LOCUS       sequence-138420-       27879 bp    DNA     circular UNA 15-DEC-2025
DEFINITION  Reprogram somatic cells to iPS cells.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 27879)
  AUTHORS   Wu S, Wu Y, Zhang X, Capecchi MR
  TITLE     Efficient germ-line transmission obtained with transgene-free 
            induced pluripotent stem cells.
  JOURNAL   Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10678-83. doi: 
            10.1073/pnas.1409933111. Epub 2014 Jul 7.
  PUBMED    25002522
REFERENCE   2  (bases 1 to 27879)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1073/pnas.1409933111"; journalName: "Proc Natl Acad Sci U S A"; 
            date: "2014-07-22- 22"; volume: "111"; issue: "29"; pages: 
            "10678-83"
COMMENT     Sequence Label: pMaster12
FEATURES             Location/Qualifiers
     source          1..27879
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     polyA_signal    87..134
                     /label=HSV TK poly(A) signal
                     /note="herpes simplex virus thymidine kinase 
                     polyadenylation signal (Cole and Stacy, 1985)"
     promoter        complement(1891..3069)
                     /label=EF-1-alpha promoter
                     /note="strong constitutive promoter for human elongation 
                     factor EF-1-alpha"
     intron          1900..2838
                     /label=EF-1-alpha intron A
                     /note="intron upstream of the start codon of human 
                     EF-1-alpha"
     polyA_signal    3090..3137
                     /label=HSV TK poly(A) signal
                     /note="herpes simplex virus thymidine kinase 
                     polyadenylation signal (Cole and Stacy, 1985)"
     CDS             complement(3369..4172)
                     /codon_start=1
                     /gene="aph(3')-II (or nptII)"
                     /product="aminoglycoside phosphotransferase from Tn5"
                     /label=NeoR/KanR
                     /note="confers resistance to neomycin, kanamycin, and G418 
                     (Geneticin(R))"
                     /translation="MGSAIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQ
                     GRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQD
                     LLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDE
                     EHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQ
                     DIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF"
     primer_bind     complement(3480..3499)
                     /label=Neo-F
                     /note="Neomycin resistance gene, forward primer"
     primer_bind     4090..4109
                     /label=Neo-R
                     /note="Neomycin resistance gene, reverse primer"
     misc_feature    join(4173..4181,4182..4184,4185..4759)
                     /label=IRES2
                     /note="internal ribosome entry site (IRES) of the 
                     encephalomyocarditis virus (EMCV)"
     primer_bind     complement(4346..4365)
                     /label=IRES-F
                     /note="IRES internal ribosome entry site, forward primer"
     primer_bind     4575..4592
                     /label=IRES reverse
                     /note="IRES internal ribosome entry site, reverse primer. 
                     Also called pCDH-rev"
     CDS             complement(4775..5905)
                     /codon_start=1
                     /product="herpes simplex virus thymidine kinase"
                     /label=HSV TK
                     /note="confers sensitivity to nucleoside analogs such as 
                     acyclovir or ganciclovir"
                     /translation="MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQK
                     MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQ
                     HRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDR
                     HPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQR
                     PGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGTAVPPQGAEPQSNAGPR
                     PHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDAL
                     LQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN"
     intron          5978..6986
                     /label=chimeric intron
                     /note="chimera between introns from chicken beta-actin and 
                     rabbit beta-globin"
     promoter        complement(6987..7262)
                     /label=chicken beta-actin promoter
     enhancer        7265..7568
                     /label=CMV enhancer
                     /note="human cytomegalovirus immediate early enhancer"
     rep_origin      7694..8149
                     /direction=RIGHT
                     /label=f1 ori
                     /note="f1 bacteriophage origin of replication; arrow 
                     indicates direction of (+) strand synthesis"
     primer_bind     complement(7781..7800)
                     /label=F1ori-R
                     /note="F1 origin, reverse primer"
     primer_bind     7991..8012
                     /label=F1ori-F
                     /note="F1 origin, forward primer"
     polyA_signal    8156..8277
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     CDS             complement(8401..9720)
                     /codon_start=1
                     /product="human c-Myc proto-oncogene"
                     /label=c-Myc
                     /translation="MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP
                     SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTE
                     LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPN
                     PARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDS
                     LLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGS
                     PSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNR
                     KCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKA
                     TAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA"
     CDS             complement(9721..9780)
                     /codon_start=1
                     /product="2A peptide from equine rhinitis A virus 
                     polyprotein"
                     /label=E2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="QCTNYALLKLAGDVESNPGP"
     CDS             complement(10741..10794)
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     CDS             complement(12214..12279)
                     /codon_start=1
                     /product="2A peptide from foot-and-mouth disease virus 
                     polyprotein"
                     /label=F2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="VKQTLNFDLLKLAGDVESNPGP"
     regulatory      13365..13374
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     promoter        complement(13382..14560)
                     /label=EF-1-alpha promoter
                     /note="strong constitutive promoter for human elongation 
                     factor EF-1-alpha"
     intron          13391..14329
                     /label=EF-1-alpha intron A
                     /note="intron upstream of the start codon of human 
                     EF-1-alpha"
     enhancer        14667..14970
                     /label=CMV enhancer
                     /note="human cytomegalovirus immediate early enhancer"
     promoter        14973..15248
                     /label=chicken beta-actin promoter
     intron          15249..16257
                     /label=chimeric intron
                     /note="chimera between introns from chicken beta-actin and 
                     rabbit beta-globin"
     polyA_signal    17251..17372
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     rep_origin      17852..19641
                     /label=oriP
                     /note="Epstein-Barr virus oriP replication origin (Yates et
                     al., 2000)"
     CDS             complement(19943..21868)
                     /codon_start=1
                     /product="Epstein-Barr nuclear antigen 1, also known as 
                     EBNA-1"
                     /label=EBNA1
                     /note="crucial for latent viral infection, and for episomal
                     amplification of vectors containing the oriP origin (Okita 
                     et al., 2013)"
                     /translation="MSDEGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRGR
                     GRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGGAG
                     AGGGAGAGGGAGGAGGAGGAGAGGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGA
                     GGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGAGGAGGAGAGGAGAGG
                     GAGGAGGAGAGGAGAGGAGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGGAGAG
                     GGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGAGGAGAGGGGRGRGGSGGRGRG
                     GSGGRGRGGSGGRRGRGRERARGGSRERARGRGRGRGEKRPRSPSSQSSSSGSPPRRPP
                     PGRRPFFHPVGEADYFEYHQEGGPDGEPDVPPGAIEQGPADDPGEGPSTGPRGQGDGGR
                     RKKGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSL
                     YNLRRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLK
                     DAIKDLVMTKPAPTCNIRVTVCSFDDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDE
                     GEEGQE"
     primer_bind     complement(22303..22321)
                     /label=pBRforEco
                     /note="pBR322 vectors, upsteam of EcoRI site, forward 
                     primer"
     promoter        22389..22493
                     /gene="bla"
                     /label=AmpR promoter
     CDS             join(22494..22562,22563..23354)
                     /codon_start=1
                     /gene="bla"
                     /product="beta-lactamase"
                     /label=AmpR
                     /note="confers resistance to ampicillin, carbenicillin, and
                     related antibiotics"
                     /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYI
                     ELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYS
                     PVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRW
                     EPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSA
                     LPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGAS
                     LIKHW"
     primer_bind     complement(22712..22731)
                     /label=Amp-R
                     /note="Ampicillin resistance gene, reverse primer"
     rep_origin      23525..24113
                     /direction=RIGHT
                     /label=ori
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of 
                     replication"
     primer_bind     24014..24033
                     /label=pBR322ori-F
                     /note="pBR322 origin, forward primer"
     polyA_signal    24344..24568
                     /label=bGH poly(A) signal
                     /note="bovine growth hormone polyadenylation signal"
     primer_bind     24557..24574
                     /label=BGH-rev
                     /note="Bovine growth hormone terminator, reverse primer. 
                     Also called BGH reverse"
     CDS             complement(25230..25295)
                     /codon_start=1
                     /product="2A peptide from foot-and-mouth disease virus 
                     polyprotein"
                     /label=F2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="VKQTLNFDLLKLAGDVESNPGP"
     intron          26288..27296
                     /label=chimeric intron
                     /note="chimera between introns from chicken beta-actin and 
                     rabbit beta-globin"
     promoter        complement(27297..27572)
                     /label=chicken beta-actin promoter
     enhancer        join(27575..27879,1..75)
                     /label=CMV enhancer
                     /note="human cytomegalovirus immediate early enhancer"
ORIGIN
        1 ggaactccat atatgggcta tgaactaatg accccgtaat tgattactat taataactag
       61 tcaataatca atgtcgaggg cgcgccgaac aaacgaccca acaccgtgcg ttttattctg
      121 tctttttatt gccgtcatag cgcgggttcc ttccggtatt gtctccttcc gtgtttcagt
      181 tagcctcccc ctagggtggg cgaagaactc cagcatgaga tccccgcgct ggaggatcat
      241 ccagccggcg tcccggaaaa cgattccgaa gcccaacctt tcatagaagg cggcggtgga
      301 atcgaaatct cgtgatggca ggttgggcgt cgcttggtcg gtcatttcga accccagagt
      361 cccgcggccg cgtcgacatt taaatttatg ctcttttggc atgcaacatt tcaatgagaa
      421 ggttattata gggcacatcc ccgttcaggt gcttgtagta gaggtattct tcagcctgca
      481 tactgatggc ccggatttcg ggtagtcgaa gaagtagctg tccaaatttc tctgtctgct
      541 gcgggtagtt acacattgtg tagtccagca gggcggcatt gacttgttcc tggacacctt
      601 ctaccagctg gaagttttca aggtttttga catctaaact aaagagcacc aagaatttca
      661 gacatacgaa ctctcgttga tcaaactgga gagaacgaag ttttgccact aactcctgtg
      721 catgactcat gaggttgttg agggtggctc cggcttgtga tgctattatg gaatagtcca
      781 cttgttgccc agtaaccagg aagatggatc cttcctttcc atgtaccact tgtcggtaaa
      841 tgtggtcgag gattaagagc tcactccagc agttctgaag cagcttcatt tggtcatcaa
      901 ccttaagttc tctgaagaag atactactcc tggcccactc gacaatggag aagagagttt
      961 gatctgccat tttgcacata agcccaaagg tgctcagctt ttcgtgcttg cttcggttag
     1021 cctgctcttg ctgcaaatag gccatgattt tagcctggac ttgaggctca tctggctcac
     1081 acttcaaaag ttccagtatc agatgtggga tgcttgctgg agagctcgtc tggtaactat
     1141 ccatatatga atagcccatt atggactcgg gtgagctggt ataggggtct gggtactcag
     1201 acttgatggc ccggctagga aagtggccat atgtttggta accttgcagg ctgccgtgag
     1261 ggggcattgt catgctaatg ggggatgtta caaagggact tctgtcatag tctgtaggag
     1321 gcaaggcagc atggttcaga ggtaggcctt tggaggcaga gtggatgttt tgaattgcag
     1381 aggaaatggt caggtcagag ggcatagctt ggatcacctg agacatggct tctagcttaa
     1441 gtccattggc tcggatgagg gcttttttct gttgcttcag ggccctgtct ctcttgtaca
     1501 ttggcccaaa cttattcctt cctccacgca ttcggtcggc ccttacagct tctagcttca
     1561 ttccaacact tagacatttt tgaaaacgac agtaaggaca acgctttctc tgtgttttgt
     1621 caatttggca gttctggttt tctatacatg tgtacctttt attattttgg actgttcgct
     1681 taaaaaatcc cttgcagctt tcacaggtga ggagcccata atggtaccca gacactttat
     1741 ctccacacac gggacaaagc tcttccagat cttcatcata ggagtaattc accattttaa
     1801 attgagacac aataggtgta agtccgtgct ttaaagactc ttgtaaatcc ccagtatctg
     1861 aattagaaga catggtggcg atcgctagct tcacgacacc tgaaatggaa gaaaaaaact
     1921 ttgaaccact gtctgaggct tgagaatgaa ccaagatcca aactcaaaaa gggcaaattc
     1981 caaggagaat tacatcaagt gccaagctgg cctaacttca gtctccaccc actcagtgtg
     2041 gggaaactcc atcgcataaa acccctcccc ccaacctaaa gacgacgtac tccaaaagct
     2101 cgagaactaa tcgaggtgcc tggacggcgc ccggtactcc gtggagtcac atgaagcgac
     2161 ggctgaggac ggaaaggccc ttttcctttg tgtgggtgac tcacccgccc gctctcccga
     2221 gcgccgcgtc ctccattttg agctccctgc agcagggccg ggaagcggcc atctttccgc
     2281 tcacgcaact ggtgccgacc gggccagcct tgccgcccag ggcggggcga tacacggcgg
     2341 cgcgaggcca ggcaccagag caggccggcc agcttgagac tacccccgtc cgattctcgg
     2401 tggccgcgct cgcaggcccc gcctcgccga acatgtgcgc tgggacgcac gggccccgtc
     2461 gccgcccgcg gccccaaaaa ccgaaatacc agtgtgcaga tcttggcccg catttacaag
     2521 actatcttgc cagaaaaaaa gcgtcgcagc aggtcatcaa aaattttaaa tggctagaga
     2581 cttatcgaaa gcagcgagac aggcgcgaag gtgccaccag attcgcacgc ggcggcccca
     2641 gcgcccaggc caggcctcaa ctcaagcacg aggcgaaggg gctccttaag cgcaaggcct
     2701 cgaactctcc cacccacttc caacccgaag ctcgggatca agaatcacgt actgcagcca
     2761 ggtggaagta attcaaggca cgcaagggcc ataacccgta aagaggccag gcccgcggga
     2821 accacacacg gcacttacct gtgttctggc ggcaaacccg ttgcgaaaaa gaacgttcac
     2881 ggcgactact gcacttatat acggttctcc cccaccctcg ggaaaaaggc ggagccagta
     2941 cacgacatca ctttcccagt ttaccccgcg ccaccttctc taggcaccgg ttcaattgcc
     3001 gacccctccc cccaacttct cggggactgt gggcgatgtg cgctctgccc actgacgggc
     3061 accggagcct cacgattaat cgccgcgccg aacaaacgac ccaacaccgt gcgttttatt
     3121 ctgtcttttt attgccgtca tagcgcgggt tccttccggt attgtctcct tccgtgtttc
     3181 agttagcctc cccctagggt gggcgaagaa ctccagcatg agatccccgc gctggaggat
     3241 catccagccg gcgtcccgga aaacgattcc gaagcccaac ctttcataga aggcggcggt
     3301 ggaatcgaaa tctcgtgatg gcaggttggg cgtcgcttgg tcggtcattt cgaaccccag
     3361 agtcccgctc agaagaactc gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga
     3421 gcggcgatac cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag ctcttcagca
     3481 atatcacggg tagccaacgc tatgtcctga tagcggtccg ccacacccag ccggccacag
     3541 tcgatgaatc cagaaaagcg gccattttcc accatgatat tcggcaagca ggcatcgcca
     3601 tgggtcacga cgagatcctc gccgtcgggc atgcgcgcct tgagcctggc gaacagttcg
     3661 gctggcgcga gcccctgatg ctcttcgtcc agatcatcct gatcgacaag accggcttcc
     3721 atccgagtac gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc
     3781 ggatcaagcg tatgcagccg ccgcattgca tcagccatga tggatacttt ctcggcagga
     3841 gcaaggtgag atgacaggag atcctgcccc ggcacttcgc ccaatagcag ccagtccctt
     3901 cccgcttcag tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac
     3961 gatagccgcg ctgcctcgtc ctgcagttca ttcagggcac cggacaggtc ggtcttgaca
     4021 aaaagaaccg ggcgcccctg cgctgacagc cggaacacgg cggcatcaga gcagccgatt
     4081 gtctgttgtg cccagtcata gccgaatagc ctctccaccc aagcggccgg agaacctgcg
     4141 tgcaatccat cttgttcaat ggcggatccc atggttgtgg ccatattatc atcgtgtttt
     4201 tcaaaggaaa accacgtccc cgtggttcgg ggggcctaga cgttttttta acctcgacta
     4261 aacacatgta aagcatgtgc accgaggccc cagatcagat cccatacaat ggggtacctt
     4321 ctgggcatcc ttcagcccct tgttgaatac gcttgaggag agccatttga ctctttccac
     4381 aactatccaa ctcacaacgt ggcactgggg ttgtgccgcc tttgcaggtg tatcttatac
     4441 acgtggcttt tggccgcaga ggcacctgtc gccaggtggg gggttccgct gcctgcaaag
     4501 ggtcgctaca gacgttgttt gtcttcaaga agcttccaga ggaactgctt ccttcacgac
     4561 attcaacaga ccttgcattc ctttggcgag aggggaaaga cccctaggaa tgctcgtcaa
     4621 gaagacaggg ccaggtttcc gggccctcac attgccaaaa gacggcaata tggtggaaaa
     4681 taacatatag acaaacgcac accggcctta ttccaagcgg cttcggccag taacgttagg
     4741 ggggggggag ggagaggggc ggatccgcgg ccgctcagtt agcctccccc atctcccggg
     4801 caaacgtgcg cgccaggtcg catatcgtcg gtatggagcc gggggtggtg acgtgggtct
     4861 ggaccatccc ggaggtaagt tgcagcaggg cgtcccggca gccggcgggc gattggtcgt
     4921 aatccaggat aaagacgtgc atggaacgga ggcgtttggc caagacgtcc aaggcccagg
     4981 caaacacgtt atacaggtcg ccgttggggg ccagcaactc gggggcccga aacagggtaa
     5041 ataacgtgtc cccgatatgg ggtcgtgggc ccgcgttgct ctggggctcg gcaccctggg
     5101 gcggcacggc cgtccccgaa agctgtcccc agtcctcccg ccacgacccg ccgcactgca
     5161 gataccgcac cgtattggca agtagcccgt aaacgcggcg aatcgcagcc agcatagcca
     5221 ggtccagccg ctcgccgggg cgctggcgtt tggccaggcg gtcgatgtgt ctgtcctccg
     5281 gaagggcccc aagcacgatg ttggtgccgg gcaaggtcgg cgggatgagg gccacgaacg
     5341 ccagcacggc ctggggggtc atgctgccca taaggtaccg cgcggccggg tagcacagga
     5401 gggcggcgat gggatggcgg tcgaagatga gggtgagggc cgggggcggg gcatgtgagc
     5461 tcccagcctc ccccccgata tgaggagcca gaacggcgtc ggtcacggca taaggcatgc
     5521 ccattgttat ctgggcgctt gtcattacca ccgccgcgtc cccggccgat atctcaccct
     5581 ggtcgaggcg gtgttgtgtg gtgtagatgt tcgcgattgt ctcggaagcc cccagcaccc
     5641 gccagtaagt catcggctcg ggtacgtaga cgatatcgtc gcgcgaaccc agggccacca
     5701 gcagttgcgt ggtggtggtt ttccccatcc cgtggggacc gtctatataa acccgcagta
     5761 gcgtgggcat tttctgctcc gggcggactt ccgtggcttc ttgctgccgg cgagggcgca
     5821 acgccgtacg tcggttgcta tggccgcgag aacgcgcagc ctggtcgaac gcagacgcgt
     5881 gttgatggcc ggggtacgaa gccatattac cctgttatcc ctagaattct ttgccaaaat
     5941 gatgagacag cacaataacc agcacgttgc ccaggagctg taggaaaaag aagaaggcat
     6001 gaacatggtt agcagaggct ctagagccgc cggtcacacg ccagaagccg aaccccgccc
     6061 tgccccgtcc cccccgaagg cagccgtccc cctgcggcag ccccgaggct ggagatggag
     6121 aaggggacgg cggcgcggcg acgcacgaag gccctccccg cccatttcct tcctgccggc
     6181 gccgcaccgc ttcgcccgcg cccgctagag ggggtgcggc ggcgcctccc agatttcggc
     6241 tccgccagat ttgggacaaa ggaagtccct gcgccctctc gcacgattac cataaaaggc
     6301 aatggctgcg gctcgccgcg cctcgacagc cgccggcgct ccggggccgc cgcgcccctc
     6361 ccccgagccc tccccggccc gaggcggccc cgccccgccc ggcaccccca cctgccgcca
     6421 ccccccgccc ggcacggcga gccccgcgcc acgccccgca cggagccccg cacccgaagc
     6481 cgggccgtgc tcagcaactc ggggaggggg gtgcaggggg gggttacagc ccgaccgccg
     6541 cgcccacacc ccctgctcac ccccccacgc acacaccccg cacgcagcct ttgttcccct
     6601 cgcagccccc ccgcaccgcg gggcaccgcc cccggccgcg ctcccctcgc gcacacgcgg
     6661 agcgcacaaa gccccgcgcc gcgcccgcag cgctcacagc cgccgggcag cgcgggccgc
     6721 acgcggcgct ccccacgcac acacacacgc acgcaccccc cgagccgctc ccccccgcac
     6781 aaagggccct cccggagccc tttaaggctt tcacgcagcc acagaaaaga aacgagccgt
     6841 cattaaacca agcgctaatt acagcccgga ggagaagggc cgtcccgccc gctcacctgt
     6901 gggagtaacg cggtcagtca gagccggggc gggcggcgcg aggcggcgcg gagcggggca
     6961 cggggcgaag gcaacgcagc gactcccgcc cgccgcgcgc ttcgcttttt atagggccgc
     7021 cgccgccgcc gcctcgccat aaaaggaaac tttcggagcg cgccgctctg attggctgcc
     7081 gccgcacctc tccgcctcgc cccgccccgc ccctcgcccc gccccgcccc gcctggcgcg
     7141 cgcccccccc ccccccgccc ccatcgctgc acaaaataat taaaaaataa ataaatacaa
     7201 aattgggggt ggggaggggg gggagatggg gagagtgaag cagaacgtgg ggctcacctc
     7261 gacccatggt aatagcgatg actaatacgt agatgtactg ccaagtagga aagtcccata
     7321 aggtcatgta ctgggcataa tgccaggcgg gccatttacc gtcattgacg tcaatagggg
     7381 gcgtacttgg catatgatac acttgatgta ctgccaagtg ggcagtttac cgtaaatagt
     7441 ccacccattg acgtcaatgg aaagtcccta ttggcgttac tatgggaaca tacgtcatta
     7501 ttgacgtcaa tgggcggggg tcgttgggcg gtcagccagg cgggccattt accgtaagtt
     7561 atgtaacgcg gaactccata tatgggctat gaactaatga ccccgtaatt gattactatt
     7621 aataactagc gctgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga
     7681 aaagtgccac ctgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg
     7741 cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct
     7801 tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta
     7861 gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt
     7921 tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg
     7981 ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat
     8041 tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt
     8101 taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc ttacaattta cgccttaaga
     8161 tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt
     8221 gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac
     8281 aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa
     8341 agcaagtaaa acctctacaa atgtggtatg gctgattatg atctagagtc gcggccgcta
     8401 ttacgcacaa gagttccgta gctgttcaag tttgtgtttc aactgttctc gtcgtttccg
     8461 caacaagtcc tcttcagaaa tgagcttttg ctcctctgct tggacggaca ggatgtatgc
     8521 tgtggctttt ttaaggataa ctaccttggg ggccttttca ttgttttcca actccgggat
     8581 ctggtcacgc agggcaaaaa agctccgttt tagctcgttc ctcctctggc gctccaagac
     8641 gttgtgtgtt cgcctcttga cattctcctc ggtgtccgag gacctggggc tggtgcattt
     8701 tcggttgttg ctgatctgtc tcaggactct gacactgtcc aacttgaccc tcttggcagc
     8761 aggatagtcc ttccgagtgg agggaggcgc tgcgtagttg tgctgatgtg tggagacgtg
     8821 gcacctcttg aggaccagtg ggctgtgagg aggtttgctg tggcctccag cagaaggtga
     8881 tccagactct gaccttttgc caggagcctg cctcttttcc acagaaacaa catcgatttc
     8941 ttcctcatct tcttgttcct cctcagagtc gctgctggtg gtgggcggtg tctcctcatg
     9001 gagcaccagg ggctcggggc tgccctgcgg ggaggactcc gtcgaggaga gcagagaatc
     9061 cgaggacgga gagaaggcgc tggagtcttg cgaggcgcag gacttgggcg agctgctgtc
     9121 gttgagaggg taggggaaga ccaccgaggg gtcgatgcac tctgaggcgg cggcgctcag
     9181 atcctgcagg tacaagctgg aggtggagca gacgctgtgg ccgcgggcgg ggttcgggct
     9241 gccgctgtct ttgcgcgcag cctggtagga ggccagcttc tctgagacga gcttggcggc
     9301 ggccgagaag ccgctccaca tacagtcctg gatgatgatg tttttgatga aggtctcgtc
     9361 gtccgggtcg cagatgaaac tctggttcac catgtctcct cccagcagct cggtcaccat
     9421 ctccagctgg tcggccgtgg agaagctccc gccaccgccg tcgttgtctc cccgaaggga
     9481 gaagggtgtg accgcaacgt aggagggcga gcagagcccg gagcggcggc taggggacag
     9541 gggcggggtg ggcagcagct cgaatttctt ccagatatcc tcgctgggcg ccgggggctg
     9601 cagctcgctc tgctgctgct gctggtagaa gttctcctcc tcgtcgcagt agaaatacgg
     9661 ctgcaccgag tcgtagtcga ggtcatagtt cctgttggtg aagctaacgt tgaggggcat
     9721 aggaccgggg ttactttcaa catcgccagc gagtttcaac aaagcgtagt tagtacattg
     9781 cccactaccc atgtgtgaga ggggcagtgt gccgttaatg gccgtgccgg gcaccgggcc
     9841 gctctggtag tgctgggaca tgtgaagtct gctgggggcg gcgggttccg gcacctcggc
     9901 gccggggaga tacatgctga tcatgtcccg gaggtccccg gcctggcagg gcgccctgga
     9961 gtgggaggaa gaggtaacca caggggggct ggagctggcc tcggacttga ccaccgaacc
    10021 catggagcca agagccatgc caggggtgcc ctgctgcgag taggacatgc tgtaggtggg
    10081 cgagccgttc atgtaggtct gcgagctggt catggagttg tactgcaggg cgctcacgtc
    10141 gtagcggtgc atgggctgca tctgcgctgc gccgtgcgca ttgaggcccg ggtgctgcgg
    10201 gtagcccagc tggtcctgca tcatgctgta gctgccgttg ctccagccgt tcatgtgcgc
    10261 gtaactgtcc atgcgctggt tcacgcccgc gcccaggccg gcgcccaccc cgaccccgct
    10321 cgccatgcta ttgccgccgg gggccagcag cccgccgggc agcgtgtact tatccttctt
    10381 catgagcgtc ttggttttcc gccggggccg gtatttataa tccgggtgct ccttcatgtg
    10441 cagcgctcgc agccgcttag cctcgtcgat gaacggccgc ttctccgtct ccgacaaaag
    10501 tttccactcg gcgcccaggc gcttgctgat ctccgagttg tgcatcttgg ggttctcctg
    10561 ggccatcttg cgccgctgcc cgcgggacca caccatgaag gcattcatgg gccgcttgac
    10621 gcggtccggg ctgtttttct ggttgccgcc ggccgccgcc gcggtggagt tgccgccgcc
    10681 gccccccgaa gtttgctgcg ggcccggcgg cttcagctcc gtctccatca tgttgtacat
    10741 ggggccgggg ttctcctcca cgtcgccgca ggtcagcagg ctgcccctgc cctcgccgct
    10801 gccaaaatgc ctcttcatgt gtaaggcgag gtggtccgac ctggaaaatg ctcggtcgca
    10861 tttttggcac tggaacgggc ggtgccccgt gtgtttacgg tagtgcctgg tcagttcatc
    10921 tgagcgggcg aatttccatc cacagccgtc ccagtcacag tggtaaggtt tctcacctgt
    10981 gtgggttcgc aggtgtgcct tgagatggga actctttgtg taggttttgc cgcagcccgc
    11041 gtaatcacaa gtgtgggtgg cggtcctttt ccggggccac gatcgtcttc ccctctttgg
    11101 cttgggctcc tctggcatgc aggaaccggg tggcatgagc tcttggtaat ggagcggcgg
    11161 gacttgcggc tgcatctgat cgggcaggaa ggatgggtaa ttgggccccg ggtggggatg
    11221 gaagccggga ggaagcggca gggcagggtg acagtccctg ctgctcagca cttcctcaag
    11281 acccagggtc ggggtagtcc tgctggggag ctgccgcccc agggggaagt cgtgtgcagc
    11341 cggccggtgg ccattgctga gagggggtcc agcgcccaag tgggtgcacg aagagaccgc
    11401 ctcctgcttg atcttggggc acgtgcgcgg cggcccgccg ttgtagggcg ccaccaccac
    11461 cgggtggctg ccgtcagggc tgcctttgct gacgctgatg accgacgggc tgccgtactc
    11521 gctgccaggg gcgctcagcg acgccttcag cacgaacttg cccatcagcc cgccacctgg
    11581 cggctgcggc tgctgcggcg gaatgtacac cgggtccaat tctggccgca ggagctcggc
    11641 cacgaagccg cccgaggggc tcacgtcgtt gatgtccgcc aggttgaagg gagccgtcgg
    11701 agggggagcg gactccctgc catagaggag gcctccgccc gtgccgcccg gcgccacgcc
    11761 cgggtcgttc ccggcccgga tcggataggt gaagctgcag gtggagggcg cgctggcagg
    11821 gccgctgctc gacggcgacg acgaagagga ggctgacgct gacgaggaca cggtggcggc
    11881 cactgactcc ggaggatggg tcagcgaatt ggagagaata aagtccaggt ccaggagatc
    11941 gttgaactcc tcggtctctc tccgaggtag gggcgccagg ttgctaccgc cgcaagccgc
    12001 accggctccg ccgctctcca ggtctgtggc cacggtcgcc gccgccaggt cataggggcg
    12061 gccgggaagc actgggggaa gtcgcttcat gtgggagagc tcctcccgcc agcggttatt
    12121 cggggcacct gcttgacgca gtgtcttctc ccttcccgcc gggccagacg cgaacgtgga
    12181 gaaagatggg agcagcgcgt cgctgacagc catgggccct gggttggact ccacgtctcc
    12241 cgccaacttg agaaggtcaa aattcaaagt ctgtttcacg ccacttccgt ttgaatgcat
    12301 gggagagccc agagtggtga cggagacagg gggaaaggct tccccctcag ggaaagggac
    12361 cgaggagtac agtgcagtga agtgagggct cccatagcct ggggtaccaa aatggggccc
    12421 tggggccaga ggaaaggaca ctggtccccc tgagaaagga gacccagcag cctcaaaatc
    12481 ctctcgttgt gcatagtcgc tgcttgatcg cttgcccttc tggcgccggt tacagaacca
    12541 cactcggacc acatccttct cgagcccaag ctgctgggcg atgtggctga tctgctgcag
    12601 tgtgggtttc gggcactgca ggaacaaatt ctccaggttg cctctcactc ggttctcgat
    12661 actggttcgc tttctctttc gggcctgcac gagggtttct gctttgcata tctcctgaag
    12721 attttcattg ttgtcagctt cctccaccca cttctgcagc aagggccgca gcttacacat
    12781 gttcttgaag ctaagctgca gagcctcaaa gcggcagatg gtcgtttggc tgaatacctt
    12841 cccaaataga acccccaggg tgagccccac atcggcctgt gtatatccca gggtgatcct
    12901 cttctgcttc aggagcttgg caaattgctc gagttctttc tgcagagctt tgatgtcctg
    12961 ggactcctcc gggttttgct ccagcttctc cttctccagc ttcacggcac caggggtgac
    13021 ggtgcagggc tccggggagg ccccatcgga gttgctctcc accccgactc ctgcttcgcc
    13081 ctcaggctga gaggtctcca agccgccttg gggcactagc cccactccaa cctggggccc
    13141 acagtacgcc atccccccac agaactcata cggcgggggg catgggggaa tcccccacac
    13201 ctcagagcct ggcccaaccc ccggcccgat tcctggccct ccaggagggc cttggaagct
    13261 tagccaggtc cgaggatcaa cccagcccgg ctccggcccc cctggcccat cacctccacc
    13321 acctggaggg ggcgagaagg cgaaatccga agccaggtgt cccgccatgg tggcgctagc
    13381 ttcacgacac ctgaaatgga agaaaaaaac tttgaaccac tgtctgaggc ttgagaatga
    13441 accaagatcc aaactcaaaa agggcaaatt ccaaggagaa ttacatcaag tgccaagctg
    13501 gcctaacttc agtctccacc cactcagtgt ggggaaactc catcgcataa aacccctccc
    13561 cccaacctaa agacgacgta ctccaaaagc tcgagaacta atcgaggtgc ctggacggcg
    13621 cccggtactc cgtggagtca catgaagcga cggctgagga cggaaaggcc cttttccttt
    13681 gtgtgggtga ctcacccgcc cgctctcccg agcgccgcgt cctccatttt gagctccctg
    13741 cagcagggcc gggaagcggc catctttccg ctcacgcaac tggtgccgac cgggccagcc
    13801 ttgccgccca gggcggggcg atacacggcg gcgcgaggcc aggcaccaga gcaggccggc
    13861 cagcttgaga ctacccccgt ccgattctcg gtggccgcgc tcgcaggccc cgcctcgccg
    13921 aacatgtgcg ctgggacgca cgggccccgt cgccgcccgc ggccccaaaa accgaaatac
    13981 cagtgtgcag atcttggccc gcatttacaa gactatcttg ccagaaaaaa agcgtcgcag
    14041 caggtcatca aaaattttaa atggctagag acttatcgaa agcagcgaga caggcgcgaa
    14101 ggtgccacca gattcgcacg cggcggcccc agcgcccagg ccaggcctca actcaagcac
    14161 gaggcgaagg ggctccttaa gcgcaaggcc tcgaactctc ccacccactt ccaacccgaa
    14221 gctcgggatc aagaatcacg tactgcagcc aggtggaagt aattcaaggc acgcaagggc
    14281 cataacccgt aaagaggcca ggcccgcggg aaccacacac ggcacttacc tgtgttctgg
    14341 cggcaaaccc gttgcgaaaa agaacgttca cggcgactac tgcacttata tacggttctc
    14401 ccccaccctc gggaaaaagg cggagccagt acacgacatc actttcccag tttaccccgc
    14461 gccaccttct ctaggcaccg gttcaattgc cgacccctcc ccccaacttc tcggggactg
    14521 tgggcgatgt gcgctctgcc cactgacggg caccggagcc tcacgattaa ttaataggga
    14581 taacagggta atttaaatag atctactagt tattaatagt aatcaattac ggggtcatta
    14641 gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc
    14701 tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg
    14761 ccaataggga ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg
    14821 gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa
    14881 tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac
    14941 atctacgtat tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac
    15001 tctccccatc tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt
    15061 ttgtgcagcg atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg
    15121 aggggcgggg cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc
    15181 gaaagtttcc ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc
    15241 ggcgggcggg agtcgctgcg ttgccttcgc cccgtgcccc gctccgcgcc gcctcgcgcc
    15301 gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt
    15361 ctcctccggg ctgtaattag cgcttggttt aatgacggct cgtttctttt ctgtggctgc
    15421 gtgaaagcct taaagggctc cgggagggcc ctttgtgcgg gggggagcgg ctcggggggt
    15481 gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggcc cgcgctgccc ggcggctgtg
    15541 agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcgt gtgcgcgagg ggagcgcggc
    15601 cgggggcggt gccccgcggt gcgggggggc tgcgagggga acaaaggctg cgtgcggggt
    15661 gtgtgcgtgg gggggtgagc agggggtgtg ggcgcggcgg tcgggctgta acccccccct
    15721 gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtgcggg
    15781 gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg
    15841 ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc ccggagcgcc
    15901 ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg
    15961 gcgcagggac ttcctttgtc ccaaatctgg cggagccgaa atctgggagg cgccgccgca
    16021 ccccctctag cgggcgcggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga
    16081 gggccttcgt gcgtcgccgc gccgccgtcc ccttctccat ctccagcctc ggggctgccg
    16141 cagggggacg gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg
    16201 accggcggct ctagagcctc tgctaaccat gttcatgcct tcttcttttt cctacagctc
    16261 ctgggcaacg tgctggttat tgtgctgtct catcattttg gcaaagaatt cgctagtcga
    16321 cgagcggccg cagctctaaa tactctgaag tccaaagaag ttgtatgttg ggtgggctcc
    16381 cttcaacttt aacatggaag tgctttctgt gactttaaaa gtaagtgctt ccatgtttta
    16441 gtaggagtga atccaattta cttctccaaa atagaacacg ctaacctcat ttgaagggat
    16501 cccctttgct ttaacatggg ggtacctgct gtgtgaaaca aaagtaagtg cttccatgtt
    16561 tcagtggagg tgtctccaag ccagcacacc ttttgttaca aaattttttt gttattgtgt
    16621 tttaaggtta ctaagcttgt tacaggttaa aggattctaa ctttttccaa gactgggctc
    16681 cccaccactt aaacgtggat gtacttgctt tgaaactaaa gaagtaagtg cttccatgtt
    16741 ttggtgatgg taagtcttcc ttttacattt ttattatttt tttagaaaat aactttattg
    16801 tattgaccgc agctcatata tttaagcttt attttgtatt tttacatctg ttaaggggcc
    16861 ccctctactt taacatggag gcacttgctg tgacatgaca aaaataagtg cttccatgtt
    16921 tgagtgtggt ggttcctacc taatcagcaa ttgcgttaac gcccacactg tgtgcagttc
    16981 ttggctacag gccattactg ttgctaatat gcaactctgt tgaatataaa ttggaattgc
    17041 actttagcaa tggtgatgga ttgttaagcc aatgacagaa tttaaaccac agacttactt
    17101 tgatagcact cttaatggta taacttcttc tcccaggcgc gtctagatca taatcagcca
    17161 taccacattg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg
    17221 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac
    17281 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt
    17341 tgtggtttgt ccaaactcat caatgtatct taaagacgtc tttaattaat cgactctaga
    17401 ggatcgatgc cccgccccgg acgaactaaa cctgactacg acatctctgc cccttcttcg
    17461 cggggcagtg catgtaatcc cttcagttgg ttggtacaac ttgccaactg ggccctgttc
    17521 cacatgtgac acgggggggg accaaacaca aaggggttct ctgactgtag ttgacatcct
    17581 tataaatgga tgtgcacatt tgccaacact gagtggcttt catcctggag cagactttgc
    17641 agtctgtgga ctgcaacaca acattgcctt tatgtgtaac tcttggctga agctcttaca
    17701 ccaatgctgg gggacatgta cctcccaggg gcccaggaag actacgggag gctacaccaa
    17761 cgtcaatcag aggggcctgt gtagctaccg ataagcggac cctcaagagg gcattagcaa
    17821 tagtgtttat aaggccccct tgttaaccct aaacgggtag catatgcttc ccgggtagta
    17881 gtatatacta tccagactaa ccctaattca atagcatatg ttacccaacg ggaagcatat
    17941 gctatcgaat tagggttagt aaaagggtcc taaggaacag cgatatctcc caccccatga
    18001 gctgtcacgg ttttatttac atggggtcag gattccacga gggtagtgaa ccattttagt
    18061 cacaagggca gtggctgaag atcaaggagc gggcagtgaa ctctcctgaa tcttcgcctg
    18121 cttcttcatt ctccttcgtt tagctaatag aataactgct gagttgtgaa cagtaaggtg
    18181 tatgtgaggt gctcgaaaac aaggtttcag gtgacgcccc cagaataaaa tttggacggg
    18241 gggttcagtg gtggcattgt gctatgacac caatataacc ctcacaaacc ccttgggcaa
    18301 taaatactag tgtaggaatg aaacattctg aatatcttta acaatagaaa tccatggggt
    18361 ggggacaagc cgtaaagact ggatgtccat ctcacacgaa tttatggcta tgggcaacac
    18421 ataatcctag tgcaatatga tactggggtt attaagatgt gtcccaggca gggaccaaga
    18481 caggtgaacc atgttgttac actctatttg taacaagggg aaagagagtg gacgccgaca
    18541 gcagcggact ccactggttg tctctaacac ccccgaaaat taaacggggc tccacgccaa
    18601 tggggcccat aaacaaagac aagtggccac tctttttttt gaaattgtgg agtgggggca
    18661 cgcgtcagcc cccacacgcc gccctgcggt tttggactgt aaaataaggg tgtaataact
    18721 tggctgattg taaccccgct aaccactgcg gtcaaaccac ttgcccacaa aaccactaat
    18781 ggcaccccgg ggaatacctg cataagtagg tgggcgggcc aagatagggg cgcgattgct
    18841 gcgatctgga ggacaaatta cacacacttg cgcctgagcg ccaagcacag ggttgttggt
    18901 cctcatattc acgaggtcgc tgagagcacg gtgggctaat gttgccatgg gtagcatata
    18961 ctacccaaat atctggatag catatgctat cctaatctat atctgggtag cataggctat
    19021 cctaatctat atctgggtag catatgctat cctaatctat atctgggtag tatatgctat
    19081 cctaatttat atctgggtag cataggctat cctaatctat atctgggtag catatgctat
    19141 cctaatctat atctgggtag tatatgctat cctaatctgt atccgggtag catatgctat
    19201 cctaatagag attagggtag tatatgctat cctaatttat atctgggtag catatactac
    19261 ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata tgctatccta
    19321 atctatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta
    19381 atctatatct gggtagtata tgctatccta atttatatct gggtagcata ggctatccta
    19441 atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta
    19501 atctgtatcc gggtagcata tgctatcctc atgcatatac agtcagcata tgatacccag
    19561 tagtagagtg ggagtgctat cctttgcata tgccgccacc tcccaagggg gcgtgaattt
    19621 tcgctgcttg tccttttcct gctggttgct cccattctta ggtgaattta aggaggccag
    19681 gctaaagccg tcgcatgtct gattgctcac caggtaaatg tcgctaatgt tttccaacgc
    19741 gagaaggtgt tgagcgcgga gctgagtgac gtgacaacat gggtatgccc aattgcccca
    19801 tgttgggagg acgaaaatgg tgacaagaca gatggccaga aatacaccaa cagcacgcat
    19861 gatgtctact ggggatttat tctttagtgc gggggaatac acggctttta atacgattga
    19921 gggcgtctcc taacaagtta catcactcct gcccttcctc accctcatct ccatcacctc
    19981 cttcatctcc gtcatctccg tcatcaccct ccgcggcagc cccttccacc ataggtggaa
    20041 accagggagg caaatctact ccatcgtcaa agctgcacac agtcaccctg atattgcagg
    20101 taggagcggg ctttgtcata acaaggtcct taatcgcatc cttcaaaacc tcagcaaata
    20161 tatgagtttg taaaaagacc atgaaataac agacaatgga ctcccttagc gggccaggtt
    20221 gtgggccggg tccaggggcc attccaaagg ggagacgact caatggtgta agacgacatt
    20281 gtggaatagc aagggcagtt cctcgcctta ggttgtaaag ggaggtctta ctacctccat
    20341 atacgaacac accggcgacc caagttcctt cgtcggtagt cctttctacg tgactcctag
    20401 ccaggagagc tcttaaacct tctgcaatgt tctcaaattt cgggttggaa cctccttgac
    20461 cacgatgctt tccaaaccac cctccttttt tgcgcctgcc tccatcaccc tgaccccggg
    20521 gtccagtgct tgggccttct cctgggtcat ctgcggggcc ctgctctatc gctcccgggg
    20581 gcacgtcagg ctcaccatct gggccacctt cttggtggta ttcaaaataa tcggcttccc
    20641 ctacagggtg gaaaaatggc cttctacctg gagggggcct gcgcggtgga gacccggatg
    20701 atgatgactg actactggga ctcctgggcc tcttttctcc acgtccacga cctctccccc
    20761 tggctctttc acgacttccc cccctggctc tttcacgtcc tctaccccgg cggcctccac
    20821 tacctcctcg accccggcct ccactacctc ctcgaccccg gcctccactg cctcctcgac
    20881 cccggcctcc acctcctgct cctgcccctc ctgctcctgc ccctcctcct gctcctgccc
    20941 ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct cctgcccctc
    21001 ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct cctcctgctc
    21061 ctgcccctcc tgcccctcct gctcctgccc ctcctgcccc tcctgctcct gcccctcctg
    21121 cccctcctgc tcctgcccct cctgctcctg cccctcctgc tcctgcccct cctgctcctg
    21181 cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgctcct gcccctcctg
    21241 cccctcctgc ccctcctgct cctgcccctc ctcctgctcc tgcccctcct gcccctcctg
    21301 cccctcctcc tgctcctgcc cctcctgccc ctcctcctgc tcctgcccct cctcctgctc
    21361 ctgcccctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg
    21421 ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgcccctcct cctgctcctg
    21481 cccctcctcc tgctcctgcc cctcctgccc ctcctgcccc tcctgcccct cctcctgctc
    21541 ctgcccctcc tcctgctcct gcccctcctg ctcctgcccc tcccgctcct gctcctgctc
    21601 ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga
    21661 caccatctct atgtcttggc cctgatcctg agccgcccgg ggctcctggt cttccgcctc
    21721 ctcgtcctcg tcctcttccc cgtcctcgtc catggttatc accccctctt ctttgaggtc
    21781 cactgccgcc ggagccttct ggtccagatg tgtctccctt ctctcctagg ccatttccag
    21841 gtcctgtacc tggcccctcg tcagacatga ttcacactaa aagagatcaa tagacatctt
    21901 tattagacga cgctcagtga atacagggag tgcagactcc tgccccctcc aacagccccc
    21961 ccaccctcat ccccttcatg gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc
    22021 tccgaaccat cctcgtcctc atcaccaatt actcgcagcc cggaaaactc ccgctgaaca
    22081 tcctcaagat ttgcgtcctg agcctcaagc caggcctcaa attcctcgtc cccctttttg
    22141 ctggacggta gggatgggga ttctcgggac ccctcctctt cctcttcaag gtcaccagac
    22201 agagatgcta ctggggcaac ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc
    22261 gatgataagc tgtcaaacat gagaattctt gaagacgaaa gggcctcgtg atacgcctat
    22321 ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg
    22381 gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc
    22441 tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta
    22501 ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg
    22561 ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg
    22621 gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac
    22681 gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg
    22741 acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt
    22801 actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg
    22861 ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac
    22921 cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt
    22981 gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgcag
    23041 caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc
    23101 aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc
    23161 ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta
    23221 tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg
    23281 ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga
    23341 ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac
    23401 ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa
    23461 tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat
    23521 cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc
    23581 taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg
    23641 gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc
    23701 acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg
    23761 ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg
    23821 ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa
    23881 cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg
    23941 aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga
    24001 gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct
    24061 gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca
    24121 gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttgaagctgt ccctgatggt
    24181 cgtcatctac ctgcctggac agcatggcct gcaacgcggg catcccgatg ccgccggaag
    24241 cgagaagaat cataatgggg aaggccatcc agcctcgcgt cgcgagcgat taaacgcgcc
    24301 aactagagga tcgagcccca gctggttctt tccgcctcag aagccataga gcccaccgca
    24361 tccccagcat gcctgctatt gtcttcccaa tcctccccct tgctgtcctg ccccacccca
    24421 ccccccagaa tagaatgaca cctactcaga caatgcgatg caatttcctc attttattag
    24481 gaaaggacag tgggagtggc accttccagg gtcaaggaag gcacggggga ggggcaaaca
    24541 acagatggct ggcaactaga aggcacagtc gaggctgatc agcgagctcg tttatcttat
    24601 caattctgtg cctccgggag cagggtaggg ctgtggattt cttcttcttc ctctcgaaag
    24661 taggttggct ttccctgtgc actagggccc tgctgggcct tcagcggaca tgaggctacc
    24721 atatggctga tgctctggca gaagtggcac ttcttgggct ggggtggcag cttgcattcc
    24781 ttggcatgat gatctagacc tccacagttg tagcacctgt ctccttttga tctgcgcttc
    24841 tgcatgctct ttccttttgg ccgcctctca ctcccaatac agaatactcc accaggtccg
    24901 gtgacacgga tggattccag acccttggct gacttcttaa aggtgaactc cactgcctca
    24961 ccctccttca agctccggaa cccttccatg tgcagcttac tctggtgcac aaagacatcc
    25021 actggggggt cgagcgcgac cccggcgcgg gcggtcatgg acaggaagcc gaaccccatg
    25081 cgcacgttga accacttaca gatgcccgca ccgtgcagca gctgaggctc gtccgccgcc
    25141 cgggccgcgt cctccggcgc ctcctcgggc gcctcttctg ccgccttggc gcagccacct
    25201 gcaaactgct ggttggacac ggagcccatg ggccctgggt tggactccac gtctcccgcc
    25261 aacttgagaa ggtcaaaatt caaagtctgt ttcacgccac ttcccacgtc ttcaggttgc
    25321 atgttcatgg agtagtttag gaataaatcc atggtttgtg gagtactaaa atacctagtg
    25381 gtctgctgta ttacattaag gccttcccca gcagcttcca aggcagcctc caagtcactg
    25441 gcaggagaat ttggctggaa ctgcatgcag gactgcagag attcctctcc acagttatag
    25501 aagggactgt tccaggcctg attgttccag gattgggtgc accaggtctg agtgttccag
    25561 gagtggttgc tccaggactg gatgttctgg gtctggttgc tccaggttga attgttccag
    25621 gtctggttgc tccacattgg aaggttccca gtcgggttca ccaggcatcc ctggtggtag
    25681 gaagagtaaa ggctggggta ggtaggtgct gaggccttct gcgtcacacc attgctattc
    25741 ttcggccagt tgtttttctg ccacctctta gatttcattc tctggttctg gaaccaggtc
    25801 ttcacctgtt tgtagctgag gttcaggatg ttggagagtt cttgcatctg ctggaggctg
    25861 aggtatttct gtctctgaaa tctatcattg agtacacaca gctgggtgga agagaacaca
    25921 gttctggtct tctgtttctt gaccgggacc ttgtcttcct tttttgcgac actcttctct
    25981 gcagaagtgg gttgtttgcc tttgggactg gtggaagaat cagggctgtc ctgaataagc
    26041 agatccatgg aggaaggaag aggagagaca gtctccgtgt gaggcatctc agcagaagac
    26101 atttgcaagg atggatagtt ttcttcaggc ccacaaatca caggcatagg tgaagattct
    26161 ttacagtcgg atgcttcaaa gcaaggcaag ctttggggac aagctggatc cacactcatg
    26221 gtggcttaat cgcgaattct ttgccaaaat gatgagacag cacaataacc agcacgttgc
    26281 ccaggagctg taggaaaaag aagaaggcat gaacatggtt agcagaggct ctagagccgc
    26341 cggtcacacg ccagaagccg aaccccgccc tgccccgtcc cccccgaagg cagccgtccc
    26401 cctgcggcag ccccgaggct ggagatggag aaggggacgg cggcgcggcg acgcacgaag
    26461 gccctccccg cccatttcct tcctgccggc gccgcaccgc ttcgcccgcg cccgctagag
    26521 ggggtgcggc ggcgcctccc agatttcggc tccgccagat ttgggacaaa ggaagtccct
    26581 gcgccctctc gcacgattac cataaaaggc aatggctgcg gctcgccgcg cctcgacagc
    26641 cgccggcgct ccggggccgc cgcgcccctc ccccgagccc tccccggccc gaggcggccc
    26701 cgccccgccc ggcaccccca cctgccgcca ccccccgccc ggcacggcga gccccgcgcc
    26761 acgccccgca cggagccccg cacccgaagc cgggccgtgc tcagcaactc ggggaggggg
    26821 gtgcaggggg gggttacagc ccgaccgccg cgcccacacc ccctgctcac ccccccacgc
    26881 acacaccccg cacgcagcct ttgttcccct cgcagccccc ccgcaccgcg gggcaccgcc
    26941 cccggccgcg ctcccctcgc gcacacgcgg agcgcacaaa gccccgcgcc gcgcccgcag
    27001 cgctcacagc cgccgggcag cgcgggccgc acgcggcgct ccccacgcac acacacacgc
    27061 acgcaccccc cgagccgctc ccccccgcac aaagggccct cccggagccc tttaaggctt
    27121 tcacgcagcc acagaaaaga aacgagccgt cattaaacca agcgctaatt acagcccgga
    27181 ggagaagggc cgtcccgccc gctcacctgt gggagtaacg cggtcagtca gagccggggc
    27241 gggcggcgcg aggcggcgcg gagcggggca cggggcgaag gcaacgcagc gactcccgcc
    27301 cgccgcgcgc ttcgcttttt atagggccgc cgccgccgcc gcctcgccat aaaaggaaac
    27361 tttcggagcg cgccgctctg attggctgcc gccgcacctc tccgcctcgc cccgccccgc
    27421 ccctcgcccc gccccgcccc gcctggcgcg cgcccccccc ccccccgccc ccatcgctgc
    27481 acaaaataat taaaaaataa ataaatacaa aattgggggt ggggaggggg gggagatggg
    27541 gagagtgaag cagaacgtgg ggctcacctc gacccatggt aatagcgatg actaatacgt
    27601 agatgtactg ccaagtagga aagtcccata aggtcatgta ctgggcataa tgccaggcgg
    27661 gccatttacc gtcattgacg tcaatagggg gcgtacttgg catatgatac acttgatgta
    27721 ctgccaagtg ggcagtttac cgtaaatagt ccacccattg acgtcaatgg aaagtcccta
    27781 ttggcgttac tatgggaaca tacgtcatta ttgacgtcaa tgggcggggg tcgttgggcg
    27841 gtcagccagg cgggccattt accgtaagtt atgtaacgc
//
