LOCUS       sequence-10516-e        1338 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Junk DJ, Vrba L, Watts GS, Oshiro MM, Martinez JD, Futscher BW
  TITLE     Different mutant/wild-type p53 combinations cause a spectrum of 
            increased invasive potential in nonmalignant immortalized human 
            mammary epithelial cells.
  JOURNAL   Neoplasia. 2008 May . 10(5):450-61.
  PUBMED    18472962
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Neoplasia. 
            2008 May . 10(5):450-61."
COMMENT     Sequence Label: pLenti6/V5-p53_R249S
FEATURES             Location/Qualifiers
     source          1..1338
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             136..1314
                     /codon_start=1
                     /gene="Homo sapiens TP53"
                     /product="human tumor suppressor protein that is often 
                     mutated in cancers"
                     /label=p53
                     /note="responds to cellular stresses to regulate the 
                     expression of target genes"
                     /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLML
                     SPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQ
                     GSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIY
                     KQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEP
                     PEVGSDCTTIHYNYMCNSSCMGGMNRSPILTIITLEDSSGNLLGRNSFEVRVCACPGRD
                     RRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEM
                     FRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD"
ORIGIN
        1 cggggggnaa tagcagagct gtttagtgaa ccgtcagatc gcctggagac gccatccacg
       61 ctgttttgac ctccatagaa gacaccgact ctagaggatc cactagtcca gtgtggtgga
      121 attgatccct tcaccatgga ggagccgcag tcagatccta gcgtcgagcc ccctctgagt
      181 caggaaacat tttcagacct atggaaacta cttcctgaaa acaacgttct gtcccccttg
      241 ccatcccaag caatggatga tttgatgctg tccccggacg atattgaaca atggttcact
      301 gaagacccag gtccagatga agctcccaga atgccagagg ctgctccccc cgtggcccct
      361 gcaccagcag ctcctacacc ggcggcccct gcaccagccc cctcctggcc cctgtcatct
      421 tctgtccctt cccagaaaac ctaccagggc agctacggtt tccgtctggg cttcttgcat
      481 tctgggacag ccaagtctgt gacttgcacg tactcccctg ccctcaacaa gatgttttgc
      541 caactggcca agacctgccc tgtgcagctg tgggttgatt ccacaccccc gcccggcacc
      601 cgcgtccgcg ccatggccat ctacaagcag tcacagcaca tgacggaggt tgtgaggcgc
      661 tgcccccacc atgagcgctg ctcagatagc gatggtctgg cccctcctca gcatcttatc
      721 cgagtggaag gaaatttgcg tgtggagtat ttggatgaca gaaacacttt tcgacatagt
      781 gtggtggtgc cctatgagcc gcctgaggtt ggctctgact gtaccaccat ccactacaac
      841 tacatgtgta acagttcctg catgggcggc atgaaccgga gccccatcct caccatcatc
      901 acactggaag actccagtgg taatctactg ggacggaaca gctttgaggt gcgtgtttgt
      961 gcctgtcctg ggagagaccg gcgcacagag gaagagaatc tccgcaagaa aggggagcct
     1021 caccacgagc tgcccccagg gagcactaag cgagcactgc ccaacaacac cagctcctct
     1081 ccccagccaa agaagaaacc actggatgga gaatatttca cccttcagat ccgtgggcgt
     1141 gagcgcttcg agatgttccg agagctgaat gaggccttgg aactcaagga tgcccaggct
     1201 gggaaggagc caggggggag cagggctcac tccagccacc tgaagtccaa aaagggtcag
     1261 tctacctccc gccataaaaa actcatgttc aagacagaag ggcctgactc agacaagggc
     1321 tcgagtctag aggcccgc
//
