LOCUS       sequence-11239-e        3891 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 3891)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 3891)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-INSRR
FEATURES             Location/Qualifiers
     source          1..3891
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             complement(1805..1816)
                     /codon_start=1
                     /product="WELQut protease recognition and cleavage site"
                     /label=WELQut site
                     /translation="WELQ"
ORIGIN
        1 atggcagtgc ctagtctgtg gccctgggga gcatgcctgc ctgtgatctt cctctccttg
       61 ggatttggcc tggatacagt agaggtgtgc cccagcctgg atattcgctc agaggtggca
      121 gagcttcgtc agctggagaa ctgcagcgtg gtggagggcc acctgcagat cctgctcatg
      181 ttcacagcca ccggggagga cttccgcggc ctcagcttcc ctcgcctcac ccaggtcacc
      241 gactacctgc tgctcttccg tgtctacgga ctggagagcc tgcgcgacct cttccccaac
      301 ctagcagtca tccgcgggac gcgcctcttc ctgggctatg cactggtcat ctttgagatg
      361 ccacatctgc gtgacgtggc actgcctgca cttggggccg tgctgcgtgg ggctgtgcgt
      421 gtggagaaga accaggagct ctgccacctc tccaccattg actggggact gctgcagcca
      481 gcacctggcg ccaaccacat cgtgggcaac aagctgggcg aggagtgtgc tgacgtgtgc
      541 cctggtgtgc tgggtgctgc tggtgagccc tgtgccaaga ccaccttcag cgggcacact
      601 gactacagat gctggacctc cagccactgc cagagagtgt gcccctgccc ccatgggatg
      661 gcttgcacag cgaggggcga gtgctgccac accgaatgcc tggggggctg cagccagcca
      721 gaagaccctc gtgcctgtgt agcttgccgc cacctctact tccagggtgc ctgcctgtgg
      781 gcctgcccgc caggcaccta ccagtatgag tcctggcgct gtgtcacagc tgagcgctgt
      841 gccagcctgc actctgtgcc cggccgtgcc tccaccttcg gcatacacca gggcagttgc
      901 ctggcccagt gcccttctgg cttcacccgt aatagcagca gcatattctg ccacaagtgc
      961 gaggggctgt gccctaaaga gtgcaaggta ggcaccaaga ccatcgactc catccaggcg
     1021 gcacaggatc ttgtgggctg cacgcatgtg gagggaagcc tcatcctcaa ccttcgccag
     1081 ggctacaacc tggagccaca gctgcagcac agcctggggc tggtagaaac cattactggc
     1141 ttcctcaaaa tcaagcactc ctttgccctc gtgtccctgg gctttttcaa gaacctcaaa
     1201 ctaatccggg gagacgccat ggtggatggg aactacactc tctacgtgct ggacaaccag
     1261 aacctacaac agctagggtc ctgggtggcc gcggggctca ccattcccgt gggcaagatc
     1321 tacttcgcct tcaacccgcg cctctgcttg gaacacatct accgactgga ggaggtgaca
     1381 ggcacgcgag gtcggcagaa caaggctgag atcaaccccc gcaccaacgg agaccgcgcc
     1441 gcctgccaga ctcgcaccct gcgcttcgtg tccaacgtga cggaggcaga ccgcatcctg
     1501 ctacgctggg agcgctatga gccactggag gcccgcgacc tgctcagctt catcgtgtac
     1561 tacaaggagt ccccattcca gaacgccaca gagcacgtgg gtccagatgc ttgtggaacc
     1621 cagagctgga acctgctgga tgtggagctg cccctaagcc gcacccagga gccaggggtg
     1681 accctagcct ccctcaagcc ttggacacag tacgcagtgt ttgtgcgggc catcacgcta
     1741 accactgagg aggacagccc tcatcaagga gcccagagtc ccatcgtcta cctccgaacg
     1801 ctgcctgcag ctcccacggt gccccaagac gtcatctcca cgtccaactc ctcctcccac
     1861 ctcctggtgc gctggaagcc accgacccag cgcaatggga acctcaccta ctacctggtg
     1921 ctgtggcagc ggctggcaga ggacggcgac ctctacctca atgactactg ccaccgcggc
     1981 ttgcggctgc ccaccagcaa caacgatccg cgcttcgacg gcgaagacgg ggatcctgag
     2041 gccgagatgg agtccgactg ctgcccttgc cagcacccac ctcctggtca ggttctgccc
     2101 ccgctggagg cgcaagaggc ctcgttccag aagaagtttg aaaactttct acacaacgcg
     2161 atcaccatcc ccatatcccc ttggaaggtg acgtccatca acaagagccc ccaaagggac
     2221 tcagggcggc accgccgggc agctgggccc ctccggctgg ggggcaacag ctcggatttc
     2281 gagatccagg aggacaaggt gccccgtgag cgagcggtgc tgagcggcct gcgccacttc
     2341 acggaatacc ggatcgacat ccatgcctgc aaccacgcgg cgcacaccgt gggctgcagc
     2401 gccgccacct tcgtctttgc gcgcaccatg ccccacagag aggctgatgg tattccagga
     2461 aaggtggcct gggaggcctc cagcaagaac agtgtccttc tgcgctggct cgagccacca
     2521 gaccccaacg gactcatcct caagtacgaa atcaagtacc gccgcttggg agaggaggcc
     2581 acagtgctgt gtgtgtcccg tcttcgatat gcgaagtttg ggggagtcca cctggccctg
     2641 ctgccccctg gaaactactc tgccagggtt agggcaacct cactggctgg caatggctct
     2701 tggacagaca gtgttgcctt ctacatcctt ggcccagagg aggaggatgc tggggggctg
     2761 catgtcctcc tcactgccac ccctgtgggg ctcacgctgc tcatcgttct tgctgccctt
     2821 ggtttcttct acggcaagaa gagaaacaga accctgtatg cttctgtgaa tccagagtac
     2881 ttcagcgcct ctgatatgta tgtccctgat gaatgggagg tgcctcggga gcagatctcg
     2941 ataatccggg aactgggcca gggctctttt gggatggtat atgaggggct ggcacgagga
     3001 cttgaggctg gagaggagtc cacacccgtg gccctgaaga cggtgaatga gctggccagc
     3061 ccacgggaat gcattgagtt cctcaaggaa gcttctgtca tgaaagcctt caagtgtcac
     3121 catgtggtgc gtctcctggg tgtggtatct cagggccagc caactctggt catcatggag
     3181 ttaatgaccc gtggggacct caagagccat cttcgatctt tgcggcctga ggcagagaac
     3241 aaccctgggc tcccacagcc agcattgggg gaaatgatcc aaatggctgg tgagattgca
     3301 gacggcatgg cctaccttgc tgccaacaag tttgtgcacc gagatctagc agcccgcaac
     3361 tgcatggtgt cccaggactt caccgtcaag atcggggact tcgggatgac tcgggacgtg
     3421 tatgagacag actattaccg caagggtggg aaggggctgc tgcccgtgcg ctggatggcc
     3481 cccgagtccc tcaaagatgg gatcttcacc acccactcgg atgtctggtc ctttggcgtg
     3541 gtactctggg agattgtgac cctggcagaa caaccctacc agggcctgtc caatgagcag
     3601 gtgctgaagt tcgtcatgga tggcggggtc ctggaggagc tggagggctg tccccttcag
     3661 ctgcaggagc tgatgagccg ctgctggcag ccgaacccac gcctgcgccc atctttcaca
     3721 cacattctgg acagcataca ggaggagctg cggccctcct tccgcctcct ctccttctac
     3781 tacagcccgg aatgccgggg ggcccggggc tccctgccta ccaccgatgc agagcctgac
     3841 tcctcaccca ctccaagaga ctgcagccct caaaatgggg gtccagggca c
//
