Plasmids for Stem Cell Research Adult cells can be reprogrammed to behave like pluripotent stem cells by the expression of defined genes. Addgene currently distributes a number of plasmids containing these genes, including the plasmids used in the seminal publications from the Yamanaka and Thomson labs. To learn more about stem cells, please visit the Wikipedia Stem Cell Page or the NIH Stem Cell Information Page.

Oct3/4    Sox2    Klf4    c-Myc    Nmyc    Nanog    Lin28

George Daley    Kathrin Plath    Miguel Ramalho-Santos    James Thomson    Shinya Yamanaka

Lowry et al. (Plath lab). Generation of human induced pluripotent stem cells from dermal fibroblasts. PNAS 2008

Park et al. (Daley lab). Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2007

Yu et al. (Thomson lab). Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science 2007

Takahashi et al. (Yamanaka lab). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007

Blelloch et al. (Ramalho-Santos lab). Generation of Induced Pluripotent Stem Cells in the Absence of Drug Selection. Cell Stem Cell, 2007

Takahashi, Yamanaka. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006

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Stem cell protocols from Thomson lab