LOCUS       sequence-11050-e        3261 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 3261)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 3261)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-PHKB
FEATURES             Location/Qualifiers
     source          1..3261
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 atggcctgct cacctgatgc agtcgtctct ccgtcttccg ctttcttaag gtctggctca
       61 gtttatgaac ctcttaaaag cattaatctt ccaagacctg ataatgaaac tctctgggat
      121 aagttggacc attattacag aattgtcaag tcaacattgc tgctgtatca aagtccaact
      181 accggtctct ttcccactaa aacatgcggt ggtgaccaga aggccaagat ccaggacagc
      241 ctatactgcg ctgctggggc ctgggctttg gctcttgcat acaggcgaat tgatgacgac
      301 aagggaagga cccatgagct ggagcactca gctataaaat gcatgagagg aattctctac
      361 tgctatatgc gtcaggccga taaggtccag cagtttaagc aggatccacg cccaacaaca
      421 tgtcttcact ctgttttcaa tgtgcataca ggagatgagt tgctttccta tgaggaatat
      481 ggtcatcttc agataaatgc agtgtcactt tatctccttt accttgtgga aatgatttcc
      541 tcaggactcc agattatcta caacactgat gaggtctctt ttattcaaaa ccttgtattt
      601 tgtgtggaaa gagtttaccg tgtgcctgac tttggtgtct gggaaagagg aagcaaatat
      661 aataatggca gcacagagct acattcgagc tcggttggtt tagcaaaagc agctctagaa
      721 gcaattaatg gattcaacct ttttggcaac cagggctgtt cgtggtcagt tatatttgtg
      781 gatctcgatg ctcacaatcg caacaggcaa actttgtgct cgctgttacc cagagaatca
      841 agatcacata atacagatgc tgccctgctc ccctgcatca gttatcctgc atttgccctg
      901 gatgatgaag ttctttttag ccagacactt gataaagtgg ttagaaaatt aaaaggaaaa
      961 tatggattta aacgtttctt gagagatggg tatagaacat cattggaaga tcccaacaga
     1021 tgctactaca agccagctga aattaagcta tttgatggca ttgaatgtga atttcccata
     1081 tttttccttt atatgatgat tgatggagtt tttagaggca atcctaagca agtacaggaa
     1141 tatcaggatc ttttgactcc agtacttcat cataccacag aaggatatcc tgttgtacca
     1201 aagtactatt atgtgccagc tgactttgta gaatatgaaa aaaataaccc tggtagtcaa
     1261 aaacgatttc ctagcaactg tggccgtgat ggaaaactgt ttctttgggg acaagcactt
     1321 tatatcatcg caaaactcct ggctgatgaa cttattagtc ctaaagacat tgatcctgtc
     1381 cagcgctatg tcccactaaa ggatcaacgt aacgtgagca tgaggttttc caatcagggc
     1441 ccactggaaa atgacttggt agttcatgtg gcacttatag cagaaagcca aagacttcaa
     1501 gtttttctga acacatatgg tattcaaact caaactcctc aacaagtaga acccattcag
     1561 atatggcctc agcaggagct tgtgaaagct tatttgcagc tgggtatcaa tgaaaagtta
     1621 ggactctctg gaaggccaga caggcccatt ggctgcctcg ggacatcaaa gatttatcgc
     1681 attctaggaa agactgtggt ttgttacccg attattttcg acctaagtga tttctacatg
     1741 tctcaggatg ttttcctgct gatagatgac ataaagaatg cgctgcagtt cattaaacaa
     1801 tattggaaaa tgcatggacg tccacttttc cttgttctca tccgggaaga caatataaga
     1861 ggtagccggt tcaaccccat attagatatg ctggcagccc ttaaaaaagg aataattgga
     1921 ggagtcaaag ttcatgtgga tcgtctacag acactaatat ctggagctgt ggtagaacaa
     1981 cttgatttcc tacgaatcag tgacacagaa gagcttccag aatttaagag ttttgaggaa
     2041 ctagaacctc ccaaacattc aaaagtcaaa cggcaaagca gcacccctag tgctcctgaa
     2101 ctgggacagc agccggatgt caacattagt gaatggaagg acaaacccac ccatgaaatt
     2161 cttcaaaaac tgaatgattg cagttgtctg gctagccaag ccatcctgct gggtatactg
     2221 ctcaaaagag aaggccccaa cttcatcaca aaggaaggta ccgtttctga tcacattgag
     2281 agagtctata gaagagctgg cagccaaaaa ctttggtcgg ttgtacgccg tgcagcaagt
     2341 cttttaagta aagtagtgga cagcctggcc ccatccatta ctaatgtttt agtgcagggc
     2401 aaacaggtaa ctctgggtgc ctttgggcat gaagaagaag ttatctctaa tcctttgtct
     2461 ccaagagtga ttcaaaacat catctattat aagtgtaaca cccatgatga gagggaagcg
     2521 gtcattcagc aagaactggt catccatatt ggctggatca tctccaataa ccctgagtta
     2581 ttcagtggca tgctgaaaat acgaatcggg tggatcatcc atgccatgga gtatgaactt
     2641 cagatccgtg gcggagacaa gccagccttg gacttgtatc agctgtcacc tagtgaagtt
     2701 aaacagcttc tgctggatat tctgcagcct caacagaatg gaagatgttg gctgaacagg
     2761 cgtcagatcg atgggtcttt gaatagaact cccaccgggt tctatgaccg agtgtggcag
     2821 attctggagc gcacgcccaa tgggatcatt gttgctggga agcatttgcc tcagcaacca
     2881 accctgtcag atatgaccat gtatgagatg aatttctctc tccttgttga agacacgttg
     2941 ggaaatattg accagccaca gtacagacag atcgttgtag agttacttat ggttgtatcc
     3001 attgtactgg aaagaaaccc cgagctagaa tttcaagaca aagtagatct agacagactg
     3061 gtcaaagaag catttaatga atttcaaaaa gatcagagtc ggctaaagga aattgaaaaa
     3121 caagatgaca tgacttcctt ttacaacact cctcccctgg gaaaaagagg aacatgcagc
     3181 tatttgacaa aggcggtgat gaatctgctg ctggaaggag aagtcaagcc aaacaatgat
     3241 gacccgtgtc tgattagcta g
//
