LOCUS       sequence-11187-e        2973 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 2973)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 2973)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-FUK
FEATURES             Location/Qualifiers
     source          1..2973
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             2877..2888
                     /codon_start=1
                     /product="WELQut protease recognition and cleavage site"
                     /label=WELQut site
                     /translation="WELQ"
ORIGIN
        1 atgggtcgag acttcccctt tgatgactgt ggcagggctt tcacctgcct ccccgtggag
       61 aaccccgagg cccccgtgga agccttggtc tgcaacctgg actgcctgct ggacatcatg
      121 acctatcggc tgggcccggg ctccccgcca ggcgtgtggg tctgcagcac cgacatgctg
      181 ctgtctgttc ctgcaaatcc tggtatcagc tgggacagct tccggggagc cagagtgatc
      241 gccctcccag ggagcccggc ctacgctcag aatcatggcg tctacctaac tgacccccag
      301 ggccttgttt tggacattta ctaccagggc actgaggcag agattcagcg gtgtgtcagg
      361 cctgatgggc gggtgccact ggtctctggg gttgtcttct tctctgtgga gactgccgag
      421 cgcctcctag ccacccacgt gagcccgccc ctggatgcct gcacctacct aggcttggac
      481 tccggagccc ggcctgtcca gctgtctctg ttttttgaca ttctccactg catggctgag
      541 aacgtgacca gggaggactt cctggtgggg aggcccccag agttggggca aggcgatgca
      601 gatgtagcgg gttatctgca gagcgcccgg gcccagctgt ggagggagct tcgcgatcag
      661 ccccttacca tggcctatgt ctccagcggc agctacagct acatgacctc ctcagccagt
      721 gagttcctgc tcagcctcac actccccggg gctcctgggg cccagattgt gcactcccag
      781 gtggaggagc agcagcttct ggcggccggg agctctgtgg tcagctgcct gctggagggc
      841 cctgtccagc tgggtcctgg gagcgtcctg cagcactgcc acctgcaggg ccccattcac
      901 ataggcgctg gctgcttggt gactggcctg gatacagccc actccaaggc cctgcatggc
      961 cgggagctgc gtgaccttgt cctgcaggga caccacacgc ggctacacgg ctccccgggc
     1021 cacgccttca ccctcgttgg ccgtctggac agctgggaga gacagggggc aggcacatat
     1081 ctcaacgtgc cctggagtga attcttcaag aggacaggtg ttcgagcctg ggacctgtgg
     1141 gaccctgaga cgctgcccgc agagtactgc cttcccagcg cccgcctctt tcctgtgctc
     1201 cacccctcga gggagctggg accccaggac ctgctgtgga tgctggacca ccaggaggat
     1261 gggggcgagg ccctgcgagc ctggcgggcc tcctggcgcc tgtcctggga gcagctgcag
     1321 ccgtgcctgg atcgggctgc cacgctggcc tctcgccggg acctgttctt ccgccaggcc
     1381 ctgcataagg cgcggcacgt gctggaggcc cggcaggacc tcagcctgcg cccgctgatc
     1441 tgggctgctg tccgcgaggg ctgccccggg cccctgctgg ccacgctgga ccaggttgca
     1501 gctggggcag gagaccctgg tgtggcggca cgggcactgg cctgtgtggc ggacgtcctg
     1561 ggctgcatgg cagagggccg tgggggcttg cggagcgggc cagctgccaa ccctgagtgg
     1621 atgcggccct tctcatacct ggagtgtgga gacctggcag cgggcgtgga ggcgcttgcc
     1681 caggagaggg acaagtggct aagcaggcca gccttgctgg tgcgagcggc ccgccactat
     1741 gagggggctg gtcagatcct gatccgccag gctgtgatgt cagcccagca ctttgtctcc
     1801 acagagcagg tggaactgcc gggacctggg cagtgggtgg tggctgagtg cccggcccgt
     1861 gtggatttct ctgggggctg gagtgacacg ccaccccttg cctatgagct tggcggggct
     1921 gtgctgggcc tggctgtgcg agtggacggc cgccggccca tcggagccag ggcacgccgc
     1981 atcccggagc ctgagctgtg gctggcggtg gggcctcggc aggatgagat gactgtgaag
     2041 atagtgtgcc ggtgcctggc tgacctgcgg gactactgcc agcctcatgc cccaggggcc
     2101 ctgctgaagg cggccttcat ctgtgcaggg atcgtgcatg tccactcgga actccagctg
     2161 agtgagcagc tgctccgcac cttcgggggc ggctttgagc tgcacacctg gtctgagctg
     2221 ccccacggct ctggcctggg caccagcagc atcctggcag gcactgccct ggctgccttg
     2281 cagcgagccg caggccgggt ggtgggcacg gaagccctga tccacgcagt gctgcacctg
     2341 gagcaggtgc tcaccactgg aggtggctgg caggaccaag taggtggcct aatgcctggc
     2401 atcaaggtgg ggcgctcccg ggctcagctg ccactgaagg tggaggtaga agaggtcacg
     2461 gtgcctgagg gctttgtcca gaagctcaat gaccacctgc tcttggtgta cactggcaag
     2521 acccgcctgg ctcggaacct gctgcaggat gtgctgagga gctggtatgc ccgacttcct
     2581 gctgtggtgc agaatgccca cagcctggta cggcaaactg aggagtgtgc tgaaggcttc
     2641 cgccaaggaa gcctgcctct gctgggccag tgcctgacct cgtactggga gcagaagaag
     2701 ctcatggctc caggctgtga gcccctgact gtgcggcgta tgatggatgt cctggccccc
     2761 cacgtgcatg gccagagcct ggctggggca ggcggtggag gctttctcta tctgttgacc
     2821 aaggagccac agcaaaagga ggccttggag gcggtgctgg ccaagaccga gggccttggg
     2881 aattacagca tccacctggt tgaagtggac actcagggcc tgagcctgaa gctgctgggg
     2941 accgaggcct caacctgttg ccctttccca tga
//
