LOCUS       sequence-10693-e        3258 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-ALPK1
FEATURES             Location/Qualifiers
     source          1..3258
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 atgaataatc aaaaagtggt agctgtgcta ctgcaagagt gcaagcaagt gctggatcag
       61 ctcttgttgg aagcgccaga tgtgtcggaa gaggacaaga gcgaggacca gcgctgcaga
      121 gctttactcc ccagcgagtt aaggaccctg atccaggagg caaaggaaat gaagtggccc
      181 ttcgtgcctg aaaagtggca gtacaaacaa gccgtgggcc cagaggacaa aacaaacctg
      241 aaggatgtga ttggcgccgg gttgcagcag ttactggcgt ccctgagggc ctccatcctc
      301 gctcgggact gtgcggctgc ggcggctatt gtgttcttgg tggaccggtt cctgtatggg
      361 ctcgacgtct ctggaaaact tctgcaggtc gccaaaggtc tccacaagtt gcagccagcc
      421 acgccaattg ccccgcaggt ggttattcgc caagcccgaa tctccgtgaa ctcaggaaaa
      481 cttttaaaag cagagtatat tctgagcagt ctaataagca acaatggagc aacgggtacc
      541 tggctgtaca gaaatgaaag tgacaaggtc ctggtgcagt cggtctgtat acagatcaga
      601 gggcagattc tgcaaaagct ggggatgtgg tacgaagcag cagagttaat atgggcctcc
      661 attgtaggat atttggcact tcctcagccg gataaaaagg gcctctccac gtcgctaggt
      721 atactggcag acatctttgt ttccatgagc aagaacgatt atgaaaagtt taaaaacaat
      781 ccacaaatta atttgagcct gctgaaggag tttgaccacc atttgctgtc cgctgcagaa
      841 gcctgcaagc tggcagctgc cttcagtgcc tatacgccgc tcttcgtgct cacagctgtg
      901 aatatccgtg gcacgtgttt attgtcctac agtagttcaa atgactgtcc tccagaattg
      961 aaaaacttac atctgtgtga agccaaagag gcctttgaga ttggcctcct caccaagaga
     1021 gatgatgagc ctgttactgg aaaacaggag cttcacagct ttgtcaaagc tgctttcggt
     1081 ctcaccacag tgcacagaag gctccatggg gagacaggga cggtccatgc agcaagtcag
     1141 ctctgtaagg aagcaatggg gaagctgtac aatttcagca cttcctccag aagtcaggac
     1201 agagaagctc tgtctcaaga agttatgtct gtgattgccc aggtgaagga acatttacaa
     1261 gttcaaagct tctcaaatgt agatgacaga tcttatgttc ccgagagttt cgagtgcagg
     1321 ttggataaac ttatcttgca tgggcaaggg gatttccaaa aaatccttga cacctattca
     1381 cagcaccata cttcggtgtg tgaagtattt gaaagtgatt gtggaaacaa caaaaatgaa
     1441 cagaaagatg caaaaacagg agtctgcatc actgctctaa aaacagaaat aaaaaacata
     1501 gatactgtga gtactactca agaaaagcca cattgtcaaa gagacacagg aatatcttcc
     1561 tccctaatgg gtaagaatgt tcagagggaa ctcagaaggg gaggaaggag aaactggacc
     1621 cattctgatg catttcgagt ctccttggat caagatgtgg agactgagac tgagccatcg
     1681 gactacagca atggtgaggg agctgttttc aacaagtctc tgagtggcag ccagacttcc
     1741 agtgcttgga gcaacttatc agggtttagt tcctctgcaa gctgggagga agtgaattat
     1801 cacgttgacg acaggtcagc cagaaaagag cctggcaaag aacatctggt ggacactcag
     1861 tgttccactg ccttgtctga ggagctagag aatgacaggg aaggcagagc tatgcattca
     1921 ttgcattcac agcttcatga tctctctctt caggaaccca acaatgacaa tttggagcct
     1981 tctcaaaatc agccacagca acagatgccc ttgacaccct tctcgcctca taatacccca
     2041 ggcattttct tggcccctgg tgcagggctt ctagaaggag ctccagaagg tatccaggaa
     2101 gtcagaaata tgggacccag aaatacttct gctcactcca gaccctcata tcgttctgct
     2161 tcttggtctt ctgattctgg taggcccaag aatatgggca cacatccttc agtccaaaaa
     2221 gaagaagcct ttgaaataat tgttgagttt ccagaaacca actgcgatgt caaagacagg
     2281 caggggaaag agcagggaga agaaattagt gaaagaggcg caggccctac atttaaagct
     2341 agtccctcct gggttgaccc agaaggagaa acagcagaaa gcactgaaga tgcaccctta
     2401 gactttcaca gggtcctgca caattctctg ggaaacattt ccatgctgcc atgtagctcc
     2461 ttcaccccta attggcctgt tcaaaatcct gactccagaa aaagtggtgg cccagtcgca
     2521 gagcagggca tcgaccctga tgcctccaca gtggatgagg aggggcaact gctcgacagc
     2581 atggatgttc cctgcacaaa tgggcacggc tctcatagac tgtgcattct gagacagccg
     2641 cctggtcaga gggcggagac ccccaattcc tctgtaagcg gtaacatcct cttccctgtc
     2701 ctcagcgagg actgcactac cacagaggaa ggaaatcagc ctggaaacat gctaaactgc
     2761 agccagaact ccagctcatc ctcagtgtgg tggctgaaat cacctgcatt ttccagtggt
     2821 tcttctgagg gggacagccc ttggtcctat ctgaattcca gtgggagttc ttgggtttca
     2881 ttgccgggaa agatgaggaa agagatcctt gaggctcgca ccttgcaacc tgatgacttt
     2941 gaaaagctgt tggcaggagt gaggcatgat tggctgtttc agagactaga gaatacgggg
     3001 gtttttaagc ccagtcaact ccaccgagca catagtgctc ttttgttaaa atattcaaaa
     3061 aaatctgaac tgtggacggc ccaggaaact attgtctatt tgggggacta cttgactgtg
     3121 aagaaaaagg cagacaaaga aatgcttttt gggttcatca tcttcatcaa gaagaaattc
     3181 tggggaggta tgttgggaaa gactataagg agcagaaggg gctctggcac cacttcactg
     3241 atgtggagcg acagatga
//
