LOCUS       sequence-10739-e         897 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 897)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-KHK
FEATURES             Location/Qualifiers
     source          1..897
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             412..423
                     /codon_start=1
                     /product="Factor Xa recognition and cleavage site"
                     /label=Factor Xa site
                     /translation="IEGR"
ORIGIN
        1 atggaagaga agcagatcct gtgcgtgggg ctagtggtgc tggacgtcat cagcctggtg
       61 gacaagtacc ctaaggagga ctcggagata aggtgtttgt cccagagatg gcagcgcgga
      121 ggcaacgcgt ccaactcctg caccattctc tccctgctcg gagccccctg tgccttcatg
      181 ggctcaatgg ctcctggcca tgttgctgat tttgtcctgg atgacctccg ccgttattct
      241 gtggacctac gctacacagt ctttcagacc acaggctccg tccccatcgc cacggtcatc
      301 atcaacgagg ccagtggtag ccgcaccatc ctatactatg acaggagcct gccagatgtg
      361 tctgctacag actttgagaa ggttgatctg acccagttca agtggatcca cattgagggc
      421 cggaacgcat cggagcaggt gaagatgctg cagcggatag acgcacacaa caccaggcag
      481 cctccagagc agaagatccg ggtgtccgtg gaggtggaga agccacgaga ggagctcttc
      541 cagctgtttg gctacggaga cgtggtgttt gtcagcaaag atgtggccaa gcacttgggg
      601 ttccagtcag cagaggaagc cttgaggggc ttgtatggtc gtgtgaggaa aggggctgtg
      661 cttgtctgtg cctgggctga ggagggcgcc gacgccctgg gccctgatgg caaattgctc
      721 cactcggatg ctttcccgcc accccgcgtg gtggatacac tgggagctgg agacaccttc
      781 aatgcctccg tcatcttcag cctctcccag gggaggagcg tgcaggaagc actgagattc
      841 gggtgccagg tggccggcaa gaagtgtggc ctgcagggct ttgatggcat cgtgtga
//
