LOCUS       sequence-11247-e        3462 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-JAK1
FEATURES             Location/Qualifiers
     source          1..3462
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 atgcagtatc taaatataaa agaggactgc aatgccatgg ctttctgtgc taaaatgagg
       61 agctccaaga agactgaggt gaacctggag gcccctgagc caggggtgga agtgatcttc
      121 tatctgtcgg acagggagcc cctccggctg ggcagtggag agtacacagc agaggaactg
      181 tgcatcaggg ctgcacaggc atgccgtatc tctcctcttt gtcacaacct ctttgccctg
      241 tatgacgaga acaccaagct ctggtatgct ccaaatcgca ccatcaccgt tgatgacaag
      301 atgtccctcc ggctccacta ccggatgagg ttctatttca ccaattggca tggaaccaac
      361 gacaatgagc agtcagtgtg gcgtcattct ccaaagaagc agaaaaatgg ctacgagaaa
      421 aaaaagattc cagatgcaac ccctctcctt gatgccagct cactggagta tctgtttgct
      481 cagggacagt atgatttggt gaaatgcctg gctcctattc gagaccccaa gaccgagcag
      541 gatggacatg atattgagaa cgagtgtcta gggatggctg tcctggccat ctcacactat
      601 gccatgatga agaagatgca gttgccagaa ctgcccaagg acatcagcta caagcgatat
      661 attccagaaa cattgaataa gtccatcaga cagaggaacc ttctcaccag gatgcggata
      721 aataatgttt tcaaggattt cctaaaggaa tttaacaaca agaccatttg tgacagcagc
      781 gtgtccacgc atgacctgaa ggtgaaatac ttggctacct tggaaacttt gacaaaacat
      841 tacggtgctg aaatatttga gacttccatg ttactgattt catcagaaaa tgagatgaat
      901 tggtttcatt cgaatgacgg tggaaacgtt ctctactacg aagtgatggt gactgggaat
      961 cttggaatcc agtggaggca taaaccaaat gttgtttctg ttgaaaagga aaaaaataaa
     1021 ctgaagcgga aaaaactgga aaataaacac aagaaggatg aggagaaaaa caagatccgg
     1081 gaagagtgga acaatttttc ttacttccct gaaatcactc acattgtaat aaaggagtct
     1141 gtggtcagca ttaacaagca ggacaacaag aaaatggaac tgaagctctc ttcccacgag
     1201 gaggccttgt cctttgtgtc cctggtagat ggctacttcc ggctcacagc agatgcccat
     1261 cattacctct gcaccgacgt ggcccccccg ttgatcgtcc acaacataca gaatggctgt
     1321 catggtccaa tctgtacaga atacgccatc aataaattgc ggcaagaagg aagcgaggag
     1381 gggatgtacg tgctgaggtg gagctgcacc gactttgaca acatcctcat gaccgtcacc
     1441 tgctttgaga agtctgagca ggtgcagggt gcccagaagc agttcaagaa ctttcagatc
     1501 gaggtgcaga agggccgcta cagtctgcac ggttcggacc gcagcttccc cagcttggga
     1561 gacctcatga gccacctcaa gaagcagatc ctgcgcacgg ataacatcag cttcatgcta
     1621 aaacgctgct gccagcccaa gccccgagaa atctccaacc tgctggtggc tactaagaaa
     1681 gcccaggagt ggcagcccgt ctaccccatg agccagctga gtttcgatcg gatcctcaag
     1741 aaggatctgg tgcagggcga gcaccttggg agaggcacga gaacacacat ctattctggg
     1801 accctgatgg attacaagga tgacgaagga acttctgaag agaagaagat aaaagtgatc
     1861 ctcaaagtct tagaccccag ccacagggat atttccctgg ccttcttcga ggcagccagc
     1921 atgatgagac aggtctccca caaacacatc gtgtacctct atggcgtctg tgtccgcgac
     1981 gtggagaata tcatggtgga agagtttgtg gaagggggtc ctctggatct cttcatgcac
     2041 cggaaaagcg atgtccttac cacaccatgg aaattcaaag ttgccaaaca gctggccagt
     2101 gccctgagct acttggagga taaagacctg gtccatggaa atgtgtgtac taaaaacctc
     2161 ctcctggccc gtgagggcat cgacagtgag tgtggcccat tcatcaagct cagtgacccc
     2221 ggcatcccca ttacggtgct gtctaggcaa gaatgcattg aacgaatccc atggattgct
     2281 cctgagtgtg ttgaggactc caagaacctg agtgtggctg ctgacaagtg gagctttgga
     2341 accacgctct gggaaatctg ctacaatggc gagatcccct tgaaagacaa gacgctgatt
     2401 gagaaagaga gattctatga aagccggtgc aggccagtga caccatcatg taaggagctg
     2461 gctgacctca tgacccgctg catgaactat gaccccaatc agaggccttt cttccgagcc
     2521 atcatgagag acattaataa gcttgaagag cagaatccag atattgtttc agaaaaaaaa
     2581 ccagcaactg aagtggaccc cacacatttt gaaaagcgct tcctaaagag gatccgtgac
     2641 ttgggagagg gccactttgg gaaggttgag ctctgcaggt atgaccccga aggggacaat
     2701 acaggggagc aggtggctgt taaatctctg aagcctgaga gtggaggtaa ccacatagct
     2761 gatctgaaaa aggaaatcga gatcttaagg aacctctatc atgagaacat tgtgaagtac
     2821 aaaggaatct gcacagaaga cggaggaaat ggtattaagc tcatcatgga atttctgcct
     2881 tcgggaagcc ttaaggaata tcttccaaag aataagaaca aaataaacct caaacagcag
     2941 ctaaaatatg ccgttcagat ttgtaagggg atggactatt tgggttctcg gcaatacgtt
     3001 caccgggact tggcagcaag aaatgtcctt gttgagagtg aacaccaagt gaaaattgga
     3061 gacttcggtt taaccaaagc aattgaaacc gataaggagt attacaccgt caaggatgac
     3121 cgggacagcc ctgtgttttg gtatgctcca gaatgtttaa tgcaatctaa attttatatt
     3181 gcctctgacg tctggtcttt tggagtcact ctgcatgagc tgctgactta ctgtgattca
     3241 gattctagtc ccatggcttt gttcctgaaa atgataggcc caacccatgg ccagatgaca
     3301 gtcacaagac ttgtgaatac gttaaaagaa ggaaaacgcc tgccgtgccc acctaactgt
     3361 ccagatgagg tttatcaact tatgaggaaa tgctgggaat tccaaccatc caatcggaca
     3421 agctttcaga accttattga aggatttgaa gcacttttaa aa
//
