LOCUS       sequence-10920-e        2484 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-PFKL
FEATURES             Location/Qualifiers
     source          1..2484
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     regulatory      1780..1789
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
ORIGIN
        1 atgtgtaacc agggtagagg tcgagagtcc tctcgtgggg gtctccatgt tcaagggagc
       61 tgccgaggct tgagcaggag cccccagcag gaaactggct ttgccaaggc ccccgctggg
      121 acagactgtt tctttcactg cagtcctggg agccgagggc aaggggacag gaaagaggaa
      181 gtgacctcag agcctggtgg caccagcatc atgtccaggc tggggggcat gaacgctgct
      241 gtccgggctg tgacgcgcat gggcatttat gtgggtgcca aagtcttcct catctacgag
      301 ggctatgagg gcctcgtgga gggaggtgag aacatcaagc aggccaactg gctgagcgtc
      361 tccaacatca tccagctggg cggcactatc attggcagcg ctcgctgcaa ggcctttacc
      421 accagggagg ggcgccgggc agcggcctac aacctggtcc agcacggcat caccaacctg
      481 tgcgtcatcg gcggggatgg cagccttaca ggtgccaaca tcttccgcag cgagtggggc
      541 agcctgctgg aggagctggt ggcggaaggt aagatctcag agactacagc ccggacctac
      601 tcgcacctga acatcgcggg cctagtgggc tccatcgata acgacttctg cggcaccgac
      661 atgaccatcg gcacggactc ggccctccac cgcatcatgg aggtcatcga tgccatcacc
      721 accactgccc agagccacca gaggaccttc gtgctggaag tgatgggccg gcactgcggg
      781 tacctggcgc tggtatctgc actggcctca ggggccgact ggctgttcat ccccgaggct
      841 ccacccgagg acggctggga gaacttcatg tgtgagaggc tgggtgagac tcggagccgt
      901 gggtcccgac tgaacatcat catcatcgct gagggtgcca ttgaccgcaa cgggaagccc
      961 atctcgtcca gctacgtgaa ggacctggtg gttcagaggc tgggcttcga cacccgtgta
     1021 actgtgctgg gccacgtgca gcggggaggg acgccctctg ccttcgaccg gatcctgagc
     1081 agcaagatgg gcatggaggc ggtgatggcg ctgctggaag ccacgcctga cacgccggcc
     1141 tgcgtggtca ccctctcggg gaaccagtca gtgcggctgc ccctcatgga gtgcgtgcag
     1201 atgaccaagg aagtgcagaa agccatggat gacaagaggt ttgacgaggc cacccagctc
     1261 cgtggtggga gcttcgagaa caactggaac atttacaagc tcctcgccca ccagaagccc
     1321 cccaaggaga agtctaactt ctccctggcc atcctgaatg tgggggcccc ggcggctggc
     1381 atgaatgcgg ccgtgcgctc ggcggtgcgg accggcatct cccatggaca cacagtatac
     1441 gtggtgcacg atggcttcga aggcctagcc aagggtcagg tgcaagaagt aggctggcac
     1501 gacgtggccg gctggttggg gcgtggtggc tccatgctgg ggaccaagag gaccctgccc
     1561 aagggccagc tggagtccat tgtggagaac atccgcatct atggtattca cgccctgctg
     1621 gtggtcggtg ggtttgaggc ctatgaaggg gtgctgcagc tggtggaggc tcgcgggcgc
     1681 tacgaggagc tctgcatcgt catgtgtgtc atcccagcca ccatcagcaa caacgtccct
     1741 ggcaccgact tcagcctggg ctccgacact gctgtaaatg ccgccatgga gagctgtgac
     1801 cgcatcaaac agtctgcctc ggggaccaag cgccgtgtgt tcatcgtgga gaccatgggg
     1861 ggttactgtg gctacctggc caccgtgact ggcattgctg tgggggccga cgccgcctac
     1921 gtcttcgagg accctttcaa catccacgac ttaaaggtca acgtggagca catgacggag
     1981 aagatgaaga cagacattca gaggggcctg gtgctgcgga acgagaagtg ccatgactac
     2041 tacaccacgg agttcctgta caacctgtac tcatcagagg gcaagggcgt cttcgactgc
     2101 aggaccaatg tcctgggcca cctgcagcag ggtggcgctc caaccccctt tgaccggaac
     2161 tatgggacca agctgggggt gaaggccatg ctgtggttgt cggagaagct gcgcgaggtt
     2221 taccgcaagg gacgggtgtt cgccaatgcc ccagactcgg cctgcgtgat cggcctgaag
     2281 aagaaggcgg tggccttcag ccccgtcact gagctcaaga aagacactga tttcgagcac
     2341 cgcatgccac gggagcagtg gtggctgagc ctgcggctca tgctgaagat gctggcacaa
     2401 taccgcatca gtatggccgc ctacgtgtca ggggagctgg agcacgtgac ccgccgcacc
     2461 ctgagcatgg acaagggctt ctga
//
