB_DA1m in neurons Li
113050pAAV-hSyn-GRAB_DA1hexpress the genetically-encoded fluorescent dopamine(DA) sensor GRAB_DA1h in neurons Li
114099pAAV-hSyn-LMO3 (sbGLuc-VChR1-EYFP)fusion protein of Gaussia luciferase variant slow burn, Volvox channelrhodopsin-1, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114100pAAV-hSyn-iLMO (slGLuc-Mac-EYFP)fusion protein of Gaussia luciferase variant superluminescent, Leptosphaeria maculans opsin, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114101pAAV-hSyn-LMO4 (GLucM23-VChR1-EYFP)fusion protein of Gaussia luciferase variant M23, Volvox channelrhodopsin-1, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114102pAAV-hSyn-iLMO4 (GLucM23-iChloC-EYFP)fusion protein of Gaussia luciferase variant M23, improved slowChloC anion conducting ChR, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114103pAAV-Hb9-LMO3 (sbGLuc-VChR1-EYFP)fusion protein of Gaussia luciferase variant slow burn, Volvox channelrhodopsin-1, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114104pAAV-CAG-LMO3 (sbGLuc-VChR1-EYFP)fusion protein of Gaussia luciferase variant slow burn, Volvox channelrhodopsin-1, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114105pAAV-EFIa-DIO-LMO3 (sbGLuc-VChR1-EYFP)Cre-dependent fusion protein of Gaussia luciferase variant slow burn, Volvox channelrhodopsin-1, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114106pAAV-hSyn-sbGLuc-ChR2(CS/DA)-EYFPfusion protein of Gaussia luciferase variant slow burn, Channelrhodopsin-2 variant C128S/D156A (stabilized step function opsin), and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114108pAAV-hSyn-sbGLuc-CheRiff-EGFPfusion protein of Gaussia luciferase variant slow burn, synthetic channelrhodopsin CheRiff, and enhanced green fluorescent protein for bioluminescent optogenetics Hochgeschwender
114111pcDNA3.1-CAG-sbGLuc-hGtARC2-EYFPfusion protein of Gaussia luciferase variant slow burn, Guillardia theta anion channelrhodopsin-2, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114112pcDNA3.1-CAG-NanoLuc-VChR1-EYFPfusion protein of NanoLuc, Volvox channelrhodopsin-1, and enhanced yellow fluorescent protein for bioluminescent optogenetics Hochgeschwender
114426Ai139 (TIT2L-GFP-ICL-TPT) targeting vectorTarget a Cre-dependent GFP and a tdTomato-P2A-tTA2 expression cassette into the mouse TIGRE locus Zeng
114427Ai140 (TIT2L-GFP-ICL-tTA2) targeting vectorTarget a Cre-dependent GFP and a tTA2 expression cassette into the mouse TIGRE locus Zeng
114428Ai148 (TIT2L-GC6f-ICL-tTA2) targeting vectorTarget a Cre-dependent GCaMP6f expression and a tTA2 cassette into the mouse TIGRE locus Zeng
114429Ai161 (TIT2L-GFP-ICR-tTA2) targeting vectorTarget a Cre-dependent GFP cassette and Dre-dependent tTA2 cassette to the mouse TIGRE locus Zeng
114430Ai163 (TIT2L-GC6s-ICL-TPT) targeting vectorTarget a Cre-dependent GCaMP6s cassette and a tdTomato-P2A-tTA2 cassette to the mouse TIGRE locus Zeng
114431Ai167 (TIT2L-ChrimsonR-tdT-ICL-tTA2) targeting vectorTarget a Cre-dependent ChrimsonR-tdTomato cassette and a tTA2 cassette into the mouse TIGRE locus Zeng
114432Ai133 (TITL-ssAPEX2tm) targeting vectorTarget a Cre-dependent electron microscopy tag ssAPEX2tm cassette into the mouse TIGRE locus Zeng
114433Ai162 (TIT2L-GC6s-ICL-tTA2) targeting vectorTarget a Cre-dependent GCaMP6s cassette and a tTA2 cassette into the mouse TIGRE locus Zeng
114435Ai170 (TIT2L-ASAP2s-Kv-ICL-tTA2) targeting vectorTarget a Cre-dependent voltage sensor ASAP2s cassette into the mouse TIGRE locus Zeng
114438Calb1-T2A-dgCre targeting vectorTarget dgCre into the endogenous mouse Calb1 locus at the stop codon Zeng
114474N222/6RMammalian Expression of anti-Clcn4 (Human) recombinant mouse monoclonal antibody Trimmer
114475N196/16RMammalian Expression of anti-PARIS/ZNF746 (Human) recombinant mouse monoclonal antibody Trimmer
114476N278/19RMammalian Expression of anti-Synaptotagmin-3 (Mouse) recombinant mouse monoclonal antibody Trimmer
114477N268/19RMammalian Expression of anti-TRPML3/Mucolipin-3 (Human) recombinant mouse monoclonal antibody Trimmer
114478N413/67RMammalian Expression of anti-GABA(A)R, Epsilon (Human) recombinant mouse monoclonal antibody Trimmer
114479N388A/10RMammalian Expression of anti-Ankyrin-R (Human) recombinant mouse monoclonal antibody Trimmer
114481N195A/16RMammalian Expression of anti-QKI-5 (Human) recombinant mouse monoclonal antibody Trimmer
114482N277/7RMammalian Expression of anti-Synaptotagmin-12 (Mouse) recombinant mouse monoclonal antibody Trimmer
114483N355/1RMammalian Expression of anti-GluA1/GluR1 glutamate receptor (Rat) recombinant mouse monoclonal antibody Trimmer
114484N346/9RMammalian Expression of anti-Stonin-2 (Human) recombinant mouse monoclonal antibody Trimmer
114485N348/82RMammalian Expression of anti-NSD3 (Human) recombinant mouse monoclonal antibody Trimmer
114486N353/13RMammalian Expression of anti-Flrt3 (Mouse) recombinant mouse monoclonal antibody Trimmer
114487N116/14RMammalian Expression of anti-Botch (Rat) recombinant mouse monoclonal antibody Trimmer
114488N331/19RMammalian Expression of anti-Dopamine D3 receptor (Human) recombinant mouse monoclonal antibody Trimmer
114490N321C/49RMammalian Expression of anti-Kirrel3, short and long (Rat) recombinant mouse monoclonal antibody Trimmer
114492N86/38.1RMammalian Expression of anti-GFP recombinant mouse monoclonal antibody Trimmer
114494N34/34.2RMammalian Expression of anti-VGlut3 (Rat) recombinant mouse monoclonal antibody Trimmer
114495N359/28RMammalian Expression of anti-Foxi3 (Mouse) recombinant mouse monoclonal antibody Trimmer
114496N11/33RMammalian Expression of anti-KCNT2/Slo2.1/Slick K+ channel (Mouse) recombinant mouse monoclonal antibody Trimmer
114497N7/18.1RMammalian Expression of anti-Cavbeta1 Ca2+ channel (Human) recombinant mouse monoclonal antibody Trimmer
114499N356/23RMammalian Expression of anti-SVOP (Rat) recombinant mouse monoclonal antibody Trimmer
114501N29/29RMammalian Expression of anti-VGlut2 (Rat) recombinant mouse monoclonal antibody Trimmer
114502L60/4RMammalian Expression of anti-Copper ATPase 1 (Menke's disease protein) (Human) recombinant mouse monoclonal antibody Trimmer
114503N341/37RMammalian Expression of anti-LRRK1 (Human) recombinant mouse monoclonal antibody Trimmer
114505N168/6.3RMammalian Expression of anti-Navbeta4 Na+ channel (Rat) recombinant mouse monoclonal antibody Trimmer
114506N114/10.1RMammalian Expression of anti-HCN4 (Human) recombinant mouse monoclonal antibody Trimmer
114509N235/22RMammalian Expression of anti-Pan-FHF-A (Human) recombinant mouse monoclonal antibody Trimmer
114510N326D/29RMammalian Expression of anti-REEP1/2 (Mouse) recombinant mouse monoclonal antibody Trimmer
114511N16B/8RMammalian Expression of anti-Kv3.1b K+ channel (Rat) recombinant mouse monoclonal antibody Trimmer
114512N70/28RMammalian Expression of anti-HCN1 (Rat) recombinant mouse monoclonal antibody Trimmer
114513N85/18.1RMammalian Expression of anti-Malin (Human) recombinant mouse monoclonal antibody Trimmer
114515N151/3.3RMammalian Expression of anti-GABA(A)R, Delta (Rat) recombinant mouse monoclonal antibody Trimmer
114516N150/21.3RMammalian Expression of anti-Doc2b (Rat) recombinant mouse monoclonal antibody Trimmer
114518N110/29.4RMammalian Expression of anti-Neuroligin-3 (Rat) recombinant mouse monoclonal antibody Trimmer
114519N133/21.2RMammalian Expression of anti-RGS14 (Rat) recombinant mouse monoclonal antibody Trimmer
114520N178A/9.1RMammalian Expression of anti-Cav3.1 Ca2+ channel (Mouse) recombinant mouse monoclonal antibody Trimmer
114521N147/6.1RMammalian Expression of anti-Pan-QKI (Human) recombinant mouse monoclonal antibody Trimmer
114525N91/27.1RMammalian Expression of anti-FGF13/FHF2 (Human) recombinant mouse monoclonal antibody Trimmer
114527N135/37.2RMammalian Expression of anti-JIP-2/IB-2 (Mouse) recombinant mouse monoclonal antibody Trimmer
114529N127/31.1RMammalian Expression of anti-Pan-SAPAP (Rat) recombinant mouse monoclonal antibody Trimmer
114530N170A/1.1RMammalian Expression of anti-Neurexin-1-Beta (Human) recombinant mouse monoclonal antibody Trimmer
114533N84/37.1RMammalian Expression of anti-Laforin (Human) recombinant mouse monoclonal antibody Trimmer
114536N206B/9RMammalian Expression of anti-GFAP R416WT (Human) recombinant mouse monoclonal antibody Trimmer
114538N94/17RMammalian Expression of anti-FGF12/FHF1 (Human) recombinant mouse monoclonal antibody Trimmer
114539N88/12.1RMammalian Expression of anti-MESD (Mouse) recombinant mouse monoclonal antibody Trimmer
114540N149/25.1RMammalian Expression of anti-Olig1 (Mouse) recombinant mouse monoclonal antibody Trimmer
114541N2/16RMammalian Expression of anti-KCNU1/Slo3 maxi-K+ channel (Mouse) recombinant mouse monoclonal antibody Trimmer
114542N164/6.1RMammalian Expression of anti-LRP4 (cytoplasmic) (Mouse) recombinant mouse monoclonal antibody Trimmer
114544N81/37.1RMammalian Expression of anti-GABA(B)R2 (Human) recombinant mouse monoclonal antibody Trimmer
114547N153/5.1RMammalian Expression of anti-Mitofusin-2 (Mouse) recombinant mouse monoclonal antibody Trimmer
114548N52A/42.1RMammalian Expression of anti-Mortalin/GRP75 (Mouse) recombinant mouse monoclonal antibody Trimmer
114549N96/55.3RMammalian Expression of anti-GABA(A)R, Beta1 (Mouse) recombinant mouse monoclonal antibody Trimmer
114550N93A/49.2RMammalian Expression of anti-GABA(B)R1 (Rat) recombinant mouse monoclonal antibody Trimmer
114551N171/17.4RMammalian Expression of anti-INPP4b (Human) recombinant mouse monoclonal antibody Trimmer
114552N419/40RMammalian Expression of anti-Pan-Nav1 Na+ channel (Human) recombinant mouse monoclonal antibody Trimmer
114553N419/78RMammalian Expression of anti-Pan-Nav1 Na+ channel (Human) recombinant mouse monoclonal antibody Trimmer
114554N97A/31RMammalian Expression of anti-Neuroligin-1 (Rat) recombinant mouse monoclonal antibody Trimmer
114555N230/21RMammalian Expression of anti-MMACHC (Human) recombinant mouse monoclonal antibody Trimmer
114556N289/16RMammalian Expression of anti-SUR1 (Rat) recombinant mouse monoclonal antibody Trimmer
114558N269/73RMammalian Expression of anti-Synaptotagmin-10 (Mouse) recombinant mouse monoclonal antibody Trimmer
114559N76/3RMammalian Expression of anti-Ataxin-1, 11NQ (Mouse) recombinant mouse monoclonal antibody Trimmer
114560N176A/35.1RMammalian Expression of anti-S100A5 (Rat) recombinant mouse monoclonal antibody Trimmer
114561N182/17.1RMammalian Expression of anti-QKI-6 (Human) recombinant mouse monoclonal antibody Trimmer
114562N244/5RMammalian Expression of anti-SynCAM4 (Mouse) recombinant mouse monoclonal antibody Trimmer
114563N291C/22RMammalian Expression of anti-TRIP8b (exon 1a/5) (Mouse) recombinant mouse monoclonal antibody Trimmer
115234pLV-CAG-FLEX-BFP2-(mCherry)’Lentiviral transfer plasmid for expression of mTagBFP2 before Cre recombination and mCherry after it Wickersham
115235pLV-CAG-F14F15S-BFP2-(mCherry)'Lentiviral transfer plasmid for expression of mTagBFP2 before Flp recombination and mCherry after it Wickersham
115236pLV-U-TVA950Lentiviral transfer plasmid for expression of TVA950 Wickersham
117380CAG-eYFP-3x-miR204-5p-TSAn AAV genome containing miRNA target sequence (TS) 204-5p to reduce expression of the fluorescent protein eYFP in astrocytes Gradinaru
117381CAG-eYFP-3x-miR708-5p-TSAn AAV genome containing miRNA target sequence (TS) 708-5p to reduce expression of the fluorescent protein eYFP in neurons Gradinaru
117382hSyn1-eYFPAn AAV genome that expresses the fluorescent protein eYFP from the hSyn1 promoter Gradinaru
117383TRE-DIO-eYFPAn AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein eYFP Gradinaru
117384CAG-GCaMP6f-3x-miR204-5p-3x-miR122-TSAn AAV genome containing miRNA target sequences (TS) 204-5p and 122 to reduce expression of GCaMP6f in astrocytes and hepatocytes, respectively Gradinaru
118025hSyn1-2xNLS-mTurquoise2An AAV genome that expresses nuclear localized mTurquoise2 from the hSyn1 promoter Gradinaru
118405pcDNA3.1(+)-ExRai-AKARcpGFP-based excitation-ratiometric biosensor for monitoring Protein Kinase A activity. Zhang
118406pcDNA3.1(+)-ExRai-AKAR(T/A)Negative-control mutant for ExRai-AKAR biosensor. Zhang
118407pcDNA3.1(+)-ExRai-AKAR-NESCytosol-targeted excitation-ratiometric biosensor for monitoring Protein Kinase A activity. Zhang
118408pcDNA3.1(+)-ExRai-AKAR-KrasPlasma membrane-targeted excitation-ratiometric biosensor for monitoring Protein Kinase A activity. Zhang
118409pcDNA3-ExRai-CKARcpGFP-based excitation-ratiometric biosensor for monitoring Protein Kinase C activity. Zhang
118410pcDNA3-ExRai-CKAR(T/A)Negative-control mutant for ExRai-CKAR biosensor. Zhang
118462pcDNA3-ExRai-AktARcpGFP-based excitation-ratiometric biosensor for monitoring Akt/Protein Kinase B activity. Zhang
118463pcDNA3-ExRai-AktAR(T/A)Negative-control mutant for ExRai-AktAR biosensor. Zhang
118464pcDNA3.1(+)-sapphireAKARcp-T-sapphire-based single-color biosensor for monitoring Protein Kinase A activity. Zhang
118465pcDNA3.1(+)-sapphireAKAR(T/A)Negative-control mutant for sapphireAKAR biosensor. Zhang
118466pcDNA3-Lyn-sapphireAKARcp-T-sapphire-based single-color PKA biosensor targeted to the plasma membrane. Zhang
118467pcDNA3.1(+)-sapphireAKAR-NLScp-T-sapphire-based single-color PKA biosensor targeted to the nucleus. Zhang
118468pcDNA3-sapphireCKARcp-T-sapphire-based single-color biosensor for monitoring Protein Kinase C activity. Zhang
118469pcDNA3-sapphireCKAR(T/A)Negative-control mutant for sapphireCKAR biosensor. Zhang
118470pcDNA3.1(+)-blueAKARcpBFP-based single-color biosensor for monitoring Protein Kinase A activity. Zhang
118471pcDNA3.1(+)-blueAKAR(T/A)Negative-control mutant for blueAKAR biosensor. Zhang
118472pcDNA3-blueCKARcpBFP-based single-color biosensor for monitoring Protein Kinase C activity. Zhang
118473pcDNA3-blueCKAR(T/A)Negative-control mutant for blueCKAR biosensor. Zhang
118474pcDNA3-RAB-EKARevddRFP-based single-color biosensor for monitoring ERK activity. Zhang
118475pcDNA3-RAB-EKARev(T/A)Negative-control mutant for RAB-EKARev biosensor. Zhang
118476pcDNA3-RAB-EKARev-NLSddRFP-based single-color ERK biosensor targeted to the nucleus. Zhang
118477pcDNA3-Lyn-RAB-EKARevddRFP-based single-color ERK biosensor targeted to the plasma membrane. Zhang
118478pcDNA3-RAB-AKARevddRFP-based single-color biosensor for monitoring Protein Kinase A activity. Zhang
118479pcDNA3-RAB-AKARev(T/A)Negative-control mutant for RAB-AKARev biosensor. Zhang
118480pcDNA3-RAB-ICUEddRFP-based single-color biosensor for monitoring cAMP dynamics. Zhang
118482pcDNA3.1(+)-PKI-GFPGFP-tagged Protein Kinase A inhibitor peptide. Zhang
120176jk95CAG:gfp:P2A:mycNRNX Zador
120177jk96CAG:mcherry:P2A:HA_NLGN Zador
121921pAAV-hSyn-GACh2.0express the genetically-encoded fluorescent acethycholine(ACh) sensor GACh2.0 Li
123308pAAV-hSyn-GRAB_NE1mExpresses the genetically-encoded fluorescent norepinephrine(NE) sensor GRAB_NE1m in neurons Li
123310pAAV-hSyn-GRAB_NEmutExpresses the genetically-encoded fluorescent norepinephrine(NE) control sensor GRAB_NEmut in neurons Li
124094pcDNA3.1-Orange_CaMBI_110orange calcium-modulated bioluminescent indicator, 110nM Lin
124095pcDNA3.1-Orange_CaMBI_300orange calcium-modulated bioluminescent indicator, 300nM Lin
124096pcDNA3.1-Green_CaMBIGreen calcium-modulated bioluminescent indicator Lin
124097pcDNA3.1-Blue_CaMBIBlue calcium-modulated bioluminescent indicator Lin
124775SLF063: Lenti-fCAG-jRGECO1aFor general lentiviral or direct expression of cytosolic jRGECO1a Cohen
125560pAAV-CAG-dLight1.3bFor expression of the genetically encoded dopamine sensor dLight1.3b Tian
127090pAAV-CAG-DIO-ChR2(H134R)-eYFPCre-dependent AAV expression of humanized ChR2 (with H134R mutation) fused to eYFP for optogenetic activation Gradinaru
127091pAAV-CAG-DIO-tTAAn AAV genome with Cre-dependent expression of tTA from the CAG promoter Gradinaru
127092pAAV-TRE-DIO-tdTomato-fAn AAV genome with tet-inducible, Cre-dependent expression of farnesylated (f) tdTomato Gradinaru
127237pAAV-hSyn-ChRger2-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter. Gradinaru
127238pAAV-CaMKIIa-ChRger2-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter. Gradinaru
127239pAAV-CAG-DIO(ChRger2-TS-YFP)High photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CAG promoter and double floxed. Gradinaru
127240pAAV-hSyn-ChRger3-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter. Gradinaru
127241pAAV-CaMKIIa-ChRger3-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter. Gradinaru
127242pAAV-CAG-DIO(ChRger3-TS-YFP)High photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CAG promoter and double floxed. Gradinaru
127243pAAV-hSyn-ChRger1-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger1) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter. Gradinaru
127244pAAV-CaMKIIa-ChRger1-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger1) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter. Gradinaru
127245pAAV-CAG-DIO(ChRger1-TS-YFP)High photocurrent, low-light sensitive channelrhodopsin (ChRger1) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CAG promoter and double floxed. Gradinaru
128612D3/71RMammalian Expression of Kv2.1 K+ Channel (Rat) recombinant mouse monocolonal antibody Trimmer
128613K13/31RMammalian Expression of Kv1.4 K+ Channel (Rat) recombinant mouse monocolonal antibody Trimmer
128614K14/16RMammalian Expression of Kv1.2 K+ Channel (Human) recombinant mouse monocolonal antibody Trimmer
128615K17/70RMammalian Expression of Kvbeta2/KCNAB2 K+ Channel (Mouse) recombinant mouse monocolonal antibody Trimmer
128616K20/78RMammalian Expression of Kv1.1 K+ Channel (Rat) recombinant mouse monocolonal antibody Trimmer
128617K25/73RMammalian Expression of Pan-Kvbeta K+ Channel Pan recombinant mouse monocolonal antibody Trimmer
128618K28/43RMammalian Expression of PSD-95 (Human) recombinant mouse monocolonal antibody Trimmer
128619K36/15RMammalian Expression of Kv1.1 K+ Channel (External) (Rat) recombinant mouse monocolonal antibody Trimmer
128620K39/25RMammalian Expression of Kv2.1 K+ Channel (External) (Human) recombinant mouse monocolonal antibody Trimmer
128621K51/1RMammalian Expression of SH3GL1/Endophilin A2 (Rat) recombinant mouse monocolonal antibody Trimmer
128622K57/1RMammalian Expression of Kv4.2 K+ Channel (External) (Human) recombinant mouse monocolonal antibody Trimmer
128623K58/35RMammalian Expression of Pan-Nav Channel recombinant mouse monocolonal antibody Trimmer
128624K64/15RMammalian Expression of SAP97 (Rat) recombinant mouse monocolonal antibody Trimmer
128625K66/38RMammalian Expression of CASPR/Neurexin IV (Rat) recombinant mouse monocolonal antibody Trimmer
128626K74/71RMammalian Expression of Nav1.1 Na+ channel (Rat) recombinant mouse monocolonal antibody Trimmer
128627K75/41RMammalian Expression of Kv4.3 K+ Channel (Rat) recombinant mouse monocolonal antibody Trimmer
128628K89/34RMammalian Expression of Kv2.1 K+ Channel (Rat) recombinant mouse monocolonal antibody Trimmer
128629K91/36RMammalian Expression of WAVE1/SCAR (Human) recombinant mouse monocolonal antibody Trimmer
128630L20/8RMammalian Expression of PICK1 (Human) recombinant mouse monocolonal antibody Trimmer
128632L42/17RMammalian Expression of SynDIG1/Tmem90b (Mouse) recombinant mouse monocolonal antibody Trimmer
128633L43/40RMammalian Expression of DLX1 (Human) recombinant mouse monocolonal antibody Trimmer
128634L6/23RMammalian Expression of Slo1/BKAlpha maxi-K+ channel (Mouse) recombinant mouse monocolonal antibody Trimmer
128635N106/43RMammalian Expression of Ankyrin-G (staining) (Human) recombinant mouse monocolonal antibody Trimmer
128636N205B/22RMammalian Expression of LRRTM4 (Human) recombinant mouse monocolonal antibody Trimmer
128637N23B/49RMammalian Expression of Pan-Shank Pan recombinant mouse monocolonal antibody Trimmer
128638N28/9RMammalian Expression of VGlut1 (Rat) recombinant mouse monocolonal antibody Trimmer
128639N351/23RMammalian Expression of Versican (Mouse) recombinant mouse monocolonal antibody Trimmer
128640N388A/60RMammalian Expression of Pan-Ankyrin Pan recombinant mouse monocolonal antibody Trimmer
128641N76/8RMammalian Expression of Ataxin-1, 11NQ (Mouse) recombinant mouse monocolonal antibody Trimmer
133268pAAV-rTH-tTAAn AAV genome that expresses tTA from the rat TH promoter Gradinaru

Additional Resources

  • To learn more please visit the BRAIN Initiative Resource List.
  • NeuroMab/Trimmer Lab Recombinant mAb Plasmid Collection. The NeuroMab Facility and James Trimmer have produced monoclonal antibodies validated for neuroscience research. The plasmids encoding these antibodies are available at Addgene.
  • AAV Viral Service. Addgene provides a viral service to help facilitate scientific research. Addgene's AAV are made from a selected set of plasmids that are currently in our repository. AAV are distributed as 100 µL of purified viral particles in solution that are suitable for in vivo use.