Addgene - pCMV5-ALK2 K235R Plasmid Data

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NM_001105

NCBI: ACVR1

ACVR1 antibodies

This is commonly
requested with

pCMV5-ALK2 wt

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Plasmid 11755: pCMV5-ALK2 K235R

Gene/insert name:		ALK2
Insert size (bp):		1500
GenBank/Entrez ID of insert:		NM_001105
Gene/insert aliases:		ACVR1, FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2
Species of gene(s):		H. sapiens (human)
Relevant mutations/deletions:		K235R: kinase dead
Vector backbone:		pCMV5 (Search Vector Database)
Type of vector:		Mammalian expression
Backbone size (bp):		4700
Cloning site 5':		SalI
Site destroyed during cloning:		Yes
Cloning site 3':		BamHI
Site destroyed during cloning:		No
5' Sequencing primer:		CMV-F (List of Sequencing Primers)
Bacteria resistance:		Ampicillin
High or low copy:		High Copy
Grow in standard E. coli @ 37C:		Yes
Sequence:		View sequence
Plasmid Provided In:		DH5a
Principal Investigator:		Jeff Wrana
Terms and Licenses:		MTA

Addgene has sequenced a portion of this plasmid for verification. Click here for the sequencing result.

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Article: Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. Macias-Silva M et al. (J Biol Chem. 1998 Oct 2. 273(40):25628-36. Pubmed)

Please acknowledge the principal investigator and cite this article if you use this plasmid in a publication.

Also, please include the text "Addgene plasmid 11755" in your Materials and Methods section. This information allows Addgene to create a link from the plasmid page to your publication.