LOCUS       sequence-10747-e        1269 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 1269)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-AGK
FEATURES             Location/Qualifiers
     source          1..1269
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             complement(620..631)
                     /codon_start=1
                     /product="Factor Xa recognition and cleavage site"
                     /label=Factor Xa site
                     /translation="IEGR"
ORIGIN
        1 atgacggtgt tctttaaaac gcttcgaaat cactggaaga aaactacagc tgggctctgc
       61 ctgctgacct ggggaggcca ttggctctat ggaaaacact gtgataacct cctaaggaga
      121 gcagcctgtc aagaagctca ggtgtttggc aatcaactca ttcctcccaa tgcacaagtg
      181 aagaaggcca ctgtttttct caatcctgca gcttgcaaag gaaaagctag gactctattt
      241 gaaaaaaatg ctgccccgat tttacattta tctggcatgg atgtgactat tgttaagaca
      301 gattatgagg gacaagccaa gaaactcctg gaactgatgg aaaacacgga tgtgatcatt
      361 gttgcaggag gagatgggac actgcaggag gttgttactg gtgttcttcg acgaacagat
      421 gaggctacct tcagtaagat tcccattgga tttatcccac tgggagagac cagtagtttg
      481 agtcataccc tctttgccga aagtggaaac aaagtccaac atattactga tgccacactt
      541 gccattgtga aaggagagac agttccactt gatgtcttgc agatcaaggg tgaaaaggaa
      601 cagcctgtat ttgcaatgac cggccttcga tggggatctt tcagagatgc tggcgtcaaa
      661 gttagcaagt actggtatct tgggcctcta aaaatcaaag cagcccactt tttcagcact
      721 cttaaggagt ggcctcagac tcatcaagcc tctatctcat acacgggacc tacagagaga
      781 cctcccaatg aaccagagga gacccctgta caaaggcctt ctttgtacag gagaatatta
      841 cgaaggcttg cgtcctactg ggcacaacca caggatgccc tttcccaaga ggtgagcccg
      901 gaggtctgga aagatgtgca gctgtccacc attgaactgt ccatcacaac acggaataat
      961 cagcttgacc cgacaagcaa agaagatttt ctgaatatct gcattgaacc tgacaccatc
     1021 agcaaaggag actttataac tataggaagt cgaaaggtga gaaaccccaa gctgcacgtg
     1081 gagggcacgg agtgtctcca agccagccag tgcactttgc ttatcccgga gggagcaggg
     1141 ggctctttta gcattgacag tgaggagtat gaagcgatgc ctgtggaggt gaaactgctc
     1201 cccaggaagc tgcagttctt ctgtgatcct aggaagagag aacagatgct cacaagcccc
     1261 acccagtga
//
