LOCUS       sequence-10515-e        1350 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Junk DJ, Vrba L, Watts GS, Oshiro MM, Martinez JD, Futscher BW
  TITLE     Different mutant/wild-type p53 combinations cause a spectrum of 
            increased invasive potential in nonmalignant immortalized human 
            mammary epithelial cells.
  JOURNAL   Neoplasia. 2008 May . 10(5):450-61.
  PUBMED    18472962
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Neoplasia. 
            2008 May . 10(5):450-61."
COMMENT     Sequence Label: pLenti6/V5-p53_R273H
FEATURES             Location/Qualifiers
     source          1..1350
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             147..1325
                     /codon_start=1
                     /gene="Homo sapiens TP53"
                     /product="human tumor suppressor protein that is often 
                     mutated in cancers"
                     /label=p53
                     /note="responds to cellular stresses to regulate the 
                     expression of target genes"
                     /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLML
                     SPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQ
                     GSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIY
                     KQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEP
                     PEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVHVCACPGRD
                     RRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEM
                     FRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD"
ORIGIN
        1 gnggggncan tagcagaanc tcgntttagt ggaaccgntc agaatcgcct gggagacgcc
       61 attccacgcc tgnttttgac ctccatagaa gacaccgact ctagaggatc cactagntcc
      121 agtgtggtgg aattgatccc ttcaccatgg aggagccgca gtcagatcct agcgtcgagc
      181 cccctctgag tcaggaaaca ttttcagacc tatggaaact acttcctgaa aacaacgttc
      241 tgtccccctt gccgtcccaa gcaatggatg atttgatgct gtccccggac gatattgaac
      301 aatggttcac tgaagaccca ggtccagatg aagctcccag aatgccagag gctgctcccc
      361 ccgtggcccc tgcaccagca gctcctacac cggcggcccc tgcaccagcc ccctcctggc
      421 ccctgtcatc ttctgtccct tcccagaaaa cctaccaggg cagctacggt ttccgtctgg
      481 gcttcttgca ttctgggaca gccaagtctg tgacttgcac gtactcccct gccctcaaca
      541 agatgttttg ccaactggcc aagacctgcc ctgtgcagct gtgggttgat tccacacccc
      601 cgcccggcac ccgcgtccgc gccatggcca tctacaagca gtcacagcac atgacggagg
      661 ttgtgaggcg ctgcccccac catgagcgct gctcagatag cgatggtctg gcccctcctc
      721 agcatcttat ccgagtggaa ggaaatttgc gtgtggagta tttggatgac agaaacactt
      781 ttcgacatag tgtggtggtg ccctatgagc cgcctgaggt tggctctgac tgtaccacca
      841 tccactacaa ctacatgtgt aacagttcct gcatgggcgg catgaaccgg aggcccatcc
      901 tcaccatcat cacactggaa gactccagtg gtaatctact gggacggaac agctttgagg
      961 tgcatgtttg tgcctgtcct gggagagacc ggcgcacaga ggaagagaat ctccgcaaga
     1021 aaggggagcc tcaccacgag ctgcccccag ggagcactaa gcgagcactg cccaacaaca
     1081 ccagctcctc tccccagcca aagaagaaac cactggatgg agaatatttc acccttcaga
     1141 tccgtgggcg tgagcgcttc gagatgttcc gagagctgaa tgaggccttg gaactcaagg
     1201 atgcccaggc tgggaaggag ccagggggga gcagggctca ctccagccac ctgaagtcca
     1261 aaaagggtca gtctacctcc cgccataaaa aactcatgtt caagacagaa gggcctgact
     1321 cagacaaggg ctcgagtcta gagggcncgc
//
