LOCUS       sequence-132939-         914 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  activating MTOR mutation.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan
            A, Beck AH, Sabatini DM
  TITLE     A diverse array of cancer-associated MTOR mutations are 
            hyperactivating and can predict rapamycin sensitivity.
  JOURNAL   Cancer Discov. 2014 May;4(5):554-63. doi: 
            10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
  PUBMED    24631838
REFERENCE   2  (bases 1 to 914)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1158/2159-8290.CD-13-0929"; journalName: "Cancer Discov"; date: 
            "2014-05"; volume: "4"; issue: "5"; pages: "554-63"
COMMENT     Sequence Label: pcDNA3-FLAG-MTOR-V2006I
FEATURES             Location/Qualifiers
     source          1..914
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             228..506
                     /codon_start=1
                     /product="FKBP-rapamycin binding domain of human FRAP"
                     /label=FRB
                     /translation="ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTL
                     KETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK"
     CDS             240..512
                     /codon_start=1
                     /product="FKBP-rapamycin binding domain of human FRAP"
                     /label=FRB
                     /translation="EMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS
                     FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQL"
ORIGIN
        1 gaattgatac gcccagaccc ttggtgggac gtctcattca ccagcttctc acagacattg
       61 gtcggtacca cccccaggcc ctcatctacc cactgacagt ggcttctaag tctaccacga
      121 cagcccggca caatgcagcc aacaagattc tgaagaacat gtgtgagcac agcaacaccc
      181 tgatccagca ggccatgatg gtgagcgagg agctgatccg agtggccatc ctctggcatg
      241 agatgtggca tgaaggcctg gaagaggcat ctcgtttgta ctttggggaa aggaacgtga
      301 aaggcatgtt tgaggtgctg gagcccttgc atgctatgat ggaacggggc ccccagactc
      361 tgaaggaaac atcctttaat caggcctatg gtcgagattt aatggaggcc caagagtggt
      421 gcaggaagta catgaaatca gggaatgtca aggacctcac ccaagcctgg gacctctatt
      481 atcatgtgtt ccgacgaatc tcaaagcagc tgcctcagct cacatcctta gagctgcaat
      541 atgtttcccc aaaacttctg atgtgccggg accttgaatt ggctgtgcca ggaacatatg
      601 accccaacca gccaatcatt cgcattcagt ccatagcacc gtctttgcaa gtcatcacat
      661 ccaagcagag gccccggaaa ttgacactta tgggcagcaa cggacatgag tttgttttcc
      721 ttctaaaagg ccatgaagat ctgcgccagg atgagcgtgt gatgcagctc ttcggcctgg
      781 ttaacaccct tctggccaat gacccaacat ctcttcggaa aaacctcagc atccagagat
      841 acgctgtcat ccctttatcg accaactcgg gcctcattgg ctgggttccc cactgtgaca
      901 cactgcacgc cctc
//
