Plasmid Land: The Plasmid Cloning Game
When the average person asks, "What is a plasmid?" we sometimes struggle to give them a basic answer. Plasmids are circular fragments of double-stranded DNA that can replicate independently of chromosomal DNA. Today, scientists can easily study and manipulate genes and other genetic elements using specifically engineered plasmids. Plasmids are essential tools for our understanding of basic biology and for making advances in medical research.
Addgene is a nonprofit plasmid repository that helps scientists share plasmids. We have created this board game for you to play during your incubation times in the lab or to teach your young children a little about what you do all day.
The game gives a very basic overview of creating a plasmid through molecular cloning. It begins with PCR and restriction enzyme digestion, followed by DNA ligation. The process proceeds to transformation, DNA purification and verification by diagnostic digest and sequencing. With a bit of lab humor worked in, of course.
We encourage scientists to share this game and Addgene's plasmid reference and molecular cloning resource with those who need a simple explanation of the topic. See below for instructions for how to add this game to your website. Enjoy!
Copy the code below to add the game to your website: