Plasmids for Stem Cell Research Adult cells can be reprogrammed to behave like pluripotent stem cells by the expression of defined genes. Addgene currently distributes a number of plasmids containing these genes, including the plasmids used in the seminal publications from the Yamanaka and Thomson labs. To learn more about stem cells, please visit the Wikipedia Stem Cell Page or the NIH Stem Cell Information Page.

Oct3/4    Sox2    Klf4    c-Myc    Nmyc    Nanog    Lin28

James Thomson    Shinya Yamanaka

Juan Carlos Izpisua Belmonte    Linzhao Cheng    George Daley    Konrad Hochedlinger    Rudolf Jaenisch
Keisuke Kaji    Andras Nagy    Kathrin Plath    Miguel Ramalho-Santos    Michel Sadelain

Papapetrou et al. (Sadelain lab). Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. PNAS 2009

Yu et al. (Thomson lab). Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences. Science 2009

Kaji K et al. (Kaji lab). Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009

Woltjen K et al. (Nagy lab). piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009

Carey et al. (Jaenisch lab). Reprogramming of murine and human somatic cells using a single polycistronic vector. PNAS 2009

Aasen et al. (Belmonte lab). Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnology 2008

Stadtfeld et al. (Hochedlinger lab). Induced Pluripotent Stem Cells Generated Without Viral Integration. Science 2008

Hockemeyer et al. (Jaenisch lab). A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell 2008

Maherali et al. (Hochedlinger lab). A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 2008

Mali et al. (Cheng lab). Improved efficiency and pace of generating induced pluripotent Stem Cells from human adult and fetal fibroblasts. Stem Cells 2008

Stadtfeld et al. (Hochedlinger lab). Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008

Brambrink et al. (Jaenisch lab). Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2008

Lowry et al. (Plath lab). Generation of human induced pluripotent stem cells from dermal fibroblasts. PNAS 2008

Park et al. (Daley lab). Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2007

Yu et al. (Thomson lab). Induced pluripotent Stem Cell lines derived from human somatic cells. Science 2007

Takahashi et al. (Yamanaka lab). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007

Blelloch et al. (Ramalho-Santos lab). Generation of induced pluripotent Stem Cells in the absence of drug selection. Cell Stem Cell, 2007

Takahashi, Yamanaka. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006

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Stem cell protocols from Thomson lab