LOCUS       sequence-132870-        1030 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  activating MTOR mutation.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1030)
  AUTHORS   Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan
            A, Beck AH, Sabatini DM
  TITLE     A diverse array of cancer-associated MTOR mutations are 
            hyperactivating and can predict rapamycin sensitivity.
  JOURNAL   Cancer Discov. 2014 May;4(5):554-63. doi: 
            10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
  PUBMED    24631838
REFERENCE   2  (bases 1 to 1030)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1158/2159-8290.CD-13-0929"; journalName: "Cancer Discov"; date: 
            "2014-05"; volume: "4"; issue: "5"; pages: "554-63"
COMMENT     Sequence Label: pcDNA3-FLAG-MTOR-T1977R
FEATURES             Location/Qualifiers
     source          1..1030
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             720..998
                     /codon_start=1
                     /product="FKBP-rapamycin binding domain of human FRAP"
                     /label=FRB
                     /translation="ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTL
                     KETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK"
     CDS             732..1004
                     /codon_start=1
                     /product="FKBP-rapamycin binding domain of human FRAP"
                     /label=FRB
                     /translation="EMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS
                     FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQL"
ORIGIN
        1 agcacgaccg cagctggtac aaggcctggc atgcgtgggc agtgatgaac ttcgaagctg
       61 tgctacacta caaacatcag aaccaagccc gcgatgagaa gaagaaactg cgtcatgcca
      121 gcggggccaa catcaccaac gccaccactg ccgccaccac ggccgccact gccaccacca
      181 ctgccagcac cgagggcagc aacagtgaga gcgaggccga gagcaccgag aacagcccca
      241 ccccatcgcc gctgcagaag aaggtcactg aggatctgtc caaaaccctc ctgatgtaca
      301 cggtgcctgc cgtccagggc ttcttccgtt ccatctcctt gtcacgaggc aacaacctcc
      361 aggatacact cagagttctc accttatggt ttgattatgg tcactggcca gatgtcaatg
      421 aggccttagt ggagggggtg aaagccatcc agattgatac ctggctacag gttatacctc
      481 agctcattgc aagaattgat acgcccagac ccttggtggg acgtctcatt caccagcttc
      541 tcacagacat tggtcggtac cacccccagg ccctcatcta cccactgaga gtggcttcta
      601 agtctaccac gacagcccgg cacaatgcag ccaacaagat tctgaagaac atgtgtgagc
      661 acagcaacac cctggtccag caggccatga tggtgagcga ggagctgatc cgagtggcca
      721 tcctctggca tgagatgtgg catgaaggcc tggaagaggc atctcgtttg tactttgggg
      781 aaaggaacgt gaaaggcatg tttgaggtgc tggagccctt gcatgctatg atggaacggg
      841 gcccccagac tctgaaggaa acatccttta atcaggccta tggtcgagat ttaatggagg
      901 cccaagagtg gtgcaggaag tacatgaaat cagggaatgt caaggacctc acccaagcct
      961 gggacctcta ttatcatgtg ttccgacgaa tctcaaagca gctgcctcag ctcacatcct
     1021 tagagctgca
//
