LOCUS       sequence-11016-e        3318 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 3318)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 3318)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-PDGFRB
FEATURES             Location/Qualifiers
     source          1..3318
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             1537..1683
                     /codon_start=1
                     /product="transmembrane domain from platelet derived growth
                     factor receptor beta"
                     /label=PDGFR-beta TM domain
                     /translation="AVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQ
                     KKPR"
ORIGIN
        1 atgcggcttc cgggtgcgat gccagctctg gccctcaaag gcgagctgct gttgctgtct
       61 ctcctgttac ttctggaacc acagatctct cagggcctgg tcgtcacacc cccggggcca
      121 gagcttgtcc tcaatgtctc cagcaccttc gttctgacct gctcgggttc agctccggtg
      181 gtgtgggaac ggatgtccca ggagccccca caggaaatgg ccaaggccca ggatggcacc
      241 ttctccagcg tgctcacact gaccaacctc actgggctag acacgggaga atacttttgc
      301 acccacaatg actcccgtgg actggagacc gatgagcgga aacggctcta catctttgtg
      361 ccagatccca ccgtgggctt cctccctaat gatgccgagg aactattcat ctttctcacg
      421 gaaataactg agatcaccat tccatgccga gtaacagacc cacagctggt ggtgacactg
      481 cacgagaaga aaggggacgt tgcactgcct gtcccctatg atcaccaacg tggctttttt
      541 ggtatctttg aggacagaag ctacatctgc aaaaccacca ttggggacag ggaggtggat
      601 tctgatgcct actatgtcta cagactccag gtgtcatcca tcaacgtctc tgtgaacgca
      661 gtgcagactg tggtccgcca gggtgagaac atcaccctca tgtgcattgt gatcgggaat
      721 gaggtggtca acttcgagtg gacatacccc cgcaaagaaa gtgggcggct ggtggagccg
      781 gtgactgact tcctcttgga tatgccttac cacatccgct ccatcctgca catccccagt
      841 gccgagttag aagactcggg gacctacacc tgcaatgtga cggagagtgt gaatgaccat
      901 caggatgaaa aggccatcaa catcaccgtg gttgagagcg gctacgtgcg gctcctggga
      961 gaggtgggca cactacaatt tgctgagctg catcggagcc ggacactgca ggtagtgttc
     1021 gaggcctacc caccgcccac tgtcctgtgg ttcaaagaca accgcaccct gggcgactcc
     1081 agcgctggcg aaatcgccct gtccacgcgc aacgtgtcgg agacccggta tgtgtcagag
     1141 ctgacactgg ttcgcgtgaa ggtggcagag gctggccact acaccatgcg ggccttccat
     1201 gaggatgctg aggtccagct ctccttccag ctacagatca atgtccctgt ccgagtgctg
     1261 gagctaagtg agagccaccc tgacagtggg gaacagacag tccgctgtcg tggccggggc
     1321 atgccccagc cgaacatcat ctggtctgcc tgcagagacc tcaaaaggtg tccacgtgag
     1381 ctgccgccca cgctgctggg gaacagttcc gaagaggaga gccagctgga gactaacgtg
     1441 acgtactggg aggaggagca ggagtttgag gtggtgagca cactgcgtct gcagcacgtg
     1501 gatcggccac tgtcggtgcg ctgcacgctg cgcaacgctg tgggccagga cacgcaggag
     1561 gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc catcctggcc
     1621 ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca gaagaagcca
     1681 cgttacgaga tccgatggaa ggtgattgag tctgtgagct ctgacggcca tgagtacatc
     1741 tacgtggacc ccatgcagct gccctatgac tccacgtggg agctgccgcg ggaccagctt
     1801 gtgctgggac gcaccctcgg ctctggggcc tttgggcagg tggtggaggc cacggctcat
     1861 ggcctgagcc attctcaggc cacgatgaaa gtggccgtca agatgcttaa atccacagcc
     1921 cgcagcagtg agaagcaagc ccttatgtcg gagctgaaga tcatgagtca ccttgggccc
     1981 cacctgaacg tggtcaacct gttgggggcc tgcaccaaag gaggacccat ctatatcatc
     2041 actgagtact gccgctacgg agacctggtg gactacctgc accgcaacaa acacaccttc
     2101 ctgcagcacc actccgacaa gcgccgcccg cccagcgcgg agctctacag caatgctctg
     2161 cccgttgggc tccccctgcc cagccatgtg tccttgaccg gggagagcga cggtggctac
     2221 atggacatga gcaaggacga gtcggtggac tatgtgccca tgctggacat gaaaggagac
     2281 gtcaaatatg cagacatcga gtcctccaac tacatggccc cttacgataa ctacgttccc
     2341 tctgcccctg agaggacctg ccgagcaact ttgatcaacg agtctccagt gctaagctac
     2401 atggacctcg tgggcttcag ctaccaggtg gccaatggca tggagtttct ggcctccaag
     2461 aactgcgtcc acagagacct ggcggctagg aacgtgctca tctgtgaagg caagctggtc
     2521 aagatctgtg actttggcct ggctcgagac atcatgcggg actcgaatta catctccaaa
     2581 ggcagcacct ttttgccttt aaagtggatg gctccggaga gcatcttcaa cagcctctac
     2641 accaccctga gcgacgtgtg gtccttcggg atcctgctct gggagatctt caccttgggt
     2701 ggcacccctt acccagagct gcccatgaac gagcagttct acaatgccat caaacggggt
     2761 taccgcatgg cccagcctgc ccatgcctcc gacgagatct atgagatcat gcagaagtgc
     2821 tgggaagaga agtttgagat tcggcccccc ttctcccagc tggtgctgct tctcgagaga
     2881 ctgttgggcg aaggttacaa aaagaagtac cagcaggtgg atgaggagtt tctgaggagt
     2941 gaccacccag ccatccttcg gtcccaggcc cgcttgcctg ggttccatgg cctccgatct
     3001 cccctggaca ccagctccgt cctctatact gccgtgcagc ccaatgaggg tgacaacgac
     3061 tatatcatcc ccctgcctga ccccaaaccc gaggttgctg acgagggccc actggagggt
     3121 tcccccagcc tagccagctc caccctgaat gaagtcaaca cctcctcaac catctcctgt
     3181 gacagccccc tggagcccca ggacgaacca gagccagagc cccagcttga gctccaggtg
     3241 gagccggagc cagagctgga acagttgccg gattcggggt gccctgcgcc tcgggcggaa
     3301 gcagaggata gcttcctg
//
