LOCUS       sequence-10514-e        1300 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Junk DJ, Vrba L, Watts GS, Oshiro MM, Martinez JD, Futscher BW
  TITLE     Different mutant/wild-type p53 combinations cause a spectrum of 
            increased invasive potential in nonmalignant immortalized human 
            mammary epithelial cells.
  JOURNAL   Neoplasia. 2008 May . 10(5):450-61.
  PUBMED    18472962
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Neoplasia. 
            2008 May . 10(5):450-61."
COMMENT     Sequence Label: pLenti6/V5-p53_R280K
FEATURES             Location/Qualifiers
     source          1..1300
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             97..1275
                     /codon_start=1
                     /gene="Homo sapiens TP53"
                     /product="human tumor suppressor protein that is often 
                     mutated in cancers"
                     /label=p53
                     /note="responds to cellular stresses to regulate the 
                     expression of target genes"
                     /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLML
                     SPDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQ
                     GSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIY
                     KQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEP
                     PEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGKD
                     RRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEM
                     FRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD"
ORIGIN
        1 tgggagacgc cattccacgc ctgttttgac ctccatagaa gacaccgact ctagaggatc
       61 cactagntcc agtgtggtgg aattgatccc ttcaccatgg aggagccgca gtcagatcct
      121 agcgtcgagc cccctctgag tcaggaaaca ttttcagacc tatggaaact acttcctgaa
      181 aacaacgttc tgtccccctt gccgtcccaa gcaatggatg atttgatgct gtccccggac
      241 gatattgaac aatggttcac tgaagaccca ggtccagatg aagctcccag aatgccagag
      301 gctgctcccc gcgtggcccc tgcaccagca gctcctacac cggcggcccc tgcaccagcc
      361 ccctcctggc ccctgtcatc ttctgtccct tcccagaaaa cctaccaggg cagctacggt
      421 ttccgtctgg gcttcttgca ttctgggaca gccaagtctg tgacttgcac gtactcccct
      481 gccctcaaca agatgttttg ccaactggcc aagacctgcc ctgtgcagct gtgggttgat
      541 tccacacccc cgcccggcac ccgcgtccgc gccatggcca tctacaagca gtcacagcac
      601 atgacggagg ttgtgaggcg ctgcccccac catgagcgct gctcagatag cgatggtctg
      661 gcccctcctc agcatcttat ccgagtggaa ggaaatttgc gtgtggagta tttggatgac
      721 agaaacactt ttcgacatag tgtggtggtg ccctatgagc cgcctgaggt tggctctgac
      781 tgtaccacca tccactacaa ctacatgtgt aacagttcct gcatgggcgg catgaaccgg
      841 aggcccatcc tcaccatcat cacactggaa gactccagtg gtaatctact gggacggaac
      901 agctttgagg tgcgtgtttg tgcctgtcct gggaaagacc ggcgcacaga ggaagagaat
      961 ctccgcaaga aaggggagcc tcaccacgag ctgcccccag ggagcactaa gcgagcactg
     1021 cccaacaaca ccagctcctc tccccagcca aagaagaaac cactggatgg agaatatttc
     1081 acccttcaga tccgtgggcg tgagcgcttc gagatgttcc gagagctgaa tgaggccttg
     1141 gaactcaagg atgcccaggc tgggaaggag ccagggggga gcagggctca ctccagccac
     1201 ctgaagtcca aaaagggtca gtctacctcc cgccataaaa aactcatgtt caagacagaa
     1261 gggcctgact cagacaaggg ctcgagtcta gagggcncgc
//
