LOCUS       sequence-10667-e        1791 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-MYLK2
FEATURES             Location/Qualifiers
     source          1..1791
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             1696..1773
                     /codon_start=1
                     /product="calmodulin-binding peptide"
                     /label=CBP
                     /note="derived from skeletal muscle myosin light chain 
                     kinase; binds calmodulin with nanomolar affinity in the 
                     presence of calcium"
                     /translation="KRRWKKNFIAVSAANRFKKISSSGAL"
ORIGIN
        1 atggcgacag aaaatggagc agttgagctg ggaattcaga acccatcaac agacaaggca
       61 cctaaaggtc ccacaggtga aagacccctg gctgcaggga aagaccctgg ccccccagac
      121 ccaaagaaag ctccggatcc acccaccctg aagaaagatg ccaaagcccc tgcctcagag
      181 aaaggggatg gtaccctggc ccaaccctca actagcagcc aaggccccaa aggagagggt
      241 gacaggggcg gggggcccgc ggagggcagt gctgggcccc cggcagccct gccccagcag
      301 actgcgacac ctgagaccag cgtcaagaag cccaaggctg agcagggagc ctcaggcagc
      361 caggatcctg gaaagcccag ggtgggcaag aaggcagcag agggccaagc agcagccagg
      421 aggggctcac ctgcctttct gcatagcccc agctgtcctg ccatcatctc cagttctgag
      481 aagctgctgg ccaagaagcc cccaagcgag gcatcagagc tcacctttga aggggtgccc
      541 atgacccaca gccccacgga tcccaggcca gccaaggcag aagaaggaaa gaacatcctg
      601 gcagagagcc agaaggaagt gggagagaaa accccaggcc aggctggcca ggctaagatg
      661 caaggggaca cctcgagggg gatcgagttc caggctgttc cctcagagaa atccgaggtg
      721 gggcaggccc tctgtctcac agccagggag gaggactgct tccagatttt ggatgattgc
      781 ccgccacctc cggccccctt ccctcaccgc atggtggagc tgaggaccgg gaatgtcagc
      841 agtgaattca gtatgaactc caaggaggcg ctcggaggtg gcaagtttgg ggcagtctgt
      901 acctgcatgg agaaagccac aggcctcaag ctggcagcca aggtcatcaa gaaacagact
      961 cccaaagaca aggaaatggt gttgctggag attgaggtca tgaaccagct gaaccaccgc
     1021 aatctgatcc agctgtatgc agccatcgag actccgcatg agatcgtcct gttcatggag
     1081 tacatcgagg gcggagagct cttcgagagg attgtggatg aggactacca tctgaccgag
     1141 gtggacacca tggtgtttgt caggcagatc tgtgacggga tcctcttcat gcacaagatg
     1201 agggttttgc acctggacct caagccagag aacatcctgt gtgtcaacac caccgggcat
     1261 ttggtgaaga tcattgactt tggcctggca cggaggtata accccaacga gaagctgaag
     1321 gtgaactttg ggaccccaga gttcctgtca cctgaggtgg tgaattatga ccaaatctcc
     1381 gataagacag acatgtggag tatgggggtg atcacctaca tgctgctgag cggcctctcc
     1441 cccttcctgg gagatgatga cacagagacc ctaaacaacg ttctatctgg caactggtac
     1501 tttgatgaag agacctttga ggccgtatca gacgaggcca aagactttgt ctccaacctc
     1561 atcgtcaagg accagagggc ccggatgaac gctgcccagt gtctcgccca tccctggctc
     1621 aacaacctgg cggagaaagc caaacgctgt aaccgacgcc ttaagtccca gatcttgctt
     1681 aagaaatacc tcatgaagag gcgctggaag aaaaacttca ttgctgtcag cgctgccaac
     1741 cgcttcaaga agatcagcag ctcgggggca ctgatggctc tgggggtctg a
//
